GREMLIN Database
XPT - Xanthine phosphoribosyltransferase
UniProt: P42085 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 194 (169)
Sequences: 4697 (2771)
Seq/√Len: 213.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
119_H146_S3.2161.00
90_N111_G2.6831.00
157_S177_R2.6371.00
53_K118_D2.5791.00
94_A138_S2.5361.00
94_A142_Q2.4501.00
160_P163_D2.3821.00
95_S106_Q2.3291.00
10_E20_L2.3161.00
97_Y104_E2.3071.00
52_T118_D2.1931.00
155_E162_R2.1701.00
162_R166_V2.1681.00
40_D71_K2.1551.00
140_V145_A2.1151.00
95_S104_E2.0201.00
9_E89_D1.9651.00
93_T106_Q1.9411.00
133_A152_I1.9291.00
134_H138_S1.9261.00
45_R173_E1.8861.00
36_Q71_K1.8641.00
3_A37_R1.8561.00
7_K34_L1.8011.00
115_S118_D1.7731.00
55_V79_A1.7721.00
43_A71_K1.7601.00
79_A136_L1.7561.00
10_E23_D1.7291.00
92_L143_A1.7251.00
51_I74_V1.7041.00
57_I136_L1.6881.00
134_H164_E1.6821.00
44_S47_A1.6821.00
93_T108_A1.6741.00
50_G119_H1.6581.00
13_V17_D1.5781.00
116_D144_G1.5711.00
7_K31_D1.5461.00
119_H148_A1.5221.00
55_V140_V1.5141.00
49_D171_R1.4971.00
137_V150_I1.4931.00
69_G76_V1.4331.00
92_L111_G1.4231.00
36_Q70_L1.4141.00
35_M66_V1.4041.00
42_F151_G1.3901.00
41_E44_S1.3841.00
46_F151_G1.3751.00
133_A150_I1.3731.00
20_L23_D1.3541.00
46_F121_L1.3371.00
150_I170_Y1.3351.00
53_K77_V1.3091.00
123_I151_G1.2981.00
163_D166_V1.2941.00
33_L73_G1.2941.00
26_L110_S1.2891.00
12_G20_L1.2661.00
141_K170_Y1.2231.00
114_L145_A1.2121.00
89_D110_S1.2111.00
42_F68_T1.1961.00
122_I136_L1.1921.00
43_A68_T1.1771.00
46_F149_G1.1741.00
163_D167_K1.1711.00
56_T76_V1.1631.00
54_I74_V1.1521.00
43_A72_L1.1401.00
126_F154_I1.1371.00
82_H106_Q1.1231.00
51_I121_L1.1221.00
65_A76_V1.1181.00
51_I72_L1.1171.00
23_D158_F1.1151.00
36_Q73_G1.1001.00
40_D70_L1.0861.00
155_E177_R1.0821.00
37_R40_D1.0811.00
50_G74_V1.0631.00
38_I153_V1.0611.00
140_V147_I1.0591.00
82_H105_S1.0561.00
137_V170_Y1.0361.00
36_Q40_D1.0331.00
7_K11_E1.0291.00
8_I176_A1.0231.00
121_L149_G1.0201.00
162_R172_V1.0201.00
46_F51_I1.0181.00
137_V141_K1.0011.00
138_S141_K0.9981.00
45_R149_G0.9971.00
174_S177_R0.9941.00
114_L140_V0.9781.00
85_L102_Q0.9761.00
92_L142_Q0.9721.00
53_K75_P0.9641.00
26_L78_F0.9511.00
141_K146_S0.9501.00
121_L148_A0.9430.99
6_R10_E0.9350.99
55_V136_L0.9280.99
43_A47_A0.9170.99
122_I133_A0.9140.99
41_E45_R0.9070.99
68_T123_I0.9070.99
39_G68_T0.9070.99
3_A6_R0.9030.99
57_I107_I0.9030.99
3_A34_L0.9020.99
147_I170_Y0.9000.99
53_K114_L0.8990.99
117_Q146_S0.8970.99
35_M67_M0.8900.99
97_Y102_Q0.8680.99
64_P153_V0.8580.99
52_T117_Q0.8480.99
28_H38_I0.8480.99
137_V147_I0.8400.99
66_V76_V0.8380.99
55_V109_V0.8290.99
38_I42_F0.8260.99
42_F45_R0.8160.99
63_A78_F0.8160.99
100_T103_T0.8140.99
155_E161_G0.8040.98
39_G67_M0.8010.98
41_E175_L0.7990.98
13_V112_T0.7970.98
138_S142_Q0.7910.98
67_M70_L0.7890.98
