GREMLIN Database
APPC - Oligopeptide transport system permease protein AppC
UniProt: P42063 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 303 (252)
Sequences: 28556 (18029)
Seq/√Len: 1135.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
185_F212_I2.7471.00
132_D182_R2.6291.00
202_T206_K2.4301.00
188_L193_Y2.4121.00
206_K210_S2.4051.00
198_K204_T2.3801.00
108_A166_I2.3641.00
120_L135_I2.3311.00
112_G170_C2.3081.00
188_L191_R2.2951.00
203_K206_K2.2451.00
78_L81_L2.2421.00
101_V240_Y2.2221.00
205_H209_F2.2001.00
254_N258_D2.0871.00
192_E195_L2.0711.00
68_S71_D2.0471.00
194_V207_I2.0131.00
194_V212_I2.0111.00
94_R255_M1.9601.00
122_A185_F1.9381.00
225_T290_G1.9201.00
123_L127_F1.9201.00
90_D93_S1.8911.00
127_F131_V1.8871.00
127_F204_T1.8751.00
115_L119_V1.8281.00
177_T227_K1.8081.00
63_P66_Q1.7631.00
161_G164_K1.7321.00
130_I134_V1.7281.00
126_Y204_T1.7191.00
193_Y215_N1.7191.00
188_L216_A1.7111.00
125_G185_F1.6971.00
47_F51_M1.6941.00
160_P164_K1.6851.00
74_K77_G1.6831.00
77_G80_H1.6601.00
53_A99_A1.6541.00
85_D89_R1.6521.00
116_I174_W1.6501.00
123_L131_V1.6231.00
82_M274_F1.6171.00
113_S173_G1.6121.00
92_F96_L1.6031.00
104_L108_A1.6031.00
116_I119_V1.5931.00
87_F94_R1.5921.00
189_R212_I1.5811.00
131_V135_I1.5651.00
166_I170_C1.5491.00
184_E187_S1.5471.00
91_I274_F1.5451.00
135_I178_A1.5271.00
114_I224_A1.5101.00
86_K258_D1.5071.00
97_Y100_R1.5031.00
139_V178_A1.5021.00
126_Y208_I1.5001.00
259_A271_Y1.4891.00
39_A292_G1.4731.00
89_R93_S1.4531.00
117_G177_T1.4441.00
187_S191_R1.4361.00
256_L275_P1.4191.00
110_V224_A1.4121.00
42_G285_C1.3881.00
55_F58_L1.3771.00
121_G125_G1.3661.00
71_D74_K1.3471.00
37_K40_I1.3451.00
149_F153_T1.3331.00
137_R140_D1.3261.00
196_A200_I1.3061.00
182_R186_L1.3031.00
120_L178_A1.3031.00
75_A79_E1.3031.00
130_I133_A1.2971.00
188_L194_V1.2851.00
121_G181_V1.2841.00
124_A135_I1.2741.00
222_V294_R1.2731.00
122_A208_I1.2691.00
117_G181_V1.2651.00
125_G189_R1.2621.00
82_M92_F1.2601.00
95_I278_F1.2581.00
269_W273_L1.2451.00
293_L296_A1.2441.00
170_C174_W1.2391.00
101_V104_L1.2381.00
188_L212_I1.2261.00
40_I44_V1.2181.00
180_L223_S1.2111.00
154_L168_I1.2081.00
49_I280_L1.2081.00
294_R298_D1.2061.00
163_D167_L1.1951.00
197_A211_H1.1861.00
51_M55_F1.1841.00
77_G81_L1.1791.00
221_I297_L1.1781.00
160_P163_D1.1691.00
89_R94_R1.1561.00
185_F216_A1.1501.00
105_V235_E1.1431.00
86_K262_F1.1381.00
197_A207_I1.1351.00
122_A213_L1.1211.00
197_A202_T1.1201.00
142_V175_T1.1081.00
292_G296_A1.1041.00
128_R189_R1.0971.00
118_T181_V1.0951.00
195_L198_K1.0921.00
133_A137_R1.0781.00
89_R97_Y1.0751.00
184_E188_L1.0631.00
80_H90_D1.0631.00
46_L281_M1.0591.00
181_V220_I1.0551.00
275_P279_I1.0541.00
145_I150_L1.0511.00
255_M271_Y1.0481.00
119_V122_A1.0471.00
