GREMLIN Database
SP5AC - Stage V sporulation protein AC
UniProt: P40868 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 150 (141)
Sequences: 669 (458)
Seq/√Len: 38.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_Y64_T7.8051.00
82_G89_S4.3201.00
67_L71_L3.5771.00
119_N122_K3.2221.00
70_A101_A2.9771.00
53_N56_T2.9061.00
40_Q44_N2.7281.00
123_L126_N2.7061.00
11_K15_Y2.6301.00
27_K30_L2.4791.00
72_L81_I2.3661.00
27_K84_F2.2861.00
120_M129_V2.2490.99
23_W27_K2.2470.99
128_I132_V2.2390.99
52_F60_P2.2200.99
68_I72_L2.0580.99
34_L38_I2.0330.99
112_L116_V1.9660.99
41_G45_F1.9460.98
42_L46_Y1.9420.98
62_A93_V1.8740.98
71_L74_G1.8010.97
101_A105_L1.8000.97
72_L77_I1.7590.97
34_L37_A1.6620.96
138_V141_I1.6440.96
42_L65_L1.5570.94
45_F50_F1.5550.94
31_V85_A1.4260.91
37_A41_G1.4160.91
38_I68_I1.3960.90
117_A129_V1.3750.89
43_Q57_A1.3640.89
85_A89_S1.3430.88
20_P23_W1.3300.88
63_A93_V1.2720.85
97_A101_A1.2660.85
21_Y25_C1.2620.85
58_G61_T1.2620.85
69_S78_Y1.2390.84
6_E9_K1.2100.82
16_Q19_P1.1960.81
139_G142_R1.1750.80
100_M133_V1.1570.79
19_P24_N1.1520.79
43_Q61_T1.1320.78
65_L78_Y1.1270.77
86_G98_N1.1190.77
70_A97_A1.1180.77
22_V26_V1.0960.75
37_A69_S1.0800.74
103_A107_Y1.0770.74
31_V84_F1.0700.73
65_L94_T1.0540.72
105_L108_K1.0400.71
30_L37_A1.0280.70
66_I112_L1.0190.70
133_V137_I1.0180.70
46_Y60_P0.9910.68
65_L69_S0.9780.66
8_Y12_V0.9670.66
42_L64_T0.9670.66
68_I71_L0.9670.66
100_M128_I0.9530.64
100_M112_L0.9450.64
52_F59_N0.9440.64
100_M129_V0.9400.63
117_A120_M0.9170.61
82_G87_A0.9160.61
59_N62_A0.9120.61
128_I133_V0.9100.61
101_A126_N0.8930.59
14_T18_K0.8790.58
78_Y89_S0.8770.58
65_L91_V0.8730.58
119_N126_N0.8630.57
42_L45_F0.8500.56
114_L135_A0.8440.55
50_F63_A0.8420.55
67_L75_F0.8360.54
133_V136_Y0.8310.54
46_Y61_T0.8290.54
36_C90_A0.8290.54
30_L34_L0.8180.53
99_S126_N0.8180.53
26_V30_L0.8170.53
102_S134_A0.8170.53
41_G44_N0.8160.53
61_T78_Y0.8150.52
108_K112_L0.8100.52
35_I89_S0.8090.52
112_L117_A0.7970.51
11_K16_Q0.7840.50
82_G91_V0.7810.49
21_Y117_A0.7700.48
38_I65_L0.7660.48
45_F52_F0.7640.48
99_S124_A0.7600.48
50_F107_Y0.7550.47
81_I114_L0.7500.47
34_L85_A0.7450.46
104_A120_M0.7430.46
129_V133_V0.7330.45
59_N63_A0.7330.45
105_L109_S0.7270.45
47_I54_E0.7260.44
12_V82_G0.7240.44
31_V89_S0.7240.44
15_Y18_K0.7230.44
64_T71_L0.7220.44
34_L48_H0.7200.44
12_V16_Q0.7150.43
