HUTG - BACSU - GREMLIN Contacts

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HUTG - Formimidoylglutamase

UniProt:	P42068	Sequences: MDKYPFLREAGSSFKDRDVTKMSDLIATWDGQDIKGPALIGVPLSKSSISHSGASFAPGTIRQALKHSSAYSAELGEHVVSELLYDLGDIDIHVTDIVKSHHHIFQTMHALLSDHPDWVPLILGGDNSISYSTIKAIAQTKGTTAVIQFDAHHDVRNTEDGGPTNGTPFRRLLDEEIIEGQHLIQLGIREFSNSQAYEAYAKKHNVNIHTMDMIREKGLIPTIKEILPVVQDKTDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIAQQPNVAGIEIVEVDPTLDFRDMTSRAAAHVLLHALKGMKLSPFK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	319 (275)
Sequences:	5225 (3402)
Seq/√Len:	205.2

ECOLI - SPEB
BACSU - HUTG SPEB ARGI
HALSA - HUTG Q9HP79
SULSO - Q97ZX8 Q97VA3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
61_I	123_L	4.002	1.00
109_H	139_Q	3.769	1.00
241_V	267_L	3.671	1.00
105_F	135_K	3.274	1.00
134_I	172_L	3.165	1.00
246_L	301_A	2.945	1.00
105_F	139_Q	2.830	1.00
251_A	298_T	2.628	1.00
59_G	89_D	2.583	1.00
243_M	254_C	2.535	1.00
283_I	309_A	2.414	1.00
41_G	62_R	2.165	1.00
102_H	106_Q	2.102	1.00
246_L	267_L	2.061	1.00
40_I	111_L	2.060	1.00
199_A	203_K	2.037	1.00
38_A	118_W	2.036	1.00
243_M	288_V	2.005	1.00
264_T	301_A	1.972	1.00
207_N	225_E	1.947	1.00
185_Q	188_I	1.928	1.00
59_G	63_Q	1.903	1.00
108_M	133_T	1.896	1.00
239_I	280_V	1.879	1.00
215_R	265_D	1.876	1.00
149_F	245_V	1.873	1.00
219_L	223_I	1.865	1.00
207_N	229_V	1.841	1.00
105_F	136_A	1.836	1.00
42_V	122_I	1.835	1.00
42_V	104_I	1.823	1.00
112_L	136_A	1.823	1.00
99_K	103_H	1.820	1.00
61_I	302_A	1.792	1.00
170_R	174_D	1.792	1.00
149_F	270_A	1.783	1.00
32_Q	114_D	1.774	1.00
131_Y	175_E	1.762	1.00
184_I	207_N	1.740	1.00
108_M	122_I	1.727	1.00
131_Y	135_K	1.707	1.00
123_L	306_L	1.706	1.00
45_S	55_S	1.691	1.00
245_V	262_L	1.684	1.00
217_K	225_E	1.666	1.00
285_I	306_L	1.660	1.00
109_H	113_S	1.656	1.00
121_L	283_I	1.587	1.00
113_S	140_T	1.580	1.00
122_I	133_T	1.576	1.00
188_I	208_I	1.528	1.00
96_D	99_K	1.524	1.00
42_V	100_S	1.514	1.00
221_P	224_K	1.506	1.00
236_F	279_N	1.492	1.00
288_V	302_A	1.482	1.00
105_F	109_H	1.476	1.00
38_A	111_L	1.473	1.00
263_Y	266_E	1.466	1.00
243_M	251_A	1.463	1.00
37_P	310_L	1.459	1.00
250_H	264_T	1.441	1.00
217_K	221_P	1.432	1.00
238_F	282_G	1.431	1.00
288_V	298_T	1.431	1.00
215_R	266_E	1.415	1.00
224_K	228_P	1.413	1.00
143_T	182_H	1.412	1.00
61_I	288_V	1.411	1.00
221_P	225_E	1.400	1.00
145_A	233_K	1.391	1.00
60_T	299_S	1.389	1.00
245_V	267_L	1.388	1.00
36_G	83_L	1.387	1.00
216_E	269_E	1.386	1.00
243_M	285_I	1.383	1.00
272_K	308_H	1.377	1.00
182_H	233_K	1.364	1.00
129_I	286_V	1.346	1.00
200_Y	204_H	1.345	1.00
137_I	144_T	1.337	1.00
227_L	273_Y	1.326	1.00
101_H	128_S	1.324	1.00
224_K	273_Y	1.318	1.00
112_L	137_I	1.318	1.00
