GREMLIN Database
YHFN - Uncharacterized metalloprotease YhfN
UniProt: P40769 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 426 (403)
Sequences: 1254 (1000)
Seq/√Len: 49.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_V132_Y5.6211.00
365_I412_A5.1141.00
123_W139_T4.7221.00
375_V409_I4.6521.00
193_I197_I4.2591.00
199_D246_Y3.8011.00
212_E268_D3.6301.00
28_D392_P3.4081.00
144_K148_I3.2861.00
216_K272_L3.2051.00
125_G137_Q3.1361.00
47_K50_E3.0701.00
270_E380_D2.9751.00
48_P52_A2.9291.00
216_K268_D2.9051.00
194_Q199_D2.8931.00
164_F179_A2.8571.00
206_Y209_K2.7931.00
211_K214_E2.7881.00
184_V295_L2.7021.00
140_A144_K2.6201.00
71_L121_L2.5391.00
199_D205_F2.5351.00
286_H359_K2.4301.00
284_M359_K2.4241.00
276_G364_G2.3931.00
290_G356_Q2.3771.00
214_E218_L2.3371.00
203_N235_N2.3251.00
362_Q411_H2.3141.00
71_L117_V2.2151.00
194_Q246_Y2.2131.00
96_V101_L2.2111.00
163_V182_L2.1681.00
210_N214_E2.1581.00
179_A302_F2.1471.00
205_F234_V2.1251.00
40_A43_A2.0941.00
396_K400_G2.0931.00
270_E376_K2.0921.00
303_Y307_K2.0651.00
269_S373_A2.0331.00
355_Y359_K2.0271.00
123_W142_W1.9981.00
289_I359_K1.9550.99
92_I109_V1.8980.99
52_A56_Q1.8900.99
50_E383_V1.8800.99
400_G404_S1.8590.99
233_E263_L1.8420.99
246_Y257_V1.8150.99
104_V108_F1.8130.99
358_N404_S1.8110.99
68_G121_L1.8030.99
145_D239_K1.7930.99
75_L117_V1.7760.99
220_L367_L1.7590.99
147_V151_W1.7560.99
224_A363_Y1.7540.99
289_I356_Q1.7270.99
330_A333_L1.6820.98
130_L135_S1.6810.98
137_Q141_S1.6690.98
356_Q359_K1.6670.98
139_T142_W1.6600.98
160_C182_L1.6600.98
186_F190_L1.6540.98
221_A228_A1.6310.98
130_L136_T1.6170.98
124_I127_Q1.6090.98
50_E53_V1.5830.98
177_L181_L1.5750.97
35_V56_Q1.5740.97
396_K404_S1.5720.97
388_Q391_P1.5720.97
24_F28_D1.5560.97
136_T241_N1.5460.97
60_V128_V1.5380.97
326_H329_A1.5290.97
404_S407_E1.5280.97
92_I102_Q1.5250.97
175_W347_P1.5240.97
89_K93_E1.5160.97
362_Q366_E1.5100.97
182_L186_F1.4990.97
41_D413_E1.4970.96
235_N238_E1.4880.96
139_T143_A1.4870.96
265_K384_T1.4860.96
396_K407_E1.4770.96
236_M240_T1.4520.96
171_H178_Y1.4480.96
53_V124_I1.4470.96
375_V413_E1.4470.96
246_Y255_R1.4430.96
67_I70_P1.4360.96
376_K380_D1.4280.95
12_Y16_G1.4150.95
129_S242_A1.4060.95
358_N411_H1.4020.95
60_V131_D1.3950.95
277_H281_H1.3850.95
112_L116_L1.3780.94
78_V82_S1.3750.94
131_D204_D1.3680.94
395_V399_R1.3590.94
217_I272_L1.3460.94
71_L75_L1.3450.94
99_R169_K1.3450.94
