GREMLIN Database
RL22 - 50S ribosomal protein L22
UniProt: P42060 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 113 (107)
Sequences: 2245 (1066)
Seq/√Len: 103.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_A50_V2.6701.00
48_E52_K2.4371.00
9_T80_P2.4241.00
7_A10_V2.4191.00
21_M76_V2.3731.00
21_M74_A2.2381.00
72_S108_S2.2061.00
29_V55_I2.1611.00
85_F93_A2.1051.00
27_K35_I2.0841.00
27_K31_E2.0311.00
37_N48_E2.0221.00
22_D25_R1.9761.00
88_R94_S1.9161.00
78_E81_T1.8401.00
24_I51_L1.7391.00
42_A46_I1.7021.00
81_T97_N1.6891.00
33_V48_E1.6601.00
21_M47_I1.6411.00
51_L55_I1.6241.00
51_L105_I1.6111.00
68_N109_E1.5511.00
81_T99_R1.5431.00
18_R77_D1.5371.00
78_E99_R1.5291.00
85_F94_S1.5181.00
59_E66_A1.5111.00
85_F95_Q1.4691.00
10_V46_I1.4651.00
73_Q106_V1.4611.00
12_I17_A1.4361.00
19_L41_R1.4311.00
86_R94_S1.4191.00
12_I43_A1.4191.00
17_A103_I1.3931.00
28_Q31_E1.3821.00
75_F104_T1.3791.00
72_S106_V1.3370.99
74_A105_I1.3080.99
33_V55_I1.2960.99
77_D104_T1.2710.99
51_L71_I1.2670.99
3_A107_V1.2230.99
58_A69_L1.2030.99
50_V103_I1.1850.99
18_R78_E1.1850.99
61_N64_M1.1670.98
87_P94_S1.1120.98
33_V51_L1.0880.97
3_A62_Y1.0770.97
33_V52_K1.0440.97
64_M109_E1.0360.97
79_G100_T1.0340.97
14_P18_R0.9830.95
79_G102_H0.9800.95
87_P93_A0.9790.95
6_V77_D0.9770.95
17_A47_I0.9700.95
23_L39_T0.9680.95
24_I74_A0.9630.95
23_L27_K0.9600.95
5_A53_S0.9490.94
18_R22_D0.9470.94
65_D68_N0.9420.94
47_I74_A0.9350.94
25_R73_Q0.9310.94
14_P78_E0.9240.94
89_A94_S0.9200.93
43_A46_I0.9200.93
90_M94_S0.9090.93
50_V107_V0.9080.93
23_L35_I0.8780.92
12_I46_I0.8770.92
15_R19_L0.8760.92
80_P100_T0.8720.92
30_G66_A0.8500.90
86_R96_I0.8500.90
12_I99_R0.8430.90
3_A64_M0.8350.90
34_S38_L0.8270.89
5_A50_V0.8200.89
6_V104_T0.8130.88
88_R96_I0.8050.88
31_E34_S0.7920.87
90_M93_A0.7730.86
50_V105_I0.7720.86
15_R97_N0.7710.86
70_V108_S0.7670.85
14_P101_S0.7620.85
13_A42_A0.7610.85
69_L107_V0.7540.84
25_R72_S0.7440.84
59_E64_M0.7270.82
71_I74_A0.7250.82
31_E35_I0.7130.81
8_R102_H0.7120.81
35_I39_T0.7080.80
53_S57_N0.7050.80
25_R75_F0.6870.78
9_T102_H0.6780.77
77_D102_H0.6760.77
33_V37_N0.6690.77
52_K56_A0.6630.76
65_D92_R0.6610.76
42_A45_P0.6560.75
76_V101_S0.6520.75
87_P91_G0.6390.73
24_I42_A0.6270.72
30_G34_S0.6220.71
80_P102_H0.6200.71
60_H90_M0.6190.71
17_A46_I0.6160.70
10_V103_I0.6130.70
72_S107_V0.6110.70
4_K106_V0.6090.70
14_P81_T0.5970.68
27_K70_V0.5860.67
62_Y68_N0.5860.67
93_A96_I0.5830.66
17_A43_A0.5820.66
47_I76_V0.5800.66
86_R93_A0.5790.66
45_P48_E0.5760.65
44_S48_E0.5750.65
40_P46_I0.5700.65
60_H64_M0.5680.64
64_M68_N0.5670.64
70_V109_E0.5630.64
12_I101_S0.5620.63
88_R95_Q0.5600.63
11_R80_P0.5590.63
26_G29_V0.5590.63
32_A93_A0.5590.63
53_S56_A0.5570.63
76_V103_I0.5510.62
11_R101_S0.5500.62
17_A101_S0.5430.61
89_A100_T0.5360.60
11_R84_R0.5350.60
30_G33_V0.5320.59
38_L45_P0.5290.59
24_I71_I0.5250.58
32_A84_R0.5240.58
3_A56_A0.5210.58
30_G38_L0.5200.58
39_T43_A0.5190.57
17_A100_T0.5180.57
47_I103_I0.5150.57
18_R107_V0.5120.56
84_R93_A0.5090.56
29_V33_V0.5070.56
4_K73_Q0.5060.56
4_K8_R0.5060.56
11_R76_V0.5050.55
82_L98_K0.5040.55
55_I66_A0.5020.55
81_T100_T0.5010.55
55_I69_L0.5010.55
56_A60_H0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j3wS 1 0.9912 100 0.128 Contact Map
4tp9S 1 0.9735 100 0.133 Contact Map
3bboU 1 1 100 0.147 Contact Map
2zjrP 1 1 100 0.172 Contact Map
4ce4W 1 0.9646 100 0.172 Contact Map
3j7yT 1 1 100 0.174 Contact Map
1i4jA 2 0.9646 100 0.175 Contact Map
1vw4O 1 0.9912 100 0.192 Contact Map
4a17Q 1 0.9912 100 0.223 Contact Map
3j3bP 1 0.9646 100 0.225 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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