GREMLIN Database
MURC - UDP-N-acetylmuramate--L-alanine ligase
UniProt: P40778 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 432 (370)
Sequences: 19907 (14878)
Seq/√Len: 773.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
167_I274_L3.7961.00
79_K83_E3.2961.00
79_K82_S2.9751.00
125_N291_S2.8381.00
165_Y274_L2.6571.00
233_N244_D2.6321.00
122_V275_C2.6281.00
221_Y270_A2.6171.00
281_D284_I2.5761.00
301_E308_V2.5481.00
102_T164_D2.5241.00
395_L398_E2.5071.00
181_S184_D2.4481.00
272_I285_I2.4231.00
167_I270_A2.4171.00
338_A362_A2.4101.00
232_R246_F2.3641.00
395_L399_D2.3341.00
256_Y290_K2.3321.00
125_N288_A2.2021.00
229_F273_A2.1781.00
244_D254_T2.1711.00
172_D318_T2.1491.00
335_E410_A2.1301.00
186_F211_K2.1241.00
196_V199_G2.0701.00
345_F374_A2.0471.00
125_N287_H2.0431.00
122_V271_V1.9811.00
180_S184_D1.9501.00
126_A284_I1.9481.00
120_A124_Q1.9351.00
128_P145_E1.9331.00
78_E82_S1.9191.00
321_K325_E1.9101.00
257_I268_S1.8991.00
190_Q215_N1.8961.00
406_A412_L1.8881.00
396_I399_D1.8801.00
204_G227_N1.8561.00
303_Q308_V1.8151.00
322_V325_E1.7951.00
121_H291_S1.7951.00
337_V364_C1.7891.00
242_T254_T1.7841.00
402_S405_K1.7841.00
104_V278_E1.7771.00
301_E310_I1.7671.00
337_V366_Y1.7451.00
105_A163_P1.7401.00
119_L271_V1.7351.00
243_F268_S1.7151.00
119_L274_L1.7071.00
184_D187_D1.6861.00
120_A132_L1.6841.00
105_A151_A1.6731.00
186_F208_H1.6721.00
268_S289_L1.6671.00
276_H282_S1.6581.00
262_H325_E1.6531.00
246_F251_F1.6481.00
230_Q246_F1.6391.00
92_K96_D1.6141.00
106_V116_T1.6131.00
242_T256_Y1.6121.00
166_A196_V1.5931.00
193_A200_I1.5881.00
164_D197_N1.5881.00
165_Y278_E1.5851.00
247_V276_H1.5821.00
126_A280_I1.5771.00
335_E364_C1.5571.00
401_T405_K1.5331.00
231_A269_L1.5311.00
137_T141_N1.5311.00
119_L275_C1.5301.00
110_H316_H1.5271.00
102_T146_Y1.5261.00
173_F176_P1.5021.00
106_V119_L1.4981.00
223_T262_H1.4871.00
166_A192_M1.4831.00
115_T169_T1.4821.00
153_E179_F1.4771.00
121_H288_A1.4731.00
244_D251_F1.4721.00
52_P57_N1.4651.00
347_R350_Q1.4491.00
103_S161_Y1.4471.00
287_H291_S1.4441.00
356_A360_S1.4401.00
123_I148_V1.4391.00
286_K290_K1.4391.00
351_F354_E1.4351.00
114_S264_N1.4201.00
188_A191_E1.4021.00
104_V119_L1.3941.00
165_Y277_Y1.3931.00
262_H329_Q1.3851.00
284_I287_H1.3821.00
235_V242_T1.3821.00
247_V250_T1.3721.00
240_G256_Y1.3681.00
401_T404_L1.3641.00
335_E363_D1.3601.00
109_A174_D1.3501.00
66_A77_I1.3481.00
275_C285_I1.3451.00
229_F276_H1.3431.00
347_R351_F1.3391.00
118_L292_F1.3381.00
54_S57_N1.3341.00
258_P293_G1.3331.00
52_P58_I1.3291.00
204_G220_Y1.3271.00
123_I146_Y1.3211.00
245_V272_I1.3141.00
243_F265_V1.3141.00
307_Q406_A1.3091.00
339_V368_C1.3031.00
232_R244_D1.2931.00
113_T295_V1.2921.00
162_Q197_N1.2901.00
325_E361_G1.2861.00
78_E81_M1.2851.00
306_D408_D1.2821.00
100_K140_G1.2751.00
123_I278_E1.2671.00
275_C280_I1.2651.00
146_Y278_E1.2651.00
77_I81_M1.2511.00
102_T145_E1.2491.00
348_T352_L1.2451.00
208_H211_K1.2391.00
190_Q212_I1.2341.00
407_H410_A1.2331.00
