GREMLIN Database
CGEB - Protein CgeB
UniProt: P42090 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 317 (292)
Sequences: 56399 (48618)
Seq/√Len: 2845.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_L209_A4.7751.00
168_T192_V3.4771.00
100_A121_Y3.3511.00
212_V242_I3.1851.00
295_E299_A2.9011.00
170_R194_S2.8551.00
164_H272_K2.8121.00
55_L313_H2.7401.00
147_I155_R2.6411.00
178_K182_K2.3211.00
109_A113_Q2.2171.00
154_N157_Q2.2031.00
144_N170_R2.1671.00
274_K277_F2.1231.00
33_M51_P2.1141.00
160_K184_V2.0571.00
160_K268_M2.0501.00
4_L51_P2.0471.00
170_R192_V2.0421.00
172_I205_Y2.0281.00
257_H260_S2.0261.00
277_F284_E2.0031.00
261_S295_E1.9961.00
281_H284_E1.9821.00
246_E293_Y1.9481.00
277_F281_H1.9381.00
30_T310_K1.8991.00
141_Y144_N1.8801.00
285_R289_A1.8591.00
145_L211_I1.8391.00
154_N217_R1.8211.00
304_E308_K1.8001.00
33_M49_F1.7941.00
164_H269_N1.7641.00
212_V247_A1.7571.00
100_A312_I1.7031.00
263_I274_K1.6941.00
126_P302_F1.6931.00
162_A169_V1.6901.00
106_Q109_A1.6751.00
276_A280_N1.6701.00
28_T307_A1.6631.00
197_V201_Q1.6621.00
109_A122_Y1.6491.00
103_T120_V1.6301.00
148_I202_A1.6241.00
106_Q122_Y1.5931.00
260_S291_A1.5771.00
157_Q217_R1.5741.00
55_L80_W1.5661.00
142_H168_T1.5541.00
158_L169_V1.5521.00
270_D274_K1.5411.00
19_R23_E1.5321.00
284_E287_K1.5211.00
28_T310_K1.5191.00
24_C303_D1.5101.00
162_A167_F1.5081.00
109_A120_V1.5041.00
287_K291_A1.5011.00
79_V98_A1.5011.00
170_R209_A1.4941.00
263_I277_F1.4841.00
24_C27_N1.4791.00
170_R205_Y1.4671.00
198_P201_Q1.4661.00
177_G180_L1.4581.00
172_I194_S1.4571.00
267_G270_D1.4461.00
294_K298_P1.4441.00
24_C306_P1.4421.00
268_M272_K1.4311.00
201_Q204_H1.4301.00
4_L35_A1.4041.00
257_H295_E1.4031.00
203_V245_C1.3871.00
265_Y274_K1.3701.00
165_L276_A1.3681.00
174_K178_K1.3551.00
158_L213_I1.3501.00
163_V188_P1.3391.00
157_Q268_M1.3371.00
164_H268_M1.3261.00
291_A294_K1.3191.00
209_A247_A1.3181.00
155_R171_V1.3001.00
102_L312_I1.2971.00
102_L309_L1.2911.00
103_T109_A1.2881.00
144_N168_T1.2821.00
304_E307_A1.2801.00
207_N245_C1.2781.00
197_V205_Y1.2771.00
235_F240_F1.2741.00
308_K311_A1.2391.00
143_S210_D1.2361.00
26_Q29_H1.2331.00
56_M77_V1.2281.00
270_D273_E1.2271.00
5_Y57_M1.2261.00
184_V188_P1.2241.00
146_L172_I1.2211.00
194_S197_V1.2191.00
262_I265_Y1.2151.00
156_V184_V1.2101.00
131_L203_V1.2081.00
143_S279_I1.2071.00
272_K276_A1.2061.00
5_Y25_F1.2051.00
305_L308_K1.2051.00
172_I197_V1.1971.00
157_Q160_K1.1871.00
151_P171_V1.1851.00
246_E290_A1.1831.00
257_H261_S1.1821.00
170_R208_G1.1681.00
214_N239_T1.1541.00
145_L275_A1.1531.00
45_K49_F1.1471.00
301_T304_E1.1401.00
284_E288_A1.1391.00
132_F245_C1.1331.00
202_A206_Y1.1281.00
215_A271_F1.1261.00
302_F305_L1.1221.00
110_L113_Q1.1191.00
161_E271_F1.1161.00
182_K186_K1.1141.00
174_K196_W1.1091.00
199_P202_A1.1021.00
286_Q290_A1.0931.00
278_Y288_A1.0871.00
138_E141_Y1.0831.00
147_I158_L1.0831.00
258_P274_K1.0791.00
144_N208_G1.0781.00
145_L213_I1.0761.00
157_Q252_D1.0751.00
17_F237_N1.0741.00
206_Y245_C1.0681.00
103_T112_Y1.0621.00
157_Q266_H1.0601.00
203_V207_N1.0591.00
289_A292_N1.0561.00
263_I288_A1.0541.00
156_V160_K1.0521.00
