GREMLIN Database
PKSG - Polyketide biosynthesis 3-hydroxy-3-methylglutaryl-ACP synthase PksG
UniProt: P40830 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 420 (317)
Sequences: 2254 (1384)
Seq/√Len: 77.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_G95_I5.0211.00
41_E293_R4.9761.00
121_F177_V4.9381.00
124_A138_A4.8311.00
128_I177_V4.1421.00
62_I176_L4.0221.00
76_L138_A3.6081.00
320_R338_I3.5621.00
245_Q319_K3.5301.00
187_D338_I3.2791.00
40_K292_Q3.2421.00
59_A139_L3.1151.00
51_P143_S3.0801.00
185_Q338_I3.0441.00
302_L323_C2.9581.00
75_E136_A2.8731.00
70_E73_R2.6191.00
125_V186_I2.5221.00
19_D22_E2.4551.00
10_N61_P2.3531.00
7_E178_G2.3521.00
56_V98_Y2.3501.00
230_E233_K2.2461.00
9_M307_A2.2411.00
45_A170_A2.2101.00
239_N242_D2.2061.00
316_D319_K2.1961.00
11_V307_A2.1921.00
75_E137_K2.1591.00
95_I141_I2.1331.00
217_L253_F2.1271.00
92_S107_L2.1231.00
114_C296_N2.1051.00
59_A99_L2.0981.00
250_H296_N2.0651.00
3_S185_Q1.9851.00
12_F54_F1.9731.00
171_G297_I1.9571.00
73_R137_K1.9521.00
40_K293_R1.9261.00
297_I300_A1.8781.00
79_T91_L1.8701.00
79_T143_S1.8571.00
117_G142_A1.8451.00
56_V95_I1.8431.00
17_Y41_E1.8411.00
58_A172_A1.7781.00
90_S112_Q1.7711.00
323_C337_G1.7421.00
8_A62_I1.6971.00
19_D41_E1.6781.00
187_D320_R1.6731.00
10_N62_I1.6551.00
253_F256_M1.6471.00
231_Y244_F1.6391.00
74_I139_L1.6361.00
22_E25_K1.6221.00
97_E197_E1.6141.00
60_K64_D1.6001.00
101_L105_C1.5911.00
184_F337_G1.5600.99
244_F336_S1.5560.99
118_T303_F1.5470.99
4_A129_L1.5370.99
50_D53_T1.5270.99
171_G304_L1.5240.99
230_E234_R1.5210.99
231_Y336_S1.5190.99
120_G140_V1.5080.99
80_C120_G1.5000.99
81_S84_G1.4890.99
228_F264_M1.4880.99
114_C250_H1.4870.99
187_D336_S1.4810.99
51_P91_L1.4800.99
192_G230_E1.4770.99
11_V304_L1.4730.99
104_N230_E1.4720.99
110_V123_M1.4630.99
60_K71_K1.4290.99
63_I71_K1.4290.99
322_G334_F1.4280.99
228_F232_Q1.4170.99
121_F303_F1.4140.99
143_S172_A1.4120.99
125_V129_L1.3930.99
307_A311_D1.3580.98
104_N234_R1.3530.98
247_L322_G1.3110.98
75_E127_F1.3040.98
294_V304_L1.2960.98
320_R336_S1.2940.98
212_D215_L1.2850.98
73_R136_A1.2740.98
238_A242_D1.2690.98
87_F205_I1.2680.98
62_I66_L1.2570.97
78_I108_F1.2560.97
137_K178_G1.2500.97
317_T341_P1.2460.97
315_F319_K1.2460.97
315_F339_T1.2320.97
12_F57_N1.2230.97
200_D203_R1.2210.97
4_A128_I1.2110.97
4_A177_V1.2100.97
46_L49_E1.2060.97
226_Q230_E1.2030.97
297_I304_L1.2020.97
198_V201_T1.1730.96
124_A177_V1.1680.96
7_E182_E1.1610.96
78_I123_M1.1560.96
246_Y319_K1.1530.96
175_V303_F1.1510.96
80_C142_A1.1500.96