17_L21_W1.3440.94
243_L265_K1.3310.93
281_H357_E1.3280.93
212_E215_S1.3160.93
209_K214_E1.3140.93
234_V259_W1.2970.92
215_S218_L1.2970.92
205_F255_R1.2870.92
25_L28_D1.2820.92
203_N234_V1.2800.92
185_P189_F1.2680.91
64_L68_G1.2670.91
146_Q150_F1.2660.91
108_F158_T1.2660.91
273_F374_A1.2520.91
205_F246_Y1.2510.91
220_L279_M1.2490.91
100_F162_L1.2460.91
184_V291_L1.2430.91
234_V246_Y1.2420.91
152_I157_F1.2340.90
277_H357_E1.2330.90
146_Q149_S1.2300.90
180_W299_L1.2260.90
73_W77_F1.2260.90
134_I242_A1.2150.90
103_T165_Y1.2120.90
89_K328_L1.1980.89
365_I370_N1.1980.89
57_Y129_S1.1950.89
79_L117_V1.1890.89
143_A147_V1.1890.89
369_E373_A1.1870.89
129_S240_T1.1810.88
17_L348_F1.1730.88
181_L185_P1.1660.88
46_M389_V1.1440.87
88_I113_I1.1320.86
42_P405_I1.1310.86
91_W109_V1.1290.86
76_F336_L1.1260.86
122_D146_Q1.1160.85
92_I105_G1.1150.85
16_G20_Y1.1060.85
91_W95_A1.1010.84
30_A62_N1.0970.84
127_Q130_L1.0940.84
141_S144_K1.0940.84
126_Y135_S1.0810.83
285_K288_Y1.0790.83
93_E102_Q1.0770.83
19_F23_F1.0760.83
24_F392_P1.0760.83
162_L166_W1.0730.83
187_S190_L1.0640.82
126_Y138_T1.0630.82
391_P400_G1.0600.82
26_S62_N1.0560.82
292_A324_G1.0540.82
382_A405_I1.0530.82
145_D260_D1.0480.81
23_F66_F1.0440.81
74_F147_V1.0430.81
243_L384_T1.0410.81
388_Q392_P1.0390.81
403_P408_R1.0340.80
171_H174_K1.0260.80
392_P396_K1.0250.80
363_Y395_V1.0240.80
26_S399_R1.0220.80
49_S53_V1.0200.80
187_S191_F1.0190.80
226_I247_V1.0190.80
10_L17_L1.0180.79
170_R181_L1.0160.79
243_L396_K1.0120.79
74_F116_L1.0120.79
224_A367_L1.0090.79
20_Y24_F1.0060.79
32_P35_V1.0060.79
302_F312_T1.0060.79
21_W398_F0.9990.78
64_L128_V0.9970.78
167_L182_L0.9960.78
245_A402_H0.9940.78
89_K326_H0.9930.78
53_V136_T0.9920.78
237_S260_D0.9880.77
274_I402_H0.9880.77
304_V334_L0.9870.77
218_L231_V0.9860.77
25_L398_F0.9820.77
393_V397_I0.9800.77
86_K407_E0.9780.77
108_F154_F0.9730.76
217_I258_L0.9720.76
106_F342_S0.9720.76
315_L330_A0.9710.76
80_L83_G0.9700.76
182_L246_Y0.9670.76
335_L338_F0.9660.76
177_L299_L0.9640.76
176_W282_Y0.9550.75
208_L233_E0.9540.75
370_N412_A0.9530.75
30_A33_E0.9520.75
104_V158_T0.9440.74
145_D202_Y0.9410.74
226_I279_M0.9400.74
89_K327_D0.9390.74
213_L263_L0.9310.73
252_A404_S0.9290.73
368_T373_A0.9280.73
115_T146_Q0.9260.73
26_S65_F0.9230.72
100_F155_P0.9210.72
19_F70_P0.9190.72
218_L222_D0.9180.72
20_Y68_G0.9130.72
127_Q131_D0.9130.72
357_E360_A0.9090.71
