GREMLIN Database
HUTI - Imidazolonepropionase
UniProt: P42084 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 421 (341)
Sequences: 28326 (22298)
Seq/√Len: 1207.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
406_M411_I5.0431.00
373_Q378_R4.6811.00
67_C384_I4.3031.00
70_R403_H4.0411.00
404_Q411_I3.7551.00
43_H48_V3.7261.00
73_T385_W3.4481.00
349_T352_E3.4401.00
375_K378_R3.2291.00
75_G144_T3.2051.00
310_R314_D3.0831.00
371_A379_S2.8651.00
49_F376_A2.8171.00
379_S408_N2.7661.00
45_Q379_S2.7311.00
73_T383_V2.6251.00
72_V384_I2.5621.00
318_C363_Y2.5171.00
370_E379_S2.4751.00
63_E414_N2.4711.00
382_L406_M2.3671.00
367_K371_A2.3621.00
46_K370_E2.3381.00
282_K315_E2.2791.00
355_H359_V2.2441.00
42_I382_L2.2381.00
40_V72_V2.2301.00
374_L382_L2.1901.00
46_K379_S2.1531.00
359_V373_Q2.0991.00
352_E355_H2.0561.00
405_V413_V2.0531.00
70_R386_Q2.0481.00
386_Q403_H2.0301.00
45_Q408_N2.0121.00
72_V382_L1.9621.00
411_I414_N1.8651.00
139_L412_V1.8641.00
123_S126_E1.8621.00
41_G62_D1.8601.00
238_K241_E1.8561.00
67_C72_V1.8491.00
59_Y62_D1.8401.00
70_R384_I1.8391.00
260_E264_K1.8251.00
383_V402_V1.7751.00
270_A273_L1.7711.00
35_I38_A1.7451.00
73_T76_L1.7281.00
40_V374_L1.7271.00
237_Q241_E1.6781.00
140_S413_V1.6571.00
261_L265_L1.6541.00
282_K286_E1.6511.00
47_I374_L1.6201.00
320_S364_A1.6111.00
40_V382_L1.6091.00
41_G49_F1.6081.00
39_V53_K1.5981.00
355_H360_N1.5821.00
313_I352_E1.5581.00
360_N363_Y1.5401.00
308_R311_A1.5331.00
278_D311_A1.5311.00
229_V233_R1.5241.00
384_I406_M1.5221.00
312_M317_V1.5021.00
50_A376_A1.4721.00
203_L207_P1.4551.00
71_L387_A1.4371.00
233_R237_Q1.4321.00
359_V363_Y1.4301.00
281_I315_E1.4251.00
404_Q414_N1.4251.00
283_K287_A1.3901.00
164_R168_K1.3901.00
367_K370_E1.3711.00
363_Y373_Q1.3631.00
77_V361_A1.3521.00
228_T231_Q1.3491.00
205_L209_I1.3461.00
79_P320_S1.3381.00
214_L217_F1.3381.00
258_G262_A1.3321.00
369_E378_R1.3311.00
384_I404_Q1.3271.00
407_K412_V1.3191.00
284_L291_A1.3121.00
354_W358_T1.3091.00
388_P391_M1.3071.00
138_M146_A1.3001.00
290_I318_C1.3001.00
257_G261_L1.3001.00
196_D200_D1.2721.00
320_S360_N1.2721.00
230_S233_R1.2641.00
247_K271_D1.2621.00
238_K242_A1.2621.00
258_G261_L1.2611.00
42_I406_M1.2591.00
38_A51_G1.2591.00
180_T183_G1.2551.00
41_G48_V1.2491.00
234_R237_Q1.2481.00
245_G366_G1.2431.00
320_S361_A1.2311.00
290_I364_A1.2311.00
41_G59_Y1.2291.00
38_A52_Q1.2271.00
260_E263_G1.2271.00
39_V51_G1.2211.00
79_P361_A1.2181.00
200_D203_L1.2161.00
197_D201_Q1.2161.00
311_A314_D1.2041.00
359_V378_R1.2011.00
73_T354_W1.1971.00
79_P292_V1.1961.00
279_E282_K1.1931.00
273_L291_A1.1931.00
203_L241_E1.1921.00
278_D308_R1.1851.00
194_D197_D1.1821.00
82_H272_H1.1781.00
256_L260_E1.1761.00
343_A353_I1.1721.00
249_H324_D1.1651.00