75_E135_G1.1470.96
52_V91_L1.1430.96
90_S93_T1.1390.95
196_Y222_D1.1360.95
69_A73_R1.1350.95
4_A125_V1.1350.95
258_K262_R1.1240.95
78_I110_V1.1140.95
214_D218_M1.1130.95
221_L224_C1.0950.94
306_L337_G1.0810.94
110_V116_S1.0790.94
340_T343_G1.0760.94
105_C139_L1.0710.94
178_G182_E1.0700.94
321_I339_T1.0680.94
126_N132_T1.0670.94
127_F136_A1.0650.94
83_S113_A1.0610.93
8_A65_A1.0300.92
21_M25_K1.0280.92
18_L44_V1.0280.92
46_L50_D1.0240.92
306_L323_C1.0220.92
258_K288_L1.0190.92
35_E40_K1.0170.92
308_S312_Q1.0140.92
29_L35_E1.0110.92
323_C335_Y1.0080.91
285_K288_L1.0070.91
291_C305_A1.0030.91
238_A244_F1.0030.91
118_T325_S0.9970.91
113_A167_S0.9930.91
234_R238_A0.9920.91
31_T35_E0.9870.91
229_L233_K0.9860.91
261_H281_L0.9820.90
32_A35_E0.9730.90
185_Q340_T0.9700.90
91_L143_S0.9610.89
63_I74_I0.9590.89
302_L335_Y0.9460.89
8_A66_L0.9420.88
198_V215_L0.9330.88
261_H284_V0.9330.88
135_G179_E0.9300.88
196_Y206_P0.9270.88
79_T112_Q0.9260.88
79_T141_I0.9250.88
171_G300_A0.9240.88
302_L325_S0.9120.87
33_R36_N0.9110.87
30_D35_E0.9110.87
77_L138_A0.9100.87
139_L174_A0.9090.87
250_H301_A0.9070.87
58_A174_A0.9010.86
214_D217_L0.8990.86
61_P65_A0.8960.86
133_S136_A0.8890.85
246_Y309_T0.8880.85
142_A300_A0.8810.85
218_M222_D0.8810.85
55_G58_A0.8740.84
340_T344_Q0.8710.84
248_A305_A0.8660.84
247_L334_F0.8650.84
184_F187_D0.8590.83
250_H328_S0.8560.83
233_K282_T0.8560.83
226_Q229_L0.8530.83
212_D216_S0.8510.83
135_G138_A0.8500.83
17_Y43_A0.8470.83
66_L69_A0.8420.82
281_L285_K0.8410.82
216_S326_Y0.8410.82
82_E298_M0.8370.82
42_K170_A0.8360.82
44_V147_R0.8350.82
118_T333_E0.8340.82
257_V284_V0.8320.81
7_E137_K0.8310.81
167_S252_P0.8290.81
89_K296_N0.8260.81
81_S91_L0.8260.81
186_I337_G0.8250.81
118_T302_L0.8230.81
82_E301_A0.8180.80
167_S296_N0.8140.80
168_A252_P0.8120.80
128_I324_F0.8120.80
192_G196_Y0.8090.80
284_V288_L0.8090.80
122_Q333_E0.8080.79
22_E26_Y0.8080.79
54_F172_A0.8080.79
53_T98_Y0.8000.79
69_A137_K0.8000.79
118_T335_Y0.7920.78
309_T321_I0.7910.78
54_F143_S0.7910.78
199_M207_D0.7900.78
287_G291_C0.7870.78
40_K233_K0.7860.78
61_P282_T0.7850.77
71_K241_Q0.7830.77
168_A298_M0.7800.77
173_V307_A0.7780.77
52_V81_S0.7770.77
38_L254_G0.7770.77
77_L105_C0.7760.77
167_S328_S0.7760.77
59_A174_A0.7700.76
9_M175_V0.7670.76
129_L132_T0.7640.76
245_Q283_R0.7620.75
252_P256_M0.7580.75
10_N176_L0.7580.75
192_G195_G0.7550.75
59_A62_I0.7540.75
39_M254_G0.7530.74
285_K289_N0.7500.74
290_Y311_D0.7450.74
232_Q236_P0.7440.74
303_F309_T0.7440.74
59_A141_I0.7430.74
151_A154_G0.7420.73