40_I	122_I	1.316	1.00
218_G	222_T	1.316	1.00
165_N	256_A	1.309	1.00
147_I	274_I	1.309	1.00
148_Q	185_Q	1.304	1.00
38_A	87_L	1.302	1.00
136_A	140_T	1.271	1.00
239_I	283_I	1.270	1.00
171_R	174_D	1.266	1.00
104_I	122_I	1.254	1.00
165_N	255_P	1.223	1.00
86_D	89_D	1.222	1.00
184_I	229_V	1.214	1.00
56_F	291_T	1.205	1.00
40_I	108_M	1.203	1.00
121_L	306_L	1.198	1.00
157_N	171_R	1.198	1.00
253_G	298_T	1.196	1.00
268_L	308_H	1.194	1.00
107_T	110_A	1.193	1.00
112_L	140_T	1.193	1.00
51_H	292_L	1.191	1.00
210_T	213_M	1.187	1.00
253_G	293_D	1.182	1.00
146_V	169_F	1.168	1.00
60_T	63_Q	1.156	1.00
127_N	240_S	1.148	1.00
62_R	89_D	1.132	1.00
153_H	191_F	1.130	1.00
106_Q	110_A	1.123	1.00
52_S	56_F	1.119	1.00
62_R	88_G	1.117	1.00
170_R	200_Y	1.114	1.00
169_F	185_Q	1.112	1.00
40_I	107_T	1.105	1.00
37_P	119_V	1.099	1.00
109_H	136_A	1.097	1.00
135_K	175_E	1.093	1.00
60_T	64_A	1.091	1.00
133_T	284_E	1.086	1.00
111_L	120_P	1.085	1.00
289_D	292_L	1.083	1.00
114_D	117_D	1.081	1.00
152_H	244_D	1.072	1.00
41_G	86_D	1.068	1.00
62_R	86_D	1.065	1.00
101_H	132_S	1.064	1.00
39_L	123_L	1.062	1.00
223_I	273_Y	1.057	1.00
71_Y	76_G	1.054	1.00
119_V	283_I	1.051	1.00
243_M	302_A	1.050	1.00
155_V	201_A	1.050	1.00
165_N	254_C	1.049	1.00
48_S	54_A	1.047	1.00
236_F	281_A	1.046	1.00
134_I	146_V	1.036	1.00
108_M	120_P	1.035	1.00
41_G	88_G	1.027	1.00
42_V	129_I	1.025	1.00
267_L	305_V	1.023	1.00
41_G	89_D	1.021	1.00
164_T	167_T	1.021	1.00
150_D	154_D	1.020	1.00
109_H	140_T	1.017	1.00
133_T	238_F	1.014	1.00
217_K	222_T	1.004	1.00
262_L	270_A	1.003	1.00
178_I	183_L	1.000	1.00
100_S	104_I	0.990	1.00
52_S	55_S	0.986	1.00
137_I	282_G	0.984	1.00
294_F	297_M	0.982	1.00
143_T	179_E	0.981	1.00
211_M	215_R	0.978	1.00
225_E	229_V	0.974	1.00
213_M	217_K	0.972	1.00
130_S	134_I	0.966	1.00
148_Q	240_S	0.966	1.00
220_I	224_K	0.953	0.99
45_S	53_G	0.947	0.99
54_A	289_D	0.947	0.99
239_I	271_V	0.945	0.99
110_A	113_S	0.945	0.99
157_N	170_R	0.941	0.99
298_T	302_A	0.939	0.99
215_R	269_E	0.935	0.99
273_Y	276_Q	0.930	0.99
99_K	102_H	0.929	0.99
251_A	301_A	0.923	0.99
36_G	118_W	0.920	0.99
153_H	185_Q	0.911	0.99
212_D	272_K	0.910	0.99
179_E	182_H	0.906	0.99
237_I	279_N	0.904	0.99
102_H	105_F	0.902	0.99
218_G	221_P	0.901	0.99
165_N	287_E	0.891	0.99
166_G	256_A	0.891	0.99
226_I	229_V	0.881	0.99
241_V	305_V	0.879	0.99
153_H	208_I	0.875	0.99
189_R	248_Q	0.871	0.99
169_F	183_L	0.871	0.99
153_H	188_I	0.868	0.99
186_L	226_I	0.859	0.99
155_V	173_L	0.859	0.99
189_R	247_D	0.856	0.99
84_L	88_G	0.848	0.99
146_V	178_I	0.845	0.99
200_Y	203_K	0.845	0.99
145_A	230_V	0.837	0.99
145_A	182_H	0.837	0.99
220_I	273_Y	0.834	0.99
45_S	54_A	0.831	0.99
149_F	262_L	0.828	0.98
142_G	236_F	0.825	0.98
