GREMLIN Database
SP5AA - Stage V sporulation protein AA
UniProt: P40866 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 206 (196)
Sequences: 297 (245)
Seq/√Len: 17.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_I29_I6.5691.00
23_V39_L5.8621.00
26_A44_L4.1291.00
113_A126_V2.9660.99
126_V179_E2.9360.99
132_E138_R2.9320.99
5_I73_I2.8980.98
182_N186_D2.8130.98
139_N143_Y2.8100.98
59_I77_T2.6950.97
163_H167_K2.5060.96
185_L189_Q2.4830.96
127_H145_L2.4650.96
38_K70_D2.3950.95
130_L166_K2.3700.95
65_A68_L2.2710.93
23_V29_I2.2350.93
47_V55_V2.1270.91
29_I39_L2.1120.90
7_I45_Y1.9550.86
36_K40_S1.9200.85
135_T154_G1.8770.84
127_H131_Y1.7780.80
32_Q129_A1.7400.79
165_F170_N1.6400.75
14_L191_V1.6160.73
13_V57_L1.5750.71
98_L197_Q1.5720.71
57_L83_T1.5340.69
39_L134_I1.5190.69
171_E195_E1.5190.69
39_L66_I1.4670.66
30_E67_H1.4460.65
21_I57_L1.4460.65
178_V198_E1.4430.65
131_Y145_L1.4000.62
150_S161_F1.3880.61
92_R187_L1.3670.60
127_H146_Q1.3650.60
163_H178_V1.3570.60
36_K59_I1.3530.59
185_L188_D1.3400.59
54_I115_M1.3350.58
5_I35_L1.3320.58
131_Y144_L1.3320.58
7_I97_V1.3290.58
57_L148_P1.3220.58
60_I198_E1.3220.58
38_K69_Q1.3080.57
62_V83_T1.3050.57
62_V181_F1.2960.56
112_L129_A1.2940.56
33_L91_K1.2880.56
19_D75_V1.2800.55
7_I51_D1.2760.55
105_L196_N1.2730.55
119_E153_L1.2580.54
8_R82_E1.2510.53
58_D184_Q1.2420.53
58_D195_E1.2370.52
10_R86_E1.2340.52
102_V131_Y1.2140.51
137_E140_D1.1950.50
21_I44_L1.1900.50
112_L119_E1.1890.50
148_P174_S1.1890.50
24_G41_A1.1840.49
71_P98_L1.1810.49
61_Q64_R1.1700.48
39_L75_V1.1550.47
142_P161_F1.1410.47
102_V113_A1.1330.46
86_E113_A1.1300.46
44_L59_I1.1190.45
63_L139_N1.1180.45
49_E61_Q1.1160.45
116_N123_M1.1110.45
29_I182_N1.1080.45
35_L73_I1.0940.44
105_L167_K1.0910.44
165_F184_Q1.0890.43
86_E179_E1.0860.43
172_E184_Q1.0820.43
4_R10_R1.0810.43
28_Q31_G1.0740.43
67_H155_L1.0720.42
8_R26_A1.0700.42
8_R39_L1.0540.41
22_T97_V1.0510.41
106_L118_H1.0430.41
181_F190_Y1.0420.41
118_H177_E1.0280.40
84_I104_L1.0210.39
54_I186_D1.0190.39
106_L154_G1.0050.39
86_E198_E0.9980.38
85_V128_I0.9970.38
38_K44_L0.9960.38
73_I89_Y0.9890.38
112_L181_F0.9860.37
13_V95_S0.9720.37
35_L93_N0.9680.36
170_N176_L0.9650.36
28_Q198_E0.9640.36
25_D151_I0.9600.36
5_I39_L0.9540.36
154_G195_E0.9540.36
21_I61_Q0.9500.35
97_V145_L0.9450.35
44_L85_V0.9380.35
133_I169_L0.9370.35
143_Y148_P0.9360.35
6_F56_I0.9270.34
88_Q169_L0.9250.34
117_F179_E0.9220.34
179_E195_E0.9150.34
4_R31_G0.9140.33
72_T151_I0.9130.33
11_H119_E0.9090.33
7_I73_I0.9030.33
7_I62_V0.8950.32
7_I137_E0.8940.32
60_I189_Q0.8900.32
69_Q75_V0.8900.32
7_I48_S0.8860.32
28_Q40_S0.8770.32
39_L42_M0.8770.32
98_L184_Q0.8640.31
116_N119_E0.8630.31
115_M126_V0.8590.31
14_L89_Y0.8460.30
107_F162_N0.8380.30
87_I118_H0.8300.29
65_A69_Q0.8180.29
42_M50_K0.8130.28
112_L117_F0.8080.28
174_S196_N0.8020.28
165_F172_E0.8000.28
98_L181_F0.8000.28
131_Y147_I0.7980.28
116_N168_R0.7980.28
17_P110_S0.7940.27
4_R44_L0.7860.27
29_I36_K0.7830.27
110_S119_E0.7770.27
44_L64_R0.7760.26
61_Q65_A0.7750.26
112_L172_E0.7750.26
18_G81_A0.7730.26
148_P170_N0.7730.26
5_I53_N0.7720.26
157_M165_F0.7720.26
13_V29_I0.7720.26
54_I98_L0.7710.26
81_A145_L0.7650.26