54_F170_A0.7400.73
41_E294_V0.7380.73
89_K144_D0.7360.73
225_E229_L0.7280.72
251_T305_A0.7260.72
10_N178_G0.7240.72
188_P236_P0.7220.71
298_M326_Y0.7100.70
146_S298_M0.7090.70
56_V92_S0.7080.70
116_S120_G0.7060.70
25_K31_T0.7050.70
39_M250_H0.7040.69
287_G305_A0.7040.69
115_Y333_E0.7020.69
227_T334_F0.6990.69
231_Y334_F0.6950.68
33_R38_L0.6910.68
78_I140_V0.6870.68
59_A63_I0.6870.68
267_K282_T0.6870.68
202_C207_D0.6860.67
75_E138_A0.6850.67
79_T107_L0.6840.67
253_F298_M0.6840.67
224_C264_M0.6820.67
116_S299_G0.6820.67
233_K237_G0.6800.67
65_A310_I0.6750.66
248_A309_T0.6720.66
89_K250_H0.6710.66
202_C208_S0.6700.66
81_S98_Y0.6670.65
168_A328_S0.6660.65
137_K179_E0.6660.65
55_G79_T0.6640.65
21_M32_A0.6620.65
195_G198_V0.6610.65
123_M127_F0.6610.65
82_E113_A0.6610.65
116_S253_F0.6600.64
115_Y119_A0.6600.64
29_L33_R0.6590.64
203_R207_D0.6580.64
223_C332_S0.6580.64
24_A32_A0.6570.64
177_V234_R0.6570.64
114_C328_S0.6560.64
96_H103_R0.6560.64
82_E86_D0.6560.64
49_E53_T0.6550.64
110_V127_F0.6530.64
185_Q320_R0.6500.63
191_N195_G0.6470.63
199_M203_R0.6450.63
39_M42_K0.6440.63
14_G170_A0.6430.62
57_N60_K0.6400.62
291_C304_L0.6400.62
201_T204_P0.6380.62
16_A46_L0.6360.62
237_G313_G0.6350.62
232_Q244_F0.6350.62
229_L234_R0.6340.61
110_V120_G0.6340.61
71_K105_C0.6310.61
238_A336_S0.6280.61
252_P298_M0.6280.61
184_F323_C0.6260.60
167_S298_M0.6260.60
248_A321_I0.6260.60
222_D225_E0.6230.60
55_G59_A0.6220.60
19_D25_K0.6220.60
85_I303_F0.6210.60
60_K99_L0.6210.60
225_E263_T0.6200.60
341_P346_R0.6200.60
289_N345_E0.6190.60
90_S113_A0.6180.59
63_I70_E0.6170.59
22_E222_D0.6160.59
3_S180_N0.6140.59
20_V39_M0.6120.59
282_T313_G0.6120.59
228_F334_F0.6120.59
52_V95_I0.6100.58
212_D217_L0.6100.58
121_F300_A0.6100.58
197_E203_R0.6100.58
251_T257_V0.6080.58
126_N133_S0.6080.58
163_Y252_P0.6080.58
10_N58_A0.6050.58
262_R266_R0.6040.58
296_N301_A0.6010.57
195_G202_C0.5990.57
187_D337_G0.5960.57
238_A312_Q0.5950.57
248_A297_I0.5920.56
21_M95_I0.5920.56
96_H195_G0.5920.56
55_G81_S0.5910.56
168_A326_Y0.5910.56
190_A262_R0.5880.56
4_A43_A0.5880.56
213_S301_A0.5880.56
66_L71_K0.5860.55
201_T208_S0.5850.55
197_E200_D0.5850.55
253_F291_C0.5850.55
60_K95_I0.5840.55
252_P326_Y0.5840.55
76_L123_M0.5840.55
164_A330_C0.5830.55
226_Q233_K0.5820.55
102_N105_C0.5820.55
76_L128_I0.5820.55
29_L34_F0.5810.55
324_F334_F0.5790.55
88_G111_K0.5770.54
80_C116_S0.5760.54
10_N14_G0.5750.54
37_L256_M0.5720.54
342_Q346_R0.5720.54
89_K147_R0.5710.54
143_S289_N0.5710.54
41_E241_Q0.5710.54
108_F123_M0.5710.54
