CORA - BACSU - GREMLIN Contacts

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CORA - Magnesium transport protein CorA

UniProt:	P40948	Sequences: MKAHTGKDWFWYQMGPQERSKARDLIHFSHWPQCEKWFENNHHVNFLRVDTTETENEAVFGSIVYDQGLGEEKDHTVFHFYITRQYFFTINFDFSILREIKGKEVVRQMERADNAIEGFLILLGELMNAYLIGVDEFEVKLRKLRWQIKDDNSKSILNRVHLLRHELMIWKNLILSAKKIEMALKETFLPQNEGKKDYQRTQLKIDRGFTYISEFEGELNNLLHSEEVITSHRGNEIVKALTIFTTLFTPITALGALWGMNFSVMPELNWKYGYLFSLLLIVTSTVLIYLYLRKKGWTGDMLQERKKKKKPRKRRTL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	317 (288)
Sequences:	5379 (3808)
Seq/√Len:	224.4

ECOLI - CORA ZNTB
BACSU - CORA YFJQ

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
263_S	269_N	9.376	1.00
83_T	86_Y	4.062	1.00
267_E	274_Y	3.853	1.00
278_L	282_V	3.161	1.00
275_L	279_L	2.874	1.00
39_E	81_Y	2.833	1.00
257_L	278_L	2.777	1.00
276_F	280_L	2.739	1.00
272_Y	276_F	2.691	1.00
80_F	87_F	2.432	1.00
63_I	123_L	2.393	1.00
273_G	277_S	2.390	1.00
147_Q	159_R	2.388	1.00
265_M	268_L	2.387	1.00
23_R	27_H	2.318	1.00
272_Y	275_L	2.280	1.00
13_Q	91_N	2.263	1.00
290_L	294_K	2.261	1.00
286_V	290_L	2.259	1.00
262_F	268_L	2.229	1.00
26_I	40_N	2.223	1.00
248_F	253_A	2.160	1.00
265_M	274_Y	2.151	1.00
270_W	276_F	2.148	1.00
11_W	89_T	2.142	1.00
87_F	118_G	2.125	1.00
264_V	271_K	2.121	1.00
140_K	159_R	2.044	1.00
14_M	25_L	2.031	1.00
80_F	89_T	2.026	1.00
253_A	257_L	2.019	1.00
254_L	277_S	1.990	1.00
270_W	273_G	1.952	1.00
29_S	88_F	1.947	1.00
271_K	275_L	1.942	1.00
127_M	201_T	1.925	1.00
235_N	238_V	1.864	1.00
39_E	58_A	1.824	1.00
128_N	204_K	1.808	1.00
257_L	281_I	1.708	1.00
262_F	265_M	1.680	1.00
39_E	55_E	1.677	1.00
287_L	291_Y	1.666	1.00
275_L	278_L	1.638	1.00
94_F	98_R	1.635	1.00
258_W	265_M	1.632	1.00
245_T	249_T	1.605	1.00
171_K	213_S	1.584	1.00
260_M	277_S	1.573	1.00
66_D	170_W	1.572	1.00
18_E	21_K	1.568	1.00
51_T	203_L	1.550	1.00
274_Y	278_L	1.536	1.00
87_F	119_F	1.535	1.00
101_K	105_V	1.520	1.00
258_W	267_E	1.514	1.00
258_W	274_Y	1.508	1.00
114_N	117_E	1.500	1.00
98_R	104_E	1.500	1.00
277_S	281_I	1.489	1.00
61_G	119_F	1.475	1.00
239_K	243_I	1.449	1.00
43_H	81_Y	1.449	1.00
258_W	268_L	1.432	1.00
124_G	128_N	1.428	1.00
262_F	273_G	1.415	1.00
94_F	97_L	1.410	1.00
141_L	219_L	1.394	1.00
291_Y	295_K	1.374	1.00
270_W	274_Y	1.364	1.00
124_G	204_K	1.362	1.00
148_I	222_L	1.354	1.00
102_G	105_V	1.340	1.00
277_S	280_L	1.335	1.00
120_L	198_Y	1.327	1.00
262_F	274_Y	1.321	1.00
267_E	270_W	1.317	1.00
20_S	23_R	1.313	1.00
48_R	62_S	1.312	1.00
289_Y	293_R	1.312	1.00
268_L	274_Y	1.307	1.00
82_I	119_F	1.295	1.00
278_L	281_I	1.295	1.00
31_W	81_Y	1.293	1.00
236_E	239_K	1.270	1.00
54_T	59_V	1.267	1.00
32_P	55_E	1.261	1.00
34_C	41_N	1.254	1.00
98_R	101_K	1.253	1.00
78_F	126_L	1.251	1.00
254_L	258_W	1.246	1.00
61_G	80_F	1.238	1.00
