GREMLIN Database
HUTG - Formimidoylglutamase
UniProt: P42068 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 319 (275)
Sequences: 5225 (3402)
Seq/√Len: 205.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_I123_L4.0021.00
109_H139_Q3.7691.00
241_V267_L3.6711.00
105_F135_K3.2741.00
134_I172_L3.1651.00
246_L301_A2.9451.00
105_F139_Q2.8301.00
251_A298_T2.6281.00
59_G89_D2.5831.00
243_M254_C2.5351.00
283_I309_A2.4141.00
41_G62_R2.1651.00
102_H106_Q2.1021.00
246_L267_L2.0611.00
40_I111_L2.0601.00
199_A203_K2.0371.00
38_A118_W2.0361.00
243_M288_V2.0051.00
264_T301_A1.9721.00
207_N225_E1.9471.00
185_Q188_I1.9281.00
59_G63_Q1.9031.00
108_M133_T1.8961.00
239_I280_V1.8791.00
215_R265_D1.8761.00
149_F245_V1.8731.00
219_L223_I1.8651.00
207_N229_V1.8411.00
105_F136_A1.8361.00
42_V122_I1.8351.00
42_V104_I1.8231.00
112_L136_A1.8231.00
99_K103_H1.8201.00
61_I302_A1.7921.00
170_R174_D1.7921.00
149_F270_A1.7831.00
32_Q114_D1.7741.00
131_Y175_E1.7621.00
184_I207_N1.7401.00
108_M122_I1.7271.00
131_Y135_K1.7071.00
123_L306_L1.7061.00
45_S55_S1.6911.00
245_V262_L1.6841.00
217_K225_E1.6661.00
285_I306_L1.6601.00
109_H113_S1.6561.00
121_L283_I1.5871.00
113_S140_T1.5801.00
122_I133_T1.5761.00
188_I208_I1.5281.00
96_D99_K1.5241.00
42_V100_S1.5141.00
221_P224_K1.5061.00
236_F279_N1.4921.00
288_V302_A1.4821.00
105_F109_H1.4761.00
38_A111_L1.4731.00
263_Y266_E1.4661.00
243_M251_A1.4631.00
37_P310_L1.4591.00
250_H264_T1.4411.00
217_K221_P1.4321.00
238_F282_G1.4311.00
288_V298_T1.4311.00
215_R266_E1.4151.00
224_K228_P1.4131.00
143_T182_H1.4121.00
61_I288_V1.4111.00
221_P225_E1.4001.00
145_A233_K1.3911.00
60_T299_S1.3891.00
245_V267_L1.3881.00
36_G83_L1.3871.00
216_E269_E1.3861.00
243_M285_I1.3831.00
272_K308_H1.3771.00
182_H233_K1.3641.00
129_I286_V1.3461.00
200_Y204_H1.3451.00
137_I144_T1.3371.00
227_L273_Y1.3261.00
101_H128_S1.3241.00
224_K273_Y1.3181.00
112_L137_I1.3181.00
40_I122_I1.3161.00
218_G222_T1.3161.00
165_N256_A1.3091.00
147_I274_I1.3091.00
148_Q185_Q1.3041.00
38_A87_L1.3021.00
136_A140_T1.2711.00
239_I283_I1.2701.00
171_R174_D1.2661.00
104_I122_I1.2541.00
165_N255_P1.2231.00
86_D89_D1.2221.00
184_I229_V1.2141.00
56_F291_T1.2051.00
40_I108_M1.2031.00
121_L306_L1.1981.00
157_N171_R1.1981.00
253_G298_T1.1961.00
268_L308_H1.1941.00
107_T110_A1.1931.00
112_L140_T1.1931.00
51_H292_L1.1911.00
210_T213_M1.1871.00
253_G293_D1.1821.00
146_V169_F1.1681.00
60_T63_Q1.1561.00
127_N240_S1.1481.00
62_R89_D1.1321.00
153_H191_F1.1301.00
106_Q110_A1.1231.00
52_S56_F1.1191.00
62_R88_G1.1171.00
170_R200_Y1.1141.00
169_F185_Q1.1121.00
40_I107_T1.1051.00
37_P119_V1.0991.00
109_H136_A1.0971.00
135_K175_E1.0931.00
60_T64_A1.0911.00
133_T284_E1.0861.00
111_L120_P1.0851.00
289_D292_L1.0831.00
114_D117_D1.0811.00
152_H244_D1.0721.00
41_G86_D1.0681.00
62_R86_D1.0651.00
101_H132_S1.0641.00
39_L123_L1.0621.00
223_I273_Y1.0571.00
71_Y76_G1.0541.00
119_V283_I1.0511.00
243_M302_A1.0501.00
155_V201_A1.0501.00
165_N254_C1.0491.00
