GREMLIN Database
PBUX - Xanthine permease
UniProt: P42086 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 438 (393)
Sequences: 4337 (2263)
Seq/√Len: 114.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
169_I192_I5.1231.00
165_T196_I5.0061.00
101_I281_G4.9361.00
145_M163_A4.0811.00
132_I405_G4.0071.00
213_V324_K3.7431.00
170_I189_G3.7371.00
50_F320_G3.6081.00
195_F199_F3.5821.00
106_L236_S3.4671.00
206_D210_D3.2411.00
94_S226_S3.1751.00
173_L188_I3.1331.00
162_L197_A3.0721.00
376_L408_T3.0191.00
95_T226_S2.9461.00
220_F282_I2.8111.00
98_G227_F2.7591.00
205_F208_V2.7521.00
162_L202_K2.6621.00
53_G317_M2.6341.00
165_T192_I2.6241.00
373_S409_A2.6171.00
365_E417_N2.4451.00
211_A324_K2.4091.00
101_I278_L2.3931.00
16_V315_I2.3821.00
167_L343_A2.3361.00
12_G311_V2.3291.00
92_G95_T2.3281.00
250_Y269_G2.3111.00
55_A276_A2.2941.00
102_A232_I2.2781.00
162_L200_M2.2671.00
9_L315_I2.1591.00
69_G263_E2.1341.00
191_L195_F2.1341.00
165_T169_I2.1301.00
8_T311_V2.1221.00
51_M283_F2.1181.00
195_F198_Y2.0861.00
105_I109_L2.0741.00
161_A165_T2.0581.00
108_I271_R2.0461.00
57_L310_V2.0081.00
209_S212_A2.0051.00
57_L313_G1.9951.00
208_V328_F1.9951.00
411_V415_V1.9921.00
169_I173_L1.9861.00
120_F414_I1.9791.00
303_I308_V1.9731.00
108_I278_L1.9681.00
169_I196_I1.9651.00
111_S271_R1.9401.00
158_S202_K1.9171.00
60_V310_V1.9151.00
157_L161_A1.8901.00
30_V84_M1.8511.00
84_M96_V1.8301.00
104_G278_L1.8261.00
110_I243_L1.8261.00
105_I278_L1.8221.00
254_G261_L1.8031.00
194_T331_I1.7921.00
207_N331_I1.7821.00
170_I340_A1.7701.00
206_D209_S1.7381.00
196_I200_M1.7241.00
173_L177_T1.7191.00
50_F317_M1.7111.00
100_I281_G1.7031.00
257_T260_R1.7021.00
135_I349_I1.6961.00
122_P413_N1.6651.00
208_V211_A1.6651.00
199_F202_K1.6581.00
211_A327_A1.6471.00
172_L176_F1.6321.00
144_N334_S1.6281.00
194_T203_V1.6241.00
262_T265_D1.5961.00
180_F184_V1.5761.00
167_L372_C1.5751.00
314_V318_A1.5631.00
265_D268_K1.5461.00
108_I274_G1.5421.00
52_C73_V1.5301.00
373_S408_T1.5221.00
161_A164_F1.5171.00
16_V312_T1.5171.00
228_H231_P1.4811.00
164_F168_S1.4711.00
369_I412_L1.4591.00
62_S69_G1.4311.00
95_T228_H1.4271.00
108_I275_L1.4251.00
177_T181_I1.4251.00
158_S200_M1.4131.00
181_I188_I1.4111.00
124_V370_V1.4111.00
193_G336_V1.4021.00
34_M88_G1.3971.00
259_R265_D1.3931.00
207_N210_D1.3911.00
219_P284_N1.3891.00
395_T399_T1.3891.00
198_Y205_F1.3801.00
57_L60_V1.3721.00
407_F411_V1.3711.00
85_I88_G1.3611.00
219_P282_I1.3561.00
376_L404_A1.3501.00
15_H294_N1.3461.00