144_T	281_A	0.824	0.98
209_H	214_I	0.824	0.98
130_S	168_P	0.824	0.98
228_P	231_Q	0.820	0.98
133_T	282_G	0.819	0.98
127_N	284_E	0.818	0.98
137_I	281_A	0.817	0.98
145_A	184_I	0.815	0.98
108_M	136_A	0.814	0.98
130_S	284_E	0.811	0.98
246_L	264_T	0.810	0.98
127_N	165_N	0.809	0.98
173_L	181_Q	0.808	0.98
127_N	287_E	0.798	0.98
111_L	118_W	0.798	0.98
199_A	202_K	0.797	0.98
230_V	233_K	0.791	0.98
273_Y	277_Q	0.788	0.98
151_A	189_R	0.786	0.98
40_I	120_P	0.786	0.98
270_A	273_Y	0.785	0.98
45_S	51_H	0.784	0.98
227_L	277_Q	0.783	0.98
147_I	230_V	0.783	0.98
183_L	206_V	0.783	0.98
246_L	250_H	0.778	0.98
121_L	310_L	0.778	0.98
262_L	267_L	0.773	0.98
45_S	52_S	0.768	0.98
146_V	172_L	0.764	0.97
157_N	163_P	0.761	0.97
288_V	299_S	0.761	0.97
297_M	301_A	0.760	0.97
80_V	84_L	0.760	0.97
120_P	137_I	0.757	0.97
189_R	258_G	0.757	0.97
141_K	281_A	0.756	0.97
154_D	244_D	0.754	0.97
190_E	258_G	0.752	0.97
225_E	228_P	0.751	0.97
44_L	97_I	0.751	0.97
202_K	208_I	0.749	0.97
264_T	268_L	0.749	0.97
293_D	296_D	0.743	0.97
147_I	186_L	0.743	0.97
254_C	257_I	0.741	0.97
114_D	118_W	0.739	0.97
219_L	269_E	0.737	0.97
201_A	206_V	0.737	0.97
122_I	129_I	0.736	0.97
90_I	103_H	0.732	0.97
106_Q	109_H	0.732	0.97
209_H	229_V	0.732	0.97
92_I	100_S	0.731	0.97
154_D	287_E	0.730	0.97
213_M	216_E	0.729	0.97
78_H	81_S	0.728	0.97
143_T	233_K	0.728	0.97
134_I	144_T	0.727	0.97
173_L	180_G	0.713	0.96
268_L	305_V	0.712	0.96
212_D	269_E	0.712	0.96
186_L	262_L	0.709	0.96
46_K	100_S	0.709	0.96
173_L	183_L	0.702	0.96
90_I	107_T	0.701	0.96
104_I	132_S	0.701	0.96
290_P	293_D	0.700	0.96
158_T	171_R	0.700	0.96
57_A	60_T	0.700	0.96
51_H	257_I	0.700	0.96
144_T	236_F	0.699	0.96
39_L	121_L	0.690	0.95
147_I	184_I	0.682	0.95
214_I	270_A	0.681	0.95
248_Q	251_A	0.680	0.95
250_H	263_Y	0.679	0.95
149_F	239_I	0.675	0.95
64_A	303_A	0.672	0.95
184_I	226_I	0.672	0.95
110_A	114_D	0.670	0.95
47_S	97_I	0.669	0.95
130_S	169_F	0.669	0.95
49_I	165_N	0.668	0.95
222_T	226_I	0.666	0.94
223_I	270_A	0.661	0.94
64_A	299_S	0.658	0.94
226_I	230_V	0.657	0.94
265_D	269_E	0.656	0.94
57_A	290_P	0.656	0.94
47_S	126_D	0.655	0.94
251_A	288_V	0.654	0.94
209_H	225_E	0.654	0.94
32_Q	118_W	0.652	0.94
238_F	284_E	0.652	0.94
35_K	118_W	0.651	0.94
239_I	309_A	0.650	0.94
216_E	220_I	0.648	0.94
220_I	269_E	0.648	0.94
39_L	84_L	0.648	0.94
253_G	288_V	0.646	0.94
72_S	75_L	0.645	0.93
214_I	266_E	0.642	0.93
306_L	309_A	0.642	0.93
63_Q	296_D	0.639	0.93
227_L	230_V	0.637	0.93
237_I	278_P	0.636	0.93
187_G	245_V	0.635	0.93
103_H	107_T	0.635	0.93
64_A	296_D	0.634	0.93
87_L	111_L	0.631	0.93
32_Q	35_K	0.630	0.93
37_P	121_L	0.629	0.93
150_D	244_D	0.629	0.93
57_A	289_D	0.628	0.93
227_L	231_Q	0.627	0.92
