SP5AD - BACSU - GREMLIN Contacts

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SP5AD - Stage V sporulation protein AD

UniProt:	P40869	Sequences: MKLTGKQTWVFEHPIFVNSAGTAAGPKEKDGPLGSLFDKTYDEMHCNQKSWEMAERQLMEDAVNVALQKNNLTKDDIDLLLAGDLLNQNVTANYVARHLKIPFLCMFGACSTSMETVAVASALVDGGFAKRALAATSSHNATAERQFRYPTEYGGQKPDTATSTVTGSGAVVISQTPGDIQITSATVGKVSDLGITDPFDMGSAMAPAAADTIKQHFKDLNRTADDYDLILTGDLSGVGSPIVKDILKEDGYPVGTKHDDCGLLIYTPDQQVFAGGSGCACSAVVTYSHIFKQLREGKLNRVFVVATGALLSPTMIQQKETIPTIAHGVVFERAGGAS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	338 (330)
Sequences:	657 (476)
Seq/√Len:	26.2

BACSU - SP5AD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
293_Q	298_K	5.120	1.00
290_I	302_V	5.097	1.00
165_V	265_I	4.467	1.00
29_K	40_T	3.780	1.00
81_L	123_L	3.595	1.00
108_G	111_S	3.401	1.00
106_M	116_T	3.392	1.00
8_T	220_L	3.091	1.00
200_D	203_S	3.086	1.00
81_L	106_M	2.921	1.00
223_T	226_D	2.915	1.00
124_V	173_I	2.697	0.99
66_A	172_V	2.686	0.99
36_L	289_H	2.679	0.99
213_I	305_V	2.655	0.99
77_I	172_V	2.600	0.99
305_V	326_A	2.556	0.99
243_V	258_H	2.495	0.99
167_G	284_V	2.440	0.99
24_A	40_T	2.400	0.99
97_R	320_E	2.388	0.99
18_N	174_S	2.311	0.98
80_L	96_A	2.288	0.98
63_V	133_L	2.202	0.98
184_S	220_L	2.182	0.97
120_A	132_A	2.151	0.97
222_R	226_D	2.125	0.97
21_G	65_V	2.116	0.97
240_S	258_H	2.107	0.97
60_E	98_H	2.081	0.96
41_Y	61_D	2.073	0.96
82_A	92_A	2.054	0.96
114_M	306_A	2.045	0.96
118_A	187_V	2.041	0.96
196_T	321_T	2.014	0.96
231_L	290_I	2.009	0.96
118_A	185_A	1.995	0.95
94_Y	315_M	1.983	0.95
299_L	302_V	1.980	0.95
216_H	227_Y	1.948	0.95
81_L	120_A	1.938	0.95
120_A	173_I	1.913	0.94
136_T	168_S	1.904	0.94
302_V	331_F	1.896	0.94
120_A	134_A	1.867	0.94
15_I	18_N	1.854	0.93
210_A	243_V	1.851	0.93
107_F	147_F	1.846	0.93
11_F	185_A	1.845	0.93
19_S	66_A	1.844	0.93
259_D	264_L	1.832	0.93
104_L	115_E	1.827	0.93
90_V	315_M	1.823	0.93
16_F	177_P	1.805	0.92
300_N	333_R	1.749	0.91
163_S	236_S	1.746	0.91
86_L	91_T	1.722	0.90
210_A	247_L	1.710	0.90
217_F	252_Y	1.705	0.90
121_S	182_I	1.700	0.90
16_F	181_Q	1.690	0.90
180_I	331_F	1.647	0.88
104_L	119_V	1.620	0.87
8_T	184_S	1.617	0.87
24_A	284_V	1.604	0.87
133_L	172_V	1.602	0.87
32_P	267_T	1.584	0.86
33_L	285_V	1.573	0.86
286_T	304_V	1.568	0.86
117_V	173_I	1.530	0.84
48_Q	57_Q	1.529	0.84
240_S	244_K	1.500	0.83
86_L	90_V	1.487	0.82
81_L	119_V	1.469	0.82
226_D	330_V	1.467	0.82
140_N	151_T	1.461	0.81
66_A	133_L	1.459	0.81
229_L	299_L	1.458	0.81
197_D	200_D	1.455	0.81
53_M	320_E	1.449	0.81
