GREMLIN Database
PKSH - Probable polyketide biosynthesis enoyl-CoA hydratase PksH
UniProt: P40805 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 259 (242)
Sequences: 30154 (19644)
Seq/√Len: 1262.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
132_S169_P3.2631.00
129_Q186_A3.1421.00
127_A181_I3.0091.00
105_S122_T2.8851.00
19_Y193_R2.6831.00
44_N95_K2.5511.00
47_E100_P2.5281.00
28_N61_E2.3451.00
10_K23_H2.2771.00
168_K198_R2.2771.00
174_E177_E2.2501.00
130_T187_E2.2171.00
13_F18_C2.2051.00
162_Y168_K2.1861.00
220_Q223_R2.1771.00
171_S174_E2.1561.00
19_Y57_E2.1271.00
139_L202_L2.0561.00
159_K178_W2.0511.00
13_F49_S2.0501.00
164_T210_Y2.0191.00
16_S52_T1.9961.00
11_V18_C1.9751.00
40_L95_K1.9551.00
106_H192_L1.9491.00
129_Q173_Q1.9401.00
21_T59_L1.9281.00
23_H59_L1.9121.00
126_I185_D1.9031.00
28_N62_V1.8881.00
112_N134_S1.8771.00
21_T57_E1.8641.00
246_I250_E1.8631.00
34_T38_E1.8531.00
243_M252_G1.8151.00
18_C46_C1.7921.00
193_R197_L1.7751.00
161_H215_S1.7621.00
14_Q193_R1.7441.00
162_Y182_D1.7351.00
157_R161_H1.7261.00
162_Y183_A1.7081.00
174_E178_W1.6771.00
45_Q49_S1.6761.00
54_V99_G1.6651.00
18_C51_V1.6581.00
123_D211_K1.6471.00
106_H191_L1.6171.00
37_E88_P1.5951.00
127_A133_F1.5891.00
14_Q19_Y1.5831.00
129_Q187_E1.5661.00
46_C54_V1.5531.00
126_I195_H1.5371.00
173_Q177_E1.5331.00
47_E95_K1.5301.00
119_V125_A1.4721.00
161_H165_L1.4611.00
20_I42_V1.4561.00
107_V119_V1.4511.00
11_V46_C1.4391.00
176_S184_F1.4371.00
125_A154_R1.4231.00
94_M98_T1.4181.00
53_V196_L1.4141.00
125_A158_Q1.4121.00
94_M222_S1.4101.00
10_K59_L1.4041.00
15_A197_L1.3971.00
40_L44_N1.3961.00
108_R130_T1.3911.00
159_K162_Y1.3831.00
108_R128_D1.3831.00
209_H234_D1.3811.00
128_D187_E1.3771.00
57_E108_R1.3741.00
161_H214_M1.3651.00
96_L103_T1.3641.00
43_L99_G1.3531.00
107_V111_V1.3451.00
97_Q150_F1.3451.00
116_L135_L1.3371.00
168_K174_E1.3311.00
163_M170_I1.3311.00
61_E108_R1.3131.00
33_D71_E1.2921.00
187_E190_V1.2891.00
14_Q197_L1.2671.00
110_K132_S1.2541.00
134_S169_P1.2531.00
47_E99_G1.2521.00
158_Q182_D1.2391.00
40_L91_D1.2321.00
32_N35_L1.2321.00
62_V110_K1.2321.00
212_Q216_S1.2151.00
159_K174_E1.2131.00
22_F35_L1.2061.00
24_R27_A1.2021.00
202_L207_I1.1971.00
13_F50_T1.1881.00
156_G159_K1.1871.00
241_N245_I1.1851.00
27_A70_Q1.1721.00
38_E42_V1.1681.00
172_V184_F1.1481.00
205_K240_Q1.1481.00
138_L167_T1.1441.00
12_R21_T1.1411.00
170_I178_W1.1311.00
216_S227_T1.1251.00
22_F64_C1.1161.00
13_F45_Q1.1101.00
128_D190_V1.1041.00
192_L196_L1.0821.00
10_K21_T1.0801.00
33_D37_E1.0761.00
12_R19_Y1.0701.00
98_T222_S1.0681.00
38_E41_Q1.0591.00
64_C115_G1.0511.00
54_V101_Y1.0501.00
