GREMLIN Database
PGK - Phosphoglycerate kinase
UniProt: P40924 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 394 (389)
Sequences: 3738 (1912)
Seq/√Len: 97.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
190_T310_S3.7561.00
384_E389_A3.7481.00
232_E288_S3.5441.00
34_D38_R3.4891.00
17_F57_A3.2341.00
27_K30_E2.9891.00
298_K301_E2.8161.00
235_K289_D2.8041.00
264_E302_T2.7261.00
79_R82_E2.7231.00
172_E176_D2.6011.00
47_L52_A2.5601.00
18_C47_L2.5481.00
9_I166_V2.4821.00
34_D79_R2.4221.00
325_D359_K2.3821.00
270_D277_N2.3131.00
46_H169_F2.2561.00
45_K49_D2.2531.00
130_L134_F2.2471.00
157_A161_E2.2161.00
282_P298_K2.2101.00
186_D311_K2.1731.00
22_F40_A2.1361.00
338_L346_S2.1251.00
53_K108_D2.0981.00
17_F159_I2.0851.00
227_K240_E2.0671.00
106_M110_D2.0671.00
107_K110_D2.0621.00
106_M112_L2.0511.00
261_Y306_V2.0471.00
218_G319_M2.0461.00
223_Y292_A2.0331.00
272_F324_I2.0291.00
79_R83_L1.9551.00
332_K360_F1.9521.00
206_E252_R1.9421.00
94_A120_Y1.9201.00
269_A276_A1.9201.00
250_M260_F1.9161.00
251_D255_E1.9101.00
332_K336_E1.9001.00
100_K136_E1.8971.00
132_K162_H1.8901.00
300_R304_A1.8821.00
210_D252_R1.8681.00
68_V71_L1.8681.00
264_E298_K1.8481.00
89_K110_D1.8381.00
279_K290_L1.8291.00
206_E248_S1.8261.00
46_H50_Q1.8251.00
15_V55_L1.8171.00
57_A138_A1.8071.00
74_T78_A1.7871.00
336_E340_E1.7851.00
212_V215_L1.7791.00
300_R333_A1.7661.00
329_Q332_K1.7571.00
7_K169_F1.7261.00
280_I297_T1.7041.00
210_D256_K1.6991.00
301_E305_D1.6951.00
81_G87_E1.6811.00
243_I247_K1.6801.00
227_K243_I1.6741.00
101_A105_E1.6691.00
307_I341_A1.6661.00
331_T356_A1.6661.00
181_A347_V1.6611.00
259_N306_V1.6381.00
128_P161_E1.6321.00
148_A156_T1.6061.00
341_A344_T1.6051.00
251_D254_K1.5821.00
11_V47_L1.5791.00
91_A102_Q1.5771.00
266_V283_I1.5731.00
214_N261_Y1.5701.00
55_L138_A1.5691.00
229_L250_M1.5611.00
193_I205_I1.5511.00
7_K172_E1.5321.00
167_A391_L1.5301.00
216_I303_Y1.5291.00
190_T214_N1.5281.00
270_D289_D1.5231.00
13_G108_D1.5111.00
274_N326_L1.5111.00
84_L111_V1.5051.00
102_Q112_L1.4911.00
202_I242_K1.4761.00
268_V281_V1.4741.00
190_T307_I1.4591.00
175_L388_V1.4521.00
41_L83_L1.4451.00
286_I292_A1.4401.00
45_K86_K1.4341.00
270_D290_L1.4331.00
72_R90_K1.4261.00
103_I112_L1.4161.00
142_V166_V1.4131.00
248_S252_R1.4111.00
48_A53_K1.4040.99
314_V380_M1.3930.99
57_A117_V1.3870.99
97_D100_K1.3860.99
244_E247_K1.3780.99
160_A390_A1.3730.99
97_D101_A1.3680.99
304_A337_A1.3670.99
92_D98_A1.3600.99
