SP5AA - BACSU - GREMLIN Contacts

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SP5AA - Stage V sporulation protein AA

UniProt:	P40866	Sequences: MERRIFIRLRHRVLAHPGDIITVGDAAQIEGQLQLKKKLSAMPLYQVSEKDKNIVILDIIQVLRAIHLQDPTIDVQTVGGAETIVEIQYRKRNLSTVLFIGVWLLLFIGSCLAIMNFHEDVSMRDVHIALYEIITGERNDYPYLLQIPYSIGLGLGMIVFFNHIFKKRLNEEPSPLEVEMFNYQLDLDQYVAMHENQETIKDLHDR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	206 (196)
Sequences:	297 (245)
Seq/√Len:	17.5

BACSU - SP5AA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
5_I	29_I	6.569	1.00
23_V	39_L	5.862	1.00
26_A	44_L	4.129	1.00
113_A	126_V	2.966	0.99
126_V	179_E	2.936	0.99
132_E	138_R	2.932	0.99
5_I	73_I	2.898	0.98
182_N	186_D	2.813	0.98
139_N	143_Y	2.810	0.98
59_I	77_T	2.695	0.97
163_H	167_K	2.506	0.96
185_L	189_Q	2.483	0.96
127_H	145_L	2.465	0.96
38_K	70_D	2.395	0.95
130_L	166_K	2.370	0.95
65_A	68_L	2.271	0.93
23_V	29_I	2.235	0.93
47_V	55_V	2.127	0.91
29_I	39_L	2.112	0.90
7_I	45_Y	1.955	0.86
36_K	40_S	1.920	0.85
135_T	154_G	1.877	0.84
127_H	131_Y	1.778	0.80
32_Q	129_A	1.740	0.79
165_F	170_N	1.640	0.75
14_L	191_V	1.616	0.73
13_V	57_L	1.575	0.71
98_L	197_Q	1.572	0.71
57_L	83_T	1.534	0.69
39_L	134_I	1.519	0.69
171_E	195_E	1.519	0.69
39_L	66_I	1.467	0.66
30_E	67_H	1.446	0.65
21_I	57_L	1.446	0.65
178_V	198_E	1.443	0.65
131_Y	145_L	1.400	0.62
150_S	161_F	1.388	0.61
92_R	187_L	1.367	0.60
127_H	146_Q	1.365	0.60
163_H	178_V	1.357	0.60
36_K	59_I	1.353	0.59
185_L	188_D	1.340	0.59
54_I	115_M	1.335	0.58
5_I	35_L	1.332	0.58
131_Y	144_L	1.332	0.58
7_I	97_V	1.329	0.58
57_L	148_P	1.322	0.58
60_I	198_E	1.322	0.58
38_K	69_Q	1.308	0.57
62_V	83_T	1.305	0.57
62_V	181_F	1.296	0.56
112_L	129_A	1.294	0.56
33_L	91_K	1.288	0.56
19_D	75_V	1.280	0.55
7_I	51_D	1.276	0.55
105_L	196_N	1.273	0.55
119_E	153_L	1.258	0.54
8_R	82_E	1.251	0.53
58_D	184_Q	1.242	0.53
58_D	195_E	1.237	0.52
10_R	86_E	1.234	0.52
102_V	131_Y	1.214	0.51
137_E	140_D	1.195	0.50
21_I	44_L	1.190	0.50
112_L	119_E	1.189	0.50
148_P	174_S	1.189	0.50
24_G	41_A	1.184	0.49
71_P	98_L	1.181	0.49
61_Q	64_R	1.170	0.48
39_L	75_V	1.155	0.47
142_P	161_F	1.141	0.47
102_V	113_A	1.133	0.46
86_E	113_A	1.130	0.46
44_L	59_I	1.119	0.45
63_L	139_N	1.118	0.45
49_E	61_Q	1.116	0.45
116_N	123_M	1.111	0.45
29_I	182_N	1.108	0.45
35_L	73_I	1.094	0.44
105_L	167_K	1.091	0.44
165_F	184_Q	1.089	0.43
86_E	179_E	1.086	0.43
172_E	184_Q	1.082	0.43
4_R	10_R	1.081	0.43
28_Q	31_G	1.074	0.43
67_H	155_L	1.072	0.42
8_R	26_A	1.070	0.42
8_R	39_L	1.054	0.41
22_T	97_V	1.051	0.41
106_L	118_H	1.043	0.41
