GREMLIN Database
PKSF - Polyketide biosynthesis malonyl-ACP decarboxylase PksF
UniProt: P40804 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 415 (388)
Sequences: 21094 (13735)
Seq/√Len: 697.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
281_I321_A3.1731.00
261_S406_Q3.1061.00
23_G26_D2.9811.00
351_V389_A2.8911.00
29_S33_S2.7701.00
101_R184_D2.7691.00
258_A352_L2.7631.00
172_I263_W2.7161.00
227_Q368_H2.6331.00
227_Q371_D2.6061.00
388_N406_Q2.5911.00
7_P247_E2.5521.00
91_E257_Y2.3951.00
359_A381_S2.3931.00
257_Y356_K2.3771.00
225_F303_P2.3151.00
88_A242_V2.2951.00
245_R248_T2.2851.00
32_L359_A2.2021.00
30_S37_A2.1921.00
178_V245_R2.1371.00
84_T238_C2.1171.00
354_Q361_H2.1121.00
297_D388_N2.1101.00
224_P334_S2.1021.00
171_V348_I2.0951.00
30_S35_R2.0701.00
348_I405_I2.0521.00
105_V177_Q2.0211.00
8_E261_S1.9921.00
244_E254_L1.9861.00
281_I285_Q1.9831.00
228_N368_H1.9581.00
362_P381_S1.9521.00
359_A383_S1.9171.00
176_Q180_S1.9131.00
108_G143_L1.9071.00
219_E230_D1.8851.00
294_L297_D1.8791.00
85_L187_I1.8611.00
244_E252_R1.8601.00
66_L74_A1.8491.00
387_K407_N1.8271.00
328_Y382_I1.7941.00
86_T90_E1.7891.00
85_L147_C1.7851.00
103_G186_C1.7821.00
293_L388_N1.7371.00
239_G345_I1.7321.00
18_A346_V1.7221.00
38_F55_A1.7151.00
101_R286_K1.7141.00
175_I260_L1.7101.00
11_V348_I1.7071.00
106_V240_A1.7001.00
246_K250_L1.6941.00
360_L378_N1.6751.00
22_Q26_D1.6711.00
248_T251_R1.6671.00
353_L357_K1.6441.00
228_N367_D1.6441.00
375_H382_I1.6381.00
281_I322_C1.6371.00
189_L240_A1.6321.00
235_G339_G1.6241.00
27_F332_T1.6221.00
148_T157_A1.6161.00
11_V352_L1.6131.00
183_V186_C1.6121.00
348_I391_S1.6081.00
353_L356_K1.6021.00
241_L348_I1.5881.00
15_G84_T1.5731.00
177_Q183_V1.5701.00
187_I242_V1.5661.00
76_F80_A1.5611.00
255_K356_K1.5611.00
39_D58_A1.5581.00
81_A147_C1.5451.00
107_G166_S1.5421.00
40_V52_F1.5291.00
36_H221_A1.5251.00
301_I319_L1.5241.00
332_T346_V1.5151.00
175_I179_L1.5081.00
61_S64_D1.5081.00
176_Q182_E1.5011.00
40_V53_I1.5001.00
226_D366_L1.4991.00
84_T240_A1.4941.00
266_K400_N1.4901.00
14_V24_K1.4761.00
169_L401_T1.4701.00
162_G165_A1.4701.00
91_E255_K1.4661.00
7_P245_R1.4661.00
261_S388_N1.4601.00
239_G349_I1.4321.00
27_F350_S1.4251.00
81_A106_V1.4201.00
32_L381_S1.4201.00
298_I388_N1.4031.00
358_S387_K1.4011.00
263_W403_V1.3971.00
102_I185_T1.3891.00
334_S364_R1.3891.00
300_Y360_L1.3731.00
9_V243_I1.3691.00
50_S204_R1.3641.00
185_T242_V1.3641.00
237_S339_G1.3611.00