132_K136_E1.3580.99
15_V53_K1.3560.99
299_T303_Y1.3530.99
223_Y266_V1.3500.99
199_K239_E1.3420.99
171_M388_V1.3220.99
26_M60_L1.3200.99
287_P290_L1.3200.99
7_K46_H1.3200.99
214_N306_V1.3170.99
345_Y367_S1.3150.99
235_K291_E1.3120.99
308_K340_E1.3060.99
152_A157_A1.3000.99
269_A293_I1.2980.99
38_R83_L1.2970.99
18_C56_L1.2800.99
126_N158_G1.2800.99
17_F138_A1.2670.99
86_K110_D1.2610.99
18_C44_I1.2510.99
89_K102_Q1.2430.99
282_P285_E1.2430.99
214_N259_N1.2400.99
44_I56_L1.2320.99
20_V56_L1.2290.99
91_A99_V1.2290.99
305_D308_K1.2260.99
131_A158_G1.2240.99
47_L54_V1.2230.99
281_V287_P1.2220.99
304_A308_K1.2200.99
122_G130_L1.2200.99
358_E363_A1.2190.99
242_K245_L1.2140.98
333_A336_E1.2000.98
214_N310_S1.1960.98
302_T306_V1.1930.98
274_N325_D1.1920.98
98_A102_Q1.1880.98
149_A171_M1.1860.98
275_D324_I1.1850.98
180_K186_D1.1830.98
181_A314_V1.1800.98
145_A148_A1.1610.98
103_I106_M1.1520.98
120_Y130_L1.1510.98
77_A81_G1.1490.98
4_K392_N1.1460.98
78_A81_G1.1340.98
12_K108_D1.1310.98
179_G379_F1.1310.98
233_V238_L1.1290.98
117_V130_L1.1290.98
9_I140_V1.1180.97
247_K251_D1.1120.97
58_S73_L1.1110.97
18_C43_T1.1000.97
229_L254_K1.0970.97
341_A346_S1.0950.97
177_V345_Y1.0890.97
216_I299_T1.0890.97
57_A159_I1.0840.97
231_Y284_S1.0780.97
267_L280_I1.0770.97
329_Q333_A1.0760.97
120_Y133_A1.0730.97
226_V231_Y1.0690.97
48_A86_K1.0680.97
214_N309_N1.0630.96
178_L379_F1.0600.96
319_M334_V1.0590.96
66_E121_P1.0590.96
179_G183_S1.0570.96
65_G68_V1.0570.96
266_V292_A1.0560.96
12_K51_G1.0490.96
281_V290_L1.0470.96
307_I337_A1.0470.96
95_Y120_Y1.0450.96
126_N157_A1.0420.96
227_K232_E1.0380.96
20_V40_A1.0290.96
295_I319_M1.0240.96
93_E96_G1.0230.96
131_A154_A1.0190.96
362_L366_M1.0140.95
95_Y133_A1.0100.95
325_D328_A1.0060.95
95_Y130_L0.9990.95
73_L90_K0.9960.95
131_A162_H0.9940.95
265_D296_G0.9920.95
220_G237_L0.9910.95
149_A156_T0.9910.95
35_T358_E0.9900.95
254_K259_N0.9770.94
306_V309_N0.9770.94
100_K133_A0.9710.94
91_A112_L0.9680.94
187_R213_D0.9670.94
78_A82_E0.9650.94
74_T90_K0.9610.94
33_D358_E0.9610.94
300_R329_Q0.9600.94
226_V262_M0.9580.94
176_D180_K0.9530.94
87_E110_D0.9520.94
138_A163_L0.9500.93
261_Y303_Y0.9460.93
267_L300_R0.9450.93
216_I306_V0.9450.93
305_D309_N0.9440.93
5_T172_E0.9430.93
6_L47_L0.9390.93
278_V326_L0.9390.93
202_I245_L0.9360.93
313_V344_T0.9340.93
27_K32_T0.9330.93
74_T92_D0.9330.93
272_F293_I0.9320.93
128_P162_H0.9270.93
103_I137_L0.9250.93
270_D279_K0.9250.93
328_A360_F0.9210.92