103_T122_T1.0331.00
51_V101_Y1.0221.00
186_A189_D1.0181.00
42_V45_Q1.0141.00
41_Q45_Q1.0051.00
124_I195_H1.0031.00
24_R68_D0.9991.00
54_V103_T0.9971.00
155_I159_K0.9881.00
57_E106_H0.9841.00
100_P208_A0.9701.00
116_L133_F0.9521.00
176_S181_I0.9481.00
17_V53_V0.9471.00
173_Q176_S0.9441.00
55_V192_L0.9411.00
149_P224_A0.9351.00
223_R226_A0.9271.00
132_S171_S0.9261.00
129_Q184_F0.9241.00
212_Q231_A0.9181.00
154_R158_Q0.9181.00
128_D188_S0.9101.00
242_Q246_I0.9091.00
183_A195_H0.9021.00
204_K208_A0.9021.00
209_H231_A0.9011.00
196_L200_R0.8981.00
36_I92_L0.8971.00
19_Y55_V0.8951.00
60_P108_R0.8941.00
157_R218_D0.8931.00
143_Y235_M0.8881.00
151_L155_I0.8841.00
107_V125_A0.8821.00
40_L88_P0.8771.00
107_V133_F0.8671.00
43_L96_L0.8661.00
19_Y191_L0.8641.00
209_H212_Q0.8631.00
83_A87_E0.8611.00
78_R81_K0.8511.00
138_L210_Y0.8491.00
89_L146_C0.8481.00
209_H235_M0.8451.00
163_M178_W0.8431.00
164_T214_M0.8391.00
176_S183_A0.8371.00
112_N169_P0.8351.00
57_E191_L0.8351.00
124_I182_D0.8291.00
13_F51_V0.8291.00
20_I54_V0.8251.00
28_N65_F0.8231.00
108_R190_V0.8191.00
47_E101_Y0.8181.00
70_Q249_V0.8141.00
44_N48_T0.8131.00
227_T230_T0.8121.00
126_I183_A0.8051.00
194_K198_R0.8011.00
33_D88_P0.7991.00
162_Y166_M0.7951.00
44_N91_D0.7921.00
185_D190_V0.7921.00
49_S101_Y0.7911.00
155_I163_M0.7881.00
117_G137_E0.7861.00
227_T231_A0.7811.00
40_L92_L0.7771.00
172_V181_I0.7741.00
148_L228_A0.7711.00
120_S180_L0.7651.00
113_A136_S0.7561.00
56_L122_T0.7561.00
139_L169_P0.7561.00
11_V42_V0.7531.00
24_R32_N0.7511.00
221_V225_K0.7511.00
37_E41_Q0.7501.00
203_N240_Q0.7501.00
156_G160_A0.7471.00
175_A180_L0.7411.00
93_W121_A0.7411.00
62_V108_R0.7391.00
31_I35_L0.7391.00
149_P152_I0.7371.00
213_F231_A0.7361.00
100_P212_Q0.7341.00
195_H198_R0.7311.00
239_P242_Q0.7311.00
46_C51_V0.7311.00
231_A234_D0.7291.00
193_R196_L0.7261.00
99_G103_T0.7251.00
9_I42_V0.7211.00
166_M195_H0.7201.00
87_E229_L0.7191.00
32_N71_E0.7171.00
245_I249_V0.7121.00
104_I196_L0.7091.00
205_K238_D0.7081.00
199_L207_I0.7061.00
107_V131_A0.7051.00
52_T204_K0.7021.00
11_V45_Q0.7011.00
181_I184_F0.6991.00
55_V106_H0.6931.00
17_V55_V0.6911.00
194_K197_L0.6901.00
28_N110_K0.6881.00
87_E91_D0.6871.00
42_V46_C0.6841.00
24_R30_T0.6841.00
56_L103_T0.6841.00
34_T37_E0.6801.00
226_A230_T0.6751.00
133_F181_I0.6731.00
229_L233_Q0.6701.00
198_R202_L0.6691.00
55_V193_R0.6681.00
126_I192_L0.6641.00
112_N136_S0.6631.00
73_Y246_I0.6591.00
157_R215_S0.6561.00
186_A190_V0.6551.00
13_F16_S0.6551.00
159_K176_S0.6551.00
16_S50_T0.6541.00
44_N47_E0.6541.00
84_S88_P0.6521.00
197_L201_R0.6511.00
157_R214_M0.6451.00
213_F227_T0.6451.00