285_T	289_Y	1.223	1.00
265_M	275_L	1.223	1.00
101_K	104_E	1.220	1.00
87_F	115_A	1.217	1.00
264_V	275_L	1.206	1.00
24_D	28_F	1.195	1.00
288_I	292_L	1.192	1.00
202_Q	206_D	1.189	1.00
249_T	253_A	1.185	1.00
99_E	102_G	1.181	1.00
237_I	242_T	1.170	1.00
182_M	202_Q	1.169	1.00
42_H	51_T	1.163	1.00
257_L	274_Y	1.162	1.00
251_I	281_I	1.161	1.00
19_R	23_R	1.161	1.00
60_F	81_Y	1.154	1.00
231_S	234_G	1.145	1.00
279_L	283_T	1.144	1.00
267_E	275_L	1.142	1.00
9_W	118_G	1.137	1.00
9_W	115_A	1.126	1.00
250_P	253_A	1.121	1.00
273_G	276_F	1.118	1.00
100_I	105_V	1.116	1.00
289_Y	298_T	1.112	1.00
283_T	287_L	1.103	1.00
17_Q	21_K	1.101	1.00
80_F	119_F	1.098	1.00
276_F	279_L	1.095	1.00
255_G	278_L	1.091	1.00
164_R	216_E	1.088	1.00
48_R	77_V	1.085	1.00
95_S	98_R	1.084	1.00
173_L	177_A	1.081	1.00
164_R	224_H	1.076	1.00
97_L	104_E	1.069	1.00
23_R	26_I	1.065	1.00
230_T	234_G	1.061	1.00
94_F	101_K	1.060	1.00
200_R	203_L	1.056	1.00
178_K	206_D	1.052	1.00
157_L	226_E	1.051	1.00
167_L	215_F	1.028	1.00
185_K	199_Q	1.024	1.00
98_R	105_V	1.023	1.00
248_F	251_I	1.023	1.00
127_M	204_K	1.021	1.00
181_E	205_I	1.020	1.00
238_V	245_T	1.015	1.00
137_F	163_L	1.014	1.00
262_F	277_S	1.006	1.00
242_T	245_T	1.005	1.00
22_A	26_I	0.999	1.00
104_E	110_E	0.993	1.00
100_I	118_G	0.989	1.00
257_L	260_M	0.989	1.00
24_D	27_H	0.987	1.00
43_H	79_H	0.987	1.00
140_K	166_E	0.985	1.00
145_R	165_H	0.976	1.00
267_E	273_G	0.975	1.00
262_F	267_E	0.973	1.00
54_T	187_T	0.966	1.00
98_R	102_G	0.962	1.00
112_A	117_E	0.957	1.00
127_M	205_I	0.952	1.00
178_K	213_S	0.947	1.00
161_H	223_L	0.943	1.00
242_T	249_T	0.942	1.00
102_G	106_V	0.941	1.00
237_I	241_L	0.940	1.00
97_L	101_K	0.940	1.00
53_E	199_Q	0.939	1.00
261_N	266_P	0.936	1.00
20_S	24_D	0.931	1.00
100_I	106_V	0.923	1.00
52_T	61_G	0.922	1.00
116_I	194_G	0.921	1.00
147_Q	156_I	0.919	0.99
73_K	166_E	0.914	0.99
293_R	298_T	0.913	0.99
266_P	273_G	0.909	0.99
175_L	210_T	0.909	0.99
41_N	128_N	0.908	0.99
141_L	215_F	0.906	0.99
251_I	277_S	0.899	0.99
191_Q	194_G	0.896	0.99
49_V	176_S	0.896	0.99
98_R	103_K	0.894	0.99
100_I	125_E	0.892	0.99
163_L	219_L	0.891	0.99
206_D	210_T	0.891	0.99
251_I	285_T	0.891	0.99
267_E	278_L	0.889	0.99
31_W	88_F	0.889	0.99
253_A	281_I	0.888	0.99
64_V	77_V	0.885	0.99
164_R	223_L	0.884	0.99
281_I	285_T	0.882	0.99
245_T	248_F	0.876	0.99
30_H	33_Q	0.875	0.99
258_W	266_P	0.875	0.99
42_H	200_R	0.875	0.99
62_S	79_H	0.874	0.99
8_D	85_Q	0.871	0.99
233_R	242_T	0.869	0.99
258_W	277_S	0.868	0.99
100_I	103_K	0.863	0.99
246_T	249_T	0.862	0.99
42_H	203_L	0.856	0.99
251_I	284_S	0.853	0.99
252_T	256_A	0.850	0.99
85_Q	115_A	0.850	0.99
168_M	218_E	0.849	0.99
32_P	39_E	0.846	0.99
251_I	254_L	0.846	0.99
16_P	92_F	0.845	0.99
265_M	270_W	0.843	0.99
46_F	92_F	0.840	0.99
49_V	210_T	0.838	0.99
