GREMLIN Database
CORA - Magnesium transport protein CorA
UniProt: P40948 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 317 (288)
Sequences: 5379 (3808)
Seq/√Len: 224.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
263_S269_N9.3761.00
83_T86_Y4.0621.00
267_E274_Y3.8531.00
278_L282_V3.1611.00
275_L279_L2.8741.00
39_E81_Y2.8331.00
257_L278_L2.7771.00
276_F280_L2.7391.00
272_Y276_F2.6911.00
80_F87_F2.4321.00
63_I123_L2.3931.00
273_G277_S2.3901.00
147_Q159_R2.3881.00
265_M268_L2.3871.00
23_R27_H2.3181.00
272_Y275_L2.2801.00
13_Q91_N2.2631.00
290_L294_K2.2611.00
286_V290_L2.2591.00
262_F268_L2.2291.00
26_I40_N2.2231.00
248_F253_A2.1601.00
265_M274_Y2.1511.00
270_W276_F2.1481.00
11_W89_T2.1421.00
87_F118_G2.1251.00
264_V271_K2.1211.00
140_K159_R2.0441.00
14_M25_L2.0311.00
80_F89_T2.0261.00
253_A257_L2.0191.00
254_L277_S1.9901.00
270_W273_G1.9521.00
29_S88_F1.9471.00
271_K275_L1.9421.00
127_M201_T1.9251.00
235_N238_V1.8641.00
39_E58_A1.8241.00
128_N204_K1.8081.00
257_L281_I1.7081.00
262_F265_M1.6801.00
39_E55_E1.6771.00
287_L291_Y1.6661.00
275_L278_L1.6381.00
94_F98_R1.6351.00
258_W265_M1.6321.00
245_T249_T1.6051.00
171_K213_S1.5841.00
260_M277_S1.5731.00
66_D170_W1.5721.00
18_E21_K1.5681.00
51_T203_L1.5501.00
274_Y278_L1.5361.00
87_F119_F1.5351.00
101_K105_V1.5201.00
258_W267_E1.5141.00
258_W274_Y1.5081.00
114_N117_E1.5001.00
98_R104_E1.5001.00
277_S281_I1.4891.00
61_G119_F1.4751.00
239_K243_I1.4491.00
43_H81_Y1.4491.00
258_W268_L1.4321.00
124_G128_N1.4281.00
262_F273_G1.4151.00
94_F97_L1.4101.00
141_L219_L1.3941.00
291_Y295_K1.3741.00
270_W274_Y1.3641.00
124_G204_K1.3621.00
148_I222_L1.3541.00
102_G105_V1.3401.00
277_S280_L1.3351.00
120_L198_Y1.3271.00
262_F274_Y1.3211.00
267_E270_W1.3171.00
20_S23_R1.3131.00
48_R62_S1.3121.00
289_Y293_R1.3121.00
268_L274_Y1.3071.00
82_I119_F1.2951.00
278_L281_I1.2951.00
31_W81_Y1.2931.00
236_E239_K1.2701.00
54_T59_V1.2671.00
32_P55_E1.2611.00
34_C41_N1.2541.00
98_R101_K1.2531.00
78_F126_L1.2511.00
254_L258_W1.2461.00
61_G80_F1.2381.00
285_T289_Y1.2231.00
265_M275_L1.2231.00
101_K104_E1.2201.00
87_F115_A1.2171.00
264_V275_L1.2061.00
24_D28_F1.1951.00
288_I292_L1.1921.00
202_Q206_D1.1891.00
249_T253_A1.1851.00
99_E102_G1.1811.00
237_I242_T1.1701.00
182_M202_Q1.1691.00
42_H51_T1.1631.00
257_L274_Y1.1621.00
251_I281_I1.1611.00
19_R23_R1.1611.00
60_F81_Y1.1541.00
231_S234_G1.1451.00
279_L283_T1.1441.00
267_E275_L1.1421.00
9_W118_G1.1371.00
9_W115_A1.1261.00
250_P253_A1.1211.00
273_G276_F1.1181.00
100_I105_V1.1161.00
289_Y298_T1.1121.00
283_T287_L1.1031.00
17_Q21_K1.1011.00
80_F119_F1.0981.00
276_F279_L1.0951.00
255_G278_L1.0911.00
164_R216_E1.0881.00
48_R77_V1.0851.00
95_S98_R1.0841.00
173_L177_A1.0811.00
164_R224_H1.0761.00
97_L104_E1.0691.00
23_R26_I1.0651.00
230_T234_G1.0611.00
94_F101_K1.0601.00
200_R203_L1.0561.00
178_K206_D1.0521.00
157_L226_E1.0511.00
167_L215_F1.0281.00
185_K199_Q1.0241.00
98_R105_V1.0231.00
248_F251_I1.0231.00
127_M204_K1.0211.00
181_E205_I1.0201.00
238_V245_T1.0151.00
137_F163_L1.0141.00
262_F277_S1.0061.00
242_T245_T1.0051.00
