GREMLIN Database
HUTM - Putative histidine permease
UniProt: P42087 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 475 (427)
Sequences: 24865 (16274)
Seq/√Len: 787.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
140_F346_M4.4371.00
328_R340_N4.3701.00
388_L392_R3.4831.00
57_G251_V3.1871.00
331_K340_N3.0831.00
380_M418_L3.0441.00
237_K241_R3.0251.00
16_K233_A2.8731.00
81_Q322_E2.7311.00
234_N237_K2.7031.00
232_S238_D2.6751.00
320_A330_K2.6651.00
172_G260_I2.6541.00
97_G319_L2.6291.00
21_F245_N2.5811.00
333_T339_L2.5431.00
133_A350_C2.4901.00
328_R331_K2.4781.00
230_G321_N2.3721.00
170_I174_A2.3681.00
17_S245_N2.3451.00
279_A282_A2.3371.00
288_Y292_I2.3371.00
383_A417_A2.2991.00
439_F443_P2.2481.00
69_E390_R2.2451.00
190_M193_N2.1991.00
141_I145_F2.1941.00
317_W321_N2.1801.00
85_T93_G2.1631.00
231_E314_R2.1581.00
343_M347_A2.1501.00
137_A350_C2.1401.00
17_S238_D2.1221.00
17_S21_F2.1151.00
140_F342_L2.0731.00
20_L232_S2.0611.00
148_K152_E2.0391.00
144_A339_L2.0361.00
88_I388_L2.0291.00
241_R245_N2.0161.00
415_I419_L2.0141.00
449_Y453_H2.0111.00
133_A353_L1.9591.00
21_F249_R1.9551.00
132_S353_L1.9521.00
85_T90_P1.9501.00
88_I384_L1.9301.00
412_L416_A1.9271.00
329_F344_I1.9151.00
58_L62_L1.9081.00
101_W345_S1.8981.00
159_S163_V1.8981.00
16_K19_H1.8971.00
323_N327_S1.8941.00
66_C383_A1.8921.00
445_I449_Y1.8891.00
11_L332_V1.8871.00
40_T49_T1.8811.00
266_S269_D1.8631.00
126_S129_W1.8291.00
269_D283_E1.8281.00
279_A283_E1.7931.00
191_L194_F1.7861.00
333_T337_I1.7581.00
244_R248_W1.7541.00
137_A346_M1.7281.00
84_A96_V1.7221.00
143_N306_N1.7171.00
451_I455_K1.7051.00
19_H155_F1.6901.00
234_N238_D1.6871.00
450_L454_F1.6711.00
447_L451_I1.6571.00
52_A211_A1.6571.00
96_V381_S1.6561.00
419_L423_A1.6511.00
24_S246_V1.6491.00
108_V349_S1.6471.00
144_A343_M1.6411.00
112_F305_A1.6311.00
163_V167_L1.6261.00
15_M19_H1.6151.00
136_A349_S1.6141.00
384_L418_L1.5961.00
335_K339_L1.5931.00
388_L391_K1.5831.00
248_W252_I1.5551.00
59_M420_L1.5411.00
89_G92_T1.5271.00
446_I450_L1.5191.00
190_M194_F1.5051.00
119_M131_W1.5001.00
145_F335_K1.4871.00
435_R438_L1.4821.00
58_L416_A1.4571.00
316_M341_A1.4571.00
228_T310_Y1.4551.00
84_A381_S1.4441.00
234_N241_R1.4441.00
340_N344_I1.4411.00
312_S345_S1.4381.00
173_G260_I1.4261.00
317_W332_V1.4231.00
327_S330_K1.4201.00
282_A290_A1.4201.00
64_M247_A1.4161.00
449_Y452_Y1.4141.00
112_F136_A1.4131.00
133_A137_A1.4101.00
77_T230_G1.4041.00
62_L416_A1.4001.00
384_L388_L1.3961.00
56_G215_V1.3951.00
331_K339_L1.3891.00
164_T296_V1.3871.00
327_S331_K1.3841.00
136_A346_M1.3821.00
11_L317_W1.3621.00
189_P192_S1.3521.00
448_C452_Y1.3491.00
12_K336_G1.3391.00
115_S298_L1.3391.00
88_I92_T1.3341.00
