GREMLIN Database
SP5AD - Stage V sporulation protein AD
UniProt: P40869 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 338 (330)
Sequences: 657 (476)
Seq/√Len: 26.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
293_Q298_K5.1201.00
290_I302_V5.0971.00
165_V265_I4.4671.00
29_K40_T3.7801.00
81_L123_L3.5951.00
108_G111_S3.4011.00
106_M116_T3.3921.00
8_T220_L3.0911.00
200_D203_S3.0861.00
81_L106_M2.9211.00
223_T226_D2.9151.00
124_V173_I2.6970.99
66_A172_V2.6860.99
36_L289_H2.6790.99
213_I305_V2.6550.99
77_I172_V2.6000.99
305_V326_A2.5560.99
243_V258_H2.4950.99
167_G284_V2.4400.99
24_A40_T2.4000.99
97_R320_E2.3880.99
18_N174_S2.3110.98
80_L96_A2.2880.98
63_V133_L2.2020.98
184_S220_L2.1820.97
120_A132_A2.1510.97
222_R226_D2.1250.97
21_G65_V2.1160.97
240_S258_H2.1070.97
60_E98_H2.0810.96
41_Y61_D2.0730.96
82_A92_A2.0540.96
114_M306_A2.0450.96
118_A187_V2.0410.96
196_T321_T2.0140.96
231_L290_I2.0090.96
118_A185_A1.9950.95
94_Y315_M1.9830.95
299_L302_V1.9800.95
216_H227_Y1.9480.95
81_L120_A1.9380.95
120_A173_I1.9130.94
136_T168_S1.9040.94
302_V331_F1.8960.94
120_A134_A1.8670.94
15_I18_N1.8540.93
210_A243_V1.8510.93
107_F147_F1.8460.93
11_F185_A1.8450.93
19_S66_A1.8440.93
259_D264_L1.8320.93
104_L115_E1.8270.93
90_V315_M1.8230.93
16_F177_P1.8050.92
300_N333_R1.7490.91
163_S236_S1.7460.91
86_L91_T1.7220.90
210_A247_L1.7100.90
217_F252_Y1.7050.90
121_S182_I1.7000.90
16_F181_Q1.6900.90
180_I331_F1.6470.88
104_L119_V1.6200.87
8_T184_S1.6170.87
24_A284_V1.6040.87
133_L172_V1.6020.87
32_P267_T1.5840.86
33_L285_V1.5730.86
286_T304_V1.5680.86
117_V173_I1.5300.84
48_Q57_Q1.5290.84
240_S244_K1.5000.83
86_L90_V1.4870.82
81_L119_V1.4690.82
226_D330_V1.4670.82
140_N151_T1.4610.81
66_A133_L1.4590.81
229_L299_L1.4580.81
197_D200_D1.4550.81
53_M320_E1.4490.81
34_G40_T1.4420.80
62_A170_A1.4410.80
131_R174_S1.4380.80
72_L77_I1.4370.80
248_K253_P1.4240.80
48_Q53_M1.4220.79
96_A190_V1.4110.79
135_A170_A1.4080.79
19_S70_N1.4070.79
177_P180_I1.4060.79
184_S330_V1.4030.78
81_L104_L1.4030.78
183_T332_E1.4000.78
55_E143_A1.3960.78
173_I182_I1.3900.78
189_K215_Q1.3860.78
72_L76_D1.3850.78
7_Q215_Q1.3780.77
292_K295_R1.3760.77
222_R227_Y1.3710.77
59_M135_A1.3670.77
265_I284_V1.3660.77
222_R330_V1.3550.76
94_Y311_L1.3550.76
226_D301_R1.3480.76
231_L264_L1.3370.75
19_S69_K1.3340.75
72_L131_R1.3240.74
303_F330_V1.3180.74
63_V99_L1.3160.74
210_A250_D1.3110.74
20_A291_F1.2980.73
16_F180_I1.2970.73
216_H328_G1.2950.73
92_A103_F1.2880.72
294_L297_G1.2700.71
17_V331_F1.2650.71
104_L187_V1.2570.70
22_T287_Y1.2540.70
38_D69_K1.2450.70
19_S172_V1.2450.70
24_A37_F1.2350.69