24_C28_T1.0471.00
214_N238_R1.0431.00
5_Y22_E1.0391.00
182_K185_L1.0331.00
239_T251_T1.0241.00
20_W23_E1.0121.00
243_A292_N1.0081.00
22_E26_Q1.0081.00
22_E34_I1.0081.00
247_A289_A1.0061.00
243_A249_Q1.0041.00
282_P285_R1.0031.00
106_Q110_L1.0031.00
288_A291_A1.0001.00
103_T108_A0.9991.00
145_L162_A0.9921.00
273_E277_F0.9911.00
194_S205_Y0.9871.00
104_I125_I0.9861.00
104_I108_A0.9831.00
212_V238_R0.9771.00
217_R266_H0.9741.00
40_A44_M0.9721.00
146_L205_Y0.9631.00
144_N210_D0.9601.00
305_L309_L0.9591.00
65_D68_T0.9541.00
12_G15_S0.9451.00
152_Y176_W0.9371.00
258_P261_S0.9361.00
242_I247_A0.9341.00
179_Y182_K0.9331.00
282_P286_Q0.9321.00
121_Y312_I0.9311.00
290_A294_K0.9311.00
158_L215_A0.9261.00
239_T249_Q0.9241.00
132_F203_V0.9221.00
20_W302_F0.9201.00
148_I206_Y0.9181.00
110_L114_E0.9121.00
111_Y114_E0.9111.00
128_N131_L0.9101.00
68_T71_K0.9081.00
252_D265_Y0.9051.00
147_I171_V0.9041.00
126_P305_L0.9021.00
265_Y271_F0.9011.00
160_K164_H0.8991.00
289_A293_Y0.8981.00
251_T264_S0.8971.00
156_V217_R0.8971.00
125_I237_N0.8941.00
205_Y208_G0.8891.00
256_A262_I0.8881.00
66_W70_L0.8881.00
129_H301_T0.8851.00
184_V187_Q0.8821.00
148_I172_I0.8781.00
161_E272_K0.8771.00
248_F289_A0.8741.00
180_L184_V0.8691.00
179_Y183_K0.8631.00
82_T237_N0.8591.00
286_Q289_A0.8571.00
157_Q271_F0.8551.00
98_A101_I0.8541.00
288_A292_N0.8511.00
167_F279_I0.8501.00
263_I278_Y0.8501.00
243_A295_E0.8381.00
16_Y20_W0.8361.00
243_A261_S0.8311.00
307_A311_A0.8281.00
135_M207_N0.8271.00
204_H208_G0.8251.00
301_T305_L0.8231.00
165_L272_K0.8211.00
263_I284_E0.8181.00
162_A190_I0.8161.00
93_Q97_L0.8151.00
199_P203_V0.8141.00
293_Y296_T0.8071.00
248_F278_Y0.8051.00
191_D195_T0.8011.00
33_M37_K0.7991.00
307_A310_K0.7981.00
140_S143_S0.7971.00
250_L274_K0.7941.00
20_W128_N0.7931.00
211_I278_Y0.7921.00
161_E268_M0.7911.00
26_Q32_Y0.7911.00
258_P263_I0.7901.00
256_A260_S0.7891.00
5_Y32_Y0.7891.00
102_L123_V0.7871.00
68_T72_G0.7861.00
206_Y247_A0.7821.00
107_N110_L0.7811.00
113_Q120_V0.7801.00
168_T190_I0.7801.00
236_N239_T0.7751.00
56_M79_V0.7741.00
123_V312_I0.7741.00
213_I275_A0.7721.00
204_H207_N0.7681.00
261_S292_N0.7661.00
147_I215_A0.7571.00
165_L279_I0.7571.00
107_N111_Y0.7541.00
138_E144_N0.7521.00
28_T303_D0.7511.00
76_P99_D0.7501.00
303_D307_A0.7471.00
180_L183_K0.7461.00
18_D57_M0.7441.00
16_Y199_P0.7441.00
302_F306_P0.7441.00
210_D285_R0.7431.00
17_F82_T0.7391.00
269_N273_E0.7331.00
124_P308_K0.7331.00
139_H142_H0.7301.00
77_V98_A0.7291.00
211_I275_A0.7251.00
7_Q14_Y0.7251.00
161_E164_H0.7231.00
273_E276_A0.7221.00
161_E165_L0.7201.00
39_E43_L0.7181.00
121_Y308_K0.7181.00
309_L313_H0.7171.00
183_K186_K0.7171.00
253_L264_S0.7171.00
160_K163_V0.7141.00
106_Q124_P0.7121.00
281_H285_R0.7091.00
269_N272_K0.7081.00
183_K187_Q0.7071.00
162_A165_L0.7051.00
258_P264_S0.7041.00
235_F300_F0.7031.00
43_L47_E0.7021.00
216_H238_R0.7021.00
108_A111_Y0.7011.00
78_Y102_L0.6991.00
20_W24_C0.6991.00
158_L162_A0.6981.00
258_P262_I0.6981.00
89_D93_Q0.6981.00
57_M82_T0.6971.00
165_L275_A0.6961.00
147_I169_V0.6961.00
250_L265_Y0.6941.00
252_D271_F0.6911.00
295_E300_F0.6901.00
185_L188_P0.6881.00
