S5AEA - BACSU - GREMLIN Contacts

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S5AEA - Stage V sporulation protein AE

UniProt:	P40870	Sequences: MTTKRKVILVTDGDVYAAKTIEYAASKVGGRCISQSKGNPSTRSGAELVKLIASAPYDPVFVMFDDSGLQGEGPGEAALTYVATHPSIEVLGVIAVASKTHQAEWTRVDVSIDRNGEITEYGVDKVGEREFDDHRMSGDTVYCLDKLDLPLIVGIGDIGKMGRKDDISKGSPITMKAVEFILERSGYHAGPQGRENSGLSESS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	203 (185)
Sequences:	134 (110)
Seq/√Len:	8.1

BACSU - S5AEA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
53_A	87_S	4.652	0.99
27_K	175_M	3.645	0.95
24_A	27_K	3.283	0.92
41_S	48_L	3.243	0.92
10_V	61_F	3.218	0.91
110_V	153_V	3.115	0.90
24_A	175_M	2.713	0.82
93_V	149_L	2.675	0.81
64_F	82_V	2.654	0.80
144_L	152_I	2.452	0.75
72_E	80_T	2.326	0.70
105_W	142_Y	2.322	0.70
111_S	130_E	2.242	0.67
111_S	163_R	2.173	0.65
61_F	178_V	2.108	0.62
20_T	171_S	2.066	0.61
93_V	144_L	2.061	0.61
21_I	61_F	2.015	0.59
105_W	145_D	1.963	0.57
19_K	91_L	1.901	0.54
10_V	21_I	1.875	0.53
44_S	179_E	1.864	0.53
5_R	58_D	1.844	0.52
5_R	43_R	1.830	0.51
158_I	179_E	1.792	0.50
30_G	178_V	1.783	0.49
94_I	178_V	1.773	0.49
149_L	152_I	1.756	0.48
24_A	61_F	1.721	0.47
114_R	128_E	1.707	0.46
31_R	34_S	1.672	0.45
111_S	120_E	1.631	0.43
45_G	78_A	1.592	0.42
49_V	54_S	1.572	0.41
24_A	178_V	1.517	0.39
103_A	142_Y	1.471	0.37
7_V	149_L	1.470	0.37
36_S	154_G	1.464	0.36
18_A	22_E	1.441	0.36
86_P	143_C	1.425	0.35
18_A	103_A	1.410	0.34
180_F	183_E	1.410	0.34
52_I	147_L	1.373	0.33
32_C	44_S	1.353	0.32
88_I	152_I	1.325	0.31
67_S	167_I	1.322	0.31
42_T	119_T	1.317	0.31
93_V	98_S	1.313	0.31
132_D	183_E	1.310	0.31
103_A	163_R	1.280	0.30
27_K	61_F	1.276	0.30
105_W	119_T	1.270	0.29
105_W	122_G	1.229	0.28
52_I	155_I	1.228	0.28
171_S	175_M	1.221	0.28
81_Y	110_V	1.217	0.28
126_V	163_R	1.214	0.28
23_Y	171_S	1.205	0.27
97_A	100_T	1.197	0.27
6_K	89_E	1.197	0.27
38_G	154_G	1.191	0.27
19_K	74_P	1.190	0.27
114_R	162_G	1.183	0.27
46_A	50_K	1.165	0.26
51_L	54_S	1.163	0.26
53_A	101_H	1.160	0.26
105_W	183_E	1.152	0.26
74_P	112_I	1.152	0.26
79_L	107_R	1.150	0.25
165_D	170_G	1.148	0.25
91_L	182_L	1.139	0.25
122_G	180_F	1.124	0.25
102_Q	117_E	1.112	0.24
122_G	142_Y	1.090	0.24
31_R	63_M	1.089	0.24
82_V	91_L	1.082	0.23
71_G	81_Y	1.074	0.23
25_A	97_A	1.071	0.23
90_V	112_I	1.067	0.23
86_P	93_V	1.065	0.23
33_I	58_D	1.060	0.23
22_E	98_S	1.058	0.23
64_F	85_H	1.057	0.23
142_Y	145_D	1.050	0.22
6_K	169_K	1.048	0.22