328_Y360_L1.3601.00
176_Q179_L1.3551.00
103_G183_V1.3511.00
98_D152_G1.3461.00
169_L399_M1.3461.00
103_G156_L1.3431.00
86_T150_Q1.3401.00
158_Y173_H1.3381.00
390_L404_C1.3371.00
81_A240_A1.3341.00
219_E223_R1.3321.00
363_S366_L1.3291.00
282_H286_K1.3231.00
154_T282_H1.3131.00
226_D368_H1.3131.00
81_A143_L1.3121.00
316_L329_I1.3111.00
8_E259_A1.3111.00
328_Y378_N1.3101.00
144_C159_T1.3071.00
223_R228_N1.3021.00
29_S35_R1.2991.00
226_D367_D1.2931.00
7_P10_V1.2881.00
384_Y387_K1.2771.00
334_S363_S1.2711.00
210_G230_D1.2701.00
360_L384_Y1.2661.00
26_D29_S1.2661.00
241_L345_I1.2661.00
300_Y330_N1.2631.00
145_G397_G1.2591.00
366_L369_P1.2531.00
390_L402_A1.2531.00
177_Q182_E1.2521.00
264_S283_V1.2491.00
257_Y352_L1.2471.00
9_V175_I1.2471.00
355_M405_I1.2471.00
266_K283_V1.2261.00
392_L402_A1.2251.00
14_V349_I1.2151.00
20_I37_A1.2131.00
336_T346_V1.2051.00
358_S407_N1.1961.00
285_Q289_E1.1911.00
29_S32_L1.1901.00
106_V189_L1.1811.00
16_V24_K1.1781.00
241_L349_I1.1781.00
264_S287_A1.1761.00
246_K408_I1.1701.00
184_D248_T1.1661.00
283_V287_A1.1631.00
171_V243_I1.1571.00
18_A239_G1.1571.00
320_R373_S1.1461.00
85_L240_A1.1431.00
223_R230_D1.1421.00
25_E91_E1.1361.00
13_G91_E1.1331.00
169_L265_I1.1271.00
190_G345_I1.1221.00
300_Y351_V1.1201.00
339_G346_V1.1161.00
176_Q290_R1.1061.00
88_A240_A1.1031.00
319_L329_I1.1011.00
36_H365_N1.0971.00
262_G290_R1.0941.00
299_D387_K1.0911.00
55_A235_G1.0911.00
332_T336_T1.0911.00
157_A267_L1.0831.00
288_L298_I1.0821.00
31_L350_S1.0781.00
8_E246_K1.0741.00
286_K290_R1.0711.00
179_L290_R1.0711.00
174_A188_A1.0681.00
246_K259_A1.0641.00
299_D384_Y1.0631.00
284_I322_C1.0601.00
14_V257_Y1.0591.00
16_V349_I1.0581.00
366_L377_V1.0571.00
168_Q401_T1.0511.00
148_T267_L1.0491.00
335_I364_R1.0361.00
293_L297_D1.0361.00
351_V355_M1.0351.00
42_K45_G1.0341.00
250_L408_I1.0321.00
28_A357_K1.0301.00
358_S385_R1.0211.00
288_L295_P1.0161.00
86_T151_F1.0101.00
378_N382_I1.0091.00
88_A187_I1.0091.00
64_D86_T1.0051.00
200_C234_Y1.0041.00
323_R390_L1.0031.00
171_V403_V1.0011.00
89_W151_F1.0001.00
16_V27_F0.9981.00
317_K321_A0.9971.00
84_T87_E0.9931.00
42_K56_E0.9891.00
12_T244_E0.9871.00
168_Q403_V0.9871.00
184_D245_R0.9841.00
284_I392_L0.9781.00
160_V173_H0.9751.00
53_I56_E0.9721.00
172_I182_E0.9711.00
328_Y376_W0.9701.00
178_V243_I0.9671.00
366_L379_E0.9651.00
316_L376_W0.9651.00
284_I390_L0.9631.00
247_E250_L0.9601.00
351_V391_S0.9601.00
220_N367_D0.9581.00
367_D379_E0.9481.00