122_I137_V0.7890.98
149_G171_R0.7830.98
35_M39_G0.7690.98
37_R41_E0.7640.98
46_F49_D0.7630.98
55_V122_I0.7610.98
82_H103_T0.7560.98
63_A76_V0.7440.97
155_E174_S0.7430.97
122_I150_I0.7420.97
42_F123_I0.7380.97
39_G70_L0.7310.97
157_S160_P0.7260.97
47_A71_K0.7250.97
127_L152_I0.7220.97
120_V140_V0.7160.97
151_G173_E0.7150.97
16_S19_V0.7070.96
91_L108_A0.7030.96
9_E27_N0.7000.96
27_N30_I0.6990.96
41_E173_E0.6970.96
48_K51_I0.6950.96
25_F29_Q0.6940.96
157_S162_R0.6900.96
4_L176_A0.6880.96
92_L109_V0.6860.96
152_I172_V0.6830.96
20_L158_F0.6710.95
96_V135_G0.6690.95
51_I54_I0.6580.95
35_M63_A0.6560.95
82_H108_A0.6560.95
53_K115_S0.6530.94
24_S27_N0.6500.94
111_G142_Q0.6480.94
4_L37_R0.6470.94
55_V114_L0.6430.94
11_E89_D0.6420.94
89_D111_G0.6410.94
11_E110_S0.6390.94
39_G71_K0.6370.94
112_T143_A0.6350.94
52_T74_V0.6340.94
49_D119_H0.6330.93
80_R85_L0.6300.93
63_A66_V0.6290.93
34_L37_R0.6200.93
45_R151_G0.6160.93
90_N112_T0.6160.93
33_L37_R0.6160.93
126_F156_K0.6130.92
149_G173_E0.6120.92
5_K176_A0.6060.92
110_S113_H0.6010.92
51_I149_G0.6000.92
27_N126_F0.6000.92
154_I178_I0.5960.91
16_S105_S0.5950.91
90_N110_S0.5940.91
82_H93_T0.5910.91
35_M64_P0.5910.91
3_A7_K0.5900.91
91_L110_S0.5900.91
131_Q164_E0.5880.91
9_E112_T0.5880.91
167_K170_Y0.5870.91
15_L86_T0.5860.91
32_P70_L0.5860.91
150_I165_L0.5830.90
38_I64_P0.5830.90
42_F153_V0.5800.90
30_I115_S0.5790.90
29_Q64_P0.5780.90
89_D112_T0.5760.90
22_V154_I0.5760.90
53_K120_V0.5750.90
54_I69_G0.5690.89
46_F173_E0.5680.89
31_D34_L0.5660.89
14_V19_V0.5650.89
166_V171_R0.5640.89
46_F54_I0.5610.89
122_I140_V0.5590.88
5_K178_I0.5550.88
3_A41_E0.5540.88
10_E158_F0.5530.88
65_A69_G0.5520.88
54_I121_L0.5520.88
114_L118_D0.5510.88
118_D145_A0.5510.88
141_K150_I0.5500.88
4_L41_E0.5480.87
8_I23_D0.5440.87
80_R105_S0.5430.87
100_T105_S0.5430.87
84_S101_K0.5420.87
152_I174_S0.5370.86
116_D146_S0.5290.86
109_V143_A0.5270.85
8_I28_H0.5260.85
64_P123_I0.5250.85
54_I72_L0.5240.85
118_D146_S0.5220.85
54_I68_T0.5220.85
75_P78_F0.5210.85
83_K103_T0.5190.85
51_I148_A0.5160.84
23_D156_K0.5160.84
127_L161_G0.5130.84
29_Q63_A0.5110.84
18_Q103_T0.5110.84
51_I119_H0.5100.84
3_A31_D0.5060.83
65_A72_L0.5050.83
83_K108_A0.5040.83
131_Q134_H0.5030.83
30_I89_D0.5020.83
120_V145_A0.5020.83
30_I63_A0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m0kA 2 0.8866 100 0.35 Contact Map
4lzaA 2 0.8763 100 0.352 Contact Map
1qb7A 2 0.9794 100 0.427 Contact Map
2dy0A 2 0.9072 100 0.46 Contact Map
1y0bA 2 0.9897 100 0.476 Contact Map
1zn8A 2 0.8866 100 0.487 Contact Map
1g2qA 2 0.866 100 0.494 Contact Map
1l1qA 2 0.9021 100 0.501 Contact Map
1o57A 2 0.9278 100 0.511 Contact Map
3qw4B 4 0.8763 99.9 0.553 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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