48_S54_A1.0471.00
236_F281_A1.0461.00
134_I146_V1.0361.00
108_M120_P1.0351.00
41_G88_G1.0271.00
42_V129_I1.0251.00
267_L305_V1.0231.00
41_G89_D1.0211.00
164_T167_T1.0211.00
150_D154_D1.0201.00
109_H140_T1.0171.00
133_T238_F1.0141.00
217_K222_T1.0041.00
262_L270_A1.0031.00
178_I183_L1.0001.00
100_S104_I0.9901.00
52_S55_S0.9861.00
137_I282_G0.9841.00
294_F297_M0.9821.00
143_T179_E0.9811.00
211_M215_R0.9781.00
225_E229_V0.9741.00
213_M217_K0.9721.00
130_S134_I0.9661.00
148_Q240_S0.9661.00
220_I224_K0.9530.99
45_S53_G0.9470.99
54_A289_D0.9470.99
239_I271_V0.9450.99
110_A113_S0.9450.99
157_N170_R0.9410.99
298_T302_A0.9390.99
215_R269_E0.9350.99
273_Y276_Q0.9300.99
99_K102_H0.9290.99
251_A301_A0.9230.99
36_G118_W0.9200.99
153_H185_Q0.9110.99
212_D272_K0.9100.99
179_E182_H0.9060.99
237_I279_N0.9040.99
102_H105_F0.9020.99
218_G221_P0.9010.99
165_N287_E0.8910.99
166_G256_A0.8910.99
226_I229_V0.8810.99
241_V305_V0.8790.99
153_H208_I0.8750.99
189_R248_Q0.8710.99
169_F183_L0.8710.99
153_H188_I0.8680.99
186_L226_I0.8590.99
155_V173_L0.8590.99
189_R247_D0.8560.99
84_L88_G0.8480.99
146_V178_I0.8450.99
200_Y203_K0.8450.99
145_A230_V0.8370.99
145_A182_H0.8370.99
220_I273_Y0.8340.99
45_S54_A0.8310.99
149_F262_L0.8280.98
142_G236_F0.8250.98
144_T281_A0.8240.98
209_H214_I0.8240.98
130_S168_P0.8240.98
228_P231_Q0.8200.98
133_T282_G0.8190.98
127_N284_E0.8180.98
137_I281_A0.8170.98
145_A184_I0.8150.98
108_M136_A0.8140.98
130_S284_E0.8110.98
246_L264_T0.8100.98
127_N165_N0.8090.98
173_L181_Q0.8080.98
127_N287_E0.7980.98
111_L118_W0.7980.98
199_A202_K0.7970.98
230_V233_K0.7910.98
273_Y277_Q0.7880.98
151_A189_R0.7860.98
40_I120_P0.7860.98
270_A273_Y0.7850.98
45_S51_H0.7840.98
227_L277_Q0.7830.98
147_I230_V0.7830.98
183_L206_V0.7830.98
246_L250_H0.7780.98
121_L310_L0.7780.98
262_L267_L0.7730.98
45_S52_S0.7680.98
146_V172_L0.7640.97
157_N163_P0.7610.97
288_V299_S0.7610.97
297_M301_A0.7600.97
80_V84_L0.7600.97
120_P137_I0.7570.97
189_R258_G0.7570.97
141_K281_A0.7560.97
154_D244_D0.7540.97
190_E258_G0.7520.97
225_E228_P0.7510.97
44_L97_I0.7510.97
202_K208_I0.7490.97
264_T268_L0.7490.97
293_D296_D0.7430.97
147_I186_L0.7430.97
254_C257_I0.7410.97
114_D118_W0.7390.97
219_L269_E0.7370.97
201_A206_V0.7370.97
122_I129_I0.7360.97
90_I103_H0.7320.97
106_Q109_H0.7320.97
209_H229_V0.7320.97
92_I100_S0.7310.97
154_D287_E0.7300.97
213_M216_E0.7290.97
78_H81_S0.7280.97
143_T233_K0.7280.97
134_I144_T0.7270.97
173_L180_G0.7130.96
268_L305_V0.7120.96
212_D269_E0.7120.96
186_L262_L0.7090.96
46_K100_S0.7090.96
173_L183_L0.7020.96
90_I107_T0.7010.96
104_I132_S0.7010.96
290_P293_D0.7000.96
158_T171_R0.7000.96
57_A60_T0.7000.96
51_H257_I0.7000.96
144_T236_F0.6990.96
39_L121_L0.6900.95
147_I184_I0.6820.95
214_I270_A0.6810.95
248_Q251_A0.6800.95
250_H263_Y0.6790.95
149_F239_I0.6750.95
64_A303_A0.6720.95
184_I226_I0.6720.95
110_A114_D0.6700.95
47_S97_I0.6690.95
130_S169_F0.6690.95
49_I165_N0.6680.95
222_T226_I0.6660.94
223_I270_A0.6610.94