171_I186_F1.2251.00
352_L356_A1.2061.00
395_L400_D1.2051.00
96_D99_K1.1981.00
118_L259_A1.1861.00
173_F182_I1.1841.00
296_K300_N1.1801.00
344_T419_D1.1781.00
337_V410_A1.1751.00
299_F310_I1.1741.00
203_C266_L1.1701.00
237_S242_T1.1691.00
231_A234_I1.1651.00
81_M88_I1.1611.00
229_F247_V1.1501.00
399_D403_V1.1431.00
355_F358_S1.1391.00
187_D215_N1.1351.00
59_K62_M1.1341.00
264_N267_N1.1341.00
104_V274_L1.1311.00
220_Y228_D1.1311.00
183_D187_D1.1271.00
287_H290_K1.1261.00
168_M171_I1.1181.00
338_A415_M1.1151.00
211_K214_A1.1131.00
156_R159_L1.1131.00
262_H266_L1.1101.00
335_E407_H1.1101.00
283_S287_H1.1031.00
372_G375_R1.1021.00
202_A218_V1.0971.00
129_T145_E1.0921.00
323_T413_I1.0811.00
320_I415_M1.0771.00
187_D191_E1.0761.00
202_A220_Y1.0751.00
343_H370_I1.0731.00
55_A79_K1.0631.00
168_M212_I1.0601.00
219_V277_Y1.0571.00
55_A58_I1.0551.00
52_P62_M1.0531.00
196_V200_I1.0511.00
173_F349_Q1.0511.00
202_A209_L1.0461.00
123_I280_I1.0461.00
299_F327_A1.0421.00
121_H124_Q1.0411.00
128_P146_Y1.0411.00
217_P277_Y1.0371.00
121_H292_F1.0331.00
191_E194_L1.0281.00
151_A158_F1.0281.00
354_E357_E1.0281.00
118_L268_S1.0251.00
219_V273_A1.0251.00
201_I277_Y1.0241.00
303_Q307_Q1.0211.00
119_L167_I1.0171.00
155_R158_F1.0161.00
126_A288_A1.0101.00
156_R188_A1.0031.00
385_D388_G1.0001.00
393_A402_S0.9991.00
318_T322_V0.9951.00
367_L376_E0.9921.00
384_G388_G0.9871.00
327_A336_I0.9851.00
169_T270_A0.9841.00
231_A265_V0.9821.00
321_K354_E0.9811.00
103_S147_F0.9801.00
165_Y201_I0.9791.00
366_Y402_S0.9761.00
110_H318_T0.9751.00
315_H320_I0.9721.00
243_F255_F0.9701.00
351_F355_F0.9681.00
396_I400_D0.9621.00
303_Q306_D0.9591.00
373_S377_N0.9581.00
353_D357_E0.9561.00
168_M193_A0.9561.00
282_S286_K0.9531.00
182_I208_H0.9521.00
77_I88_I0.9461.00
186_F190_Q0.9461.00
300_N311_D0.9431.00
116_T132_L0.9401.00
400_D404_L0.9391.00
122_V285_I0.9391.00
223_T266_L0.9351.00
349_Q353_D0.9351.00
64_V80_A0.9341.00
126_A281_D0.9341.00
385_D389_K0.9321.00
406_A410_A0.9321.00
201_I273_A0.9281.00
59_K83_E0.9271.00
117_G295_V0.9241.00
174_D316_H0.9241.00
386_L389_K0.9231.00
350_Q354_E0.9211.00
308_V411_V0.9211.00
205_D266_L0.9211.00
398_E401_T0.9191.00
110_H319_E0.9171.00
347_R354_E0.9151.00
120_A130_S0.9141.00
72_D81_M0.9131.00
204_G210_P0.9121.00
272_I276_H0.9071.00
132_L135_D0.9071.00
334_R409_K0.9071.00
325_E358_S0.9051.00
274_L278_E0.9051.00
63_T87_V0.9021.00
280_I284_I0.9011.00
184_D188_A0.9011.00
210_P214_A0.8971.00
255_F286_K0.8951.00
368_C399_D0.8921.00
183_D208_H0.8891.00
207_E211_K0.8891.00
121_H125_N0.8851.00
209_L213_H0.8851.00
252_Y286_K0.8821.00
131_F139_Q0.8781.00
263_H322_V0.8761.00
299_F326_A0.8751.00
154_Y178_Y0.8751.00
339_V414_F0.8731.00
122_V288_A0.8671.00
125_N284_I0.8661.00
202_A213_H0.8641.00
107_T189_F0.8591.00
220_Y227_N0.8571.00
191_E195_Q0.8571.00
164_D198_K0.8551.00
224_G262_H0.8521.00
348_T351_F0.8351.00
364_C391_H0.8331.00
194_L215_N0.8331.00
232_R251_F0.8321.00
386_L390_I0.8321.00