181_F	190_Y	1.042	0.41
118_H	177_E	1.028	0.40
84_I	104_L	1.021	0.39
54_I	186_D	1.019	0.39
106_L	154_G	1.005	0.39
86_E	198_E	0.998	0.38
85_V	128_I	0.997	0.38
38_K	44_L	0.996	0.38
73_I	89_Y	0.989	0.38
112_L	181_F	0.986	0.37
13_V	95_S	0.972	0.37
35_L	93_N	0.968	0.36
170_N	176_L	0.965	0.36
28_Q	198_E	0.964	0.36
25_D	151_I	0.960	0.36
5_I	39_L	0.954	0.36
154_G	195_E	0.954	0.36
21_I	61_Q	0.950	0.35
97_V	145_L	0.945	0.35
44_L	85_V	0.938	0.35
133_I	169_L	0.937	0.35
143_Y	148_P	0.936	0.35
6_F	56_I	0.927	0.34
88_Q	169_L	0.925	0.34
117_F	179_E	0.922	0.34
179_E	195_E	0.915	0.34
4_R	31_G	0.914	0.33
72_T	151_I	0.913	0.33
11_H	119_E	0.909	0.33
7_I	73_I	0.903	0.33
7_I	62_V	0.895	0.32
7_I	137_E	0.894	0.32
60_I	189_Q	0.890	0.32
69_Q	75_V	0.890	0.32
7_I	48_S	0.886	0.32
28_Q	40_S	0.877	0.32
39_L	42_M	0.877	0.32
98_L	184_Q	0.864	0.31
116_N	119_E	0.863	0.31
115_M	126_V	0.859	0.31
14_L	89_Y	0.846	0.30
107_F	162_N	0.838	0.30
87_I	118_H	0.830	0.29
65_A	69_Q	0.818	0.29
42_M	50_K	0.813	0.28
112_L	117_F	0.808	0.28
174_S	196_N	0.802	0.28
165_F	172_E	0.800	0.28
98_L	181_F	0.800	0.28
131_Y	147_I	0.798	0.28
116_N	168_R	0.798	0.28
17_P	110_S	0.794	0.27
4_R	44_L	0.786	0.27
29_I	36_K	0.783	0.27
110_S	119_E	0.777	0.27
44_L	64_R	0.776	0.26
61_Q	65_A	0.775	0.26
112_L	172_E	0.775	0.26
18_G	81_A	0.773	0.26
148_P	170_N	0.773	0.26
5_I	53_N	0.772	0.26
157_M	165_F	0.772	0.26
13_V	29_I	0.772	0.26
54_I	98_L	0.771	0.26
81_A	145_L	0.765	0.26
6_F	27_A	0.758	0.26
104_L	128_I	0.756	0.26
99_F	103_W	0.752	0.25
123_M	172_E	0.750	0.25
133_I	176_L	0.748	0.25
41_A	75_V	0.743	0.25
75_V	199_T	0.743	0.25
24_G	70_D	0.741	0.25
23_V	130_L	0.738	0.25
146_Q	176_L	0.737	0.25
102_V	127_H	0.732	0.24
80_G	174_S	0.721	0.24
142_P	148_P	0.717	0.24
112_L	127_H	0.716	0.24
31_G	36_K	0.715	0.24
129_A	145_L	0.714	0.24
168_R	194_H	0.712	0.24
98_L	158_I	0.709	0.23
62_V	167_K	0.708	0.23
7_I	74_D	0.708	0.23
43_P	147_I	0.707	0.23
21_I	85_V	0.705	0.23
108_I	174_S	0.701	0.23
52_K	153_L	0.698	0.23
10_R	88_Q	0.698	0.23
62_V	176_L	0.693	0.23
22_T	43_P	0.692	0.23
123_M	142_P	0.689	0.23
65_A	90_R	0.688	0.23
78_V	111_C	0.688	0.23
58_D	165_F	0.687	0.22
7_I	46_Q	0.686	0.22
106_L	146_Q	0.686	0.22
101_G	110_S	0.685	0.22
101_G	108_I	0.685	0.22
130_L	192_A	0.685	0.22
143_Y	147_I	0.681	0.22
70_D	189_Q	0.679	0.22
108_I	145_L	0.679	0.22
142_P	154_G	0.677	0.22
116_N	146_Q	0.676	0.22
24_G	40_S	0.675	0.22
67_H	90_R	0.674	0.22
106_L	126_V	0.674	0.22
182_N	192_A	0.673	0.22
177_E	191_V	0.671	0.22
123_M	146_Q	0.671	0.22
128_I	143_Y	0.669	0.22
83_T	118_H	0.667	0.22