177_V222_D0.5700.53
62_I174_A0.5700.53
93_T195_G0.5700.53
103_R196_Y0.5690.53
81_S301_A0.5680.53
73_R135_G0.5680.53
89_K220_Y0.5670.53
5_G49_E0.5670.53
110_V139_L0.5660.53
197_E201_T0.5660.53
297_I301_A0.5650.53
242_D282_T0.5650.53
267_K314_R0.5640.53
51_P55_G0.5640.53
256_M260_A0.5640.53
204_P207_D0.5640.53
254_G292_Q0.5630.53
47_P83_S0.5620.52
127_F135_G0.5620.52
37_L284_V0.5610.52
240_Y245_Q0.5560.52
201_T209_E0.5560.52
205_I208_S0.5550.51
3_S129_L0.5520.51
30_D33_R0.5510.51
68_E345_E0.5510.51
52_V94_Y0.5500.51
194_Y227_T0.5500.51
113_A298_M0.5480.51
289_N312_Q0.5470.50
9_M183_V0.5470.50
119_A333_E0.5470.50
80_C298_M0.5460.50
62_I139_L0.5430.50
285_K312_Q0.5430.50
257_V287_G0.5420.50
313_G341_P0.5410.50
239_N316_D0.5410.50
52_V85_I0.5400.50
62_I71_K0.5400.50
120_G227_T0.5390.49
267_K283_R0.5390.49
201_T328_S0.5390.49
37_L166_P0.5390.49
121_F186_I0.5380.49
245_Q320_R0.5380.49
54_F306_L0.5360.49
124_A142_A0.5360.49
285_K293_R0.5360.49
245_Q285_K0.5360.49
301_A328_S0.5360.49
101_L124_A0.5350.49
14_G54_F0.5330.49
236_P242_D0.5330.49
63_I66_L0.5330.49
296_N302_L0.5310.48
250_H256_M0.5300.48
94_Y199_M0.5300.48
82_E216_S0.5290.48
199_M202_C0.5290.48
19_D197_E0.5290.48
266_R283_R0.5280.48
229_L232_Q0.5280.48
198_V203_R0.5250.48
18_L301_A0.5250.48
205_I290_Y0.5250.48
236_P281_L0.5240.48
221_L256_M0.5240.48
59_A71_K0.5240.48
117_G325_S0.5240.48
307_A310_I0.5230.47
253_F326_Y0.5230.47
72_D342_Q0.5230.47
21_M69_A0.5230.47
66_L176_L0.5210.47
339_T342_Q0.5200.47
74_I101_L0.5200.47
17_Y22_E0.5200.47
289_N313_G0.5190.47
258_K284_V0.5180.47
64_D72_D0.5160.47
254_G288_L0.5160.47
81_S171_G0.5150.46
76_L127_F0.5150.46
223_C228_F0.5140.46
69_A321_I0.5130.46
116_S325_S0.5120.46
93_T123_M0.5110.46
289_N293_R0.5110.46
281_L284_V0.5080.45
182_E346_R0.5080.45
289_N317_T0.5070.45
211_G217_L0.5050.45
177_V225_E0.5050.45
55_G345_E0.5050.45
113_A250_H0.5040.45
77_L187_D0.5020.45
128_I138_A0.5020.45
201_T205_I0.5020.45
82_E88_G0.5010.45
110_V138_A0.5010.45
110_V236_P0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2f82A 2 0.9357 100 0.26 Contact Map
2p8uA 2 0.9429 100 0.265 Contact Map
2wyaA 2 0.9429 100 0.266 Contact Map
1xpmA 2 0.9167 100 0.297 Contact Map
3v4nA 2 0.9048 100 0.311 Contact Map
3sqzA 2 0.9119 100 0.321 Contact Map
3vs8A 2 0.7476 100 0.505 Contact Map
3il3A 2 0.731 100 0.517 Contact Map
1tedA 2 0.7571 100 0.519 Contact Map
3gwaA 2 0.7381 100 0.52 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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