115_T271_V0.8291.00
213_H220_Y0.8281.00
334_R410_A0.8271.00
155_R178_Y0.8221.00
137_T140_G0.8201.00
58_I85_I0.8191.00
105_A192_M0.8151.00
321_K357_E0.8141.00
200_I216_V0.8121.00
115_T270_A0.8081.00
100_K137_T0.8071.00
313_Y418_G0.8021.00
116_T148_V0.8021.00
352_L355_F0.8011.00
378_A384_G0.8001.00
391_H402_S0.7991.00
155_R194_L0.7991.00
90_Y93_F0.7971.00
353_D356_A0.7931.00
350_Q353_D0.7891.00
103_S149_F0.7891.00
80_A85_I0.7871.00
203_C206_D0.7841.00
89_R92_K0.7831.00
205_D222_G0.7831.00
89_R93_F0.7831.00
86_P96_D0.7821.00
190_Q194_L0.7821.00
245_V269_L0.7791.00
223_T231_A0.7781.00
384_G387_Q0.7751.00
399_D402_S0.7711.00
102_T278_E0.7691.00
227_N230_Q0.7651.00
310_I411_V0.7651.00
136_G139_Q0.7621.00
357_E360_S0.7611.00
320_I340_F0.7601.00
398_E402_S0.7601.00
182_I186_F0.7591.00
222_G266_L0.7591.00
183_D186_F0.7581.00
126_A275_C0.7581.00
307_Q409_K0.7541.00
309_L414_F0.7501.00
397_E401_T0.7491.00
156_R178_Y0.7441.00
91_H96_D0.7401.00
362_A365_V0.7401.00
66_A72_D0.7391.00
390_I393_A0.7381.00
348_T385_D0.7351.00
334_R411_V0.7331.00
310_I327_A0.7311.00
374_A377_N0.7301.00
285_I288_A0.7301.00
119_L148_V0.7301.00
332_P411_V0.7241.00
259_A292_F0.7201.00
355_F359_L0.7191.00
276_H285_I0.7181.00
128_P143_N0.7151.00
339_V412_L0.7141.00
118_L271_V0.7121.00
210_P213_H0.7121.00
237_S256_Y0.7111.00
306_D409_K0.7101.00
120_A148_V0.7091.00
327_A413_I0.7081.00
297_R311_D0.7071.00
396_I403_V0.7071.00
187_D190_Q0.7061.00
323_T415_M0.7061.00
321_K360_S0.7011.00
396_I405_K0.7001.00
138_G142_E0.6971.00
64_V76_E0.6961.00
101_F147_F0.6961.00
314_A415_M0.6931.00
73_T78_E0.6931.00
324_I338_A0.6921.00
55_A76_E0.6901.00
67_G70_F0.6901.00
90_Y95_G0.6861.00
81_M87_V0.6841.00
151_A163_P0.6831.00
153_E188_A0.6821.00
272_I289_L0.6811.00
238_T241_T0.6801.00
309_L412_L0.6801.00
282_S285_I0.6801.00
210_P220_Y0.6791.00
314_A323_T0.6781.00
168_M186_F0.6781.00
58_I62_M0.6771.00
236_K241_T0.6771.00
272_I282_S0.6761.00
337_V406_A0.6751.00
129_T144_S0.6711.00
204_G209_L0.6711.00
223_T234_I0.6701.00
236_K262_H0.6691.00
104_V146_Y0.6641.00
92_K160_S0.6601.00
211_K215_N0.6591.00
237_S240_G0.6591.00
355_F386_L0.6581.00
205_D223_T0.6551.00
72_D77_I0.6531.00
122_V126_A0.6521.00
97_Y162_Q0.6521.00
92_K95_G0.6511.00
342_P351_F0.6511.00
131_F134_G0.6511.00
233_N236_K0.6511.00
131_F135_D0.6491.00
333_D411_V0.6491.00
63_T86_P0.6481.00
179_F188_A0.6481.00
182_I185_V0.6471.00
107_T151_A0.6451.00
373_S392_N0.6451.00
173_F318_T0.6441.00
325_E329_Q0.6421.00
371_F374_A0.6411.00
182_I207_E0.6391.00
53_F67_G0.6381.00
328_R336_I0.6351.00
391_H394_K0.6331.00
186_F212_I0.6331.00
136_G140_G0.6331.00
206_D266_L0.6321.00
396_I401_T0.6321.00
305_G408_D0.6281.00
172_D182_I0.6271.00
203_C221_Y0.6271.00
241_T265_V0.6271.00
348_T371_F0.6251.00
66_A74_H0.6251.00
314_A319_E0.6231.00
171_I182_I0.6221.00
114_S118_L0.6221.00
304_L307_Q0.6201.00
419_D422_K0.6201.00
99_K162_Q0.6191.00
110_H172_D0.6191.00
387_Q390_I0.6181.00
164_D199_G0.6161.00
120_A131_F0.6161.00