313_T342_L1.3301.00
162_I166_I1.3251.00
140_F343_M1.3171.00
189_P193_N1.3161.00
115_S135_F1.3091.00
74_M86_T1.3081.00
19_H151_A1.3071.00
15_M20_L1.3021.00
169_I256_G1.2921.00
87_F385_S1.2891.00
238_D241_R1.2851.00
291_D295_F1.2731.00
63_V383_A1.2711.00
64_M243_I1.2711.00
17_S241_R1.2691.00
235_P240_P1.2591.00
448_C451_I1.2521.00
423_A427_G1.2521.00
252_I256_G1.2511.00
275_S279_A1.2461.00
18_R22_M1.2431.00
65_Q244_R1.2361.00
316_M325_I1.2331.00
400_V403_L1.2331.00
111_E304_V1.2301.00
15_M151_A1.2241.00
28_V250_T1.2231.00
76_V82_K1.2171.00
436_I443_P1.2171.00
35_L114_A1.2051.00
193_N197_H1.2031.00
47_G208_V1.2001.00
139_L305_A1.1981.00
82_K86_T1.1821.00
410_Y414_P1.1781.00
409_L413_M1.1741.00
50_I259_F1.1691.00
273_I279_A1.1661.00
20_L242_S1.1631.00
101_W316_M1.1601.00
172_G264_L1.1581.00
41_L49_T1.1571.00
451_I454_F1.1541.00
168_F172_G1.1471.00
91_S452_Y1.1451.00
176_M179_L1.1441.00
66_C414_P1.1431.00
380_M422_S1.1411.00
130_M134_I1.1411.00
403_L406_R1.1381.00
387_L415_I1.1361.00
233_A238_D1.1341.00
437_A441_G1.1311.00
73_A403_L1.1291.00
67_L80_F1.1211.00
443_P446_I1.1191.00
167_L171_L1.1181.00
193_N196_D1.1181.00
190_M195_T1.1161.00
154_E306_N1.1071.00
399_D403_L1.1071.00
398_G401_K1.1051.00
23_I228_T1.1011.00
14_T233_A1.0971.00
142_C153_T1.0951.00
282_A287_P1.0941.00
436_I439_F1.0931.00
24_S225_I1.0911.00
153_T157_F1.0901.00
76_V86_T1.0801.00
386_Q414_P1.0771.00
84_A92_T1.0771.00
411_P415_I1.0691.00
340_N343_M1.0671.00
444_C448_C1.0601.00
94_F98_I1.0511.00
435_R439_F1.0481.00
332_V336_G1.0441.00
445_I448_C1.0421.00
71_S83_Y1.0421.00
25_L249_R1.0391.00
81_Q318_S1.0391.00
152_E156_W1.0371.00
187_D190_M1.0361.00
173_G177_F1.0351.00
443_P447_L1.0241.00
166_I170_I1.0211.00
422_S426_I1.0211.00
412_L415_I1.0201.00
25_L250_T1.0181.00
116_G131_W1.0161.00
321_N330_K1.0131.00
174_A178_G1.0131.00
134_I138_L1.0101.00
405_F408_P1.0051.00
434_Q438_L1.0041.00
137_A141_I1.0001.00
204_G207_A0.9991.00
44_A47_G0.9981.00
127_S130_M0.9951.00
432_P435_R0.9951.00
147_V310_Y0.9951.00
69_E72_V0.9931.00
229_A239_I0.9931.00
140_F144_A0.9901.00
188_A191_L0.9901.00
73_A401_K0.9831.00
409_L412_L0.9771.00
285_G289_A0.9731.00
438_L441_G0.9731.00
188_A194_F0.9731.00
433_N436_I0.9681.00
418_L422_S0.9681.00
425_C428_L0.9671.00
383_A418_L0.9631.00
401_K404_T0.9631.00
266_S283_E0.9551.00
434_Q437_A0.9441.00
22_M155_F0.9431.00
347_A351_L0.9421.00
220_S375_G0.9411.00
417_A421_C0.9391.00
62_L413_M0.9371.00
380_M421_C0.9351.00
119_M298_L0.9341.00
54_V255_I0.9331.00
144_A337_I0.9321.00
139_L306_N0.9321.00
309_L346_M0.9261.00
161_K300_A0.9241.00
223_E227_V0.9231.00
429_A433_N0.9221.00
50_I262_S0.9201.00
144_A333_T0.9201.00
169_I260_I0.9181.00