7_Q18_D0.6881.00
146_L206_Y0.6871.00
113_Q116_G0.6861.00
287_K290_A0.6841.00
22_E32_Y0.6841.00
16_Y19_R0.6831.00
261_S291_A0.6821.00
121_Y124_P0.6801.00
12_G150_Y0.6801.00
55_L309_L0.6781.00
210_D282_P0.6761.00
277_F280_N0.6761.00
111_Y115_L0.6761.00
214_N236_N0.6741.00
250_L278_Y0.6721.00
78_Y100_A0.6701.00
73_K76_P0.6641.00
104_I237_N0.6631.00
26_Q30_T0.6611.00
17_F125_I0.6611.00
197_V202_A0.6581.00
43_L72_G0.6561.00
145_L167_F0.6561.00
240_F300_F0.6541.00
149_G155_R0.6521.00
175_E178_K0.6511.00
157_Q161_E0.6481.00
283_E287_K0.6451.00
84_D87_Y0.6421.00
133_K207_N0.6411.00
163_V187_Q0.6401.00
58_V61_R0.6391.00
128_N132_F0.6381.00
147_I212_V0.6371.00
265_Y270_D0.6341.00
236_N240_F0.6341.00
92_L96_K0.6331.00
139_H144_N0.6331.00
143_S211_I0.6331.00
306_P310_K0.6321.00
89_D92_L0.6281.00
78_Y313_H0.6281.00
299_A304_E0.6261.00
70_L77_V0.6251.00
17_F80_W0.6231.00
9_G15_S0.6221.00
123_V308_K0.6211.00
205_Y209_A0.6201.00
153_P238_R0.6201.00
238_R242_I0.6161.00
159_M185_L0.6161.00
185_L193_V0.6121.00
28_T306_P0.6121.00
148_I212_V0.6111.00
291_A295_E0.6111.00
133_K136_G0.6101.00
212_V249_Q0.6081.00
278_Y285_R0.6081.00
53_F313_H0.6081.00
153_P216_H0.6071.00
76_P79_V0.6071.00
27_N303_D0.6061.00
40_A43_L0.6041.00
44_M48_A0.6041.00
67_L70_L0.6031.00
156_V180_L0.6011.00
113_Q117_Y0.6001.00
213_I271_F0.6001.00
53_F78_Y0.5991.00
123_V309_L0.5971.00
69_W73_K0.5961.00
51_P75_I0.5921.00
46_I51_P0.5911.00
292_N295_E0.5901.00
143_S167_F0.5901.00
256_A264_S0.5871.00
243_A289_A0.5821.00
285_R288_A0.5801.00
146_L212_V0.5771.00
154_N266_H0.5771.00
216_H236_N0.5701.00
242_I249_Q0.5701.00
33_M45_K0.5681.00
4_L33_M0.5661.00
45_K48_A0.5661.00
124_P235_F0.5651.00
240_F296_T0.5641.00
21_A24_C0.5621.00
57_M80_W0.5601.00
21_A309_L0.5571.00
145_L279_I0.5561.00
17_F21_A0.5561.00
290_A293_Y0.5541.00
113_Q119_N0.5531.00
181_P185_L0.5531.00
129_H244_A0.5471.00
131_L199_P0.5471.00
124_P300_F0.5471.00
243_A296_T0.5461.00
20_W237_N0.5451.00
248_F285_R0.5441.00
82_T104_I0.5421.00
103_T122_Y0.5421.00
11_G196_W0.5371.00
93_Q96_K0.5341.00
23_E26_Q0.5331.00
29_H32_Y0.5321.00
211_I250_L0.5301.00
256_A261_S0.5301.00
144_N209_A0.5291.00
146_L170_R0.5281.00
250_L275_A0.5281.00
211_I279_I0.5251.00
283_E286_Q0.5231.00
130_R133_K0.5231.00
246_E289_A0.5211.00
24_C302_F0.5211.00
182_K187_Q0.5201.00
54_T75_I0.5191.00
161_E213_I0.5181.00
14_Y58_V0.5181.00
272_K275_A0.5161.00
23_E27_N0.5141.00
47_E73_K0.5131.00
10_Y19_R0.5111.00
7_Q10_Y0.5111.00
107_N255_A0.5091.00
113_Q118_Q0.5091.00
17_F309_L0.5071.00
215_A252_D0.5041.00
149_G153_P0.5011.00
127_V244_A0.5011.00
166_P190_I0.5011.00
259_F277_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n9wA 1 0.9085 100 0.224 Contact Map
2r60A 1 0.9527 100 0.224 Contact Map
3c48A 2 0.9306 100 0.252 Contact Map
1rzuA 1 0.9432 100 0.253 Contact Map
2qzsA 1 0.9432 100 0.255 Contact Map
3froA 3 0.9495 100 0.256 Contact Map
2x6qA 1 0.9338 100 0.266 Contact Map
3okpA 1 0.9653 100 0.267 Contact Map
2x0dA 2 0.8927 100 0.268 Contact Map
3oy2A 2 0.9495 100 0.274 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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