146_A154_F1.3351.00
104_G277_V1.3291.00
196_I199_F1.3281.00
101_I225_P1.3091.00
6_G10_S1.3021.00
87_I231_P1.2930.99
56_T73_V1.2900.99
255_D358_R1.2880.99
192_I196_I1.2830.99
81_V85_I1.2750.99
298_V304_K1.2620.99
61_W310_V1.2620.99
19_M23_A1.2530.99
54_V317_M1.2480.99
221_Y284_N1.2480.99
361_F370_V1.2180.99
184_V188_I1.2160.99
177_T182_K1.2140.99
91_Y228_H1.2080.99
253_L298_V1.2030.99
109_L113_F1.2000.99
50_F283_F1.1890.99
324_K327_A1.1880.99
359_I366_N1.1880.99
57_L317_M1.1860.99
168_S172_L1.1830.99
72_V253_L1.1800.99
153_D156_D1.1770.99
372_C408_T1.1720.99
227_F232_I1.1720.99
249_V292_S1.1690.99
60_V309_I1.1650.99
64_R268_K1.1610.99
104_G274_G1.1540.99
75_G291_F1.1290.99
132_I377_G1.1280.99
215_Q323_P1.1250.99
124_V128_S1.1130.98
77_T242_S1.1030.98
101_I282_I1.1000.98
79_T242_S1.0990.98
107_V242_S1.0870.98
245_E289_T1.0860.98
188_I192_I1.0800.98
87_I235_M1.0800.98
142_M379_G1.0800.98
374_V378_L1.0770.98
161_A200_M1.0680.98
229_A232_I1.0600.98
318_A322_F1.0390.98
368_L372_C1.0350.98
394_L398_T1.0320.97
246_S250_Y1.0270.97
74_L290_A1.0270.97
394_L397_L1.0240.97
18_A297_L1.0200.97
250_Y273_E1.0160.97
131_T374_V1.0140.97
249_V295_V1.0130.97
204_Q207_N1.0110.97
103_S239_A1.0030.97
322_F326_A1.0020.97
62_S275_L1.0010.97
83_P238_V0.9910.97
280_G288_Y0.9870.97
13_I315_I0.9860.97
165_T200_M0.9850.97
64_R69_G0.9800.97
3_N305_K0.9710.96
88_G96_V0.9700.96
111_S267_S0.9620.96
54_V58_L0.9550.96
94_S223_G0.9530.96
158_S161_A0.9480.96
151_S156_D0.9480.96
220_F223_G0.9460.96
150_G154_F0.9460.96
384_P398_T0.9430.96
98_G102_A0.9410.96
26_V78_F0.9410.96
73_V312_T0.9390.96
5_F9_L0.9370.96
3_N308_V0.9300.95
307_A310_V0.9300.95
72_V290_A0.9290.95
143_N154_F0.9270.95
198_Y203_V0.9200.95
54_V279_L0.9200.95
220_F225_P0.9170.95
197_A201_G0.9170.95
91_Y95_T0.9150.95
246_S269_G0.9150.95
59_Q70_L0.9140.95
279_L283_F0.9120.95
9_L13_I0.9110.95
156_D159_N0.9020.94
57_L314_V0.9000.94
158_S162_L0.8990.94
172_L415_V0.8990.94
212_A215_Q0.8870.94
138_M375_G0.8830.94
187_L191_L0.8810.94
3_N8_T0.8770.94
178_K182_K0.8730.93
86_A89_S0.8720.93
101_I227_F0.8710.93
150_G153_D0.8680.93
131_T353_I0.8620.93
15_H18_A0.8610.93
99_S103_S0.8590.93
362_A366_N0.8570.93
121_F406_S0.8560.93
325_I328_F0.8550.93
350_A367_L0.8520.93
218_Q221_Y0.8500.93
275_L279_L0.8490.93
349_I374_V0.8480.92
15_H19_M0.8470.92
197_A202_K0.8410.92
51_M279_L0.8410.92
99_S231_P0.8400.92
77_T289_T0.8390.92
53_G313_G0.8380.92
173_L181_I0.8370.92
114_F270_Y0.8330.92
257_T304_K0.8310.92