157_F303_S0.9181.00
380_M384_L0.9071.00
110_S217_F0.9031.00
433_N437_A0.9031.00
189_P194_F0.9021.00
57_G219_F0.9011.00
434_Q439_F0.8961.00
286_I289_A0.8941.00
78_G82_K0.8931.00
125_D128_V0.8901.00
162_I253_F0.8901.00
29_I32_G0.8861.00
401_K406_R0.8851.00
431_D434_Q0.8821.00
14_T148_K0.8801.00
325_I329_F0.8781.00
245_N249_R0.8781.00
138_L302_L0.8771.00
209_F423_A0.8741.00
98_I325_I0.8701.00
190_M196_D0.8701.00
333_T336_G0.8701.00
116_G132_S0.8681.00
452_Y455_K0.8681.00
85_T322_E0.8621.00
339_L343_M0.8601.00
169_I173_G0.8591.00
408_P412_L0.8541.00
402_D406_R0.8491.00
18_R155_F0.8471.00
329_F340_N0.8471.00
19_H152_E0.8461.00
251_V255_I0.8461.00
391_K411_P0.8461.00
432_P436_I0.8421.00
119_M123_F0.8421.00
287_P291_D0.8411.00
110_S368_V0.8391.00
61_Y65_Q0.8381.00
447_L452_Y0.8361.00
92_T381_S0.8361.00
168_F281_F0.8331.00
441_G445_I0.8331.00
187_D191_L0.8331.00
259_F263_G0.8321.00
89_G453_H0.8321.00
264_L280_V0.8291.00
131_W134_I0.8291.00
423_A426_I0.8281.00
430_F433_N0.8251.00
449_Y455_K0.8231.00
210_I214_S0.8211.00
61_Y244_R0.8191.00
11_L231_E0.8171.00
205_F208_V0.8151.00
70_L386_Q0.8151.00
86_T398_G0.8141.00
126_S130_M0.8141.00
62_L66_C0.8141.00
17_S242_S0.8111.00
421_C424_S0.8111.00
436_I449_Y0.8101.00
152_E155_F0.8081.00
399_D402_D0.8081.00
432_P439_F0.8081.00
346_M350_C0.8071.00
176_M263_G0.8071.00
100_Y104_W0.8051.00
78_G81_Q0.8011.00
11_L314_R0.8001.00
192_S195_T0.8001.00
29_I161_K0.7991.00
54_V58_L0.7981.00
51_L208_V0.7971.00
141_I144_A0.7971.00
431_D435_R0.7921.00
387_L391_K0.7911.00
276_P281_F0.7911.00
113_T367_M0.7901.00
447_L450_L0.7891.00
115_S301_L0.7881.00
139_L309_L0.7871.00
433_N438_L0.7871.00
441_G444_C0.7861.00
442_V446_I0.7851.00
402_D405_F0.7831.00
224_L311_A0.7831.00
281_F284_I0.7791.00
188_A192_S0.7781.00
174_A179_L0.7761.00
447_L453_H0.7721.00
385_S389_F0.7711.00
84_A385_S0.7691.00
145_F149_L0.7671.00
449_Y454_F0.7631.00
72_V404_T0.7631.00
430_F434_Q0.7621.00
29_I34_F0.7591.00
105_V348_V0.7571.00
276_P280_V0.7571.00
136_A353_L0.7511.00
115_S302_L0.7501.00
173_G256_G0.7461.00
220_S379_W0.7441.00
370_I374_A0.7431.00
392_R398_G0.7401.00
414_P421_C0.7391.00
51_L55_I0.7391.00
70_L83_Y0.7391.00
411_P414_P0.7391.00
125_D129_W0.7371.00
446_I449_Y0.7361.00
410_Y413_M0.7351.00
276_P284_I0.7341.00
21_F242_S0.7311.00
107_T371_A0.7311.00
30_G34_F0.7301.00
28_V246_V0.7281.00
63_V421_C0.7251.00
334_S339_L0.7231.00
275_S278_V0.7221.00
424_S428_L0.7221.00
439_F442_V0.7211.00
438_L445_I0.7201.00
169_I257_A0.7161.00
240_P243_I0.7151.00
194_F197_H0.7121.00
14_T147_V0.7111.00
81_Q85_T0.7091.00
234_N240_P0.7081.00
109_G367_M0.7081.00
288_Y291_D0.7071.00
441_G446_I0.7051.00
194_F199_G0.7031.00
26_G158_S0.7021.00