269_S368_T0.9080.71
152_I184_V0.9080.71
26_S29_S0.9060.71
258_L263_L0.9050.71
18_F21_W0.9050.71
195_P248_T0.8970.70
115_T150_F0.8960.70
129_S134_I0.8950.70
152_I197_I0.8930.70
263_L271_I0.8910.70
199_D248_T0.8870.69
16_G21_W0.8820.69
213_L217_I0.8780.69
140_A155_P0.8780.69
194_Q257_V0.8770.68
126_Y130_L0.8760.68
108_F150_F0.8750.68
263_L268_D0.8710.68
281_H361_D0.8700.68
297_V342_S0.8690.68
266_L380_D0.8680.68
113_I186_F0.8660.67
145_D244_N0.8660.67
10_L34_A0.8650.67
244_N261_T0.8630.67
157_F161_V0.8620.67
395_V400_G0.8600.67
41_D410_Q0.8580.67
112_L115_T0.8540.66
268_D272_L0.8540.66
214_E287_V0.8460.66
123_W143_A0.8450.66
159_L162_L0.8420.65
104_V301_G0.8410.65
211_K215_S0.8370.65
156_I352_V0.8340.65
166_W170_R0.8320.64
163_V186_F0.8310.64
348_F352_V0.8250.64
112_L296_L0.8250.64
134_I239_K0.8250.64
196_V253_N0.8250.64
200_P255_R0.8200.63
89_K329_A0.8190.63
51_L386_L0.8170.63
257_V261_T0.8090.62
77_F363_Y0.8090.62
104_V165_Y0.8070.62
38_T48_P0.8070.62
353_S401_S0.8060.62
245_A260_D0.8050.62
247_V261_T0.8030.62
27_G31_I0.8030.62
138_T141_S0.8020.61
51_L389_V0.8000.61
79_L84_V0.7940.61
370_N373_A0.7910.60
314_R318_S0.7910.60
10_L293_G0.7890.60
220_L256_I0.7880.60
22_Y399_R0.7880.60
15_Y73_W0.7880.60
195_P205_F0.7830.60
172_E308_L0.7820.60
164_F330_A0.7800.59
128_V274_I0.7790.59
247_V282_Y0.7730.59
30_A34_A0.7720.59
380_D389_V0.7700.58
206_Y233_E0.7690.58
400_G407_E0.7670.58
357_E361_D0.7670.58
119_L309_Y0.7660.58
145_D261_T0.7650.58
329_A333_L0.7650.58
103_T328_L0.7640.58
234_V272_L0.7640.58
277_H402_H0.7600.57
37_G90_K0.7580.57
74_F304_V0.7570.57
145_D203_N0.7570.57
216_K219_E0.7560.57
187_S363_Y0.7560.57
282_Y285_K0.7550.57
199_D203_N0.7520.57
53_V204_D0.7520.57
203_N246_Y0.7520.57
274_I377_T0.7510.56
26_S283_V0.7510.56
13_V20_Y0.7480.56
49_S90_K0.7460.56
374_A378_F0.7430.56
141_S239_K0.7410.55
259_W262_T0.7410.55
358_N407_E0.7390.55
51_L55_E0.7360.55
46_M256_I0.7350.55
13_V19_F0.7340.55
128_V294_Y0.7330.55
120_P205_F0.7330.55
155_P159_L0.7320.54
234_V257_V0.7310.54
293_G352_V0.7310.54
112_L150_F0.7310.54
183_T302_F0.7300.54
244_N278_E0.7300.54
202_Y260_D0.7220.53
239_K259_W0.7190.53
176_W303_Y0.7160.53
9_G13_V0.7150.53
392_P397_I0.7150.53
98_F101_L0.7140.53
176_W391_P0.7140.53
270_E386_L0.7130.53
345_V412_A0.7120.52
13_V27_G0.7110.52
184_V299_L0.7090.52
372_E413_E0.7080.52
164_F302_F0.7070.52
396_K412_A0.7060.52