34_G	40_T	1.442	0.80
62_A	170_A	1.441	0.80
131_R	174_S	1.438	0.80
72_L	77_I	1.437	0.80
248_K	253_P	1.424	0.80
48_Q	53_M	1.422	0.79
96_A	190_V	1.411	0.79
135_A	170_A	1.408	0.79
19_S	70_N	1.407	0.79
177_P	180_I	1.406	0.79
184_S	330_V	1.403	0.78
81_L	104_L	1.403	0.78
183_T	332_E	1.400	0.78
55_E	143_A	1.396	0.78
173_I	182_I	1.390	0.78
189_K	215_Q	1.386	0.78
72_L	76_D	1.385	0.78
7_Q	215_Q	1.378	0.77
292_K	295_R	1.376	0.77
222_R	227_Y	1.371	0.77
59_M	135_A	1.367	0.77
265_I	284_V	1.366	0.77
222_R	330_V	1.355	0.76
94_Y	311_L	1.355	0.76
226_D	301_R	1.348	0.76
231_L	264_L	1.337	0.75
19_S	69_K	1.334	0.75
72_L	131_R	1.324	0.74
303_F	330_V	1.318	0.74
63_V	99_L	1.316	0.74
210_A	250_D	1.311	0.74
20_A	291_F	1.298	0.73
16_F	180_I	1.297	0.73
216_H	328_G	1.295	0.73
92_A	103_F	1.288	0.72
294_L	297_G	1.270	0.71
17_V	331_F	1.265	0.71
104_L	187_V	1.257	0.70
22_T	287_Y	1.254	0.70
38_D	69_K	1.245	0.70
19_S	172_V	1.245	0.70
24_A	37_F	1.235	0.69
245_D	249_E	1.233	0.69
108_G	279_C	1.233	0.69
27_K	163_S	1.222	0.68
18_N	131_R	1.210	0.67
280_A	284_V	1.209	0.67
72_L	172_V	1.203	0.67
77_I	101_I	1.201	0.67
113_S	287_Y	1.197	0.66
122_A	128_F	1.196	0.66
111_S	279_C	1.187	0.66
159_D	162_T	1.183	0.65
186_T	216_H	1.181	0.65
114_M	304_V	1.161	0.64
167_G	280_A	1.157	0.64
23_A	62_A	1.148	0.63
238_V	274_A	1.140	0.63
116_T	134_A	1.137	0.62
36_L	288_S	1.128	0.62
10_V	184_S	1.121	0.61
130_K	175_Q	1.118	0.61
20_A	171_V	1.114	0.61
286_T	291_F	1.102	0.60
162_T	236_S	1.101	0.60
106_M	119_V	1.101	0.60
291_F	294_L	1.095	0.59
183_T	222_R	1.084	0.59
79_L	129_A	1.074	0.58
169_G	280_A	1.069	0.58
292_K	296_E	1.067	0.57
231_L	259_D	1.064	0.57
62_A	66_A	1.059	0.57
82_A	112_T	1.056	0.57
214_K	247_L	1.042	0.56
26_P	30_D	1.037	0.55
44_M	141_A	1.036	0.55
10_V	220_L	1.030	0.55
242_I	245_D	1.022	0.54
216_H	330_V	1.019	0.54
24_A	29_K	1.013	0.53
7_Q	216_H	1.010	0.53
237_G	268_P	1.001	0.53
79_L	104_L	0.998	0.52
231_L	302_V	0.997	0.52
67_L	77_I	0.993	0.52
229_L	259_D	0.983	0.51
229_L	290_I	0.980	0.51
276_G	281_C	0.979	0.51
93_N	145_R	0.967	0.50
186_T	328_G	0.965	0.50
23_A	65_V	0.963	0.50
301_R	332_E	0.952	0.49
216_H	222_R	0.951	0.49
268_P	272_V	0.949	0.49
39_K	61_D	0.946	0.48
15_I	162_T	0.942	0.48
224_A	257_K	0.941	0.48
73_T	76_D	0.939	0.48
291_F	295_R	0.937	0.48
59_M	95_V	0.929	0.47
79_L	132_A	0.919	0.46
147_F	326_A	0.918	0.46
293_Q	296_E	0.918	0.46
17_V	291_F	0.917	0.46
293_Q	299_L	0.917	0.46
41_Y	58_L	0.903	0.45
162_T	212_T	0.902	0.45
50_S	319_K	0.888	0.44
301_R	311_L	0.884	0.44