6_F27_A0.7580.26
104_L128_I0.7560.26
99_F103_W0.7520.25
123_M172_E0.7500.25
133_I176_L0.7480.25
41_A75_V0.7430.25
75_V199_T0.7430.25
24_G70_D0.7410.25
23_V130_L0.7380.25
146_Q176_L0.7370.25
102_V127_H0.7320.24
80_G174_S0.7210.24
142_P148_P0.7170.24
112_L127_H0.7160.24
31_G36_K0.7150.24
129_A145_L0.7140.24
168_R194_H0.7120.24
98_L158_I0.7090.23
62_V167_K0.7080.23
7_I74_D0.7080.23
43_P147_I0.7070.23
21_I85_V0.7050.23
108_I174_S0.7010.23
52_K153_L0.6980.23
10_R88_Q0.6980.23
62_V176_L0.6930.23
22_T43_P0.6920.23
123_M142_P0.6890.23
65_A90_R0.6880.23
78_V111_C0.6880.23
58_D165_F0.6870.22
7_I46_Q0.6860.22
106_L146_Q0.6860.22
101_G110_S0.6850.22
101_G108_I0.6850.22
130_L192_A0.6850.22
143_Y147_I0.6810.22
70_D189_Q0.6790.22
108_I145_L0.6790.22
142_P154_G0.6770.22
116_N146_Q0.6760.22
24_G40_S0.6750.22
67_H90_R0.6740.22
106_L126_V0.6740.22
182_N192_A0.6730.22
177_E191_V0.6710.22
123_M146_Q0.6710.22
128_I143_Y0.6690.22
83_T118_H0.6670.22
10_R60_I0.6590.21
34_Q48_S0.6560.21
172_E181_F0.6550.21
93_N166_K0.6530.21
51_D103_W0.6500.21
52_K94_L0.6480.21
3_R104_L0.6480.21
84_I185_L0.6470.21
24_G104_L0.6470.21
143_Y146_Q0.6470.21
180_M199_T0.6430.21
57_L73_I0.6400.21
118_H190_Y0.6390.21
29_I32_Q0.6390.21
116_N165_F0.6380.20
38_K73_I0.6370.20
13_V85_V0.6360.20
157_M172_E0.6350.20
110_S113_A0.6320.20
56_I84_I0.6300.20
129_A169_L0.6290.20
58_D186_D0.6270.20
129_A176_L0.6260.20
48_S133_I0.6230.20
45_Y57_L0.6180.20
33_L73_I0.6160.20
75_V178_V0.6150.20
11_H193_M0.6140.20
5_I66_I0.6130.20
106_L142_P0.6120.19
6_F110_S0.6060.19
42_M139_N0.6050.19
82_E196_N0.6010.19
116_N172_E0.6000.19
106_L110_S0.5980.19
143_Y174_S0.5940.19
102_V177_E0.5920.19
135_T143_Y0.5920.19
118_H123_M0.5840.18
31_G87_I0.5800.18
71_P97_V0.5790.18
127_H176_L0.5750.18
161_F198_E0.5690.18
115_M127_H0.5680.18
24_G90_R0.5670.18
115_M192_A0.5670.18
6_F186_D0.5650.18
8_R90_R0.5650.18
45_Y126_V0.5640.18
85_V171_E0.5620.18
26_A55_V0.5620.18
28_Q134_I0.5620.18
81_A133_I0.5560.17
184_Q188_D0.5550.17
8_R77_T0.5530.17
39_L96_T0.5520.17
117_F161_F0.5490.17
79_G183_Y0.5490.17
112_L123_M0.5450.17
9_L27_A0.5430.17
74_D97_V0.5410.17
14_L198_E0.5400.17
71_P76_Q0.5390.17
171_E185_L0.5390.17
128_I138_R0.5370.17
159_V174_S0.5360.17
173_P183_Y0.5350.17
100_I194_H0.5350.17
139_N142_P0.5330.17
174_S181_F0.5280.16
46_Q63_L0.5250.16
43_P73_I0.5240.16
39_L154_G0.5230.16
50_K72_T0.5200.16
52_K108_I0.5190.16
110_S192_A0.5160.16
178_V187_L0.5150.16
45_Y65_A0.5150.16
106_L116_N0.5140.16
111_C117_F0.5130.16
103_W118_H0.5100.16
87_I113_A0.5100.16
162_N172_E0.5100.16
131_Y174_S0.5090.16
113_A176_L0.5080.16
7_I38_K0.5070.16
161_F190_Y0.5050.16
14_L50_K0.5030.16
69_Q85_V0.5020.16
40_S166_K0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3g74A 3 0.432 100 0.683 Contact Map
4k0jA 3 0.8058 51.4 0.955 Contact Map
3w9iA 3 0.9272 36.8 0.959 Contact Map
4r86A 1 0.4175 27 0.962 Contact Map
3ne5A 3 0.9417 16.3 0.966 Contact Map
3effK 4 0.4951 7.1 0.971 Contact Map
4dx5A 3 0.9223 5.4 0.972 Contact Map
3j20R 1 0.2621 4 0.974 Contact Map
4ui9G 1 0.1214 3.7 0.974 Contact Map
1dowB 1 0.1359 3.4 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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