120_Q124_P0.7011.00
116_G119_M0.7001.00
347_A350_C0.6991.00
46_P262_S0.6981.00
88_I91_S0.6971.00
143_N342_L0.6971.00
67_L382_I0.6961.00
400_V404_T0.6961.00
448_C455_K0.6951.00
60_M222_T0.6891.00
328_R344_I0.6881.00
316_M344_I0.6861.00
434_Q441_G0.6851.00
87_F388_L0.6841.00
65_Q413_M0.6831.00
143_N310_Y0.6821.00
133_A354_V0.6821.00
18_R152_E0.6801.00
439_F444_C0.6801.00
144_A335_K0.6801.00
440_C444_C0.6791.00
87_F389_F0.6781.00
338_P341_A0.6781.00
149_L152_E0.6781.00
191_L263_G0.6761.00
174_A177_F0.6741.00
14_T18_R0.6711.00
387_L414_P0.6681.00
33_L257_A0.6681.00
448_C453_H0.6671.00
51_L54_V0.6661.00
119_M135_F0.6661.00
320_A329_F0.6651.00
309_L313_T0.6641.00
151_A155_F0.6621.00
403_L407_T0.6611.00
329_F341_A0.6611.00
176_M260_I0.6601.00
447_L454_F0.6601.00
437_A442_V0.6571.00
407_T410_Y0.6571.00
37_T258_V0.6571.00
103_N375_G0.6521.00
144_A342_L0.6521.00
50_I255_I0.6511.00
417_A420_L0.6501.00
230_G317_W0.6501.00
354_V357_I0.6491.00
99_M378_V0.6491.00
438_L442_V0.6491.00
55_I212_M0.6491.00
313_T341_A0.6471.00
139_L302_L0.6441.00
135_F305_A0.6431.00
77_T317_W0.6421.00
386_Q390_R0.6421.00
438_L443_P0.6421.00
112_F116_G0.6411.00
414_P418_L0.6401.00
36_S368_V0.6401.00
450_L453_H0.6401.00
249_R253_F0.6381.00
151_A306_N0.6381.00
175_A178_G0.6361.00
89_G93_G0.6361.00
47_G200_L0.6341.00
245_N248_W0.6331.00
88_I385_S0.6331.00
314_R317_W0.6331.00
50_I54_V0.6311.00
209_F427_G0.6281.00
49_T258_V0.6281.00
440_C443_P0.6271.00
387_L411_P0.6261.00
249_R252_I0.6261.00
73_A404_T0.6251.00
106_V370_I0.6231.00
53_Y218_A0.6231.00
64_M222_T0.6221.00
121_R294_N0.6211.00
160_V296_V0.6211.00
193_N199_G0.6201.00
73_A399_D0.6201.00
27_G308_G0.6191.00
409_L414_P0.6171.00
18_R21_F0.6161.00
71_S226_G0.6141.00
81_Q97_G0.6141.00
437_A443_P0.6121.00
107_T110_S0.6111.00
226_G243_I0.6101.00
80_F223_E0.6091.00
155_F159_S0.6081.00
43_Q46_P0.6071.00
104_W308_G0.6061.00
27_G307_S0.6031.00
21_F24_S0.6031.00
436_I441_G0.6021.00
260_I263_G0.6011.00
191_L196_D0.6011.00
257_A261_L0.6011.00
140_F309_L0.6011.00
147_V228_T0.6001.00
191_L195_T0.6001.00
70_L87_F0.6001.00
188_A193_N0.5991.00
436_I440_C0.5991.00
39_Y42_H0.5981.00
295_F299_T0.5981.00
81_Q93_G0.5941.00
91_S95_M0.5941.00
235_P238_D0.5941.00
220_S223_E0.5931.00
98_I443_P0.5931.00
39_Y365_V0.5921.00
29_I253_F0.5921.00
69_E405_F0.5901.00
50_I53_Y0.5891.00
137_A140_F0.5891.00
300_A303_S0.5881.00
111_E301_L0.5881.00
111_E114_A0.5881.00
65_Q408_P0.5881.00
136_A350_C0.5871.00
236_Q402_D0.5871.00
446_I452_Y0.5861.00
171_L286_I0.5851.00
445_I452_Y0.5841.00
437_A444_C0.5841.00
416_A419_L0.5831.00
442_V445_I0.5831.00
205_F209_F0.5831.00
129_W133_A0.5831.00
68_G72_V0.5811.00
192_S196_D0.5811.00
227_V311_A0.5791.00