133_T	137_I	0.627	0.92
155_V	200_Y	0.624	0.92
285_I	305_V	0.623	0.92
44_L	100_S	0.619	0.92
211_M	262_L	0.618	0.92
43_P	89_D	0.616	0.92
132_S	136_A	0.616	0.92
173_L	206_V	0.614	0.92
42_V	133_T	0.614	0.92
97_I	101_H	0.614	0.92
240_S	286_V	0.612	0.92
148_Q	169_F	0.611	0.92
135_K	172_L	0.611	0.92
117_D	120_P	0.607	0.91
60_T	296_D	0.602	0.91
158_T	161_G	0.600	0.91
57_A	255_P	0.598	0.91
254_C	289_D	0.598	0.91
184_I	209_H	0.596	0.90
231_Q	279_N	0.596	0.90
249_S	264_T	0.595	0.90
146_V	183_L	0.593	0.90
240_S	284_E	0.592	0.90
223_I	226_I	0.591	0.90
60_T	290_P	0.590	0.90
296_D	299_S	0.585	0.90
149_F	186_L	0.584	0.90
87_L	107_T	0.584	0.90
103_H	106_Q	0.583	0.90
209_H	213_M	0.581	0.89
250_H	301_A	0.577	0.89
238_F	281_A	0.573	0.89
252_P	298_T	0.571	0.89
219_L	270_A	0.571	0.89
148_Q	256_A	0.569	0.88
147_I	237_I	0.569	0.88
117_D	140_T	0.569	0.88
46_K	97_I	0.566	0.88
96_D	162_G	0.566	0.88
271_V	312_G	0.565	0.88
308_H	311_K	0.563	0.88
49_I	255_P	0.561	0.88
100_S	103_H	0.560	0.88
156_R	256_A	0.560	0.88
138_A	175_E	0.557	0.87
138_A	144_T	0.554	0.87
145_A	236_F	0.554	0.87
237_I	280_V	0.552	0.87
107_T	111_L	0.549	0.87
153_H	156_R	0.549	0.87
186_L	214_I	0.548	0.86
155_V	204_H	0.548	0.86
274_I	278_P	0.545	0.86
127_N	152_H	0.543	0.86
172_L	178_I	0.541	0.86
167_T	171_R	0.541	0.86
127_N	238_F	0.541	0.86
296_D	300_R	0.541	0.86
143_T	236_F	0.539	0.86
141_K	236_F	0.538	0.85
218_G	266_E	0.536	0.85
97_I	164_T	0.536	0.85
130_S	286_V	0.535	0.85
48_S	52_S	0.532	0.85
275_A	280_V	0.531	0.85
131_Y	171_R	0.531	0.85
269_E	273_Y	0.531	0.85
299_S	303_A	0.529	0.84
42_V	92_I	0.528	0.84
126_D	165_N	0.528	0.84
124_G	129_I	0.527	0.84
149_F	267_L	0.526	0.84
56_F	59_G	0.525	0.84
223_I	227_L	0.524	0.84
60_T	288_V	0.520	0.83
113_S	117_D	0.518	0.83
127_N	286_V	0.517	0.83
153_H	201_A	0.516	0.83
153_H	198_E	0.514	0.83
46_K	49_I	0.509	0.82
130_S	238_F	0.508	0.82
101_H	104_I	0.508	0.82
108_M	132_S	0.507	0.82
59_G	296_D	0.506	0.82
283_I	306_L	0.506	0.82
108_M	112_L	0.506	0.82
260_G	268_L	0.504	0.82
61_I	306_L	0.504	0.82
78_H	82_E	0.503	0.81
70_A	73_A	0.502	0.81
303_A	306_L	0.502	0.81
251_A	254_C	0.502	0.81
89_D	93_H	0.500	0.81
211_M	247_D	0.500	0.81

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3m1rA	5	0.9843	100	0.171	Contact Map
1xfkA	1	0.9467	100	0.174	Contact Map
3niqA	5	0.9655	100	0.189	Contact Map
1gq6A	5	0.931	100	0.193	Contact Map
3nioA	5	0.9467	100	0.196	Contact Map
4mykA	3	0.8871	100	0.206	Contact Map
1wohA	5	0.9342	100	0.212	Contact Map
4dz4A	5	0.953	100	0.221	Contact Map
2cevA	5	0.8433	100	0.225	Contact Map
4g3hA	1	0.8276	100	0.235	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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