44_V48_I1.0471.00
168_I172_T1.0461.00
206_K209_F1.0451.00
174_W178_A1.0381.00
181_V185_F1.0331.00
259_A272_P1.0261.00
82_M95_I1.0251.00
151_L168_I1.0241.00
138_V142_V1.0201.00
228_V286_F1.0161.00
100_R104_L1.0051.00
84_T90_D1.0001.00
91_I271_Y0.9981.00
163_D166_I0.9971.00
132_D136_M0.9951.00
42_G292_G0.9931.00
109_S170_C0.9821.00
56_A97_Y0.9801.00
76_P79_E0.9801.00
41_L44_V0.9791.00
200_I211_H0.9781.00
197_A200_I0.9741.00
49_I282_T0.9721.00
181_V216_A0.9711.00
257_Q261_N0.9701.00
274_F277_L0.9641.00
93_S97_Y0.9641.00
198_K207_I0.9641.00
98_G255_M0.9621.00
136_M178_A0.9611.00
91_I255_M0.9581.00
60_A93_S0.9551.00
44_V47_F0.9521.00
131_V134_V0.9521.00
109_S113_S0.9511.00
128_R190_S0.9471.00
94_R271_Y0.9471.00
95_I274_F0.9451.00
45_I285_C0.9431.00
46_L285_C0.9391.00
218_G294_R0.9361.00
133_A136_M0.9191.00
202_T207_I0.9191.00
270_W274_F0.9191.00
132_D186_L0.9181.00
45_I281_M0.9151.00
42_G284_L0.9151.00
42_G288_F0.9101.00
43_A47_F0.9081.00
104_L107_F0.9071.00
134_V138_V0.9031.00
109_S169_F0.9011.00
48_I52_S0.8931.00
139_V175_T0.8891.00
158_F164_K0.8861.00
285_C289_V0.8841.00
147_D234_A0.8841.00
121_G185_F0.8761.00
204_T207_I0.8731.00
43_A289_V0.8691.00
84_T88_G0.8671.00
114_I118_T0.8671.00
118_T220_I0.8671.00
223_S227_K0.8611.00
96_L100_R0.8591.00
104_L162_V0.8581.00
169_F234_A0.8561.00
286_F290_G0.8551.00
115_L118_T0.8541.00
216_A219_P0.8511.00
221_I290_G0.8441.00
75_A78_L0.8371.00
209_F212_I0.8301.00
52_S96_L0.8281.00
70_L74_K0.8221.00
183_G186_L0.8171.00
99_A282_T0.8161.00
62_Y93_S0.8161.00
94_R97_Y0.8141.00
258_D261_N0.8131.00
114_I119_V0.8121.00
119_V123_L0.8061.00
74_K78_L0.8021.00
76_P80_H0.8011.00
147_D151_L0.8001.00
188_L215_N0.7991.00
93_S96_L0.7961.00
185_F189_R0.7951.00
191_R195_L0.7941.00
204_T208_I0.7921.00
38_L42_G0.7851.00
167_L170_C0.7821.00
273_L277_L0.7821.00
74_K79_E0.7811.00
55_F59_I0.7811.00
162_V166_I0.7791.00
258_D262_F0.7761.00
120_L174_W0.7751.00
73_Y78_L0.7751.00
58_L269_W0.7751.00
255_M275_P0.7741.00
125_G186_L0.7711.00
109_S231_V0.7691.00
54_V58_L0.7681.00
195_L199_T0.7671.00
62_Y79_E0.7661.00
114_I177_T0.7631.00
108_A240_Y0.7601.00
61_P93_S0.7561.00
39_A43_A0.7541.00
108_A111_V0.7531.00
107_F111_V0.7521.00
164_K167_L0.7511.00
39_A288_F0.7471.00
279_I283_V0.7431.00
129_G133_A0.7421.00
112_G166_I0.7421.00
295_D301_N0.7351.00
143_L175_T0.7351.00
257_Q260_Q0.7351.00
274_F278_F0.7331.00
159_K164_K0.7301.00
52_S99_A0.7301.00
202_T211_H0.7281.00
207_I212_I0.7271.00
124_A132_D0.7221.00
76_P270_W0.7191.00
73_Y76_P0.7181.00
184_E219_P0.7181.00
181_V184_E0.7171.00
102_S106_G0.7161.00
205_H208_I0.7151.00
50_I277_L0.7071.00
129_G132_D0.6971.00
116_I170_C0.6921.00
73_Y268_A0.6901.00
96_L99_A0.6891.00
184_E216_A0.6861.00
85_D268_A0.6851.00