374_A378_V0.5791.00
406_R411_P0.5781.00
25_L158_S0.5771.00
429_A432_P0.5761.00
434_Q443_P0.5761.00
196_D199_G0.5751.00
118_L297_I0.5751.00
121_R124_P0.5741.00
193_N198_G0.5741.00
160_V164_T0.5741.00
69_E408_P0.5711.00
312_S316_M0.5701.00
146_S149_L0.5691.00
138_L142_C0.5691.00
420_L424_S0.5681.00
158_S161_K0.5681.00
236_Q404_T0.5681.00
71_S239_I0.5651.00
432_P438_L0.5641.00
109_G352_S0.5621.00
24_S28_V0.5611.00
27_G224_L0.5601.00
437_A440_C0.5601.00
111_E305_A0.5601.00
256_G260_I0.5601.00
365_V368_V0.5601.00
437_A445_I0.5601.00
277_F281_F0.5591.00
277_F280_V0.5591.00
187_D192_S0.5581.00
231_E338_P0.5581.00
257_A277_F0.5581.00
444_C447_L0.5551.00
398_G402_D0.5541.00
80_F227_V0.5531.00
66_C417_A0.5531.00
232_S239_I0.5521.00
11_L14_T0.5511.00
239_I243_I0.5491.00
79_S226_G0.5461.00
421_C425_C0.5461.00
231_E332_V0.5451.00
433_N439_F0.5441.00
399_D404_T0.5441.00
265_I269_D0.5441.00
435_R441_G0.5431.00
344_I348_V0.5431.00
56_G219_F0.5431.00
400_V405_F0.5431.00
114_A118_L0.5421.00
105_V352_S0.5421.00
400_V406_R0.5421.00
414_P428_L0.5421.00
115_S119_M0.5421.00
188_A195_T0.5411.00
417_A428_L0.5411.00
135_F139_L0.5411.00
30_G254_F0.5401.00
122_W295_F0.5391.00
149_L153_T0.5391.00
23_I26_G0.5371.00
64_M68_G0.5371.00
220_S371_A0.5361.00
273_I276_P0.5361.00
177_F263_G0.5351.00
232_S242_S0.5291.00
96_V378_V0.5281.00
316_M320_A0.5271.00
292_I296_V0.5261.00
414_P417_A0.5261.00
270_A273_I0.5251.00
107_T111_E0.5241.00
261_L277_F0.5221.00
150_F310_Y0.5211.00
105_V345_S0.5211.00
433_N444_C0.5201.00
137_A343_M0.5201.00
52_A55_I0.5201.00
390_R410_Y0.5201.00
433_N449_Y0.5201.00
122_W294_N0.5201.00
254_F258_V0.5191.00
29_I36_S0.5181.00
225_I239_I0.5161.00
419_L422_S0.5161.00
199_G202_P0.5161.00
99_M103_N0.5151.00
281_F286_I0.5151.00
445_I453_H0.5151.00
328_R332_V0.5141.00
46_P50_I0.5131.00
399_D406_R0.5131.00
436_I445_I0.5121.00
40_T44_A0.5121.00
43_Q210_I0.5081.00
154_E303_S0.5071.00
435_R443_P0.5051.00
332_V335_K0.5051.00
34_F161_K0.5041.00
147_V151_A0.5041.00
40_T211_A0.5031.00
70_L73_A0.5031.00
33_L36_S0.5021.00
31_T217_F0.5021.00
135_F302_L0.5011.00
309_L342_L0.5011.00
223_E379_W0.5011.00
120_Q128_V0.5011.00
314_R332_V0.5001.00
189_P195_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.88 100 0.299 Contact Map
3giaA 1 0.8947 100 0.366 Contact Map
4djkA 2 0.8653 100 0.368 Contact Map
3dh4A 3 0.9179 99 0.856 Contact Map
2xq2A 2 0.9221 98.9 0.859 Contact Map
2jlnA 1 0.8842 98.8 0.864 Contact Map
4xp4A 1 0.9179 97.9 0.895 Contact Map
4wgvA 2 0.7663 97.6 0.903 Contact Map
2a65A 2 0.9116 97 0.912 Contact Map
4us3A 1 0.8442 96.3 0.919 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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