38_I41_G0.7140.43
16_Q117_A0.7130.43
28_A86_G0.7110.43
58_G62_A0.7090.43
4_I7_N0.7070.43
67_L78_Y0.7020.42
10_S75_F0.6970.42
119_N134_A0.6950.42
34_L41_G0.6910.41
67_L109_S0.6880.41
10_S14_T0.6840.41
67_L112_L0.6820.41
36_C98_N0.6780.40
87_A98_N0.6730.40
117_A133_V0.6720.40
68_I75_F0.6720.40
64_T68_I0.6710.40
52_F56_T0.6660.39
141_I145_F0.6660.39
39_G78_Y0.6660.39
38_I81_I0.6550.38
44_N48_H0.6550.38
82_G98_N0.6540.38
51_D126_N0.6490.38
57_A105_L0.6340.36
71_L101_A0.6330.36
110_E116_V0.6290.36
13_K58_G0.6260.36
12_V15_Y0.6260.36
7_N117_A0.6240.36
76_G135_A0.6240.36
8_Y65_L0.6140.35
9_K64_T0.6110.35
7_N10_S0.6100.35
9_K145_F0.6100.35
103_A128_I0.6080.34
74_G105_L0.6070.34
83_Q109_S0.6040.34
19_P76_G0.6030.34
113_V127_V0.6000.34
30_L41_G0.5990.34
19_P116_V0.5990.34
57_A61_T0.5970.33
87_A127_V0.5960.33
107_Y118_T0.5950.33
53_N61_T0.5940.33
55_K58_G0.5940.33
7_N137_I0.5920.33
81_I89_S0.5900.33
56_T105_L0.5860.33
52_F118_T0.5830.32
11_K14_T0.5830.32
128_I137_I0.5810.32
101_A128_I0.5780.32
42_L61_T0.5760.32
31_V34_L0.5750.32
28_A135_A0.5750.32
83_Q119_N0.5740.32
74_G101_A0.5710.31
37_A44_N0.5700.31
104_A118_T0.5680.31
10_S13_K0.5670.31
43_Q58_G0.5660.31
57_A97_A0.5630.31
76_G79_D0.5620.31
137_I141_I0.5620.31
13_K31_V0.5590.30
122_K136_Y0.5550.30
79_D85_A0.5550.30
79_D105_L0.5540.30
75_F85_A0.5490.30
65_L85_A0.5490.30
7_N26_V0.5480.30
31_V38_I0.5470.30
116_V142_R0.5460.30
36_C86_G0.5440.29
39_G65_L0.5430.29
82_G99_S0.5430.29
25_C66_I0.5420.29
12_V136_Y0.5420.29
114_L132_V0.5420.29
71_L75_F0.5410.29
60_P135_A0.5340.29
99_S107_Y0.5270.28
5_K84_F0.5270.28
57_A75_F0.5260.28
54_E144_A0.5250.28
85_A145_F0.5250.28
69_S101_A0.5240.28
120_M128_I0.5220.28
36_C126_N0.5200.28
14_T145_F0.5170.27
66_I75_F0.5170.27
94_T126_N0.5130.27
103_A135_A0.5120.27
8_Y94_T0.5110.27
38_I144_A0.5040.26
78_Y98_N0.5000.26
38_I69_S0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gfpA 2 0.9267 24 0.952 Contact Map
3o7qA 1 0.8733 23 0.952 Contact Map
1pw4A 1 0.8467 18.5 0.954 Contact Map
4lz6A 1 0.96 10.5 0.959 Contact Map
4j05A 3 0.8133 9.8 0.96 Contact Map
4w6vA 1 0.8933 9.2 0.96 Contact Map
3wdoA 1 0.9 9.2 0.96 Contact Map
4xnjA 1 0.9 8.9 0.96 Contact Map
3w4tA 1 0.8267 7 0.962 Contact Map
1byyA 1 0.1067 6.5 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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