CGEB - BACSU - GREMLIN Contacts

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CGEB - Protein CgeB

UniProt:	P42090	Sequences: MKVLYIQSGYGGIYSYFDRWAEECFQNTHTEYMIADKPEAESLMKIEAFQPDFTLMMVGDRVPHDWLTWLKGKDIPVYVWLTEDPFYMDISLQVIKLADAILTIEQNAALYYQELGYQNVYYVPIPVNHRLFKKMGTEHSYHSNLLIIGYPYPNRVQLMKEAVHLPFTVRVIGKEWGKYLPKKVLKQPHIDVVSTWVPPEQAVHYYNGADIVINAHRPYHFAFNQNTMRIKNASFNNRTFDIAACEAFQLTDLPAAHPFSSIISYHGMNDFKEKAAFYINHPEERQKAAAANYKETVPAFTFDELPAKLKAIHLALS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	317 (292)
Sequences:	56399 (48618)
Seq/√Len:	2845.2

ECOLI - WCAL GLGA RFAB RFAG WCAI WCAC WBBK
BACSU - CGEB YKVP YQGM YTCC YPJH TUAC EPSD EPSF GLGA COTSA TUAH TAGE
HALSA - Q9HRP8 Q9HQQ0 Q9HSW1 Q9HS45 Q9HSV4 Q9HSV2 Q9HRP9 Q9HQT2
SULSO - Q97V61 Q97UM0 Q97XU2 Q97XT7 Q980C8 Q97VL4 Q7LXI2 Q7LXM9 Q97XT8 Q97V80 Q97UU3 Q97XT1 Q7LXF8 Q97XT6 Q97XT9 Q97XF6 Q97ZD3 Q97XT5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
146_L	209_A	4.775	1.00
168_T	192_V	3.477	1.00
100_A	121_Y	3.351	1.00
212_V	242_I	3.185	1.00
295_E	299_A	2.901	1.00
170_R	194_S	2.855	1.00
164_H	272_K	2.812	1.00
55_L	313_H	2.740	1.00
147_I	155_R	2.641	1.00
178_K	182_K	2.321	1.00
109_A	113_Q	2.217	1.00
154_N	157_Q	2.203	1.00
144_N	170_R	2.167	1.00
274_K	277_F	2.123	1.00
33_M	51_P	2.114	1.00
160_K	184_V	2.057	1.00
160_K	268_M	2.050	1.00
4_L	51_P	2.047	1.00
170_R	192_V	2.042	1.00
172_I	205_Y	2.028	1.00
257_H	260_S	2.026	1.00
277_F	284_E	2.003	1.00
261_S	295_E	1.996	1.00
281_H	284_E	1.982	1.00
246_E	293_Y	1.948	1.00
277_F	281_H	1.938	1.00
30_T	310_K	1.899	1.00
141_Y	144_N	1.880	1.00
285_R	289_A	1.859	1.00
145_L	211_I	1.839	1.00
154_N	217_R	1.821	1.00
304_E	308_K	1.800	1.00
33_M	49_F	1.794	1.00
164_H	269_N	1.764	1.00
212_V	247_A	1.757	1.00
100_A	312_I	1.703	1.00
263_I	274_K	1.694	1.00
126_P	302_F	1.693	1.00
162_A	169_V	1.690	1.00
106_Q	109_A	1.675	1.00
276_A	280_N	1.670	1.00
28_T	307_A	1.663	1.00
197_V	201_Q	1.662	1.00
109_A	122_Y	1.649	1.00
103_T	120_V	1.630	1.00
148_I	202_A	1.624	1.00
106_Q	122_Y	1.593	1.00
260_S	291_A	1.577	1.00
157_Q	217_R	1.574	1.00
55_L	80_W	1.566	1.00
142_H	168_T	1.554	1.00
158_L	169_V	1.552	1.00
270_D	274_K	1.541	1.00
19_R	23_E	1.532	1.00
284_E	287_K	1.521	1.00
28_T	310_K	1.519	1.00
24_C	303_D	1.510	1.00
162_A	167_F	1.508	1.00
109_A	120_V	1.504	1.00