194_T205_F0.8290.92
230_A234_T0.8290.92
216_M321_L0.8240.91
173_L189_G0.8220.91
130_V249_V0.8210.91
310_V313_G0.8210.91
213_V322_F0.8160.91
98_G225_P0.8150.91
162_L196_I0.8130.91
194_T332_I0.8100.91
9_L311_V0.8080.91
72_V250_Y0.8080.91
197_A200_M0.8070.90
95_T231_P0.8070.90
208_V327_A0.8040.90
141_A166_V0.8030.90
319_F325_I0.8020.90
343_A368_L0.8010.90
107_V274_G0.8000.90
73_V309_I0.7960.90
246_S273_E0.7950.90
159_N335_A0.7950.90
28_L31_G0.7940.90
111_S274_G0.7940.90
51_M285_A0.7930.90
28_L337_L0.7890.89
60_V306_N0.7870.89
136_T402_I0.7870.89
51_M280_G0.7850.89
144_N345_F0.7830.89
22_G345_F0.7800.89
365_E369_I0.7760.89
168_S171_V0.7760.89
22_G293_Q0.7740.89
154_F383_V0.7730.89
11_L15_H0.7730.89
79_T344_M0.7720.88
154_F157_L0.7720.88
208_V324_K0.7720.88
115_G267_S0.7690.88
240_I244_V0.7680.88
58_L62_S0.7660.88
295_V298_V0.7610.88
151_S154_F0.7600.88
195_F318_A0.7600.88
112_F271_R0.7590.88
174_Y300_L0.7540.87
72_V297_L0.7540.87
242_S289_T0.7520.87
26_V76_C0.7520.87
146_A155_G0.7520.87
151_S159_N0.7510.87
86_A90_E0.7450.87
23_A52_C0.7430.86
369_I373_S0.7420.86
21_A27_P0.7420.86
88_G91_Y0.7420.86
81_V240_I0.7410.86
87_I99_S0.7400.86
213_V217_I0.7390.86
141_A163_A0.7390.86
315_I319_F0.7390.86
246_S289_T0.7360.86
301_T315_I0.7340.86
105_I108_I0.7330.86
107_V239_A0.7290.85
82_S85_I0.7290.85
247_T266_L0.7260.85
167_L171_V0.7250.85
151_S155_G0.7250.85
169_I189_G0.7240.85
128_S373_S0.7230.85
229_A233_I0.7230.85
371_A375_G0.7210.85
205_F331_I0.7190.85
208_V331_I0.7190.85
143_N146_A0.7150.84
48_D286_F0.7130.84
206_D211_A0.7130.84
4_G7_K0.7110.84
102_A227_F0.7090.84
277_V288_Y0.7080.84
9_L209_S0.7080.84
16_V319_F0.7080.84
146_A160_L0.7070.84
144_N337_L0.7070.84
76_C80_A0.7060.84
19_M294_N0.7040.83
58_L272_A0.7030.83
380_V404_A0.7020.83
350_A370_V0.7020.83
174_Y368_L0.7010.83
50_F321_L0.7010.83
101_I105_I0.7010.83
91_Y231_P0.6990.83
190_I340_A0.6970.83
310_V314_V0.6960.83
71_P309_I0.6940.83
120_F410_V0.6940.83
47_I51_M0.6940.83
46_S326_A0.6930.82
95_T99_S0.6930.82
77_T80_A0.6900.82
48_D76_C0.6880.82
314_V358_R0.6880.82
183_S417_N0.6860.82
93_V97_Y0.6860.82
130_V133_I0.6840.82
25_V144_N0.6830.82
74_L246_S0.6800.81
94_S97_Y0.6790.81
12_G312_T0.6780.81
186_I297_L0.6770.81
240_I252_A0.6750.81
377_G405_G0.6730.81
253_L290_A0.6730.81
23_A48_D0.6720.80
131_T356_L0.6710.80
376_L380_V0.6710.80
191_L328_F0.6700.80
116_K120_F0.6700.80
48_D52_C0.6690.80
346_G350_A0.6650.80
121_F179_G0.6650.80
107_V243_L0.6650.80
47_I50_F0.6630.80