261_L264_K1.1601.00
77_V145_T1.1571.00
48_V376_A1.1551.00
145_T371_A1.1541.00
311_A315_E1.1531.00
385_W402_V1.1521.00
201_Q204_S1.1431.00
216_S219_D1.1391.00
263_G287_A1.1371.00
172_S176_D1.1341.00
63_E411_I1.1161.00
61_A64_I1.1111.00
239_A246_L1.1091.00
283_K286_E1.1071.00
207_P211_E1.1071.00
266_K269_S1.1041.00
79_P365_I1.1031.00
67_C70_R1.1011.00
65_I406_M1.0971.00
204_S207_P1.0921.00
336_Q340_S1.0901.00
160_L164_R1.0891.00
47_I382_L1.0871.00
147_E365_I1.0821.00
77_V371_A1.0791.00
240_A268_V1.0781.00
219_D222_T1.0761.00
161_K164_R1.0671.00
155_E158_T1.0671.00
259_A263_G1.0621.00
215_A219_D1.0551.00
336_Q339_M1.0491.00
58_G62_D1.0451.00
132_H136_Q1.0431.00
38_A50_A1.0381.00
370_E378_R1.0361.00
41_G61_A1.0321.00
356_A360_N1.0301.00
149_K247_K1.0171.00
285_A317_V1.0131.00
65_I404_Q1.0121.00
202_M209_I1.0091.00
199_L203_L1.0061.00
277_S280_G1.0041.00
208_E212_Q1.0041.00
339_M353_I1.0021.00
214_L219_D1.0021.00
383_V405_V0.9951.00
77_V365_I0.9921.00
198_F201_Q0.9911.00
344_L347_K0.9911.00
348_M356_A0.9871.00
292_V320_S0.9861.00
198_F202_M0.9851.00
256_L261_L0.9841.00
41_G51_G0.9811.00
197_D200_D0.9771.00
56_E59_Y0.9731.00
357_V361_A0.9671.00
139_L407_K0.9651.00
139_L413_V0.9631.00
180_T184_A0.9631.00
82_H324_D0.9601.00
77_V362_A0.9591.00
207_P210_K0.9581.00
303_K307_A0.9551.00
207_P242_A0.9511.00
154_L157_E0.9471.00
181_F184_A0.9451.00
183_G186_A0.9261.00
294_L297_T0.9251.00
135_L139_L0.9201.00
240_A265_L0.9121.00
204_S208_E0.9111.00
343_A347_K0.9091.00
189_P192_Q0.9081.00
218_A221_F0.9051.00
51_G56_E0.9051.00
78_D323_T0.9031.00
341_I345_H0.8991.00
214_L218_A0.8981.00
39_V56_E0.8941.00
402_V405_V0.8931.00
34_V351_E0.8921.00
193_N197_D0.8891.00
185_H188_P0.8871.00
195_P198_F0.8871.00
285_A315_E0.8801.00
219_D224_T0.8751.00
256_L264_K0.8721.00
80_H324_D0.8661.00
184_A188_P0.8641.00
58_G61_A0.8621.00
219_D225_G0.8591.00
78_D81_T0.8581.00
260_E283_K0.8581.00
276_T312_M0.8571.00
273_L276_T0.8531.00
80_H249_H0.8521.00
196_D199_L0.8471.00
163_L166_A0.8451.00
166_A169_L0.8421.00
83_L134_H0.8421.00
39_V49_F0.8421.00
335_I357_V0.8361.00
263_G267_A0.8351.00
222_T225_G0.8341.00
174_P177_L0.8301.00
335_I339_M0.8281.00
338_I341_I0.8271.00
32_L355_H0.8271.00
213_E219_D0.8271.00
187_I190_E0.8211.00
318_C360_N0.8181.00
233_R265_L0.8151.00
166_A171_E0.8141.00
270_A284_L0.8131.00
183_G188_P0.8131.00
262_A265_L0.8101.00
137_R140_S0.8091.00
173_Q176_D0.8081.00
166_A170_H0.8071.00
82_H249_H0.8051.00
162_Q165_V0.8031.00
221_F224_T0.8021.00
38_A53_K0.7991.00
161_K165_V0.7961.00
334_N340_S0.7951.00
83_L135_L0.7901.00
83_L146_A0.7851.00
139_L405_V0.7851.00
37_D68_S0.7841.00
332_T336_Q0.7841.00
373_Q376_A0.7791.00
124_E164_R0.7771.00
257_G260_E0.7761.00
208_E211_E0.7721.00