287_K	291_A	1.501	1.00
79_V	98_A	1.501	1.00
170_R	209_A	1.494	1.00
263_I	277_F	1.484	1.00
24_C	27_N	1.479	1.00
170_R	205_Y	1.467	1.00
198_P	201_Q	1.466	1.00
177_G	180_L	1.458	1.00
172_I	194_S	1.457	1.00
267_G	270_D	1.446	1.00
294_K	298_P	1.444	1.00
24_C	306_P	1.442	1.00
268_M	272_K	1.431	1.00
201_Q	204_H	1.430	1.00
4_L	35_A	1.404	1.00
257_H	295_E	1.403	1.00
203_V	245_C	1.387	1.00
265_Y	274_K	1.370	1.00
165_L	276_A	1.368	1.00
174_K	178_K	1.355	1.00
158_L	213_I	1.350	1.00
163_V	188_P	1.339	1.00
157_Q	268_M	1.337	1.00
164_H	268_M	1.326	1.00
291_A	294_K	1.319	1.00
209_A	247_A	1.318	1.00
155_R	171_V	1.300	1.00
102_L	312_I	1.297	1.00
102_L	309_L	1.291	1.00
103_T	109_A	1.288	1.00
144_N	168_T	1.282	1.00
304_E	307_A	1.280	1.00
207_N	245_C	1.278	1.00
197_V	205_Y	1.277	1.00
235_F	240_F	1.274	1.00
308_K	311_A	1.239	1.00
143_S	210_D	1.236	1.00
26_Q	29_H	1.233	1.00
56_M	77_V	1.228	1.00
270_D	273_E	1.227	1.00
5_Y	57_M	1.226	1.00
184_V	188_P	1.224	1.00
146_L	172_I	1.221	1.00
194_S	197_V	1.219	1.00
262_I	265_Y	1.215	1.00
156_V	184_V	1.210	1.00
131_L	203_V	1.208	1.00
143_S	279_I	1.207	1.00
272_K	276_A	1.206	1.00
5_Y	25_F	1.205	1.00
305_L	308_K	1.205	1.00
172_I	197_V	1.197	1.00
157_Q	160_K	1.187	1.00
151_P	171_V	1.185	1.00
246_E	290_A	1.183	1.00
257_H	261_S	1.182	1.00
170_R	208_G	1.168	1.00
214_N	239_T	1.154	1.00
145_L	275_A	1.153	1.00
45_K	49_F	1.147	1.00
301_T	304_E	1.140	1.00
284_E	288_A	1.139	1.00
132_F	245_C	1.133	1.00
202_A	206_Y	1.128	1.00
215_A	271_F	1.126	1.00
302_F	305_L	1.122	1.00
110_L	113_Q	1.119	1.00
161_E	271_F	1.116	1.00
182_K	186_K	1.114	1.00
174_K	196_W	1.109	1.00
199_P	202_A	1.102	1.00
286_Q	290_A	1.093	1.00
278_Y	288_A	1.087	1.00
138_E	141_Y	1.083	1.00
147_I	158_L	1.083	1.00
258_P	274_K	1.079	1.00
144_N	208_G	1.078	1.00
145_L	213_I	1.076	1.00
157_Q	252_D	1.075	1.00
17_F	237_N	1.074	1.00
206_Y	245_C	1.068	1.00
103_T	112_Y	1.062	1.00
157_Q	266_H	1.060	1.00
203_V	207_N	1.059	1.00
289_A	292_N	1.056	1.00
263_I	288_A	1.054	1.00
156_V	160_K	1.052	1.00
24_C	28_T	1.047	1.00
214_N	238_R	1.043	1.00
5_Y	22_E	1.039	1.00
182_K	185_L	1.033	1.00
239_T	251_T	1.024	1.00
20_W	23_E	1.012	1.00
243_A	292_N	1.008	1.00
22_E	26_Q	1.008	1.00
22_E	34_I	1.008	1.00
247_A	289_A	1.006	1.00
243_A	249_Q	1.004	1.00
282_P	285_R	1.003	1.00
106_Q	110_L	1.003	1.00