119_T	145_D	1.048	0.22
41_S	119_T	1.038	0.22
129_R	146_K	1.037	0.22
70_Q	126_V	1.010	0.21
43_R	106_T	0.997	0.21
130_E	147_L	0.994	0.21
111_S	166_D	0.986	0.21
21_I	112_I	0.980	0.21
113_D	150_P	0.979	0.20
5_R	29_G	0.976	0.20
22_E	34_S	0.976	0.20
54_S	176_K	0.973	0.20
18_A	35_Q	0.971	0.20
5_R	30_G	0.964	0.20
105_W	132_D	0.957	0.20
64_F	174_T	0.956	0.20
135_R	183_E	0.954	0.20
30_G	172_P	0.952	0.20
173_I	184_R	0.943	0.20
115_N	131_F	0.943	0.20
26_S	101_H	0.938	0.19
49_V	144_L	0.938	0.19
106_T	187_Y	0.936	0.19
89_E	155_I	0.930	0.19
115_N	129_R	0.925	0.19
100_T	103_A	0.923	0.19
26_S	32_C	0.918	0.19
60_V	94_I	0.918	0.19
43_R	51_L	0.915	0.19
134_H	158_I	0.913	0.19
50_K	54_S	0.907	0.19
130_E	166_D	0.906	0.19
56_P	98_S	0.895	0.18
135_R	144_L	0.889	0.18
4_K	55_A	0.874	0.18
20_T	23_Y	0.861	0.17
136_M	155_I	0.858	0.17
174_T	186_G	0.858	0.17
58_D	141_V	0.857	0.17
35_Q	54_S	0.856	0.17
9_L	58_D	0.854	0.17
58_D	82_V	0.853	0.17
64_F	83_A	0.852	0.17
59_P	90_V	0.850	0.17
50_K	188_H	0.834	0.17
5_R	55_A	0.833	0.17
16_Y	99_K	0.833	0.17
71_G	115_N	0.831	0.17
21_I	173_I	0.830	0.17
102_Q	130_E	0.829	0.17
29_G	32_C	0.827	0.17
128_E	164_K	0.823	0.17
119_T	134_H	0.822	0.17
20_T	80_T	0.808	0.16
4_K	112_I	0.800	0.16
72_E	162_G	0.800	0.16
20_T	175_M	0.797	0.16
94_I	113_D	0.793	0.16
120_E	130_E	0.785	0.16
67_S	119_T	0.782	0.16
58_D	116_G	0.781	0.16
93_V	109_D	0.778	0.16
19_K	53_A	0.777	0.16
162_G	168_S	0.774	0.16
103_A	126_V	0.771	0.15
15_V	102_Q	0.770	0.15
120_E	167_I	0.762	0.15
91_L	186_G	0.762	0.15
53_A	74_P	0.761	0.15
83_A	148_D	0.760	0.15
119_T	162_G	0.758	0.15
57_Y	89_E	0.757	0.15
47_E	50_K	0.755	0.15
28_V	162_G	0.755	0.15
105_W	121_Y	0.754	0.15
107_R	118_I	0.752	0.15
103_A	111_S	0.750	0.15
113_D	117_E	0.745	0.15
101_H	121_Y	0.744	0.15
84_T	93_V	0.743	0.15
28_V	178_V	0.742	0.15
41_S	69_L	0.742	0.15
53_A	120_E	0.740	0.15
67_S	105_W	0.736	0.15
99_K	102_Q	0.732	0.15
91_L	113_D	0.731	0.15
57_Y	131_F	0.719	0.14
113_D	145_D	0.718	0.14
73_G	92_G	0.718	0.14
82_V	90_V	0.718	0.14
113_D	122_G	0.715	0.14
63_M	90_V	0.715	0.14
17_A	94_I	0.712	0.14
122_G	132_D	0.712	0.14
18_A	146_K	0.709	0.14
10_V	18_A	0.706	0.14
22_E	63_M	0.705	0.14
87_S	112_I	0.704	0.14
5_R	57_Y	0.704	0.14
31_R	51_L	0.699	0.14
4_K	48_L	0.684	0.14
21_I	35_Q	0.684	0.14
30_G	55_A	0.679	0.14
10_V	152_I	0.678	0.14
79_L	169_K	0.677	0.14
89_E	166_D	0.675	0.13
69_L	163_R	0.672	0.13
23_Y	164_K	0.671	0.13
106_T	176_K	0.671	0.13