16_F	179_D	0.882	0.44
213_I	257_K	0.879	0.43
301_R	330_V	0.864	0.42
67_L	71_N	0.859	0.42
183_T	330_V	0.859	0.42
97_R	321_T	0.857	0.42
209_A	307_T	0.855	0.42
94_Y	316_I	0.854	0.42
212_T	328_G	0.850	0.41
79_L	187_V	0.847	0.41
157_K	287_Y	0.839	0.41
95_V	190_V	0.838	0.41
306_A	317_Q	0.835	0.40
67_L	74_K	0.833	0.40
169_G	283_A	0.833	0.40
23_A	46_C	0.832	0.40
83_G	112_T	0.826	0.40
125_D	128_F	0.825	0.40
189_K	211_D	0.825	0.40
181_Q	332_E	0.822	0.39
145_R	318_Q	0.822	0.39
63_V	135_A	0.821	0.39
214_K	250_D	0.820	0.39
136_T	279_C	0.816	0.39
117_V	329_V	0.814	0.39
213_I	217_F	0.808	0.38
58_L	75_D	0.807	0.38
132_A	276_G	0.803	0.38
82_A	135_A	0.795	0.37
32_P	51_W	0.791	0.37
54_A	139_H	0.789	0.37
55_E	279_C	0.789	0.37
152_E	285_V	0.786	0.37
213_I	243_V	0.785	0.37
259_D	263_L	0.784	0.37
145_R	158_P	0.783	0.37
213_I	247_L	0.783	0.37
107_F	274_A	0.782	0.37
293_Q	297_G	0.781	0.37
13_H	125_D	0.775	0.36
217_F	224_A	0.766	0.36
140_N	287_Y	0.761	0.35
50_S	180_I	0.761	0.35
87_N	318_Q	0.756	0.35
111_S	270_Q	0.754	0.35
29_K	230_I	0.752	0.35
33_L	264_L	0.750	0.34
65_V	68_Q	0.750	0.34
243_V	305_V	0.747	0.34
67_L	333_R	0.745	0.34
146_Q	313_P	0.744	0.34
15_I	177_P	0.743	0.34
214_K	218_K	0.740	0.34
16_F	162_T	0.739	0.34
265_I	315_M	0.738	0.34
80_L	236_S	0.736	0.33
311_L	316_I	0.734	0.33
227_Y	325_I	0.734	0.33
291_F	331_F	0.734	0.33
111_S	320_E	0.731	0.33
140_N	157_K	0.729	0.33
145_R	316_I	0.724	0.33
180_I	333_R	0.721	0.33
219_D	222_R	0.720	0.32
149_Y	167_G	0.716	0.32
91_T	137_S	0.716	0.32
174_S	252_Y	0.715	0.32
107_F	115_E	0.713	0.32
136_T	280_A	0.712	0.32
191_S	211_D	0.709	0.32
214_K	252_Y	0.709	0.32
87_N	313_P	0.706	0.32
121_S	187_V	0.705	0.31
313_P	316_I	0.705	0.31
209_A	232_T	0.705	0.31
97_R	317_Q	0.703	0.31
89_N	96_A	0.701	0.31
113_S	171_V	0.701	0.31
16_F	332_E	0.697	0.31
313_P	318_Q	0.695	0.31
254_V	258_H	0.695	0.31
17_V	266_Y	0.694	0.31
122_A	126_G	0.693	0.31
240_S	263_L	0.693	0.31
183_T	216_H	0.692	0.31
41_Y	44_M	0.690	0.31
149_Y	317_Q	0.688	0.30
50_S	331_F	0.687	0.30
321_T	324_T	0.685	0.30
42_D	217_F	0.684	0.30
126_G	129_A	0.683	0.30
87_N	180_I	0.683	0.30
267_T	270_Q	0.682	0.30
114_M	287_Y	0.681	0.30
16_F	178_G	0.679	0.30
62_A	168_S	0.679	0.30
62_A	296_E	0.678	0.30
122_A	160_T	0.678	0.30
152_E	204_A	0.677	0.30
51_W	55_E	0.677	0.30
21_G	304_V	0.676	0.30
200_D	236_S	0.675	0.30
162_T	317_Q	0.674	0.30
21_G	62_A	0.671	0.29
29_K	328_G	0.667	0.29
4_T	221_N	0.666	0.29
87_N	229_L	0.665	0.29
4_T	10_V	0.664	0.29
203_S	236_S	0.663	0.29