288_A	291_A	1.000	1.00
103_T	108_A	0.999	1.00
145_L	162_A	0.992	1.00
273_E	277_F	0.991	1.00
194_S	205_Y	0.987	1.00
104_I	125_I	0.986	1.00
104_I	108_A	0.983	1.00
212_V	238_R	0.977	1.00
217_R	266_H	0.974	1.00
40_A	44_M	0.972	1.00
146_L	205_Y	0.963	1.00
144_N	210_D	0.960	1.00
305_L	309_L	0.959	1.00
65_D	68_T	0.954	1.00
12_G	15_S	0.945	1.00
152_Y	176_W	0.937	1.00
258_P	261_S	0.936	1.00
242_I	247_A	0.934	1.00
179_Y	182_K	0.933	1.00
282_P	286_Q	0.932	1.00
121_Y	312_I	0.931	1.00
290_A	294_K	0.931	1.00
158_L	215_A	0.926	1.00
239_T	249_Q	0.924	1.00
132_F	203_V	0.922	1.00
20_W	302_F	0.920	1.00
148_I	206_Y	0.918	1.00
110_L	114_E	0.912	1.00
111_Y	114_E	0.911	1.00
128_N	131_L	0.910	1.00
68_T	71_K	0.908	1.00
252_D	265_Y	0.905	1.00
147_I	171_V	0.904	1.00
126_P	305_L	0.902	1.00
265_Y	271_F	0.901	1.00
160_K	164_H	0.899	1.00
289_A	293_Y	0.898	1.00
251_T	264_S	0.897	1.00
156_V	217_R	0.897	1.00
125_I	237_N	0.894	1.00
205_Y	208_G	0.889	1.00
256_A	262_I	0.888	1.00
66_W	70_L	0.888	1.00
129_H	301_T	0.885	1.00
184_V	187_Q	0.882	1.00
148_I	172_I	0.878	1.00
161_E	272_K	0.877	1.00
248_F	289_A	0.874	1.00
180_L	184_V	0.869	1.00
179_Y	183_K	0.863	1.00
82_T	237_N	0.859	1.00
286_Q	289_A	0.857	1.00
157_Q	271_F	0.855	1.00
98_A	101_I	0.854	1.00
288_A	292_N	0.851	1.00
167_F	279_I	0.850	1.00
263_I	278_Y	0.850	1.00
243_A	295_E	0.838	1.00
16_Y	20_W	0.836	1.00
243_A	261_S	0.831	1.00
307_A	311_A	0.828	1.00
135_M	207_N	0.827	1.00
204_H	208_G	0.825	1.00
301_T	305_L	0.823	1.00
165_L	272_K	0.821	1.00
263_I	284_E	0.818	1.00
162_A	190_I	0.816	1.00
93_Q	97_L	0.815	1.00
199_P	203_V	0.814	1.00
293_Y	296_T	0.807	1.00
248_F	278_Y	0.805	1.00
191_D	195_T	0.801	1.00
33_M	37_K	0.799	1.00
307_A	310_K	0.798	1.00
140_S	143_S	0.797	1.00
250_L	274_K	0.794	1.00
20_W	128_N	0.793	1.00
211_I	278_Y	0.792	1.00
161_E	268_M	0.791	1.00
26_Q	32_Y	0.791	1.00
258_P	263_I	0.790	1.00
256_A	260_S	0.789	1.00
5_Y	32_Y	0.789	1.00
102_L	123_V	0.787	1.00
68_T	72_G	0.786	1.00
206_Y	247_A	0.782	1.00
107_N	110_L	0.781	1.00
113_Q	120_V	0.780	1.00
168_T	190_I	0.780	1.00
236_N	239_T	0.775	1.00
56_M	79_V	0.774	1.00
123_V	312_I	0.774	1.00
213_I	275_A	0.772	1.00
204_H	207_N	0.768	1.00
261_S	292_N	0.766	1.00
147_I	215_A	0.757	1.00
165_L	279_I	0.757	1.00
107_N	111_Y	0.754	1.00
138_E	144_N	0.752	1.00