225_S	239_K	0.837	0.99
131_L	208_G	0.836	0.99
100_I	104_E	0.835	0.99
232_H	239_K	0.832	0.99
149_K	229_I	0.829	0.99
220_N	224_H	0.827	0.99
48_R	200_R	0.819	0.99
138_E	215_F	0.819	0.99
167_L	219_L	0.814	0.99
231_S	238_V	0.807	0.99
61_G	82_I	0.807	0.99
247_L	285_T	0.801	0.99
229_I	232_H	0.800	0.99
67_Q	93_D	0.799	0.99
76_T	91_N	0.796	0.99
258_W	261_N	0.795	0.99
178_K	182_M	0.785	0.98
147_Q	153_S	0.784	0.98
282_V	286_V	0.782	0.98
32_P	58_A	0.780	0.98
243_I	250_P	0.777	0.98
67_Q	72_E	0.776	0.98
108_Q	111_R	0.773	0.98
258_W	292_L	0.769	0.98
267_E	272_Y	0.768	0.98
94_F	100_I	0.766	0.98
96_I	100_I	0.766	0.98
279_L	286_V	0.764	0.98
236_E	249_T	0.761	0.98
271_K	290_L	0.759	0.98
174_I	208_G	0.758	0.98
255_G	274_Y	0.756	0.98
134_V	137_F	0.747	0.98
34_C	53_E	0.746	0.98
211_Y	215_F	0.741	0.98
260_M	265_M	0.736	0.98
95_S	101_K	0.734	0.98
113_D	117_E	0.730	0.97
287_L	290_L	0.729	0.97
254_L	281_I	0.729	0.97
67_Q	70_G	0.728	0.97
41_N	124_G	0.726	0.97
192_N	195_K	0.726	0.97
124_G	127_M	0.723	0.97
252_T	257_L	0.723	0.97
34_C	197_D	0.720	0.97
75_H	169_I	0.719	0.97
123_L	201_T	0.718	0.97
140_K	143_K	0.718	0.97
265_M	277_S	0.717	0.97
96_I	99_E	0.711	0.97
257_L	265_M	0.709	0.97
174_I	209_F	0.705	0.97
251_I	255_G	0.699	0.97
178_K	209_F	0.696	0.97
32_P	197_D	0.694	0.97
253_A	285_T	0.688	0.96
258_W	270_W	0.687	0.96
96_I	101_K	0.685	0.96
248_F	255_G	0.682	0.96
280_L	284_S	0.681	0.96
234_G	238_V	0.681	0.96
270_W	275_L	0.680	0.96
244_F	250_P	0.679	0.96
253_A	256_A	0.677	0.96
273_G	280_L	0.676	0.96
96_I	102_G	0.675	0.96
231_S	235_N	0.674	0.96
258_W	264_V	0.673	0.96
67_Q	74_D	0.672	0.96
20_S	286_V	0.671	0.96
250_P	284_S	0.667	0.96
34_C	42_H	0.665	0.96
42_H	204_K	0.664	0.96
202_Q	205_I	0.663	0.96
32_P	42_H	0.660	0.95
97_L	100_I	0.660	0.95
264_V	274_Y	0.659	0.95
233_R	237_I	0.654	0.95
59_V	82_I	0.653	0.95
182_M	206_D	0.650	0.95
268_L	278_L	0.647	0.95
216_E	224_H	0.647	0.95
274_Y	277_S	0.645	0.95
52_T	180_I	0.644	0.95
258_W	262_F	0.643	0.95
161_H	225_S	0.643	0.95
246_T	251_I	0.642	0.95
238_V	256_A	0.636	0.94
266_P	274_Y	0.635	0.94
82_I	116_I	0.634	0.94
240_A	248_F	0.633	0.94
42_H	53_E	0.632	0.94
175_L	209_F	0.626	0.94
110_E	113_D	0.625	0.94
65_Y	94_F	0.624	0.94
66_D	133_G	0.623	0.94
65_Y	76_T	0.622	0.94
221_N	224_H	0.622	0.94
290_L	293_R	0.620	0.94
110_E	114_N	0.618	0.94
247_L	251_I	0.618	0.94
143_K	150_D	0.614	0.93
118_G	122_L	0.613	0.93
220_N	225_S	0.613	0.93
14_M	90_I	0.613	0.93
15_G	93_D	0.612	0.93
27_H	30_H	0.611	0.93
49_V	128_N	0.611	0.93
201_T	204_K	0.608	0.93
68_G	71_E	0.608	0.93
224_H	227_E	0.607	0.93
63_I	80_F	0.602	0.93
177_A	207_R	0.601	0.93
234_G	237_I	0.601	0.93
89_T	122_L	0.600	0.93
133_G	170_W	0.598	0.92
265_M	273_G	0.594	0.92
52_T	59_V	0.594	0.92
7_K	10_F	0.594	0.92
99_E	125_E	0.593	0.92