313_V338_L0.9200.92
81_G113_V0.9180.92
268_V290_L0.9090.92
220_G233_V0.9060.92
44_I111_V0.9030.92
129_E132_K0.8980.91
248_S251_D0.8960.91
348_I357_V0.8940.91
238_L243_I0.8910.91
348_I353_S0.8880.91
328_A332_K0.8880.91
56_L113_V0.8860.91
270_D276_A0.8850.91
92_D102_Q0.8840.91
278_V324_I0.8830.91
200_D203_G0.8810.91
389_A392_N0.8800.91
10_D50_Q0.8790.91
89_K105_E0.8790.91
94_A134_F0.8780.90
304_A333_A0.8770.90
301_E304_A0.8760.90
99_V114_L0.8740.90
46_H49_D0.8720.90
48_A111_V0.8720.90
41_L84_L0.8700.90
53_K103_I0.8690.90
223_Y283_I0.8650.90
307_I334_V0.8610.90
191_A212_V0.8600.90
72_R115_E0.8600.90
38_R79_R0.8570.89
53_K106_M0.8560.89
147_G372_G0.8550.89
302_T305_D0.8550.89
300_R334_V0.8530.89
252_R255_E0.8500.89
354_A358_E0.8420.89
233_V292_A0.8420.89
68_V124_E0.8400.88
192_I338_L0.8380.88
48_A110_D0.8360.88
69_E72_R0.8350.88
226_V283_I0.8340.88
227_K238_L0.8330.88
271_D291_E0.8330.88
34_D83_L0.8300.88
117_V134_F0.8300.88
245_L248_S0.8260.88
26_M32_T0.8230.87
240_E243_I0.8200.87
143_N149_A0.8120.87
156_T160_A0.8110.87
117_V155_S0.8100.87
35_T39_A0.8090.87
45_K85_G0.8070.86
274_N324_I0.8040.86
177_V367_S0.8040.86
122_G133_A0.8030.86
160_A165_A0.8030.86
31_V80_L0.7970.86
180_K345_Y0.7970.86
270_D287_P0.7960.86
295_I299_T0.7920.85
35_T354_A0.7910.85
115_E119_F0.7910.85
253_A258_V0.7900.85
69_E119_F0.7880.85
31_V79_R0.7870.85
93_E99_V0.7860.85
44_I54_V0.7830.85
102_Q105_E0.7810.85
226_V266_V0.7800.84
295_I330_G0.7800.84
76_V113_V0.7790.84
98_A101_A0.7790.84
48_A54_V0.7720.84
337_A341_A0.7720.84
278_V290_L0.7710.84
220_G238_L0.7690.84
26_M29_G0.7680.84
227_K233_V0.7680.84
58_S148_A0.7670.83
101_A104_S0.7660.83
18_C54_V0.7660.83
203_G206_E0.7640.83
10_D14_K0.7610.83
268_V279_K0.7600.83
140_V166_V0.7590.83
100_K137_L0.7570.83
368_H376_S0.7560.83
148_A153_H0.7560.83
357_V366_M0.7550.83
30_E78_A0.7550.83
100_K104_S0.7550.83
384_E392_N0.7550.83
264_E299_T0.7500.82
143_N148_A0.7470.82
129_E133_A0.7430.81
22_F56_L0.7420.81
89_K106_M0.7410.81
293_I321_V0.7380.81
338_L366_M0.7360.81
348_I366_M0.7330.81
244_E248_S0.7330.81
185_P312_L0.7320.81
11_V16_V0.7300.80
273_S324_I0.7290.80
335_A357_V0.7270.80
124_E153_H0.7270.80
281_V286_I0.7270.80
127_D131_A0.7240.80
239_E242_K0.7240.80
94_A130_L0.7240.80
209_L258_V0.7190.79
128_P132_K0.7190.79
143_N153_H0.7170.79
237_L291_E0.7170.79
293_I324_I0.7140.79
261_Y302_T0.7120.79
267_L329_Q0.7100.78
11_V50_Q0.7090.78
37_I79_R0.7080.78
178_L182_V0.7050.78
