GREMLIN Database
S5AEA - Stage V sporulation protein AE
UniProt: P40870 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 203 (185)
Sequences: 134 (110)
Seq/√Len: 8.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_A87_S4.6520.99
27_K175_M3.6450.95
24_A27_K3.2830.92
41_S48_L3.2430.92
10_V61_F3.2180.91
110_V153_V3.1150.90
24_A175_M2.7130.82
93_V149_L2.6750.81
64_F82_V2.6540.80
144_L152_I2.4520.75
72_E80_T2.3260.70
105_W142_Y2.3220.70
111_S130_E2.2420.67
111_S163_R2.1730.65
61_F178_V2.1080.62
20_T171_S2.0660.61
93_V144_L2.0610.61
21_I61_F2.0150.59
105_W145_D1.9630.57
19_K91_L1.9010.54
10_V21_I1.8750.53
44_S179_E1.8640.53
5_R58_D1.8440.52
5_R43_R1.8300.51
158_I179_E1.7920.50
30_G178_V1.7830.49
94_I178_V1.7730.49
149_L152_I1.7560.48
24_A61_F1.7210.47
114_R128_E1.7070.46
31_R34_S1.6720.45
111_S120_E1.6310.43
45_G78_A1.5920.42
49_V54_S1.5720.41
24_A178_V1.5170.39
103_A142_Y1.4710.37
7_V149_L1.4700.37
36_S154_G1.4640.36
18_A22_E1.4410.36
86_P143_C1.4250.35
18_A103_A1.4100.34
180_F183_E1.4100.34
52_I147_L1.3730.33
32_C44_S1.3530.32
88_I152_I1.3250.31
67_S167_I1.3220.31
42_T119_T1.3170.31
93_V98_S1.3130.31
132_D183_E1.3100.31
103_A163_R1.2800.30
27_K61_F1.2760.30
105_W119_T1.2700.29
105_W122_G1.2290.28
52_I155_I1.2280.28
171_S175_M1.2210.28
81_Y110_V1.2170.28
126_V163_R1.2140.28
23_Y171_S1.2050.27
97_A100_T1.1970.27
6_K89_E1.1970.27
38_G154_G1.1910.27
19_K74_P1.1900.27
114_R162_G1.1830.27
46_A50_K1.1650.26
51_L54_S1.1630.26
53_A101_H1.1600.26
105_W183_E1.1520.26
74_P112_I1.1520.26
79_L107_R1.1500.25
165_D170_G1.1480.25
91_L182_L1.1390.25
122_G180_F1.1240.25
102_Q117_E1.1120.24
122_G142_Y1.0900.24
31_R63_M1.0890.24
82_V91_L1.0820.23
71_G81_Y1.0740.23
25_A97_A1.0710.23
90_V112_I1.0670.23
86_P93_V1.0650.23
33_I58_D1.0600.23
22_E98_S1.0580.23
64_F85_H1.0570.23
142_Y145_D1.0500.22
6_K169_K1.0480.22
119_T145_D1.0480.22
41_S119_T1.0380.22
129_R146_K1.0370.22
70_Q126_V1.0100.21
43_R106_T0.9970.21
130_E147_L0.9940.21
111_S166_D0.9860.21
21_I112_I0.9800.21
113_D150_P0.9790.20
5_R29_G0.9760.20
22_E34_S0.9760.20
54_S176_K0.9730.20
18_A35_Q0.9710.20
5_R30_G0.9640.20
105_W132_D0.9570.20
64_F174_T0.9560.20
135_R183_E0.9540.20
30_G172_P0.9520.20
173_I184_R0.9430.20
115_N131_F0.9430.20
26_S101_H0.9380.19
49_V144_L0.9380.19
106_T187_Y0.9360.19
89_E155_I0.9300.19
115_N129_R0.9250.19
100_T103_A0.9230.19
26_S32_C0.9180.19
60_V94_I0.9180.19
43_R51_L0.9150.19
134_H158_I0.9130.19
50_K54_S0.9070.19
130_E166_D0.9060.19
56_P98_S0.8950.18
135_R144_L0.8890.18
4_K55_A0.8740.18
20_T23_Y0.8610.17
136_M155_I0.8580.17
174_T186_G0.8580.17
58_D141_V0.8570.17
35_Q54_S0.8560.17
9_L58_D0.8540.17
58_D82_V0.8530.17
64_F83_A0.8520.17
59_P90_V0.8500.17
50_K188_H0.8340.17
5_R55_A0.8330.17
16_Y99_K0.8330.17
71_G115_N0.8310.17
21_I173_I0.8300.17
102_Q130_E0.8290.17
29_G32_C0.8270.17
128_E164_K0.8230.17
119_T134_H0.8220.17
20_T80_T0.8080.16
4_K112_I0.8000.16
72_E162_G0.8000.16
20_T175_M0.7970.16
94_I113_D0.7930.16
120_E130_E0.7850.16
67_S119_T0.7820.16
58_D116_G0.7810.16
93_V109_D0.7780.16