172_L177_T0.6620.79
369_I417_N0.6620.79
88_G93_V0.6610.79
115_G119_S0.6590.79
23_A26_V0.6580.79
361_F366_N0.6560.79
181_I185_S0.6530.79
211_A323_P0.6520.78
377_G401_G0.6510.78
15_H297_L0.6480.78
173_L192_I0.6480.78
82_S86_A0.6470.78
164_F200_M0.6460.78
160_L164_F0.6440.78
169_I188_I0.6420.77
235_M335_A0.6410.77
84_M100_I0.6400.77
189_G192_I0.6390.77
175_R350_A0.6380.77
372_C412_L0.6380.77
214_V322_F0.6370.77
70_L269_G0.6370.77
19_M73_V0.6360.77
327_A330_T0.6360.77
101_I224_A0.6360.77
278_L282_I0.6360.77
224_A282_I0.6350.77
92_G226_S0.6350.77
25_V28_L0.6340.77
33_A221_Y0.6330.76
245_E273_E0.6320.76
256_L299_Q0.6320.76
361_F367_L0.6310.76
236_S239_A0.6300.76
155_G159_N0.6300.76
253_L295_V0.6290.76
242_S245_E0.6290.76
161_A196_I0.6280.76
170_I343_A0.6250.76
124_V366_N0.6250.76
145_M342_V0.6240.75
327_A331_I0.6240.75
52_C72_V0.6230.75
126_T323_P0.6220.75
401_G405_G0.6200.75
264_I268_K0.6200.75
138_M378_L0.6200.75
162_L335_A0.6150.74
292_S351_Y0.6140.74
200_M325_I0.6130.74
299_Q354_K0.6110.74
175_R348_V0.6080.74
188_I191_L0.6070.73
129_V167_L0.6050.73
169_I172_L0.6050.73
99_S232_I0.6050.73
173_L176_F0.6050.73
190_I337_L0.6030.73
97_Y101_I0.6020.73
165_T203_V0.5990.72
144_N341_M0.5990.72
71_P99_S0.5990.72
25_V29_I0.5980.72
277_V280_G0.5980.72
146_A150_G0.5980.72
375_G378_L0.5970.72
192_I195_F0.5960.72
19_M354_K0.5960.72
12_G130_V0.5960.72
98_G226_S0.5950.72
122_P296_G0.5950.72
116_K263_E0.5950.72
173_L185_S0.5930.72
190_I244_V0.5910.71
249_V290_A0.5910.71
405_G409_A0.5860.71
216_M320_G0.5860.71
346_G367_L0.5850.71
195_F209_S0.5850.71
234_T397_L0.5850.71
116_K121_F0.5840.71
128_S409_A0.5840.71
136_T400_N0.5830.70
249_V351_Y0.5780.70
143_N151_S0.5770.70
71_P257_T0.5730.69
201_G336_V0.5730.69
84_M235_M0.5710.69
87_I96_V0.5710.69
252_A351_Y0.5700.69
239_A277_V0.5690.69
269_G273_E0.5680.68
3_N417_N0.5680.68
131_T170_I0.5680.68
292_S403_V0.5680.68
53_G57_L0.5670.68
250_Y261_L0.5660.68
51_M276_A0.5650.68
131_T349_I0.5640.68
216_M219_P0.5640.68
170_I174_Y0.5620.68
248_G377_G0.5610.67
294_N297_L0.5600.67
261_L265_D0.5600.67
138_M371_A0.5590.67
87_I98_G0.5590.67
170_I173_L0.5590.67
293_Q345_F0.5580.67
57_L61_W0.5580.67
87_I234_T0.5580.67
193_G201_G0.5570.67
30_V190_I0.5570.67
5_F314_V0.5560.67
127_G352_G0.5560.67
258_N304_K0.5560.67
54_V283_F0.5560.67
354_K361_F0.5550.67
351_Y354_K0.5540.67
23_A316_L0.5540.67
59_Q306_N0.5540.67
83_P86_A0.5530.66
23_A76_C0.5520.66
58_L108_I0.5510.66
136_T401_G0.5510.66
192_I199_F0.5500.66