90_K102_Q0.7040.78
190_T306_V0.7030.78
103_I110_D0.7010.78
133_A136_E0.7000.78
7_K50_Q0.6990.77
321_V324_I0.6980.77
47_L142_V0.6950.77
67_V120_Y0.6950.77
270_D273_S0.6950.77
378_E383_K0.6940.77
89_K112_L0.6920.77
304_A340_E0.6910.77
74_T77_A0.6910.77
354_A357_V0.6910.77
277_N290_L0.6900.76
65_G71_L0.6900.76
253_A257_G0.6900.76
259_N302_T0.6880.76
209_L253_A0.6870.76
41_L45_K0.6850.76
311_K343_D0.6850.76
167_A171_M0.6840.76
49_D86_K0.6840.76
93_E120_Y0.6800.75
300_R337_A0.6790.75
81_G86_K0.6790.75
348_I354_A0.6760.75
94_A117_V0.6760.75
90_K117_V0.6750.75
205_I209_L0.6710.74
78_A87_E0.6700.74
231_Y282_P0.6680.74
94_A122_G0.6680.74
279_K287_P0.6670.74
26_M75_P0.6660.74
159_I163_L0.6660.74
328_A359_K0.6650.74
228_A246_A0.6650.74
173_K177_V0.6640.74
315_W335_A0.6610.73
157_A390_A0.6610.73
325_D329_Q0.6600.73
203_G383_K0.6590.73
270_D278_V0.6590.73
272_F321_V0.6580.73
318_P322_F0.6580.73
193_I354_A0.6580.73
273_S276_A0.6570.73
272_F291_E0.6560.73
242_K368_H0.6550.73
12_K50_Q0.6530.72
67_V72_R0.6510.72
55_L112_L0.6500.72
58_S117_V0.6480.72
165_A391_L0.6470.72
222_A266_V0.6460.72
143_N390_A0.6420.71
353_S376_S0.6410.71
313_V341_A0.6390.71
332_K359_K0.6370.71
114_L134_F0.6320.70
43_T169_F0.6320.70
206_E245_L0.6310.70
27_K274_N0.6310.70
71_L117_V0.6300.70
56_L111_V0.6290.70
340_E365_K0.6280.70
231_Y283_I0.6250.69
252_R256_K0.6240.69
32_T355_A0.6240.69
291_E324_I0.6240.69
57_A114_L0.6240.69
272_F276_A0.6240.69
191_A216_I0.6210.69
169_F172_E0.6200.69
206_E249_F0.6190.68
48_A108_D0.6170.68
298_K302_T0.6160.68
134_F155_S0.6160.68
29_G75_P0.6140.68
141_Y160_A0.6140.68
326_L329_Q0.6130.68
147_G170_L0.6130.68
128_P158_G0.6130.68
231_Y266_V0.6120.68
200_D205_I0.6120.68
125_K128_P0.6090.67
207_S210_D0.6080.67
15_V104_S0.6060.67
273_S326_L0.6050.67
196_A200_D0.6040.67
11_V52_A0.6040.67
175_L179_G0.6030.66
281_V285_E0.6030.66
276_A324_I0.6020.66
145_A153_H0.5990.66
366_M369_I0.5960.66
117_V156_T0.5950.65
216_I261_Y0.5950.65
244_E251_D0.5940.65
4_K9_I0.5920.65
55_L137_L0.5910.65
96_G102_Q0.5900.65
54_V111_V0.5870.64
199_K221_L0.5860.64
188_P312_L0.5850.64
307_I310_S0.5850.64
209_L215_L0.5850.64
3_K392_N0.5850.64
166_V392_N0.5830.64
47_L163_L0.5820.64
141_Y153_H0.5820.64
295_I300_R0.5820.64
20_V31_V0.5780.63
14_K139_D0.5780.63
249_F260_F0.5770.63
199_K241_D0.5770.63
306_V310_S0.5770.63
20_V57_A0.5760.63
355_A359_K0.5760.63
131_A159_I0.5750.63
190_T309_N0.5740.63
173_K368_H0.5740.63
152_A158_G0.5740.63