245_D249_E1.2330.69
108_G279_C1.2330.69
27_K163_S1.2220.68
18_N131_R1.2100.67
280_A284_V1.2090.67
72_L172_V1.2030.67
77_I101_I1.2010.67
113_S287_Y1.1970.66
122_A128_F1.1960.66
111_S279_C1.1870.66
159_D162_T1.1830.65
186_T216_H1.1810.65
114_M304_V1.1610.64
167_G280_A1.1570.64
23_A62_A1.1480.63
238_V274_A1.1400.63
116_T134_A1.1370.62
36_L288_S1.1280.62
10_V184_S1.1210.61
130_K175_Q1.1180.61
20_A171_V1.1140.61
286_T291_F1.1020.60
162_T236_S1.1010.60
106_M119_V1.1010.60
291_F294_L1.0950.59
183_T222_R1.0840.59
79_L129_A1.0740.58
169_G280_A1.0690.58
292_K296_E1.0670.57
231_L259_D1.0640.57
62_A66_A1.0590.57
82_A112_T1.0560.57
214_K247_L1.0420.56
26_P30_D1.0370.55
44_M141_A1.0360.55
10_V220_L1.0300.55
242_I245_D1.0220.54
216_H330_V1.0190.54
24_A29_K1.0130.53
7_Q216_H1.0100.53
237_G268_P1.0010.53
79_L104_L0.9980.52
231_L302_V0.9970.52
67_L77_I0.9930.52
229_L259_D0.9830.51
229_L290_I0.9800.51
276_G281_C0.9790.51
93_N145_R0.9670.50
186_T328_G0.9650.50
23_A65_V0.9630.50
301_R332_E0.9520.49
216_H222_R0.9510.49
268_P272_V0.9490.49
39_K61_D0.9460.48
15_I162_T0.9420.48
224_A257_K0.9410.48
73_T76_D0.9390.48
291_F295_R0.9370.48
59_M95_V0.9290.47
79_L132_A0.9190.46
147_F326_A0.9180.46
293_Q296_E0.9180.46
17_V291_F0.9170.46
293_Q299_L0.9170.46
41_Y58_L0.9030.45
162_T212_T0.9020.45
50_S319_K0.8880.44
301_R311_L0.8840.44
16_F179_D0.8820.44
213_I257_K0.8790.43
301_R330_V0.8640.42
67_L71_N0.8590.42
183_T330_V0.8590.42
97_R321_T0.8570.42
209_A307_T0.8550.42
94_Y316_I0.8540.42
212_T328_G0.8500.41
79_L187_V0.8470.41
157_K287_Y0.8390.41
95_V190_V0.8380.41
306_A317_Q0.8350.40
67_L74_K0.8330.40
169_G283_A0.8330.40
23_A46_C0.8320.40
83_G112_T0.8260.40
125_D128_F0.8250.40
189_K211_D0.8250.40
181_Q332_E0.8220.39
145_R318_Q0.8220.39
63_V135_A0.8210.39
214_K250_D0.8200.39
136_T279_C0.8160.39
117_V329_V0.8140.39
213_I217_F0.8080.38
58_L75_D0.8070.38
132_A276_G0.8030.38
82_A135_A0.7950.37
32_P51_W0.7910.37
54_A139_H0.7890.37
55_E279_C0.7890.37
152_E285_V0.7860.37
213_I243_V0.7850.37
259_D263_L0.7840.37
145_R158_P0.7830.37
213_I247_L0.7830.37
107_F274_A0.7820.37
293_Q297_G0.7810.37
13_H125_D0.7750.36
217_F224_A0.7660.36
140_N287_Y0.7610.35
50_S180_I0.7610.35
87_N318_Q0.7560.35
111_S270_Q0.7540.35
29_K230_I0.7520.35
33_L264_L0.7500.34
65_V68_Q0.7500.34
243_V305_V0.7470.34
67_L333_R0.7450.34
146_Q313_P0.7440.34
15_I177_P0.7430.34
214_K218_K0.7400.34
16_F162_T0.7390.34
265_I315_M0.7380.34
80_L236_S0.7360.33
311_L316_I0.7340.33
227_Y325_I0.7340.33
291_F331_F0.7340.33
111_S320_E0.7310.33
140_N157_K0.7290.33
145_R316_I0.7240.33
180_I333_R0.7210.33
219_D222_R0.7200.32