145_T381_D0.7721.00
51_G57_A0.7701.00
205_L208_E0.7681.00
81_T138_M0.7671.00
76_L357_V0.7651.00
351_E355_H0.7651.00
40_V50_A0.7641.00
362_A372_G0.7631.00
337_L340_S0.7601.00
250_A270_A0.7601.00
57_A62_D0.7591.00
200_D204_S0.7591.00
136_Q140_S0.7591.00
337_L341_I0.7591.00
340_S344_L0.7561.00
168_K171_E0.7531.00
219_D223_E0.7531.00
259_A262_A0.7531.00
303_K306_Y0.7531.00
70_R404_Q0.7511.00
294_L322_A0.7491.00
290_I320_S0.7491.00
202_M206_L0.7481.00
182_M185_H0.7441.00
386_Q401_H0.7431.00
133_F136_Q0.7421.00
194_D198_F0.7421.00
334_N338_I0.7421.00
321_L356_A0.7401.00
165_V168_K0.7401.00
72_V406_M0.7361.00
186_A190_E0.7331.00
258_G263_G0.7321.00
297_T301_L0.7311.00
381_D408_N0.7281.00
362_A378_R0.7231.00
257_G280_G0.7221.00
34_V37_D0.7211.00
201_Q205_L0.7201.00
188_P191_Y0.7181.00
193_N196_D0.7141.00
188_P192_Q0.7141.00
202_M205_L0.7131.00
220_I223_E0.7111.00
128_L165_V0.7051.00
37_D53_K0.7011.00
284_L289_T0.7011.00
165_V169_L0.6981.00
38_A374_L0.6971.00
294_L298_T0.6951.00
218_A225_G0.6931.00
159_E166_A0.6911.00
128_L132_H0.6911.00
195_P202_M0.6911.00
205_L210_K0.6901.00
404_Q413_V0.6891.00
253_I304_S0.6831.00
206_L209_I0.6821.00
196_D202_M0.6781.00
133_F137_R0.6781.00
162_Q167_K0.6771.00
371_A381_D0.6761.00
53_K57_A0.6741.00
257_G262_A0.6691.00
186_A191_Y0.6691.00
214_L220_I0.6671.00
370_E373_Q0.6671.00
206_L210_K0.6661.00
154_L159_E0.6621.00
145_T367_K0.6591.00
262_A268_V0.6581.00
144_T405_V0.6571.00
170_H174_P0.6561.00
237_Q240_A0.6551.00
185_H190_E0.6531.00
271_D274_V0.6531.00
76_L335_I0.6521.00
371_A378_R0.6521.00
166_A173_Q0.6511.00
221_F225_G0.6511.00
236_L240_A0.6481.00
348_M352_E0.6481.00
124_E128_L0.6471.00
187_I192_Q0.6461.00
236_L246_L0.6441.00
408_N411_I0.6441.00
67_C404_Q0.6421.00
76_L402_V0.6421.00
171_E176_D0.6411.00
229_V264_K0.6401.00
159_E162_Q0.6391.00
256_L259_A0.6371.00
258_G268_V0.6351.00
282_K285_A0.6331.00
183_G187_I0.6291.00
159_E163_L0.6281.00
332_T337_L0.6271.00
171_E174_P0.6261.00
310_R313_I0.6261.00
162_Q166_A0.6251.00
281_I285_A0.6251.00
145_T365_I0.6241.00
128_L168_K0.6231.00
291_A317_V0.6231.00
284_L287_A0.6221.00
194_D202_M0.6221.00
264_K283_K0.6181.00
334_N337_L0.6171.00
235_Y238_K0.6151.00
260_E279_E0.6151.00
167_K170_H0.6141.00
333_E336_Q0.6141.00
310_R352_E0.6121.00
37_D50_A0.6121.00
217_F221_F0.6121.00
67_C382_L0.6081.00
281_I311_A0.6071.00
220_I224_T0.6051.00
181_F185_H0.6051.00
258_G269_S0.6051.00
382_L411_I0.6051.00
144_T381_D0.6041.00
339_M357_V0.6031.00
229_V261_L0.6011.00
65_I411_I0.6001.00
71_L385_W0.5991.00
258_G265_L0.5981.00
184_A187_I0.5971.00
263_G289_T0.5951.00
170_H173_Q0.5931.00
185_H189_P0.5921.00
128_L164_R0.5911.00
76_L143_T0.5901.00
291_A312_M0.5901.00
278_D315_E0.5891.00
41_G57_A0.5871.00
41_G56_E0.5871.00
