GREMLIN Database
YTXH - Uncharacterized protein YtxH
UniProt: P40780 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 151 (116)
Sequences: 1632 (1470)
Seq/√Len: 136.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_L33_S2.4951.00
107_S111_Q2.4621.00
103_K107_S2.4371.00
78_T82_A2.1341.00
126_D129_L2.0431.00
74_T78_T2.0141.00
34_G38_R1.9851.00
62_K65_Q1.9381.00
49_R53_D1.9221.00
84_Q87_Q1.8711.00
57_A60_K1.8141.00
38_R42_G1.7941.00
35_K38_R1.7891.00
34_G37_L1.7291.00
75_S78_T1.7131.00
39_D43_S1.6841.00
115_E118_M1.6321.00
118_M122_D1.6261.00
51_K54_K1.6051.00
56_T60_K1.5661.00
125_K129_L1.5601.00
131_T134_D1.5551.00
34_G41_L1.5481.00
35_K39_D1.5131.00
30_A33_S1.4901.00
85_S125_K1.4881.00
86_G89_M1.4871.00
85_S89_M1.4701.00
68_S72_D1.4701.00
41_L44_Q1.4621.00
73_K76_N1.4571.00
96_R100_K1.4431.00
114_R118_M1.4391.00
63_G103_K1.4381.00
46_V57_A1.4331.00
36_E40_D1.3541.00
120_A124_T1.3531.00
33_S36_E1.3301.00
125_K136_K1.2561.00
133_E137_D1.2411.00
98_R101_S1.2321.00
52_T59_A1.2301.00
110_M114_R1.2111.00
30_A34_G1.2001.00
45_A85_S1.1961.00
118_M129_L1.1891.00
119_Q130_Q1.1690.99
125_K132_K1.1400.99
137_D140_K1.1370.99
136_K140_K1.1370.99
95_L98_R1.1350.99
92_V132_K1.1240.99
79_Q82_A1.1170.99
41_L81_V1.1110.99
136_K139_L1.1050.99
40_D44_Q1.0980.99
61_E72_D1.0870.99
39_D50_D1.0850.99
89_M92_V1.0470.99
37_L48_L1.0220.99
112_D123_E1.0200.98
85_S88_I1.0050.98
34_G74_T1.0010.98
44_Q47_A0.9920.98
97_D101_S0.9900.98
50_D61_E0.9900.98
46_V50_D0.9770.98
51_K55_M0.9610.98
31_P40_D0.9550.98
34_G40_D0.9550.98
89_M93_K0.9480.98
104_T107_S0.9430.97
112_D116_E0.9370.97
113_M117_A0.9340.97
38_R49_R0.9310.97
88_I128_V0.9280.97
46_V49_R0.9180.97
52_T55_M0.8890.96
29_L34_G0.8840.96
113_M116_E0.8740.96
96_R99_S0.8680.96
133_E136_K0.8660.96
31_P36_E0.8620.96
116_E134_D0.8600.96
31_P35_K0.8560.96
93_K97_D0.8550.96
124_T128_V0.8520.95
36_E47_A0.8440.95
131_T142_A0.8430.95
43_S47_A0.8390.95
40_D43_S0.8380.95
62_K66_Y0.8340.95
63_G70_A0.8330.95
31_P34_G0.8320.95
126_D130_Q0.8280.95
75_S79_Q0.8260.95
64_T68_S0.8240.95
121_A124_T0.8230.94
47_A55_M0.8210.94
132_K136_K0.8200.94
79_Q119_Q0.8110.94
119_Q122_D0.8100.94
58_D69_I0.8050.94
56_T96_R0.7980.94
79_Q83_D0.7950.93
48_L88_I0.7870.93
111_Q115_E0.7860.93
68_S71_K0.7860.93
90_N94_D0.7830.93
63_G67_V0.7750.93
74_T114_R0.7660.92
50_D72_D0.7660.92
87_Q98_R0.7630.92
31_P42_G0.7610.92
121_A128_V0.7580.92
62_K102_D0.7510.91
74_T96_R0.7400.91
29_L38_R0.7320.90
110_M113_M0.7250.90
31_P37_L0.7250.90
121_A125_K0.7180.89
31_P39_D0.7180.89
105_D116_E0.7180.89
33_S41_L0.7100.89
96_R136_K0.7000.88
89_M100_K0.6960.88
42_G46_V0.6960.88
127_Q131_T0.6940.88
33_S37_L0.6940.88
52_T56_T0.6930.88
137_D141_D0.6810.87
117_A120_A0.6810.87
138_E141_D0.6810.87
53_D57_A0.6770.86
108_T111_Q0.6660.86
123_E134_D0.6650.85
44_Q84_Q0.6500.84
38_R41_L0.6480.84
45_A48_L0.6380.83
35_K46_V0.6340.83
78_T81_V0.6330.83
81_V84_Q0.6330.83
103_K106_S0.6250.82
45_A49_R0.6220.81
52_T92_V0.6090.80
32_K42_G0.6090.80
121_A134_D0.6070.80
81_V121_A0.6050.80
91_K95_L0.6010.79
54_K65_Q0.5990.79
65_Q105_D0.5990.79
130_Q140_K0.5950.79
121_A143_Q0.5890.78
68_S97_D0.5870.78
114_R121_A0.5770.76
87_Q127_Q0.5730.76
67_V70_A0.5700.76
61_E65_Q0.5690.75
135_V138_E0.5550.74
83_D94_D0.5540.74
102_D131_T0.5540.74
47_A58_D0.5510.73
123_E130_Q0.5370.71
56_T67_V0.5340.71
72_D83_D0.5340.71
61_E101_S0.5310.70
134_D138_E0.5230.69
130_Q134_D0.5230.69
64_T67_V0.5200.69
86_G97_D0.5150.68
131_T139_L0.5050.67
108_T112_D0.5040.66
138_E142_A0.5030.66
130_Q133_E0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2a01A 1 0.9669 89.9 0.771 Contact Map
2l7bA 1 0.9536 89.7 0.772 Contact Map
3s84A 2 0.8742 87 0.782 Contact Map
1eq1A 1 0.8543 76.6 0.806 Contact Map
2lemA 1 0.8212 71.5 0.814 Contact Map
3r2pA 2 0.8079 70.4 0.815 Contact Map
1nfnA 1 0.7086 59.6 0.827 Contact Map
2d4yA 1 0.7219 52.7 0.834 Contact Map
4ut1A 1 0.6821 41.5 0.845 Contact Map
2j69A 1 0.8675 35.7 0.851 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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