28_T	303_D	0.751	1.00
76_P	99_D	0.750	1.00
303_D	307_A	0.747	1.00
180_L	183_K	0.746	1.00
18_D	57_M	0.744	1.00
16_Y	199_P	0.744	1.00
302_F	306_P	0.744	1.00
210_D	285_R	0.743	1.00
17_F	82_T	0.739	1.00
269_N	273_E	0.733	1.00
124_P	308_K	0.733	1.00
139_H	142_H	0.730	1.00
77_V	98_A	0.729	1.00
211_I	275_A	0.725	1.00
7_Q	14_Y	0.725	1.00
161_E	164_H	0.723	1.00
273_E	276_A	0.722	1.00
161_E	165_L	0.720	1.00
39_E	43_L	0.718	1.00
121_Y	308_K	0.718	1.00
309_L	313_H	0.717	1.00
183_K	186_K	0.717	1.00
253_L	264_S	0.717	1.00
160_K	163_V	0.714	1.00
106_Q	124_P	0.712	1.00
281_H	285_R	0.709	1.00
269_N	272_K	0.708	1.00
183_K	187_Q	0.707	1.00
162_A	165_L	0.705	1.00
258_P	264_S	0.704	1.00
235_F	300_F	0.703	1.00
43_L	47_E	0.702	1.00
216_H	238_R	0.702	1.00
108_A	111_Y	0.701	1.00
78_Y	102_L	0.699	1.00
20_W	24_C	0.699	1.00
158_L	162_A	0.698	1.00
258_P	262_I	0.698	1.00
89_D	93_Q	0.698	1.00
57_M	82_T	0.697	1.00
165_L	275_A	0.696	1.00
147_I	169_V	0.696	1.00
250_L	265_Y	0.694	1.00
252_D	271_F	0.691	1.00
295_E	300_F	0.690	1.00
185_L	188_P	0.688	1.00
7_Q	18_D	0.688	1.00
146_L	206_Y	0.687	1.00
113_Q	116_G	0.686	1.00
287_K	290_A	0.684	1.00
22_E	32_Y	0.684	1.00
16_Y	19_R	0.683	1.00
261_S	291_A	0.682	1.00
121_Y	124_P	0.680	1.00
12_G	150_Y	0.680	1.00
55_L	309_L	0.678	1.00
210_D	282_P	0.676	1.00
277_F	280_N	0.676	1.00
111_Y	115_L	0.676	1.00
214_N	236_N	0.674	1.00
250_L	278_Y	0.672	1.00
78_Y	100_A	0.670	1.00
73_K	76_P	0.664	1.00
104_I	237_N	0.663	1.00
26_Q	30_T	0.661	1.00
17_F	125_I	0.661	1.00
197_V	202_A	0.658	1.00
43_L	72_G	0.656	1.00
145_L	167_F	0.656	1.00
240_F	300_F	0.654	1.00
149_G	155_R	0.652	1.00
175_E	178_K	0.651	1.00
157_Q	161_E	0.648	1.00
283_E	287_K	0.645	1.00
84_D	87_Y	0.642	1.00
133_K	207_N	0.641	1.00
163_V	187_Q	0.640	1.00
58_V	61_R	0.639	1.00
128_N	132_F	0.638	1.00
147_I	212_V	0.637	1.00
265_Y	270_D	0.634	1.00
236_N	240_F	0.634	1.00
92_L	96_K	0.633	1.00
139_H	144_N	0.633	1.00
143_S	211_I	0.633	1.00
306_P	310_K	0.632	1.00
89_D	92_L	0.628	1.00
78_Y	313_H	0.628	1.00
299_A	304_E	0.626	1.00
70_L	77_V	0.625	1.00
17_F	80_W	0.623	1.00
9_G	15_S	0.622	1.00
123_V	308_K	0.621	1.00
205_Y	209_A	0.620	1.00
153_P	238_R	0.620	1.00
238_R	242_I	0.616	1.00
159_M	185_L	0.616	1.00
185_L	193_V	0.612	1.00
28_T	306_P	0.612	1.00
148_I	212_V	0.611	1.00
291_A	295_E	0.611	1.00