199_F203_V0.5490.66
160_L381_T0.5480.66
370_V374_V0.5480.66
99_S236_S0.5480.66
242_S250_Y0.5470.66
83_P401_G0.5470.66
410_V414_I0.5470.66
13_I146_A0.5470.66
79_T289_T0.5460.65
273_E289_T0.5460.65
159_N162_L0.5460.65
95_T98_G0.5450.65
79_T133_I0.5440.65
80_A277_V0.5430.65
16_V234_T0.5430.65
320_G326_A0.5430.65
74_L277_V0.5430.65
217_I343_A0.5430.65
56_T313_G0.5400.65
140_V144_N0.5400.65
354_K358_R0.5400.65
356_L367_L0.5400.65
50_F302_G0.5390.64
11_L121_F0.5390.64
55_A272_A0.5380.64
216_M240_I0.5370.64
247_T251_F0.5370.64
306_N310_V0.5360.64
359_I367_L0.5360.64
354_K362_A0.5360.64
372_C378_L0.5360.64
222_F225_P0.5350.64
189_G340_A0.5350.64
159_N163_A0.5340.64
337_L340_A0.5320.63
76_C289_T0.5310.63
177_T180_F0.5300.63
360_D366_N0.5300.63
57_L305_K0.5300.63
85_I216_M0.5290.63
170_I353_I0.5280.63
358_R362_A0.5280.63
143_N191_L0.5280.63
356_L359_I0.5260.63
214_V218_Q0.5260.63
27_P31_G0.5230.62
99_S107_V0.5230.62
198_Y415_V0.5220.62
303_I337_L0.5220.62
168_S191_L0.5220.62
369_I414_I0.5190.62
205_F328_F0.5190.62
273_E371_A0.5180.61
77_T280_G0.5180.61
125_V413_N0.5180.61
191_L415_V0.5160.61
144_N163_A0.5160.61
207_N283_F0.5150.61
11_L292_S0.5150.61
299_Q405_G0.5150.61
381_T384_P0.5140.61
49_I83_P0.5140.61
393_A396_L0.5130.61
307_A311_V0.5120.60
406_S409_A0.5120.60
119_S414_I0.5120.60
88_G323_P0.5120.60
106_L110_I0.5110.60
243_L288_Y0.5110.60
138_M342_V0.5110.60
17_L369_I0.5110.60
318_A397_L0.5100.60
246_S290_A0.5100.60
60_V313_G0.5100.60
50_F399_T0.5100.60
74_L250_Y0.5090.60
416_Y419_F0.5090.60
350_A371_A0.5090.60
179_G182_K0.5090.60
194_T198_Y0.5080.60
397_L407_F0.5080.60
155_G378_L0.5080.60
150_G155_G0.5070.60
311_V315_I0.5070.60
69_G85_I0.5060.60
216_M419_F0.5060.60
179_G189_G0.5060.60
133_I291_F0.5050.59
55_A72_V0.5050.59
124_V369_I0.5050.59
376_L381_T0.5040.59
195_F214_V0.5040.59
293_Q347_M0.5030.59
253_L329_T0.5020.59
292_S295_V0.5020.59
53_G301_T0.5010.59
198_Y201_G0.5010.59
110_I113_F0.5000.59
162_L190_I0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qe7A 2 0.895 100 0.403 Contact Map
2cfqA 1 0.895 96.3 0.941 Contact Map
1pw4A 1 0.8881 95.3 0.946 Contact Map
3wdoA 1 0.8904 95 0.946 Contact Map
4pypA 1 0.8973 93 0.951 Contact Map
4ikvA 1 0.9018 92.5 0.952 Contact Map
4j05A 3 0.8607 91.7 0.953 Contact Map
4tphA 2 0.8676 87.5 0.957 Contact Map
4m64A 1 0.8813 85.7 0.958 Contact Map
4ldsA 2 0.879 85.1 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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