64_A299_S0.6580.94
226_I230_V0.6570.94
265_D269_E0.6560.94
57_A290_P0.6560.94
47_S126_D0.6550.94
251_A288_V0.6540.94
209_H225_E0.6540.94
32_Q118_W0.6520.94
238_F284_E0.6520.94
35_K118_W0.6510.94
239_I309_A0.6500.94
216_E220_I0.6480.94
220_I269_E0.6480.94
39_L84_L0.6480.94
253_G288_V0.6460.94
72_S75_L0.6450.93
214_I266_E0.6420.93
306_L309_A0.6420.93
63_Q296_D0.6390.93
227_L230_V0.6370.93
237_I278_P0.6360.93
187_G245_V0.6350.93
103_H107_T0.6350.93
64_A296_D0.6340.93
87_L111_L0.6310.93
32_Q35_K0.6300.93
37_P121_L0.6290.93
150_D244_D0.6290.93
57_A289_D0.6280.93
227_L231_Q0.6270.92
133_T137_I0.6270.92
155_V200_Y0.6240.92
285_I305_V0.6230.92
44_L100_S0.6190.92
211_M262_L0.6180.92
43_P89_D0.6160.92
132_S136_A0.6160.92
173_L206_V0.6140.92
42_V133_T0.6140.92
97_I101_H0.6140.92
240_S286_V0.6120.92
148_Q169_F0.6110.92
135_K172_L0.6110.92
117_D120_P0.6070.91
60_T296_D0.6020.91
158_T161_G0.6000.91
57_A255_P0.5980.91
254_C289_D0.5980.91
184_I209_H0.5960.90
231_Q279_N0.5960.90
249_S264_T0.5950.90
146_V183_L0.5930.90
240_S284_E0.5920.90
223_I226_I0.5910.90
60_T290_P0.5900.90
296_D299_S0.5850.90
149_F186_L0.5840.90
87_L107_T0.5840.90
103_H106_Q0.5830.90
209_H213_M0.5810.89
250_H301_A0.5770.89
238_F281_A0.5730.89
252_P298_T0.5710.89
219_L270_A0.5710.89
148_Q256_A0.5690.88
147_I237_I0.5690.88
117_D140_T0.5690.88
46_K97_I0.5660.88
96_D162_G0.5660.88
271_V312_G0.5650.88
308_H311_K0.5630.88
49_I255_P0.5610.88
100_S103_H0.5600.88
156_R256_A0.5600.88
138_A175_E0.5570.87
138_A144_T0.5540.87
145_A236_F0.5540.87
237_I280_V0.5520.87
107_T111_L0.5490.87
153_H156_R0.5490.87
186_L214_I0.5480.86
155_V204_H0.5480.86
274_I278_P0.5450.86
127_N152_H0.5430.86
172_L178_I0.5410.86
167_T171_R0.5410.86
127_N238_F0.5410.86
296_D300_R0.5410.86
143_T236_F0.5390.86
141_K236_F0.5380.85
218_G266_E0.5360.85
97_I164_T0.5360.85
130_S286_V0.5350.85
48_S52_S0.5320.85
275_A280_V0.5310.85
131_Y171_R0.5310.85
269_E273_Y0.5310.85
299_S303_A0.5290.84
42_V92_I0.5280.84
126_D165_N0.5280.84
124_G129_I0.5270.84
149_F267_L0.5260.84
56_F59_G0.5250.84
223_I227_L0.5240.84
60_T288_V0.5200.83
113_S117_D0.5180.83
127_N286_V0.5170.83
153_H201_A0.5160.83
153_H198_E0.5140.83
46_K49_I0.5090.82
130_S238_F0.5080.82
101_H104_I0.5080.82
108_M132_S0.5070.82
59_G296_D0.5060.82
283_I306_L0.5060.82
108_M112_L0.5060.82
260_G268_L0.5040.82
61_I306_L0.5040.82
78_H82_E0.5030.81
70_A73_A0.5020.81
303_A306_L0.5020.81
251_A254_C0.5020.81
89_D93_H0.5000.81
211_M247_D0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3m1rA 5 0.9843 100 0.171 Contact Map
1xfkA 1 0.9467 100 0.174 Contact Map
3niqA 5 0.9655 100 0.189 Contact Map
1gq6A 5 0.931 100 0.193 Contact Map
3nioA 5 0.9467 100 0.196 Contact Map
4mykA 3 0.8871 100 0.206 Contact Map
1wohA 5 0.9342 100 0.212 Contact Map
4dz4A 5 0.953 100 0.221 Contact Map
2cevA 5 0.8433 100 0.225 Contact Map
4g3hA 1 0.8276 100 0.235 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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