149_Y167_G0.7160.32
91_T137_S0.7160.32
174_S252_Y0.7150.32
107_F115_E0.7130.32
136_T280_A0.7120.32
191_S211_D0.7090.32
214_K252_Y0.7090.32
87_N313_P0.7060.32
121_S187_V0.7050.31
313_P316_I0.7050.31
209_A232_T0.7050.31
97_R317_Q0.7030.31
89_N96_A0.7010.31
113_S171_V0.7010.31
16_F332_E0.6970.31
313_P318_Q0.6950.31
254_V258_H0.6950.31
17_V266_Y0.6940.31
122_A126_G0.6930.31
240_S263_L0.6930.31
183_T216_H0.6920.31
41_Y44_M0.6900.31
149_Y317_Q0.6880.30
50_S331_F0.6870.30
321_T324_T0.6850.30
42_D217_F0.6840.30
126_G129_A0.6830.30
87_N180_I0.6830.30
267_T270_Q0.6820.30
114_M287_Y0.6810.30
16_F178_G0.6790.30
62_A168_S0.6790.30
62_A296_E0.6780.30
122_A160_T0.6780.30
152_E204_A0.6770.30
51_W55_E0.6770.30
21_G304_V0.6760.30
200_D236_S0.6750.30
162_T317_Q0.6740.30
21_G62_A0.6710.29
29_K328_G0.6670.29
4_T221_N0.6660.29
87_N229_L0.6650.29
4_T10_V0.6640.29
203_S236_S0.6630.29
106_M284_V0.6630.29
158_P167_G0.6620.29
7_Q189_K0.6600.29
8_T217_F0.6600.29
294_L331_F0.6600.29
111_S219_D0.6580.29
193_L210_A0.6560.28
57_Q61_D0.6560.28
51_W76_D0.6560.28
43_E47_N0.6560.28
198_P216_H0.6550.28
167_G332_E0.6530.28
280_A286_T0.6520.28
55_E142_T0.6520.28
311_L324_T0.6520.28
149_Y155_G0.6510.28
145_R199_F0.6510.28
55_E91_T0.6500.28
107_F195_I0.6490.28
167_G265_I0.6480.28
290_I304_V0.6480.28
106_M157_K0.6470.28
113_S145_R0.6470.28
15_I180_I0.6460.28
47_N130_K0.6450.28
67_L99_L0.6440.28
14_P173_I0.6410.28
59_M91_T0.6410.28
20_A287_Y0.6410.28
156_Q315_M0.6390.27
143_A314_T0.6370.27
146_Q195_I0.6350.27
114_M118_A0.6340.27
120_A123_L0.6320.27
187_V217_F0.6320.27
140_N163_S0.6310.27
231_L304_V0.6290.27
33_L37_F0.6280.27
15_I175_Q0.6270.27
174_S178_G0.6270.27
69_K136_T0.6260.27
55_E86_L0.6250.27
58_L245_D0.6180.26
86_L126_G0.6170.26
113_S157_K0.6160.26
303_F328_G0.6160.26
249_E258_H0.6150.26
46_C58_L0.6150.26
189_K250_D0.6140.26
157_K273_F0.6120.26
13_H329_V0.6100.26
111_S217_F0.6090.26
266_Y272_V0.6080.26
248_K255_G0.6080.26
44_M264_L0.6060.26
151_T157_K0.6050.25
89_N93_N0.6030.25
9_W266_Y0.6020.25
264_L299_L0.6020.25
215_Q219_D0.6010.25
96_A168_S0.6010.25
243_V254_V0.6000.25
32_P37_F0.6000.25
193_L317_Q0.6000.25
130_K189_K0.5960.25
24_A276_G0.5960.25
117_V171_V0.5950.25
183_T331_F0.5940.25
48_Q60_E0.5920.25
187_V300_N0.5910.25
165_V284_V0.5870.24
56_R111_S0.5870.24
107_F311_L0.5870.24
80_L133_L0.5830.24
104_L185_A0.5830.24
224_A254_V0.5820.24
4_T121_S0.5810.24
94_Y194_G0.5770.24
211_D215_Q0.5760.24
92_A142_T0.5750.24
69_K169_G0.5720.24
19_S81_L0.5700.24
240_S254_V0.5700.24
191_S250_D0.5690.23
104_L118_A0.5690.23
60_E123_L0.5670.23
127_G175_Q0.5670.23
218_K245_D0.5670.23