10_R	60_I	0.659	0.21
34_Q	48_S	0.656	0.21
172_E	181_F	0.655	0.21
93_N	166_K	0.653	0.21
51_D	103_W	0.650	0.21
52_K	94_L	0.648	0.21
3_R	104_L	0.648	0.21
84_I	185_L	0.647	0.21
24_G	104_L	0.647	0.21
143_Y	146_Q	0.647	0.21
180_M	199_T	0.643	0.21
57_L	73_I	0.640	0.21
118_H	190_Y	0.639	0.21
29_I	32_Q	0.639	0.21
116_N	165_F	0.638	0.20
38_K	73_I	0.637	0.20
13_V	85_V	0.636	0.20
157_M	172_E	0.635	0.20
110_S	113_A	0.632	0.20
56_I	84_I	0.630	0.20
129_A	169_L	0.629	0.20
58_D	186_D	0.627	0.20
129_A	176_L	0.626	0.20
48_S	133_I	0.623	0.20
45_Y	57_L	0.618	0.20
33_L	73_I	0.616	0.20
75_V	178_V	0.615	0.20
11_H	193_M	0.614	0.20
5_I	66_I	0.613	0.20
106_L	142_P	0.612	0.19
6_F	110_S	0.606	0.19
42_M	139_N	0.605	0.19
82_E	196_N	0.601	0.19
116_N	172_E	0.600	0.19
106_L	110_S	0.598	0.19
143_Y	174_S	0.594	0.19
102_V	177_E	0.592	0.19
135_T	143_Y	0.592	0.19
118_H	123_M	0.584	0.18
31_G	87_I	0.580	0.18
71_P	97_V	0.579	0.18
127_H	176_L	0.575	0.18
161_F	198_E	0.569	0.18
115_M	127_H	0.568	0.18
24_G	90_R	0.567	0.18
115_M	192_A	0.567	0.18
6_F	186_D	0.565	0.18
8_R	90_R	0.565	0.18
45_Y	126_V	0.564	0.18
85_V	171_E	0.562	0.18
26_A	55_V	0.562	0.18
28_Q	134_I	0.562	0.18
81_A	133_I	0.556	0.17
184_Q	188_D	0.555	0.17
8_R	77_T	0.553	0.17
39_L	96_T	0.552	0.17
117_F	161_F	0.549	0.17
79_G	183_Y	0.549	0.17
112_L	123_M	0.545	0.17
9_L	27_A	0.543	0.17
74_D	97_V	0.541	0.17
14_L	198_E	0.540	0.17
71_P	76_Q	0.539	0.17
171_E	185_L	0.539	0.17
128_I	138_R	0.537	0.17
159_V	174_S	0.536	0.17
173_P	183_Y	0.535	0.17
100_I	194_H	0.535	0.17
139_N	142_P	0.533	0.17
174_S	181_F	0.528	0.16
46_Q	63_L	0.525	0.16
43_P	73_I	0.524	0.16
39_L	154_G	0.523	0.16
50_K	72_T	0.520	0.16
52_K	108_I	0.519	0.16
110_S	192_A	0.516	0.16
178_V	187_L	0.515	0.16
45_Y	65_A	0.515	0.16
106_L	116_N	0.514	0.16
111_C	117_F	0.513	0.16
103_W	118_H	0.510	0.16
87_I	113_A	0.510	0.16
162_N	172_E	0.510	0.16
131_Y	174_S	0.509	0.16
113_A	176_L	0.508	0.16
7_I	38_K	0.507	0.16
161_F	190_Y	0.505	0.16
14_L	50_K	0.503	0.16
69_Q	85_V	0.502	0.16
40_S	166_K	0.500	0.16

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3g74A	3	0.432	100	0.683	Contact Map
4k0jA	3	0.8058	51.4	0.955	Contact Map
3w9iA	3	0.9272	36.8	0.959	Contact Map
4r86A	1	0.4175	27	0.962	Contact Map
3ne5A	3	0.9417	16.3	0.966	Contact Map
3effK	4	0.4951	7.1	0.971	Contact Map
4dx5A	3	0.9223	5.4	0.972	Contact Map
3j20R	1	0.2621	4	0.974	Contact Map
4ui9G	1	0.1214	3.7	0.974	Contact Map
1dowB	1	0.1359	3.4	0.975	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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