133_K	136_G	0.610	1.00
212_V	249_Q	0.608	1.00
278_Y	285_R	0.608	1.00
53_F	313_H	0.608	1.00
153_P	216_H	0.607	1.00
76_P	79_V	0.607	1.00
27_N	303_D	0.606	1.00
40_A	43_L	0.604	1.00
44_M	48_A	0.604	1.00
67_L	70_L	0.603	1.00
156_V	180_L	0.601	1.00
113_Q	117_Y	0.600	1.00
213_I	271_F	0.600	1.00
53_F	78_Y	0.599	1.00
123_V	309_L	0.597	1.00
69_W	73_K	0.596	1.00
51_P	75_I	0.592	1.00
46_I	51_P	0.591	1.00
292_N	295_E	0.590	1.00
143_S	167_F	0.590	1.00
256_A	264_S	0.587	1.00
243_A	289_A	0.582	1.00
285_R	288_A	0.580	1.00
146_L	212_V	0.577	1.00
154_N	266_H	0.577	1.00
216_H	236_N	0.570	1.00
242_I	249_Q	0.570	1.00
33_M	45_K	0.568	1.00
4_L	33_M	0.566	1.00
45_K	48_A	0.566	1.00
124_P	235_F	0.565	1.00
240_F	296_T	0.564	1.00
21_A	24_C	0.562	1.00
57_M	80_W	0.560	1.00
21_A	309_L	0.557	1.00
145_L	279_I	0.556	1.00
17_F	21_A	0.556	1.00
290_A	293_Y	0.554	1.00
113_Q	119_N	0.553	1.00
181_P	185_L	0.553	1.00
129_H	244_A	0.547	1.00
131_L	199_P	0.547	1.00
124_P	300_F	0.547	1.00
243_A	296_T	0.546	1.00
20_W	237_N	0.545	1.00
248_F	285_R	0.544	1.00
82_T	104_I	0.542	1.00
103_T	122_Y	0.542	1.00
11_G	196_W	0.537	1.00
93_Q	96_K	0.534	1.00
23_E	26_Q	0.533	1.00
29_H	32_Y	0.532	1.00
211_I	250_L	0.530	1.00
256_A	261_S	0.530	1.00
144_N	209_A	0.529	1.00
146_L	170_R	0.528	1.00
250_L	275_A	0.528	1.00
211_I	279_I	0.525	1.00
283_E	286_Q	0.523	1.00
130_R	133_K	0.523	1.00
246_E	289_A	0.521	1.00
24_C	302_F	0.521	1.00
182_K	187_Q	0.520	1.00
54_T	75_I	0.519	1.00
161_E	213_I	0.518	1.00
14_Y	58_V	0.518	1.00
272_K	275_A	0.516	1.00
23_E	27_N	0.514	1.00
47_E	73_K	0.513	1.00
10_Y	19_R	0.511	1.00
7_Q	10_Y	0.511	1.00
107_N	255_A	0.509	1.00
113_Q	118_Q	0.509	1.00
17_F	309_L	0.507	1.00
215_A	252_D	0.504	1.00
149_G	153_P	0.501	1.00
127_V	244_A	0.501	1.00
166_P	190_I	0.501	1.00
259_F	277_F	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4n9wA	1	0.9085	100	0.224	Contact Map
2r60A	1	0.9527	100	0.224	Contact Map
3c48A	2	0.9306	100	0.252	Contact Map
1rzuA	1	0.9432	100	0.253	Contact Map
2qzsA	1	0.9432	100	0.255	Contact Map
3froA	3	0.9495	100	0.256	Contact Map
2x6qA	1	0.9338	100	0.266	Contact Map
3okpA	1	0.9653	100	0.267	Contact Map
2x0dA	2	0.8927	100	0.268	Contact Map
3oy2A	2	0.9495	100	0.274	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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