272_F275_D0.5730.63
223_Y291_E0.5720.62
266_V284_S0.5710.62
239_E246_A0.5690.62
141_Y390_A0.5680.62
40_A147_G0.5650.61
308_K337_A0.5650.61
207_S382_G0.5640.61
188_P213_D0.5640.61
279_K285_E0.5620.61
245_L249_F0.5610.61
20_V58_S0.5610.61
189_F314_V0.5610.61
203_G242_K0.5610.61
18_C142_V0.5600.61
94_A133_A0.5600.61
197_K351_G0.5590.61
41_L77_A0.5590.61
44_I80_L0.5590.61
95_Y134_F0.5570.60
200_D242_K0.5560.60
5_T176_D0.5540.60
143_N160_A0.5540.60
346_S367_S0.5500.59
363_A369_I0.5500.59
200_D354_A0.5490.59
351_G374_G0.5490.59
193_I200_D0.5470.59
319_M360_F0.5470.59
295_I334_V0.5470.59
240_E244_E0.5460.59
177_V181_A0.5460.59
4_K166_V0.5440.59
337_A340_E0.5420.58
138_A159_I0.5420.58
220_G321_V0.5420.58
53_K107_K0.5410.58
213_D256_K0.5400.58
215_L260_F0.5400.58
268_V278_V0.5400.58
58_S145_A0.5400.58
117_V120_Y0.5390.58
67_V92_D0.5390.58
65_G124_E0.5380.58
217_I221_L0.5370.58
55_L103_I0.5370.58
177_V347_V0.5370.58
94_A99_V0.5370.58
322_F356_A0.5340.57
203_G381_E0.5340.57
247_K254_K0.5340.57
189_F200_D0.5330.57
3_K175_L0.5310.57
60_L76_V0.5310.57
90_K99_V0.5300.57
186_D345_Y0.5300.57
199_K312_L0.5300.57
271_D275_D0.5300.57
16_V166_V0.5300.57
67_V119_F0.5280.56
235_K271_D0.5260.56
339_A365_K0.5250.56
71_L124_E0.5250.56
228_A247_K0.5250.56
71_L119_F0.5240.56
64_K124_E0.5220.55
269_A327_F0.5210.55
228_A243_I0.5200.55
67_V71_L0.5180.55
60_L71_L0.5180.55
265_D299_T0.5170.55
333_A337_A0.5160.55
207_S383_K0.5160.55
55_L106_M0.5150.55
354_A369_I0.5140.54
126_N156_T0.5130.54
335_A362_L0.5130.54
125_K129_E0.5120.54
99_V103_I0.5110.54
99_V102_Q0.5100.54
104_S108_D0.5100.54
314_V347_V0.5080.54
295_I303_Y0.5080.54
122_G134_F0.5080.54
65_G69_E0.5070.53
22_F58_S0.5070.53
4_K8_D0.5060.53
200_D368_H0.5060.53
222_A263_P0.5050.53
3_K8_D0.5040.53
171_M391_L0.5040.53
96_G112_L0.5040.53
207_S211_K0.5030.53
299_T302_T0.5020.53
177_V180_K0.5010.53
329_Q336_E0.5000.52
156_T387_G0.5000.52
61_G202_I0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1phpA 1 1 100 -0.043 Contact Map
1vpeA 1 0.9975 100 -0.034 Contact Map
3q3vA 1 0.9873 100 -0.029 Contact Map
3zlbA 1 0.9924 100 -0.027 Contact Map
1v6sA 1 0.9873 100 -0.027 Contact Map
1qpgA 1 0.9975 100 -0.026 Contact Map
4ng4A 1 0.9772 100 -0.024 Contact Map
16pkA 1 0.9924 100 -0.023 Contact Map
3oz7A 2 0.9949 100 -0.021 Contact Map
2wzbA 1 0.9949 100 -0.018 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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