41_L45_I0.6851.00
289_V293_L0.6831.00
281_M285_C0.6801.00
294_R301_N0.6801.00
128_R132_D0.6801.00
225_T286_F0.6761.00
273_L276_G0.6751.00
69_L73_Y0.6701.00
49_I281_M0.6681.00
283_V287_N0.6641.00
173_G176_T0.6621.00
172_T175_T0.6581.00
154_L164_K0.6581.00
134_V137_R0.6561.00
113_S170_C0.6471.00
116_I120_L0.6461.00
42_G45_I0.6411.00
61_P92_F0.6391.00
45_I49_I0.6381.00
147_D150_L0.6361.00
272_P276_G0.6341.00
69_L72_K0.6341.00
186_L189_R0.6301.00
70_L73_Y0.6301.00
95_I275_P0.6261.00
235_E239_S0.6261.00
233_L236_S0.6261.00
165_L235_E0.6231.00
236_S254_N0.6201.00
57_P100_R0.6191.00
233_L237_A0.6181.00
126_Y189_R0.6161.00
110_V227_K0.6151.00
127_F208_I0.6111.00
177_T223_S0.6081.00
124_A136_M0.6081.00
136_M139_V0.6071.00
40_I43_A0.6071.00
137_R141_I0.6071.00
52_S56_A0.6051.00
69_L81_L0.6011.00
234_A237_A0.6011.00
106_G231_V0.6001.00
103_L107_F0.6001.00
71_D80_H0.5991.00
46_L286_F0.5991.00
75_A270_W0.5991.00
117_G121_G0.5971.00
135_I139_V0.5961.00
37_K41_L0.5951.00
139_V174_W0.5921.00
80_H84_T0.5891.00
232_I236_S0.5881.00
110_V228_V0.5871.00
126_Y209_F0.5871.00
176_T227_K0.5861.00
177_T181_V0.5851.00
153_T157_I0.5841.00
255_M258_D0.5841.00
53_A276_G0.5841.00
62_Y267_Q0.5841.00
231_V234_A0.5821.00
111_V115_L0.5811.00
99_A103_L0.5801.00
288_F292_G0.5761.00
125_G132_D0.5761.00
202_T205_H0.5761.00
128_R186_L0.5761.00
222_V225_T0.5681.00
142_V174_W0.5661.00
150_L172_T0.5661.00
255_M259_A0.5621.00
236_S257_Q0.5621.00
171_L174_W0.5611.00
60_A97_Y0.5561.00
72_K76_P0.5551.00
114_I220_I0.5531.00
291_D294_R0.5491.00
49_I53_A0.5491.00
62_Y80_H0.5481.00
147_D171_L0.5471.00
73_Y271_Y0.5461.00
194_V198_K0.5451.00
105_V165_L0.5451.00
100_R103_L0.5411.00
209_F214_P0.5411.00
256_L279_I0.5411.00
155_V159_K0.5371.00
65_E78_L0.5371.00
173_G227_K0.5361.00
57_P97_Y0.5351.00
167_L171_L0.5341.00
108_A163_D0.5321.00
236_S258_D0.5281.00
120_L123_L0.5281.00
176_T223_S0.5251.00
94_R98_G0.5251.00
270_W273_L0.5241.00
217_L221_I0.5191.00
203_K207_I0.5191.00
38_L41_L0.5191.00
124_A182_R0.5181.00
110_V114_I0.5161.00
56_A59_I0.5151.00
81_L92_F0.5141.00
68_S72_K0.5131.00
46_L289_V0.5131.00
50_I54_V0.5121.00
67_Q87_F0.5121.00
175_T178_A0.5101.00
70_L78_L0.5101.00
180_L184_E0.5031.00
117_G178_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquM 1 0.835 99.9 0.63 Contact Map
3d31C 2 0.7624 99.9 0.644 Contact Map
3tuiA 2 0.6667 99.9 0.659 Contact Map
3rlfF 1 0.9208 99.9 0.66 Contact Map
2onkC 2 0.7822 99.9 0.666 Contact Map
3rlfG 1 0.8416 99.9 0.682 Contact Map
4tquN 1 0.8614 99.8 0.685 Contact Map
4ymuD 2 0.6832 99.8 0.691 Contact Map
3j9pD 4 0.7756 65.7 0.94 Contact Map
2kogA 1 0.1881 54.6 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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