341_Q416_G0.6161.00
123_I275_C0.6161.00
130_S133_I0.6151.00
265_V269_L0.6141.00
228_D248_R0.6141.00
233_N254_T0.6131.00
340_F367_L0.6131.00
368_C423_Y0.6121.00
225_E230_Q0.6121.00
220_Y224_G0.6111.00
95_G98_M0.6081.00
354_E358_S0.6071.00
117_G121_H0.6071.00
141_N144_S0.6061.00
343_H371_F0.6031.00
104_V123_I0.6021.00
274_L277_Y0.6011.00
81_M86_P0.6001.00
234_I265_V0.6001.00
343_H373_S0.5991.00
235_V254_T0.5991.00
162_Q195_Q0.5981.00
80_A84_G0.5971.00
99_K102_T0.5951.00
169_T221_Y0.5941.00
53_F57_N0.5931.00
351_F358_S0.5921.00
93_F97_Y0.5921.00
221_Y224_G0.5911.00
367_L392_N0.5901.00
90_Y94_L0.5901.00
344_T374_A0.5901.00
367_L387_Q0.5901.00
122_V289_L0.5891.00
140_G144_S0.5861.00
204_G222_G0.5861.00
262_H265_V0.5841.00
140_G147_F0.5841.00
66_A88_I0.5841.00
273_A277_Y0.5831.00
280_I285_I0.5811.00
69_A72_D0.5771.00
336_I411_V0.5751.00
250_T282_S0.5751.00
318_T321_K0.5751.00
269_L273_A0.5741.00
320_I324_I0.5721.00
151_A161_Y0.5721.00
347_R352_L0.5701.00
349_Q352_L0.5691.00
183_D211_K0.5681.00
259_A264_N0.5641.00
155_R159_L0.5641.00
387_Q391_H0.5641.00
213_H216_V0.5641.00
106_V167_I0.5631.00
255_F268_S0.5611.00
153_E178_Y0.5611.00
331_Y334_R0.5601.00
209_L212_I0.5591.00
261_G264_N0.5571.00
81_M84_G0.5561.00
201_I274_L0.5561.00
218_V222_G0.5541.00
219_V222_G0.5531.00
338_A365_V0.5511.00
316_H319_E0.5501.00
106_V115_T0.5501.00
249_N276_H0.5491.00
257_I289_L0.5491.00
219_V229_F0.5471.00
138_G141_N0.5461.00
124_Q129_T0.5441.00
314_A320_I0.5441.00
284_I288_A0.5431.00
154_Y177_D0.5431.00
162_Q199_G0.5421.00
229_F248_R0.5421.00
367_L375_R0.5421.00
64_V77_I0.5421.00
131_F144_S0.5411.00
158_F195_Q0.5401.00
218_V221_Y0.5381.00
336_I363_D0.5371.00
321_K361_G0.5351.00
241_T244_D0.5341.00
129_T134_G0.5341.00
342_P371_F0.5311.00
176_P181_S0.5301.00
406_A409_K0.5291.00
176_P180_S0.5291.00
118_L257_I0.5281.00
201_I219_V0.5271.00
75_P79_K0.5261.00
223_T269_L0.5231.00
352_L358_S0.5231.00
272_I275_C0.5221.00
376_E392_N0.5221.00
367_L390_I0.5201.00
130_S134_G0.5201.00
83_E86_P0.5161.00
213_H218_V0.5161.00
129_T132_L0.5151.00
375_R378_A0.5151.00
208_H212_I0.5141.00
117_G296_K0.5141.00
343_H421_Q0.5131.00
95_G99_K0.5131.00
206_D210_P0.5131.00
366_Y399_D0.5131.00
94_L98_M0.5101.00
266_L322_V0.5091.00
320_I338_A0.5091.00
64_V67_G0.5071.00
299_F323_T0.5071.00
366_Y393_A0.5071.00
283_S286_K0.5041.00
252_Y282_S0.5031.00
133_I139_Q0.5021.00
320_I351_F0.5021.00
73_T76_E0.5011.00
53_F56_E0.5011.00
76_E80_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1j6uA 1 0.9421 100 0.222 Contact Map
1p3dA 1 0.9931 100 0.223 Contact Map
2x5oA 1 0.9491 100 0.229 Contact Map
3hn7A 1 0.9769 100 0.23 Contact Map
4hv4A 1 0.9931 100 0.235 Contact Map
3lk7A 1 0.9491 100 0.259 Contact Map
4bucA 1 0.9028 100 0.271 Contact Map
4c12A 2 0.9282 100 0.321 Contact Map
3zm6A 1 0.9259 100 0.329 Contact Map
4bubA 1 0.919 100 0.331 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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