373_S376_W0.9401.00
355_M358_S0.9361.00
288_L323_R0.9331.00
286_K289_E0.9331.00
105_V186_C0.9321.00
14_V352_L0.9321.00
376_W382_I0.9291.00
171_V188_A0.9271.00
51_R54_G0.9271.00
309_F372_D0.9261.00
28_A361_H0.9181.00
102_I153_I0.9161.00
234_Y340_L0.9161.00
38_F53_I0.9141.00
174_A186_C0.9141.00
259_A406_Q0.9111.00
167_G190_G0.9101.00
15_G88_A0.9101.00
175_I290_R0.9091.00
52_F56_E0.9091.00
352_L405_I0.9051.00
21_G30_S0.9021.00
249_A256_P0.9021.00
25_E29_S0.8961.00
305_G311_G0.8941.00
288_L293_L0.8931.00
237_S346_V0.8931.00
54_G57_I0.8921.00
173_H176_Q0.8901.00
167_G345_I0.8871.00
313_E317_K0.8871.00
52_F55_A0.8861.00
81_A189_L0.8811.00
303_P329_I0.8801.00
22_Q58_A0.8801.00
302_N347_E0.8771.00
80_A238_C0.8761.00
298_I323_R0.8751.00
347_E391_S0.8721.00
355_M386_I0.8701.00
18_A349_I0.8631.00
10_V246_K0.8591.00
32_L357_K0.8581.00
34_G362_P0.8571.00
89_W187_I0.8561.00
10_V259_A0.8541.00
298_I404_C0.8521.00
210_G223_R0.8491.00
23_G87_E0.8491.00
175_I263_W0.8481.00
172_I176_Q0.8461.00
27_F336_T0.8441.00
41_M46_R0.8431.00
111_F140_D0.8371.00
15_G87_E0.8361.00
277_L317_K0.8331.00
287_A404_C0.8331.00
21_G37_A0.8321.00
301_I390_L0.8281.00
104_L153_I0.8251.00
17_T87_E0.8251.00
185_T188_A0.8241.00
305_G331_A0.8221.00
38_F233_I0.8201.00
34_G380_K0.8191.00
293_L404_C0.8191.00
57_I80_A0.8171.00
162_G169_L0.8151.00
154_T278_E0.8131.00
284_I318_A0.8131.00
287_A291_A0.8111.00
28_A32_L0.8091.00
168_Q344_G0.8041.00
89_W242_V0.8021.00
28_A353_L0.7981.00
266_K282_H0.7981.00
36_H364_R0.7961.00
14_V91_E0.7941.00
67_S70_M0.7931.00
351_V354_Q0.7911.00
323_R327_A0.7901.00
108_G140_D0.7891.00
331_A363_S0.7881.00
14_V353_L0.7861.00
278_E281_I0.7851.00
201_E204_R0.7851.00
20_I30_S0.7841.00
187_I240_A0.7831.00
17_T83_V0.7801.00
280_E394_M0.7801.00
60_L83_V0.7791.00
316_L320_R0.7791.00
145_G157_A0.7771.00
25_E357_K0.7751.00
50_S207_G0.7721.00
352_L355_M0.7671.00
299_D388_N0.7671.00
284_I288_L0.7661.00
304_H308_S0.7651.00
22_Q30_S0.7641.00
105_V183_V0.7631.00
285_Q322_C0.7621.00
135_G202_A0.7621.00
285_Q321_A0.7601.00
246_K256_P0.7591.00
245_R250_L0.7581.00
171_V345_I0.7551.00
378_N381_S0.7551.00
185_T248_T0.7521.00
282_H285_Q0.7521.00
248_T252_R0.7521.00
320_R324_L0.7521.00
46_R52_F0.7451.00
109_S341_S0.7451.00
75_S115_E0.7411.00
92_A242_V0.7391.00
369_P377_V0.7391.00
261_S293_L0.7381.00
82_L150_Q0.7371.00
302_N350_S0.7371.00
10_V256_P0.7371.00
51_R204_R0.7361.00
100_S184_D0.7361.00
37_A55_A0.7351.00