22_A26_I0.9991.00
104_E110_E0.9931.00
100_I118_G0.9891.00
257_L260_M0.9891.00
24_D27_H0.9871.00
43_H79_H0.9871.00
140_K166_E0.9851.00
145_R165_H0.9761.00
267_E273_G0.9751.00
262_F267_E0.9731.00
54_T187_T0.9661.00
98_R102_G0.9621.00
112_A117_E0.9571.00
127_M205_I0.9521.00
178_K213_S0.9471.00
161_H223_L0.9431.00
242_T249_T0.9421.00
102_G106_V0.9411.00
237_I241_L0.9401.00
97_L101_K0.9401.00
53_E199_Q0.9391.00
261_N266_P0.9361.00
20_S24_D0.9311.00
100_I106_V0.9231.00
52_T61_G0.9221.00
116_I194_G0.9211.00
147_Q156_I0.9190.99
73_K166_E0.9140.99
293_R298_T0.9130.99
266_P273_G0.9090.99
175_L210_T0.9090.99
41_N128_N0.9080.99
141_L215_F0.9060.99
251_I277_S0.8990.99
191_Q194_G0.8960.99
49_V176_S0.8960.99
98_R103_K0.8940.99
100_I125_E0.8920.99
163_L219_L0.8910.99
206_D210_T0.8910.99
251_I285_T0.8910.99
267_E278_L0.8890.99
31_W88_F0.8890.99
253_A281_I0.8880.99
64_V77_V0.8850.99
164_R223_L0.8840.99
281_I285_T0.8820.99
245_T248_F0.8760.99
30_H33_Q0.8750.99
258_W266_P0.8750.99
42_H200_R0.8750.99
62_S79_H0.8740.99
8_D85_Q0.8710.99
233_R242_T0.8690.99
258_W277_S0.8680.99
100_I103_K0.8630.99
246_T249_T0.8620.99
42_H203_L0.8560.99
251_I284_S0.8530.99
252_T256_A0.8500.99
85_Q115_A0.8500.99
168_M218_E0.8490.99
32_P39_E0.8460.99
251_I254_L0.8460.99
16_P92_F0.8450.99
265_M270_W0.8430.99
46_F92_F0.8400.99
49_V210_T0.8380.99
225_S239_K0.8370.99
131_L208_G0.8360.99
100_I104_E0.8350.99
232_H239_K0.8320.99
149_K229_I0.8290.99
220_N224_H0.8270.99
48_R200_R0.8190.99
138_E215_F0.8190.99
167_L219_L0.8140.99
231_S238_V0.8070.99
61_G82_I0.8070.99
247_L285_T0.8010.99
229_I232_H0.8000.99
67_Q93_D0.7990.99
76_T91_N0.7960.99
258_W261_N0.7950.99
178_K182_M0.7850.98
147_Q153_S0.7840.98
282_V286_V0.7820.98
32_P58_A0.7800.98
243_I250_P0.7770.98
67_Q72_E0.7760.98
108_Q111_R0.7730.98
258_W292_L0.7690.98
267_E272_Y0.7680.98
94_F100_I0.7660.98
96_I100_I0.7660.98
279_L286_V0.7640.98
236_E249_T0.7610.98
271_K290_L0.7590.98
174_I208_G0.7580.98
255_G274_Y0.7560.98
134_V137_F0.7470.98
34_C53_E0.7460.98
211_Y215_F0.7410.98
260_M265_M0.7360.98
95_S101_K0.7340.98
113_D117_E0.7300.97
287_L290_L0.7290.97
254_L281_I0.7290.97
67_Q70_G0.7280.97
41_N124_G0.7260.97
192_N195_K0.7260.97
124_G127_M0.7230.97
252_T257_L0.7230.97
34_C197_D0.7200.97
75_H169_I0.7190.97
123_L201_T0.7180.97
140_K143_K0.7180.97
265_M277_S0.7170.97
96_I99_E0.7110.97
257_L265_M0.7090.97
174_I209_F0.7050.97
251_I255_G0.6990.97
178_K209_F0.6960.97
32_P197_D0.6940.97
253_A285_T0.6880.96
258_W270_W0.6870.96
96_I101_K0.6850.96
248_F255_G0.6820.96
280_L284_S0.6810.96
234_G238_V0.6810.96
270_W275_L0.6800.96
244_F250_P0.6790.96
253_A256_A0.6770.96
273_G280_L0.6760.96
96_I102_G0.6750.96
231_S235_N0.6740.96
258_W264_V0.6730.96
67_Q74_D0.6720.96
20_S286_V0.6710.96
250_P284_S0.6670.96
34_C42_H0.6650.96
42_H204_K0.6640.96
202_Q205_I0.6630.96
32_P42_H0.6600.95
97_L100_I0.6600.95
264_V274_Y0.6590.95
233_R237_I0.6540.95
59_V82_I0.6530.95
182_M206_D0.6500.95
268_L278_L0.6470.95
216_E224_H0.6470.95
274_Y277_S0.6450.95
52_T180_I0.6440.95
258_W262_F0.6430.95
161_H225_S0.6430.95
246_T251_I0.6420.95