19_K53_A0.7770.16
162_G168_S0.7740.16
103_A126_V0.7710.15
15_V102_Q0.7700.15
120_E167_I0.7620.15
91_L186_G0.7620.15
53_A74_P0.7610.15
83_A148_D0.7600.15
119_T162_G0.7580.15
57_Y89_E0.7570.15
47_E50_K0.7550.15
28_V162_G0.7550.15
105_W121_Y0.7540.15
107_R118_I0.7520.15
103_A111_S0.7500.15
113_D117_E0.7450.15
101_H121_Y0.7440.15
84_T93_V0.7430.15
28_V178_V0.7420.15
41_S69_L0.7420.15
53_A120_E0.7400.15
67_S105_W0.7360.15
99_K102_Q0.7320.15
91_L113_D0.7310.15
57_Y131_F0.7190.14
113_D145_D0.7180.14
73_G92_G0.7180.14
82_V90_V0.7180.14
113_D122_G0.7150.14
63_M90_V0.7150.14
17_A94_I0.7120.14
122_G132_D0.7120.14
18_A146_K0.7090.14
10_V18_A0.7060.14
22_E63_M0.7050.14
87_S112_I0.7040.14
5_R57_Y0.7040.14
31_R51_L0.6990.14
4_K48_L0.6840.14
21_I35_Q0.6840.14
30_G55_A0.6790.14
10_V152_I0.6780.14
79_L169_K0.6770.14
89_E166_D0.6750.13
69_L163_R0.6720.13
23_Y164_K0.6710.13
106_T176_K0.6710.13
48_L109_D0.6690.13
99_K130_E0.6690.13
20_T28_V0.6670.13
131_F162_G0.6660.13
16_Y105_W0.6660.13
83_A149_L0.6650.13
74_P87_S0.6630.13
29_G158_I0.6570.13
23_Y27_K0.6540.13
134_H145_D0.6510.13
173_I176_K0.6480.13
44_S50_K0.6430.13
16_Y67_S0.6420.13
27_K133_D0.6380.13
75_G170_G0.6310.13
39_N141_V0.6310.13
42_T115_N0.6270.13
67_S180_F0.6270.13
64_F158_I0.6260.13
84_T171_S0.6240.13
80_T146_K0.6200.12
43_R144_L0.6200.12
98_S166_D0.6200.12
72_E134_H0.6170.12
106_T147_L0.6090.12
41_S188_H0.6040.12
112_I116_G0.6000.12
117_E152_I0.5990.12
15_V121_Y0.5990.12
64_F78_A0.5970.12
53_A81_Y0.5960.12
134_H168_S0.5960.12
78_A85_H0.5930.12
111_S175_M0.5900.12
10_V28_V0.5890.12
37_K80_T0.5870.12
104_E145_D0.5870.12
151_L187_Y0.5840.12
130_E164_K0.5840.12
67_S142_Y0.5840.12
42_T103_A0.5830.12
16_Y182_L0.5790.12
114_R168_S0.5790.12
118_I130_E0.5740.12
43_R60_V0.5740.12
10_V146_K0.5730.12
49_V91_L0.5730.12
83_A147_L0.5720.12
16_Y143_C0.5700.12
59_P85_H0.5690.12
4_K98_S0.5680.12
6_K173_I0.5670.12
38_G63_M0.5630.11
56_P174_T0.5620.11
24_A43_R0.5520.11
134_H174_T0.5490.11
79_L164_K0.5480.11
171_S176_K0.5470.11
119_T129_R0.5460.11
121_Y145_D0.5440.11
135_R174_T0.5440.11
47_E167_I0.5400.11
110_V183_E0.5370.11
26_S47_E0.5330.11
63_M70_Q0.5330.11
46_A89_E0.5320.11
150_P182_L0.5310.11
5_R31_R0.5300.11
47_E171_S0.5270.11
176_K188_H0.5250.11
75_G165_D0.5240.11
122_G183_E0.5230.11
51_L85_H0.5220.11
146_K167_I0.5170.11
56_P117_E0.5120.11
45_G49_V0.5110.11
71_G99_K0.5080.11
104_E122_G0.5070.11
61_F82_V0.5070.11
25_A30_G0.5060.11
121_Y142_Y0.5050.11
16_Y142_Y0.5030.11
111_S169_K0.5000.10
118_I132_D0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yhgA 1 0.5764 69.2 0.956 Contact Map
2fcjA 2 0.3448 65.6 0.957 Contact Map
3hebA 2 0.6552 65 0.957 Contact Map
3h7iA 1 0.8916 63.8 0.958 Contact Map
3ilhA 2 0.5911 63.3 0.958 Contact Map
3fz0A 3 0.5468 58.9 0.959 Contact Map
1nuiA 1 0.2956 58.5 0.959 Contact Map
2rdmA 4 0.6059 57.6 0.959 Contact Map
2qzjA 1 0.5961 56.1 0.96 Contact Map
3cg0A 4 0.6108 55.9 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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