339_G342_A0.7351.00
265_I401_T0.7341.00
278_E282_H0.7341.00
168_Q391_S0.7311.00
85_L151_F0.7301.00
266_K286_K0.7291.00
26_D30_S0.7281.00
156_L183_V0.7241.00
188_A243_I0.7241.00
108_G159_T0.7211.00
130_I201_E0.7201.00
355_M407_N0.7201.00
191_A238_C0.7181.00
51_R56_E0.7181.00
308_S311_G0.7181.00
30_S33_S0.7171.00
105_V158_Y0.7151.00
56_E59_S0.7141.00
85_L88_A0.7141.00
320_R374_F0.7131.00
100_S154_T0.7111.00
284_I319_L0.7081.00
258_A405_I0.7041.00
182_E290_R0.7031.00
24_K353_L0.7021.00
104_L147_C0.7021.00
291_A404_C0.6981.00
50_S53_I0.6981.00
46_R49_D0.6981.00
89_W153_I0.6931.00
17_T84_T0.6921.00
109_S112_Q0.6921.00
285_Q325_S0.6881.00
277_L281_I0.6881.00
78_S142_D0.6881.00
208_A232_F0.6831.00
19_S339_G0.6831.00
95_D98_D0.6821.00
153_I187_I0.6821.00
310_I314_I0.6811.00
260_L403_V0.6801.00
360_L386_I0.6791.00
13_G88_A0.6781.00
288_L404_C0.6781.00
171_V241_L0.6761.00
328_Y375_H0.6711.00
299_D386_I0.6711.00
313_E372_D0.6661.00
283_V402_A0.6641.00
76_F79_R0.6641.00
277_L318_A0.6611.00
300_Y389_A0.6601.00
358_S383_S0.6601.00
352_L356_K0.6561.00
112_Q116_N0.6551.00
43_R76_F0.6521.00
77_S191_A0.6511.00
158_Y162_G0.6491.00
142_D396_F0.6481.00
41_M200_C0.6481.00
168_Q393_S0.6481.00
262_G287_A0.6451.00
317_K372_D0.6421.00
328_Y377_V0.6421.00
171_V260_L0.6391.00
81_A85_L0.6381.00
97_A102_I0.6371.00
332_T350_S0.6361.00
301_I327_A0.6361.00
210_G219_E0.6351.00
141_S163_A0.6341.00
222_C232_F0.6321.00
277_L314_I0.6321.00
27_F346_V0.6311.00
99_S152_G0.6301.00
223_R367_D0.6291.00
384_Y389_A0.6271.00
31_L353_L0.6271.00
177_Q186_C0.6271.00
250_L256_P0.6261.00
8_E179_L0.6251.00
266_K279_G0.6241.00
139_M142_D0.6221.00
87_E91_E0.6221.00
41_M56_E0.6211.00
229_R370_I0.6211.00
20_I39_D0.6191.00
316_L373_S0.6181.00
203_L208_A0.6171.00
11_V405_I0.6171.00
203_L396_F0.6161.00
78_S143_L0.6151.00
42_K46_R0.6141.00
232_F340_L0.6141.00
39_D56_E0.6111.00
9_V178_V0.6091.00
274_D310_I0.6081.00
363_S377_V0.6071.00
240_A345_I0.6051.00
360_L382_I0.6041.00
265_I399_M0.6041.00
192_L340_L0.6031.00
185_T244_E0.6031.00
386_I407_N0.6021.00
188_A345_I0.6001.00
24_K91_E0.5981.00
51_R55_A0.5961.00
101_R282_H0.5961.00
188_A241_L0.5941.00
180_S290_R0.5931.00
154_T279_G0.5921.00
40_V46_R0.5901.00
103_G177_Q0.5901.00
53_I221_A0.5891.00
24_K27_F0.5891.00
247_E251_R0.5881.00
336_T339_G0.5871.00
278_E321_A0.5861.00
281_I318_A0.5861.00
9_V245_R0.5841.00
330_N361_H0.5841.00
354_Q384_Y0.5831.00
89_W97_A0.5831.00
41_M54_G0.5831.00