106_M	284_V	0.663	0.29
158_P	167_G	0.662	0.29
7_Q	189_K	0.660	0.29
8_T	217_F	0.660	0.29
294_L	331_F	0.660	0.29
111_S	219_D	0.658	0.29
193_L	210_A	0.656	0.28
57_Q	61_D	0.656	0.28
51_W	76_D	0.656	0.28
43_E	47_N	0.656	0.28
198_P	216_H	0.655	0.28
167_G	332_E	0.653	0.28
280_A	286_T	0.652	0.28
55_E	142_T	0.652	0.28
311_L	324_T	0.652	0.28
149_Y	155_G	0.651	0.28
145_R	199_F	0.651	0.28
55_E	91_T	0.650	0.28
107_F	195_I	0.649	0.28
167_G	265_I	0.648	0.28
290_I	304_V	0.648	0.28
106_M	157_K	0.647	0.28
113_S	145_R	0.647	0.28
15_I	180_I	0.646	0.28
47_N	130_K	0.645	0.28
67_L	99_L	0.644	0.28
14_P	173_I	0.641	0.28
59_M	91_T	0.641	0.28
20_A	287_Y	0.641	0.28
156_Q	315_M	0.639	0.27
143_A	314_T	0.637	0.27
146_Q	195_I	0.635	0.27
114_M	118_A	0.634	0.27
120_A	123_L	0.632	0.27
187_V	217_F	0.632	0.27
140_N	163_S	0.631	0.27
231_L	304_V	0.629	0.27
33_L	37_F	0.628	0.27
15_I	175_Q	0.627	0.27
174_S	178_G	0.627	0.27
69_K	136_T	0.626	0.27
55_E	86_L	0.625	0.27
58_L	245_D	0.618	0.26
86_L	126_G	0.617	0.26
113_S	157_K	0.616	0.26
303_F	328_G	0.616	0.26
249_E	258_H	0.615	0.26
46_C	58_L	0.615	0.26
189_K	250_D	0.614	0.26
157_K	273_F	0.612	0.26
13_H	329_V	0.610	0.26
111_S	217_F	0.609	0.26
266_Y	272_V	0.608	0.26
248_K	255_G	0.608	0.26
44_M	264_L	0.606	0.26
151_T	157_K	0.605	0.25
89_N	93_N	0.603	0.25
9_W	266_Y	0.602	0.25
264_L	299_L	0.602	0.25
215_Q	219_D	0.601	0.25
96_A	168_S	0.601	0.25
243_V	254_V	0.600	0.25
32_P	37_F	0.600	0.25
193_L	317_Q	0.600	0.25
130_K	189_K	0.596	0.25
24_A	276_G	0.596	0.25
117_V	171_V	0.595	0.25
183_T	331_F	0.594	0.25
48_Q	60_E	0.592	0.25
187_V	300_N	0.591	0.25
165_V	284_V	0.587	0.24
56_R	111_S	0.587	0.24
107_F	311_L	0.587	0.24
80_L	133_L	0.583	0.24
104_L	185_A	0.583	0.24
224_A	254_V	0.582	0.24
4_T	121_S	0.581	0.24
94_Y	194_G	0.577	0.24
211_D	215_Q	0.576	0.24
92_A	142_T	0.575	0.24
69_K	169_G	0.572	0.24
19_S	81_L	0.570	0.24
240_S	254_V	0.570	0.24
191_S	250_D	0.569	0.23
104_L	118_A	0.569	0.23
60_E	123_L	0.567	0.23
127_G	175_Q	0.567	0.23
218_K	245_D	0.567	0.23
51_W	127_G	0.566	0.23
24_A	51_W	0.566	0.23
227_Y	330_V	0.566	0.23
215_Q	328_G	0.565	0.23
92_A	104_L	0.564	0.23
45_H	271_Q	0.564	0.23
210_A	258_H	0.564	0.23
7_Q	227_Y	0.562	0.23
224_A	230_I	0.561	0.23
107_F	112_T	0.561	0.23
140_N	304_V	0.559	0.23
92_A	128_F	0.558	0.23
222_R	332_E	0.558	0.23
259_D	302_V	0.557	0.23
73_T	196_T	0.557	0.23
118_A	121_S	0.557	0.23
229_L	264_L	0.556	0.23
117_V	182_I	0.556	0.23
70_N	133_L	0.556	0.23
95_V	304_V	0.553	0.23
75_D	168_S	0.553	0.23
100_K	297_G	0.552	0.23