48_L	109_D	0.669	0.13
99_K	130_E	0.669	0.13
20_T	28_V	0.667	0.13
131_F	162_G	0.666	0.13
16_Y	105_W	0.666	0.13
83_A	149_L	0.665	0.13
74_P	87_S	0.663	0.13
29_G	158_I	0.657	0.13
23_Y	27_K	0.654	0.13
134_H	145_D	0.651	0.13
173_I	176_K	0.648	0.13
44_S	50_K	0.643	0.13
16_Y	67_S	0.642	0.13
27_K	133_D	0.638	0.13
75_G	170_G	0.631	0.13
39_N	141_V	0.631	0.13
42_T	115_N	0.627	0.13
67_S	180_F	0.627	0.13
64_F	158_I	0.626	0.13
84_T	171_S	0.624	0.13
80_T	146_K	0.620	0.12
43_R	144_L	0.620	0.12
98_S	166_D	0.620	0.12
72_E	134_H	0.617	0.12
106_T	147_L	0.609	0.12
41_S	188_H	0.604	0.12
112_I	116_G	0.600	0.12
117_E	152_I	0.599	0.12
15_V	121_Y	0.599	0.12
64_F	78_A	0.597	0.12
53_A	81_Y	0.596	0.12
134_H	168_S	0.596	0.12
78_A	85_H	0.593	0.12
111_S	175_M	0.590	0.12
10_V	28_V	0.589	0.12
37_K	80_T	0.587	0.12
104_E	145_D	0.587	0.12
151_L	187_Y	0.584	0.12
130_E	164_K	0.584	0.12
67_S	142_Y	0.584	0.12
42_T	103_A	0.583	0.12
16_Y	182_L	0.579	0.12
114_R	168_S	0.579	0.12
118_I	130_E	0.574	0.12
43_R	60_V	0.574	0.12
10_V	146_K	0.573	0.12
49_V	91_L	0.573	0.12
83_A	147_L	0.572	0.12
16_Y	143_C	0.570	0.12
59_P	85_H	0.569	0.12
4_K	98_S	0.568	0.12
6_K	173_I	0.567	0.12
38_G	63_M	0.563	0.11
56_P	174_T	0.562	0.11
24_A	43_R	0.552	0.11
134_H	174_T	0.549	0.11
79_L	164_K	0.548	0.11
171_S	176_K	0.547	0.11
119_T	129_R	0.546	0.11
121_Y	145_D	0.544	0.11
135_R	174_T	0.544	0.11
47_E	167_I	0.540	0.11
110_V	183_E	0.537	0.11
26_S	47_E	0.533	0.11
63_M	70_Q	0.533	0.11
46_A	89_E	0.532	0.11
150_P	182_L	0.531	0.11
5_R	31_R	0.530	0.11
47_E	171_S	0.527	0.11
176_K	188_H	0.525	0.11
75_G	165_D	0.524	0.11
122_G	183_E	0.523	0.11
51_L	85_H	0.522	0.11
146_K	167_I	0.517	0.11
56_P	117_E	0.512	0.11
45_G	49_V	0.511	0.11
71_G	99_K	0.508	0.11
104_E	122_G	0.507	0.11
61_F	82_V	0.507	0.11
25_A	30_G	0.506	0.11
121_Y	142_Y	0.505	0.11
16_Y	142_Y	0.503	0.11
111_S	169_K	0.500	0.10
118_I	132_D	0.500	0.10

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2yhgA	1	0.5764	69.2	0.956	Contact Map
2fcjA	2	0.3448	65.6	0.957	Contact Map
3hebA	2	0.6552	65	0.957	Contact Map
3h7iA	1	0.8916	63.8	0.958	Contact Map
3ilhA	2	0.5911	63.3	0.958	Contact Map
3fz0A	3	0.5468	58.9	0.959	Contact Map
1nuiA	1	0.2956	58.5	0.959	Contact Map
2rdmA	4	0.6059	57.6	0.959	Contact Map
2qzjA	1	0.5961	56.1	0.96	Contact Map
3cg0A	4	0.6108	55.9	0.96	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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