240_A	244_F	0.593	0.92
97_L	122_L	0.592	0.92
184_L	198_Y	0.586	0.92
12_Y	88_F	0.583	0.91
171_K	178_K	0.578	0.91
65_Y	91_N	0.577	0.91
233_R	236_E	0.576	0.91
71_E	162_L	0.576	0.91
82_I	127_M	0.575	0.91
142_R	178_K	0.574	0.91
120_L	197_D	0.573	0.91
187_T	190_P	0.572	0.91
181_E	202_Q	0.572	0.91
13_Q	89_T	0.571	0.91
120_L	200_R	0.570	0.91
15_G	91_N	0.567	0.90
22_A	40_N	0.567	0.90
293_R	296_G	0.566	0.90
142_R	172_N	0.566	0.90
64_V	75_H	0.566	0.90
129_A	132_I	0.565	0.90
256_A	259_G	0.565	0.90
243_I	289_Y	0.563	0.90
64_V	173_L	0.563	0.90
158_N	229_I	0.563	0.90
153_S	156_I	0.562	0.90
40_N	43_H	0.559	0.90
49_V	206_D	0.558	0.90
14_M	21_K	0.558	0.90
252_T	277_S	0.558	0.90
178_K	202_Q	0.557	0.90
103_K	121_I	0.556	0.89
240_A	266_P	0.556	0.89
174_I	212_I	0.555	0.89
264_V	273_G	0.555	0.89
34_C	55_E	0.555	0.89
213_S	217_G	0.553	0.89
103_K	125_E	0.552	0.89
113_D	193_E	0.551	0.89
263_S	271_K	0.548	0.89
100_I	121_I	0.548	0.89
255_G	281_I	0.544	0.88
12_Y	86_Y	0.544	0.88
55_E	58_A	0.544	0.88
61_G	180_I	0.543	0.88
116_I	191_Q	0.542	0.88
273_G	292_L	0.541	0.88
63_I	126_L	0.540	0.88
197_D	201_T	0.539	0.88
120_L	201_T	0.538	0.88
185_K	202_Q	0.538	0.88
80_F	122_L	0.535	0.88
137_F	166_E	0.535	0.88
249_T	252_T	0.534	0.88
168_M	172_N	0.532	0.87
17_Q	91_N	0.530	0.87
245_T	253_A	0.529	0.87
117_E	197_D	0.528	0.87
111_R	117_E	0.528	0.87
43_H	90_I	0.528	0.87
258_W	296_G	0.528	0.87
97_L	103_K	0.523	0.86
96_I	104_E	0.523	0.86
240_A	291_Y	0.523	0.86
165_H	218_E	0.522	0.86
253_A	288_I	0.521	0.86
131_L	207_R	0.519	0.86
233_R	295_K	0.518	0.86
115_A	191_Q	0.518	0.86
52_T	73_K	0.517	0.86
22_A	44_V	0.515	0.86
19_R	286_V	0.515	0.86
52_T	187_T	0.514	0.85
233_R	239_K	0.512	0.85
263_S	267_E	0.512	0.85
191_Q	195_K	0.512	0.85
136_E	290_L	0.512	0.85
243_I	298_T	0.511	0.85
290_L	296_G	0.511	0.85
150_D	153_S	0.511	0.85
242_T	292_L	0.511	0.85
124_G	197_D	0.510	0.85
130_Y	208_G	0.509	0.85
262_F	270_W	0.508	0.85
136_E	140_K	0.508	0.85
284_S	287_L	0.507	0.85
157_L	173_L	0.507	0.85
260_M	268_L	0.507	0.85
34_C	201_T	0.507	0.85
260_M	281_I	0.506	0.85
65_Y	78_F	0.506	0.85
239_K	277_S	0.505	0.84
114_N	194_G	0.504	0.84
47_L	51_T	0.503	0.84
272_Y	278_L	0.502	0.84
48_R	51_T	0.501	0.84
112_A	193_E	0.500	0.84
282_V	285_T	0.500	0.84

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4i0uA	4	0.9211	100	0.176	Contact Map
4ev6A	3	0.9243	100	0.182	Contact Map
4egwA	1	0.7129	100	0.502	Contact Map
3ck6A	3	0.6909	100	0.542	Contact Map
3nvoA	2	0.6877	100	0.547	Contact Map
2bbhA	2	0.5678	100	0.588	Contact Map
2hn1A	2	0.6435	100	0.59	Contact Map
3rkgA	1	0.6877	90.8	0.926	Contact Map
2kncA	1	0.1577	31.3	0.954	Contact Map
4jo7E	2	0.2808	30.1	0.954	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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