238_V256_A0.6360.94
266_P274_Y0.6350.94
82_I116_I0.6340.94
240_A248_F0.6330.94
42_H53_E0.6320.94
175_L209_F0.6260.94
110_E113_D0.6250.94
65_Y94_F0.6240.94
66_D133_G0.6230.94
65_Y76_T0.6220.94
221_N224_H0.6220.94
290_L293_R0.6200.94
110_E114_N0.6180.94
247_L251_I0.6180.94
143_K150_D0.6140.93
118_G122_L0.6130.93
220_N225_S0.6130.93
14_M90_I0.6130.93
15_G93_D0.6120.93
27_H30_H0.6110.93
49_V128_N0.6110.93
201_T204_K0.6080.93
68_G71_E0.6080.93
224_H227_E0.6070.93
63_I80_F0.6020.93
177_A207_R0.6010.93
234_G237_I0.6010.93
89_T122_L0.6000.93
133_G170_W0.5980.92
265_M273_G0.5940.92
52_T59_V0.5940.92
7_K10_F0.5940.92
99_E125_E0.5930.92
240_A244_F0.5930.92
97_L122_L0.5920.92
184_L198_Y0.5860.92
12_Y88_F0.5830.91
171_K178_K0.5780.91
65_Y91_N0.5770.91
233_R236_E0.5760.91
71_E162_L0.5760.91
82_I127_M0.5750.91
142_R178_K0.5740.91
120_L197_D0.5730.91
187_T190_P0.5720.91
181_E202_Q0.5720.91
13_Q89_T0.5710.91
120_L200_R0.5700.91
15_G91_N0.5670.90
22_A40_N0.5670.90
293_R296_G0.5660.90
142_R172_N0.5660.90
64_V75_H0.5660.90
129_A132_I0.5650.90
256_A259_G0.5650.90
243_I289_Y0.5630.90
64_V173_L0.5630.90
158_N229_I0.5630.90
153_S156_I0.5620.90
40_N43_H0.5590.90
49_V206_D0.5580.90
14_M21_K0.5580.90
252_T277_S0.5580.90
178_K202_Q0.5570.90
103_K121_I0.5560.89
240_A266_P0.5560.89
174_I212_I0.5550.89
264_V273_G0.5550.89
34_C55_E0.5550.89
213_S217_G0.5530.89
103_K125_E0.5520.89
113_D193_E0.5510.89
263_S271_K0.5480.89
100_I121_I0.5480.89
255_G281_I0.5440.88
12_Y86_Y0.5440.88
55_E58_A0.5440.88
61_G180_I0.5430.88
116_I191_Q0.5420.88
273_G292_L0.5410.88
63_I126_L0.5400.88
197_D201_T0.5390.88
120_L201_T0.5380.88
185_K202_Q0.5380.88
80_F122_L0.5350.88
137_F166_E0.5350.88
249_T252_T0.5340.88
168_M172_N0.5320.87
17_Q91_N0.5300.87
245_T253_A0.5290.87
117_E197_D0.5280.87
111_R117_E0.5280.87
43_H90_I0.5280.87
258_W296_G0.5280.87
97_L103_K0.5230.86
96_I104_E0.5230.86
240_A291_Y0.5230.86
165_H218_E0.5220.86
253_A288_I0.5210.86
131_L207_R0.5190.86
233_R295_K0.5180.86
115_A191_Q0.5180.86
52_T73_K0.5170.86
22_A44_V0.5150.86
19_R286_V0.5150.86
52_T187_T0.5140.85
233_R239_K0.5120.85
263_S267_E0.5120.85
191_Q195_K0.5120.85
136_E290_L0.5120.85
243_I298_T0.5110.85
290_L296_G0.5110.85
150_D153_S0.5110.85
242_T292_L0.5110.85
124_G197_D0.5100.85
130_Y208_G0.5090.85
262_F270_W0.5080.85
136_E140_K0.5080.85
284_S287_L0.5070.85
157_L173_L0.5070.85
260_M268_L0.5070.85
34_C201_T0.5070.85
260_M281_I0.5060.85
65_Y78_F0.5060.85
239_K277_S0.5050.84
114_N194_G0.5040.84
47_L51_T0.5030.84
272_Y278_L0.5020.84
48_R51_T0.5010.84
112_A193_E0.5000.84
282_V285_T0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i0uA 4 0.9211 100 0.176 Contact Map
4ev6A 3 0.9243 100 0.182 Contact Map
4egwA 1 0.7129 100 0.502 Contact Map
3ck6A 3 0.6909 100 0.542 Contact Map
3nvoA 2 0.6877 100 0.547 Contact Map
2bbhA 2 0.5678 100 0.588 Contact Map
2hn1A 2 0.6435 100 0.59 Contact Map
3rkgA 1 0.6877 90.8 0.926 Contact Map
2kncA 1 0.1577 31.3 0.954 Contact Map
4jo7E 2 0.2808 30.1 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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