163_L168_K0.5871.00
262_A267_A0.5871.00
361_A364_A0.5841.00
195_P206_L0.5841.00
181_F188_P0.5841.00
193_N202_M0.5841.00
186_A189_P0.5831.00
167_K171_E0.5831.00
310_R346_L0.5821.00
280_G283_K0.5811.00
217_F220_I0.5791.00
157_E161_K0.5781.00
42_I48_V0.5781.00
217_F222_T0.5781.00
198_F203_L0.5781.00
245_G268_V0.5781.00
160_L165_V0.5781.00
273_L284_L0.5771.00
332_T335_I0.5761.00
398_G401_H0.5751.00
196_D201_Q0.5751.00
47_I378_R0.5751.00
251_D274_V0.5741.00
281_I312_M0.5731.00
332_T338_I0.5721.00
350_A390_Y0.5711.00
319_V356_A0.5681.00
233_R264_K0.5681.00
40_V47_I0.5661.00
284_L317_V0.5651.00
183_G189_P0.5641.00
215_A221_F0.5641.00
49_F59_Y0.5631.00
295_P298_T0.5631.00
184_A189_P0.5631.00
84_V151_G0.5631.00
231_Q234_R0.5621.00
276_T308_R0.5621.00
165_V170_H0.5611.00
218_A224_T0.5611.00
126_E129_Q0.5591.00
261_L267_A0.5591.00
182_M186_A0.5591.00
215_A218_A0.5571.00
212_Q218_A0.5571.00
168_K172_S0.5551.00
193_N198_F0.5541.00
154_L158_T0.5521.00
314_D352_E0.5521.00
37_D52_Q0.5511.00
213_E218_A0.5461.00
147_E271_D0.5441.00
149_K271_D0.5431.00
185_H191_Y0.5421.00
203_L238_K0.5421.00
39_V50_A0.5421.00
216_S222_T0.5411.00
187_I191_Y0.5391.00
294_L301_L0.5371.00
288_G318_C0.5371.00
271_D292_V0.5361.00
216_S221_F0.5351.00
258_G264_K0.5341.00
335_I338_I0.5341.00
313_I348_M0.5341.00
35_I351_E0.5331.00
198_F206_L0.5331.00
169_L172_S0.5331.00
124_E161_K0.5311.00
216_S220_I0.5311.00
198_F205_L0.5301.00
344_L353_I0.5301.00
278_D282_K0.5291.00
382_L404_Q0.5291.00
334_N341_I0.5281.00
49_F58_G0.5281.00
217_F225_G0.5271.00
194_D199_L0.5271.00
239_A244_F0.5261.00
199_L206_L0.5241.00
376_A379_S0.5231.00
50_A374_L0.5231.00
234_R238_K0.5221.00
172_S175_V0.5221.00
212_Q215_A0.5201.00
214_L224_T0.5191.00
215_A220_I0.5191.00
323_T334_N0.5181.00
53_K56_E0.5181.00
76_L354_W0.5171.00
341_I346_L0.5161.00
321_L357_V0.5151.00
212_Q219_D0.5131.00
297_T300_Y0.5131.00
332_T340_S0.5131.00
270_A289_T0.5131.00
285_A288_G0.5131.00
183_G191_Y0.5121.00
233_R261_L0.5121.00
75_G381_D0.5111.00
231_Q235_Y0.5111.00
132_H172_S0.5111.00
159_E167_K0.5101.00
405_V411_I0.5101.00
195_P199_L0.5091.00
269_S364_A0.5041.00
214_L225_G0.5031.00
181_F186_A0.5031.00
160_L163_L0.5021.00
293_L298_T0.5011.00
380_A406_M0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bb0A 2 0.981 100 0.29 Contact Map
2q09A 2 0.9406 100 0.344 Contact Map
3lnpA 2 0.9074 100 0.362 Contact Map
4dzhA 2 0.9169 100 0.372 Contact Map
3ls9A 2 0.9311 100 0.379 Contact Map
3hpaA 2 0.9026 100 0.381 Contact Map
4v1xA 5 0.9287 100 0.389 Contact Map
2pajA 2 0.8504 100 0.389 Contact Map
4f0rA 2 0.9121 100 0.39 Contact Map
2i9uA 2 0.8907 100 0.393 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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