GREMLIN Database
SP5AB - Stage V sporulation protein AB
UniProt: P40867 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 141 (134)
Sequences: 287 (244)
Seq/√Len: 21.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_T49_Y7.1681.00
40_T49_Y4.0421.00
33_I53_V2.6710.99
30_M101_V2.6460.98
94_A98_V2.3310.96
17_I104_I2.3290.96
52_A100_N2.3180.96
31_G60_G2.1360.94
79_P83_L2.0280.92
94_A101_V1.9640.91
7_F110_G1.9330.90
26_F30_M1.8500.88
25_A95_L1.8320.88
31_G64_T1.8160.87
14_G18_T1.7810.86
80_V84_A1.7280.85
12_G81_G1.7140.84
27_L62_W1.6480.82
29_V91_L1.6110.80
28_T133_H1.5880.79
53_V136_Y1.5700.78
26_F31_G1.5550.78
72_L79_P1.5200.76
11_V128_A1.4830.74
21_A57_A1.4590.73
39_L123_V1.4240.71
27_L77_A1.4140.70
22_G103_P1.3830.69
42_T46_V1.3600.67
39_L93_A1.3550.67
20_G93_A1.3520.67
63_E67_M1.3190.65
132_F136_Y1.3080.64
60_G122_I1.3060.64
87_F122_I1.2980.64
40_T46_V1.2870.63
40_T80_V1.2800.63
34_P101_V1.2680.62
25_A100_N1.2530.61
29_V93_A1.2500.61
92_A121_A1.2370.60
24_V57_A1.2240.59
52_A104_I1.2200.59
24_V90_M1.2190.59
60_G64_T1.2150.58
15_G106_A1.2080.58
98_V101_V1.1770.56
131_L135_L1.1650.55
6_L121_A1.1600.55
12_G49_Y1.1600.55
115_I128_A1.1570.55
59_C124_I1.1530.54
90_M134_W1.1510.54
9_I78_V1.1390.53
29_V34_P1.1250.53
10_F110_G1.1080.51
48_A52_A1.1050.51
25_A36_L1.1050.51
12_G20_G1.0980.51
28_T122_I1.0780.49
59_C70_L1.0750.49
62_W80_V1.0710.49
20_G134_W1.0710.49
26_F32_I1.0680.49
17_I21_A1.0610.48
36_L90_M1.0360.47
7_F52_A1.0240.46
34_P130_S1.0240.46
22_G84_A1.0210.46
19_V92_A1.0180.45
24_V39_L1.0120.45
40_T67_M1.0010.44
107_K118_L0.9840.43
116_I120_M0.9820.43
86_L99_L0.9770.43
22_G132_F0.9710.42
13_L135_L0.9670.42
91_L102_L0.9660.42
40_T48_A0.9570.41
93_A96_T0.9530.41
23_F41_K0.9520.41
7_F79_P0.9400.40
61_G64_T0.9310.40
37_M50_E0.9260.39
27_L53_V0.9230.39
53_V58_V0.9190.39
62_W66_H0.9150.39
96_T103_P0.9060.38
9_I44_R0.9010.38
15_G100_N0.9000.38
7_F86_L0.9000.38
79_P128_A0.8930.37
45_F79_P0.8870.37
11_V124_I0.8860.37
41_K105_L0.8850.37
39_L92_A0.8830.37
116_I119_L0.8670.36
14_G128_A0.8660.36
53_V126_K0.8610.35
6_L9_I0.8600.35
55_L104_I0.8580.35
3_V121_A0.8460.35
59_C68_N0.8390.34
110_G127_I0.8390.34
19_V101_V0.8370.34
75_W92_A0.8350.34
107_K134_W0.8320.34
63_E77_A0.8290.34
35_R38_Q0.8270.33
30_M83_L0.8240.33
130_S134_W0.8170.33
59_C63_E0.8170.33
83_L118_L0.8110.32
13_L122_I0.8050.32
94_A102_L0.7830.31
32_I130_S0.7700.30
4_S109_I0.7530.29
10_F14_G0.7420.29
4_S78_V0.7350.28
13_L109_I0.7320.28
30_M91_L0.7230.28
38_Q92_A0.7190.27
11_V82_L0.7170.27
76_I99_L0.7170.27
77_A115_I0.7100.27
10_F98_V0.7090.27
72_L124_I0.7050.27
52_A63_E0.6980.26
18_T21_A0.6880.26
57_A93_A0.6870.26
7_F10_F0.6850.26
19_V29_V0.6830.25
70_L73_T0.6830.25
13_L129_G0.6800.25
8_I11_V0.6760.25
7_F124_I0.6750.25
54_I86_L0.6750.25
41_K116_I0.6740.25
44_R128_A0.6690.25
26_F133_H0.6690.25
52_A79_P0.6610.24
45_F48_A0.6520.24
72_L128_A0.6420.23
38_Q110_G0.6400.23
36_L93_A0.6350.23
102_L127_I0.6310.23
36_L134_W0.6310.23
4_S88_V0.6310.23
21_A88_V0.6260.23
104_I113_S0.6190.22
92_A100_N0.6190.22
31_G99_L0.6190.22
20_G29_V0.6180.22
72_L78_V0.6160.22
127_I130_S0.6120.22
105_L118_L0.6080.22
93_A103_P0.6020.22
23_F38_Q0.5990.21
59_C135_L0.5980.21
21_A31_G0.5970.21
58_V61_G0.5970.21
70_L75_W0.5960.21
66_H84_A0.5950.21
95_L116_I0.5870.21
21_A54_I0.5870.21
128_A131_L0.5800.21
111_L136_Y0.5790.21
102_L113_S0.5790.21
62_W104_I0.5780.21
60_G129_G0.5780.21
57_A133_H0.5770.20
3_V131_L0.5710.20
30_M81_G0.5670.20
18_T99_L0.5650.20
8_I83_L0.5640.20
66_H80_V0.5630.20
52_A82_L0.5620.20
20_G73_T0.5580.20
34_P38_Q0.5520.19
12_G91_L0.5520.19
110_G119_L0.5510.19
29_V51_A0.5480.19
37_M80_V0.5460.19
10_F119_L0.5460.19
86_L127_I0.5460.19
132_F135_L0.5440.19
71_Y76_I0.5410.19
17_I118_L0.5360.19
79_P82_L0.5340.19
13_L23_F0.5280.18
75_W79_P0.5270.18
84_A88_V0.5260.18
8_I66_H0.5200.18
10_F21_A0.5200.18
8_I40_T0.5190.18
57_A96_T0.5110.18
102_L123_V0.5090.18
50_E88_V0.5080.18
63_E88_V0.5030.17
78_V122_I0.5000.17
26_F95_L0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.6383 15.6 0.945 Contact Map
4djkA 2 0.6028 10.4 0.95 Contact Map
4huqS 1 0.6383 6.8 0.954 Contact Map
2cfqA 1 0.9291 6.6 0.954 Contact Map
2nwlA 3 0.6312 6.6 0.954 Contact Map
4hzuS 1 0.6879 5.9 0.955 Contact Map
2zy9A 2 0.9433 5.9 0.955 Contact Map
2qi9A 2 0.6312 4.4 0.957 Contact Map
2nq2A 2 0.6241 4.4 0.957 Contact Map
3giaA 1 0.6596 4.2 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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