51_W127_G0.5660.23
24_A51_W0.5660.23
227_Y330_V0.5660.23
215_Q328_G0.5650.23
92_A104_L0.5640.23
45_H271_Q0.5640.23
210_A258_H0.5640.23
7_Q227_Y0.5620.23
224_A230_I0.5610.23
107_F112_T0.5610.23
140_N304_V0.5590.23
92_A128_F0.5580.23
222_R332_E0.5580.23
259_D302_V0.5570.23
73_T196_T0.5570.23
118_A121_S0.5570.23
229_L264_L0.5560.23
117_V182_I0.5560.23
70_N133_L0.5560.23
95_V304_V0.5530.23
75_D168_S0.5530.23
100_K297_G0.5520.23
33_L231_L0.5520.23
4_T217_F0.5490.22
178_G249_E0.5490.22
4_T11_F0.5490.22
137_S155_G0.5480.22
217_F223_T0.5480.22
213_I291_F0.5480.22
69_K297_G0.5460.22
218_K221_N0.5450.22
194_G207_P0.5450.22
248_K296_E0.5420.22
219_D330_V0.5420.22
69_K103_F0.5420.22
64_N73_T0.5420.22
44_M151_T0.5420.22
146_Q152_E0.5420.22
152_E229_L0.5410.22
123_L126_G0.5410.22
75_D172_V0.5410.22
86_L142_T0.5410.22
155_G272_V0.5400.22
120_A124_V0.5400.22
41_Y46_C0.5400.22
59_M82_A0.5400.22
77_I305_V0.5390.22
290_I331_F0.5390.22
132_A135_A0.5380.22
36_L292_K0.5360.22
103_F217_F0.5350.22
104_L217_F0.5350.22
90_V279_C0.5350.22
68_Q249_E0.5350.22
294_L333_R0.5340.22
231_L299_L0.5340.22
27_K266_Y0.5340.22
261_C282_S0.5340.22
18_N72_L0.5330.22
136_T305_V0.5320.22
30_D173_I0.5310.22
22_T284_V0.5300.21
142_T187_V0.5300.21
134_A242_I0.5300.21
216_H301_R0.5280.21
58_L142_T0.5280.21
229_L294_L0.5270.21
76_D97_R0.5270.21
21_G67_L0.5270.21
116_T288_S0.5250.21
77_I122_A0.5240.21
9_W79_L0.5240.21
286_T331_F0.5230.21
26_P96_A0.5220.21
134_A279_C0.5170.21
57_Q142_T0.5170.21
93_N96_A0.5150.21
220_L330_V0.5150.21
115_E325_I0.5150.21
225_D257_K0.5140.21
147_F236_S0.5140.21
111_S280_A0.5140.21
62_A226_D0.5130.21
61_D227_Y0.5130.21
22_T203_S0.5120.21
89_N313_P0.5120.21
107_F128_F0.5120.21
160_T204_A0.5120.21
78_D130_K0.5110.21
87_N146_Q0.5110.21
49_K141_A0.5100.20
8_T106_M0.5100.20
317_Q320_E0.5100.20
29_K219_D0.5100.20
23_A267_T0.5090.20
174_S177_P0.5080.20
42_D294_L0.5080.20
175_Q252_Y0.5060.20
172_V294_L0.5050.20
20_A286_T0.5040.20
306_A318_Q0.5030.20
6_K218_K0.5030.20
90_V312_S0.5030.20
165_V280_A0.5030.20
162_T180_I0.5020.20
215_Q218_K0.5020.20
254_V294_L0.5010.20
19_S24_A0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lmaA 2 0.9675 100 0.668 Contact Map
3h78A 2 0.8609 99.7 0.889 Contact Map
3wxyA 2 0.8846 99.7 0.895 Contact Map
3tsyA 2 0.9172 99.7 0.895 Contact Map
3wd8A 2 0.8905 99.6 0.899 Contact Map
3e1hA 2 0.8787 99.6 0.901 Contact Map
3euoA 2 0.8639 99.6 0.902 Contact Map
1xpmA 2 0.8787 99.5 0.905 Contact Map
3a5rA 2 0.8935 99.5 0.906 Contact Map
3s21A 2 0.8669 99.5 0.907 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0266 seconds.