143_Y213_F0.6431.00
35_L38_E0.6391.00
106_H190_V0.6361.00
117_G145_A0.6341.00
91_D94_M0.6341.00
53_V104_I0.6331.00
108_R187_E0.6331.00
243_M247_R0.6321.00
127_A131_A0.6271.00
240_Q244_G0.6271.00
134_S167_T0.6251.00
246_I249_V0.6231.00
17_V196_L0.6231.00
155_I178_W0.6231.00
230_T234_D0.6211.00
27_A30_T0.6161.00
41_Q44_N0.6151.00
110_K169_P0.6131.00
105_S125_A0.6121.00
99_G102_V0.6111.00
137_E144_P0.6111.00
67_A72_I0.6061.00
52_T200_R0.6061.00
11_V20_I0.6051.00
83_A230_T0.6041.00
91_D95_K0.6041.00
154_R182_D0.6041.00
144_P210_Y0.6021.00
39_C92_L0.6021.00
205_K235_M0.6011.00
46_C101_Y0.6011.00
173_Q184_F0.6011.00
27_A68_D0.6001.00
124_I199_L0.6001.00
187_E191_L0.5991.00
222_S226_A0.5991.00
165_L207_I0.5981.00
243_M246_I0.5981.00
170_I175_A0.5961.00
239_P243_M0.5931.00
53_V200_R0.5921.00
135_L164_T0.5891.00
210_Y213_F0.5851.00
166_M198_R0.5831.00
119_V122_T0.5781.00
162_Y174_E0.5781.00
117_G135_L0.5761.00
152_I155_I0.5731.00
83_A233_Q0.5711.00
130_T172_V0.5711.00
153_R220_Q0.5691.00
20_I56_L0.5691.00
20_I43_L0.5661.00
137_E232_N0.5661.00
172_V176_S0.5651.00
243_M250_E0.5651.00
43_L95_K0.5641.00
171_S177_E0.5631.00
17_V193_R0.5621.00
43_L103_T0.5581.00
138_L202_L0.5581.00
244_G247_R0.5581.00
73_Y249_V0.5581.00
241_N244_G0.5571.00
149_P153_R0.5541.00
142_L241_N0.5451.00
117_G147_V0.5451.00
116_L180_L0.5441.00
144_P164_T0.5431.00
159_K177_E0.5381.00
114_G146_C0.5381.00
128_D131_A0.5371.00
125_A181_I0.5371.00
105_S119_V0.5321.00
88_P91_D0.5311.00
36_I40_L0.5271.00
20_I46_C0.5261.00
143_Y210_Y0.5261.00
106_H196_L0.5251.00
69_F140_F0.5231.00
155_I160_A0.5231.00
34_T71_E0.5231.00
31_I114_G0.5221.00
113_A135_L0.5211.00
67_A114_G0.5211.00
108_R131_A0.5181.00
226_A229_L0.5171.00
46_C99_G0.5171.00
136_S140_F0.5151.00
235_M238_D0.5141.00
161_H211_K0.5131.00
32_N68_D0.5121.00
51_V54_V0.5111.00
97_Q221_V0.5101.00
170_I180_L0.5101.00
73_Y245_I0.5101.00
90_Y94_M0.5091.00
175_A181_I0.5081.00
211_K215_S0.5071.00
9_I38_E0.5071.00
158_Q161_H0.5071.00
138_L207_I0.5051.00
166_M199_L0.5031.00
17_V200_R0.5031.00
43_L54_V0.5021.00
152_I217_L0.5011.00
135_L151_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hp0A 3 0.9691 100 0.094 Contact Map
4mi2A 3 0.9768 100 0.123 Contact Map
2fbmA 3 0.9421 100 0.124 Contact Map
4k3wA 3 0.9807 100 0.124 Contact Map
4lk5A 3 0.9498 100 0.133 Contact Map
3tlfA 5 0.9884 100 0.133 Contact Map
3hinA 5 0.9768 100 0.136 Contact Map
4nnqA 3 0.8919 100 0.136 Contact Map
4jfcA 3 0.9691 100 0.137 Contact Map
2gtrA 3 0.973 100 0.137 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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