GREMLIN Database
YTXG - UPF0478 protein YtxG
UniProt: P40779 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 140 (131)
Sequences: 435 (324)
Seq/√Len: 28.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_V12_I8.1941.00
68_D72_K3.4531.00
4_I10_A3.1091.00
11_L17_L3.0901.00
5_L9_V2.9541.00
50_G54_E2.3260.99
38_A51_I2.2280.98
37_V41_L2.1390.98
58_L61_K1.8620.95
33_T62_T1.8060.94
79_V83_V1.7590.93
33_T38_A1.7560.93
118_V122_S1.7360.92
5_L8_S1.6950.91
32_L35_K1.6690.91
5_L59_L1.5820.88
92_Q98_K1.5750.88
27_L41_L1.5540.87
65_L85_G1.5480.87
6_Y9_V1.5120.86
21_I25_K1.5100.86
12_I16_F1.5000.85
8_S12_I1.4930.85
16_F19_L1.4870.85
28_K32_L1.4510.83
82_A94_N1.4460.83
29_S35_K1.4120.82
7_L102_G1.4070.81
75_K84_Q1.3750.80
125_A129_W1.3730.80
16_F62_T1.3640.79
97_M101_A1.3510.79
122_S126_M1.3490.79
8_S70_Q1.3480.79
64_R98_K1.3270.77
35_K115_I1.3260.77
22_Y93_F1.2520.73
54_E87_G1.2290.72
76_L87_G1.2130.71
75_K81_H1.2030.70
104_V115_I1.2000.70
30_L44_L1.1990.70
40_T44_L1.1960.70
14_V106_A1.1850.69
21_I114_K1.1840.69
26_T29_S1.1830.69
39_S42_E1.1820.69
55_T100_A1.1780.68
22_Y28_K1.1620.67
55_T96_S1.1460.66
5_L12_I1.1420.66
49_K86_V1.1420.66
7_L10_A1.1300.65
44_L51_I1.1290.65
44_L48_M1.1270.65
104_V109_R1.1190.64
40_T96_S1.1170.64
14_V18_V1.1110.64
84_Q87_G1.1010.63
18_V134_Q1.0940.63
65_L73_S1.0840.62
25_K31_Q1.0670.61
79_V89_S1.0660.61
30_L125_A1.0600.60
15_A19_L1.0550.60
48_M51_I1.0440.59
54_E60_H1.0200.57
61_K94_N1.0150.57
42_E75_K1.0080.56
12_I17_L0.9990.55
65_L89_S0.9790.54
62_T66_A0.9790.54
62_T73_S0.9720.53
52_T64_R0.9640.53
4_I8_S0.9610.53
95_T102_G0.9590.52
74_E77_N0.9440.51
23_L108_V0.9310.50
34_L37_V0.9170.49
8_S20_V0.9160.49
66_A94_N0.9150.49
21_I34_L0.9110.49
82_A85_G0.9100.49
59_L62_T0.9080.48
18_V64_R0.9040.48
109_R133_K0.9030.48
6_Y117_Q0.8900.47
81_H103_S0.8870.47
58_L81_H0.8810.46
91_Q125_A0.8710.46
5_L20_V0.8650.45
55_T97_M0.8540.44
25_K29_S0.8380.43
12_I51_I0.8330.43
8_S82_A0.8290.42
17_L101_A0.8290.42
111_N123_Q0.8280.42
51_I93_F0.8250.42
8_S13_A0.8180.42
90_V94_N0.8180.42
16_F20_V0.8140.41
61_K64_R0.8120.41
89_S94_N0.8070.41
8_S28_K0.8040.41
85_G91_Q0.8000.40
48_M71_E0.7880.39
102_G110_E0.7840.39
48_M62_T0.7790.39
7_L11_L0.7640.38
23_L35_K0.7600.37
68_D77_N0.7560.37
83_V112_Q0.7540.37
67_E80_V0.7450.36
73_S118_V0.7390.36
17_L21_I0.7300.35
17_L24_S0.7270.35
23_L89_S0.7260.35
20_V27_L0.7250.35
58_L62_T0.7250.35
88_A98_K0.7210.35
41_L44_L0.7150.34
70_Q78_T0.7140.34
49_K99_Q0.7140.34
75_K93_F0.7130.34
15_A20_V0.7020.33
57_E124_A0.7020.33
68_D80_V0.6940.33
10_A62_T0.6840.32
24_S28_K0.6810.32
5_L17_L0.6790.32
59_L89_S0.6790.32
21_I92_Q0.6780.32
45_E93_F0.6770.32
26_T31_Q0.6690.31
4_I24_S0.6650.31
42_E81_H0.6630.31
46_G55_T0.6620.31
84_Q132_W0.6600.30
33_T122_S0.6600.30
8_S18_V0.6510.30
41_L92_Q0.6510.30
53_T76_L0.6510.30
29_S38_A0.6490.30
54_E72_K0.6490.30
84_Q88_A0.6460.30
128_I133_K0.6440.29
122_S128_I0.6430.29
48_M92_Q0.6390.29
46_G58_L0.6350.29
46_G50_G0.6260.28
26_T38_A0.6200.28
50_G104_V0.6170.28
17_L129_W0.6110.27
50_G55_T0.6100.27
106_A110_E0.6080.27
15_A104_V0.5920.26
88_A105_S0.5910.26
60_H76_L0.5860.26
61_K89_S0.5810.26
22_Y58_L0.5800.25
98_K105_S0.5800.25
85_G98_K0.5790.25
12_I56_A0.5780.25
53_T56_A0.5760.25
47_Q91_Q0.5710.25
71_E85_G0.5710.25
53_T125_A0.5680.25
25_K95_T0.5660.25
72_K77_N0.5640.25
18_V24_S0.5640.25
11_L90_V0.5630.24
36_N71_E0.5590.24
21_I24_S0.5480.24
14_V81_H0.5460.24
59_L96_S0.5450.23
53_T60_H0.5440.23
14_V31_Q0.5430.23
23_L95_T0.5410.23
44_L52_T0.5380.23
4_I108_V0.5320.23
4_I124_A0.5320.23
26_T101_A0.5310.23
49_K53_T0.5270.22
55_T77_N0.5270.22
81_H134_Q0.5210.22
13_A58_L0.5180.22
53_T105_S0.5170.22
30_L33_T0.5110.22
46_G85_G0.5100.22
116_N131_K0.5100.22
16_F33_T0.5080.21
73_S76_L0.5060.21
105_S125_A0.5040.21
59_L72_K0.5040.21
58_L96_S0.5040.21
30_L93_F0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ch7A 2 0.8357 80.2 0.89 Contact Map
4cq4A 4 0.5643 76.7 0.893 Contact Map
3zx6A 2 0.8214 76.3 0.893 Contact Map
4i3mA 2 0.85 71.2 0.898 Contact Map
2f95B 2 0.1286 70.3 0.898 Contact Map
4q4gX 1 0 69.6 0.899 Contact Map
4cgkA 3 0.6571 63 0.903 Contact Map
4gycB 2 0.1429 54.9 0.908 Contact Map
2mi2A 1 0.7071 46.7 0.912 Contact Map
1qu7A 2 0.9 41.6 0.915 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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