386_I406_Q0.5821.00
83_V87_E0.5821.00
316_L374_F0.5801.00
163_A396_F0.5801.00
98_D102_I0.5801.00
302_N351_V0.5791.00
355_M408_I0.5781.00
27_F31_L0.5771.00
208_A396_F0.5771.00
288_L402_A0.5761.00
20_I27_F0.5751.00
173_H177_Q0.5751.00
94_L185_T0.5731.00
328_Y384_Y0.5731.00
223_R365_N0.5731.00
106_V144_C0.5711.00
88_A92_A0.5691.00
244_E248_T0.5691.00
303_P331_A0.5671.00
12_T185_T0.5651.00
60_L65_R0.5641.00
222_C307_G0.5621.00
355_M389_A0.5621.00
77_S143_L0.5611.00
105_V173_H0.5611.00
7_P179_L0.5601.00
293_L298_I0.5591.00
24_K349_I0.5551.00
54_G200_C0.5541.00
74_A146_I0.5531.00
12_T254_L0.5521.00
41_M44_S0.5501.00
280_E318_A0.5491.00
354_Q389_A0.5481.00
178_V248_T0.5481.00
260_L405_I0.5461.00
66_L83_V0.5461.00
8_E247_E0.5461.00
87_E90_E0.5451.00
326_H373_S0.5441.00
66_L71_L0.5421.00
226_D365_N0.5391.00
53_I57_I0.5381.00
108_G111_F0.5371.00
166_S170_A0.5371.00
228_N366_L0.5371.00
385_R407_N0.5361.00
64_D90_E0.5351.00
239_G342_A0.5341.00
311_G314_I0.5341.00
13_G257_Y0.5331.00
126_R129_F0.5321.00
109_S140_D0.5321.00
80_A193_M0.5301.00
303_P319_L0.5291.00
296_E326_H0.5281.00
204_R207_G0.5281.00
219_E233_I0.5281.00
99_S154_T0.5281.00
169_L173_H0.5251.00
348_I352_L0.5251.00
94_L242_V0.5251.00
273_P310_I0.5241.00
181_G245_R0.5231.00
288_L322_C0.5221.00
276_S279_G0.5211.00
177_Q180_S0.5211.00
132_P202_A0.5201.00
13_G255_K0.5201.00
330_N360_L0.5201.00
78_S146_I0.5181.00
172_I265_I0.5181.00
55_A59_S0.5171.00
222_C233_I0.5161.00
335_I362_P0.5150.99
112_Q195_L0.5140.99
345_I349_I0.5130.99
299_D355_M0.5120.99
351_V405_I0.5110.99
347_E351_V0.5100.99
273_P277_L0.5100.99
174_A243_I0.5090.99
271_R276_S0.5090.99
97_A185_T0.5090.99
386_I389_A0.5080.99
347_E393_S0.5080.99
43_R47_Q0.5070.99
65_R83_V0.5060.99
115_E198_M0.5060.99
277_L321_A0.5060.99
21_G26_D0.5060.99
318_A322_C0.5040.99
144_C157_A0.5030.99
224_P232_F0.5030.99
178_V181_G0.5030.99
12_T94_L0.5030.99
391_S403_V0.5020.99
94_L244_E0.5020.99
17_T80_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vz8A 2 0.9446 100 0.073 Contact Map
4na1A 2 0.947 100 0.135 Contact Map
4tktA 1 0.9446 100 0.155 Contact Map
4oqjA 2 0.9639 100 0.157 Contact Map
2hg4A 2 0.9614 100 0.159 Contact Map
4qyrA 2 0.947 100 0.159 Contact Map
4kc5A 2 0.9639 100 0.159 Contact Map
4zdnA 2 0.9446 100 0.159 Contact Map
4mz0A 2 0.9566 100 0.16 Contact Map
4opeA 2 0.9542 100 0.162 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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