33_L	231_L	0.552	0.23
4_T	217_F	0.549	0.22
178_G	249_E	0.549	0.22
4_T	11_F	0.549	0.22
137_S	155_G	0.548	0.22
217_F	223_T	0.548	0.22
213_I	291_F	0.548	0.22
69_K	297_G	0.546	0.22
218_K	221_N	0.545	0.22
194_G	207_P	0.545	0.22
248_K	296_E	0.542	0.22
219_D	330_V	0.542	0.22
69_K	103_F	0.542	0.22
64_N	73_T	0.542	0.22
44_M	151_T	0.542	0.22
146_Q	152_E	0.542	0.22
152_E	229_L	0.541	0.22
123_L	126_G	0.541	0.22
75_D	172_V	0.541	0.22
86_L	142_T	0.541	0.22
155_G	272_V	0.540	0.22
120_A	124_V	0.540	0.22
41_Y	46_C	0.540	0.22
59_M	82_A	0.540	0.22
77_I	305_V	0.539	0.22
290_I	331_F	0.539	0.22
132_A	135_A	0.538	0.22
36_L	292_K	0.536	0.22
103_F	217_F	0.535	0.22
104_L	217_F	0.535	0.22
90_V	279_C	0.535	0.22
68_Q	249_E	0.535	0.22
294_L	333_R	0.534	0.22
231_L	299_L	0.534	0.22
27_K	266_Y	0.534	0.22
261_C	282_S	0.534	0.22
18_N	72_L	0.533	0.22
136_T	305_V	0.532	0.22
30_D	173_I	0.531	0.22
22_T	284_V	0.530	0.21
142_T	187_V	0.530	0.21
134_A	242_I	0.530	0.21
216_H	301_R	0.528	0.21
58_L	142_T	0.528	0.21
229_L	294_L	0.527	0.21
76_D	97_R	0.527	0.21
21_G	67_L	0.527	0.21
116_T	288_S	0.525	0.21
77_I	122_A	0.524	0.21
9_W	79_L	0.524	0.21
286_T	331_F	0.523	0.21
26_P	96_A	0.522	0.21
134_A	279_C	0.517	0.21
57_Q	142_T	0.517	0.21
93_N	96_A	0.515	0.21
220_L	330_V	0.515	0.21
115_E	325_I	0.515	0.21
225_D	257_K	0.514	0.21
147_F	236_S	0.514	0.21
111_S	280_A	0.514	0.21
62_A	226_D	0.513	0.21
61_D	227_Y	0.513	0.21
22_T	203_S	0.512	0.21
89_N	313_P	0.512	0.21
107_F	128_F	0.512	0.21
160_T	204_A	0.512	0.21
78_D	130_K	0.511	0.21
87_N	146_Q	0.511	0.21
49_K	141_A	0.510	0.20
8_T	106_M	0.510	0.20
317_Q	320_E	0.510	0.20
29_K	219_D	0.510	0.20
23_A	267_T	0.509	0.20
174_S	177_P	0.508	0.20
42_D	294_L	0.508	0.20
175_Q	252_Y	0.506	0.20
172_V	294_L	0.505	0.20
20_A	286_T	0.504	0.20
306_A	318_Q	0.503	0.20
6_K	218_K	0.503	0.20
90_V	312_S	0.503	0.20
165_V	280_A	0.503	0.20
162_T	180_I	0.502	0.20
215_Q	218_K	0.502	0.20
254_V	294_L	0.501	0.20
19_S	24_A	0.500	0.20

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3lmaA	2	0.9675	100	0.668	Contact Map
3h78A	2	0.8609	99.7	0.889	Contact Map
3wxyA	2	0.8846	99.7	0.895	Contact Map
3tsyA	2	0.9172	99.7	0.895	Contact Map
3wd8A	2	0.8905	99.6	0.899	Contact Map
3e1hA	2	0.8787	99.6	0.901	Contact Map
3euoA	2	0.8639	99.6	0.902	Contact Map
1xpmA	2	0.8787	99.5	0.905	Contact Map
3a5rA	2	0.8935	99.5	0.906	Contact Map
3s21A	2	0.8669	99.5	0.907	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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