97_P109_V0.7060.52
357_E402_H0.7030.52
90_K98_F0.7030.52
379_Q409_I0.7010.51
83_G329_A0.7010.51
189_F193_I0.6990.51
382_A389_V0.6980.51
240_T275_M0.6980.51
41_D47_K0.6970.51
85_S106_F0.6920.50
199_D234_V0.6890.50
24_F31_I0.6890.50
112_L146_Q0.6880.50
402_H408_R0.6860.50
243_L282_Y0.6850.50
224_A279_M0.6820.49
145_D237_S0.6800.49
174_K185_P0.6790.49
309_Y325_R0.6780.49
256_I316_T0.6780.49
218_L228_A0.6770.49
14_L18_F0.6760.49
65_F73_W0.6760.49
79_L110_L0.6760.49
12_Y34_A0.6750.49
141_S148_I0.6750.49
350_N377_T0.6750.49
168_I175_W0.6750.49
124_I254_K0.6750.49
67_I348_F0.6740.49
213_L272_L0.6740.49
289_I304_V0.6720.48
132_Y221_A0.6720.48
244_N385_G0.6720.48
361_D408_R0.6710.48
350_N386_L0.6710.48
256_I284_M0.6710.48
37_G151_W0.6700.48
273_F378_F0.6700.48
22_Y189_F0.6700.48
111_S161_V0.6690.48
96_V102_Q0.6680.48
394_L409_I0.6680.48
55_E59_N0.6670.48
164_F212_E0.6670.48
14_L24_F0.6660.48
232_Y255_R0.6660.48
281_H360_A0.6660.48
44_S163_V0.6630.47
30_A78_V0.6620.47
378_F405_I0.6610.47
135_S145_D0.6610.47
244_N402_H0.6600.47
47_K52_A0.6600.47
54_A190_L0.6590.47
14_L21_W0.6590.47
127_Q300_A0.6580.47
77_F91_W0.6570.47
125_G128_V0.6530.46
267_D380_D0.6510.46
111_S143_A0.6510.46
12_Y352_V0.6480.46
213_L268_D0.6460.46
13_V16_G0.6450.46
22_Y33_E0.6440.46
71_L209_K0.6430.45
88_I337_L0.6430.45
191_F194_Q0.6410.45
12_Y81_V0.6390.45
61_K373_A0.6380.45
96_V105_G0.6360.45
235_N239_K0.6360.45
245_A274_I0.6350.45
87_K91_W0.6350.45
221_A256_I0.6340.45
274_I388_Q0.6330.44
77_F81_V0.6300.44
52_A151_W0.6270.44
303_Y306_D0.6260.44
126_Y240_T0.6260.44
406_M410_Q0.6230.43
106_F328_L0.6230.43
345_V349_S0.6220.43
13_V31_I0.6210.43
182_L407_E0.6200.43
116_L363_Y0.6190.43
27_G66_F0.6170.43
290_G294_Y0.6160.43
320_F333_L0.6140.42
142_W363_Y0.6140.42
112_L223_E0.6130.42
288_Y303_Y0.6130.42
154_F158_T0.6130.42
13_V92_I0.6120.42
290_G353_S0.6110.42
12_Y27_G0.6110.42
17_L20_Y0.6110.42
120_P200_P0.6100.42
41_D409_I0.6090.42
219_E222_D0.6090.42
134_I202_Y0.6090.42
256_I275_M0.6070.42
113_I323_E0.6050.42
365_I373_A0.6040.41
234_V247_V0.6040.41
203_N239_K0.6040.41
20_Y372_E0.6040.41
198_I228_A0.6030.41
174_K177_L0.6020.41
93_E98_F0.6020.41
107_V161_V0.6020.41
256_I363_Y0.6010.41
11_A33_E0.6000.41
278_E402_H0.6000.41
243_L385_G0.5960.41
361_D403_P0.5910.40
266_L384_T0.5910.40
129_S135_S0.5890.40
207_P381_L0.5870.40
352_V355_Y0.5870.40
170_R304_V0.5860.40
219_E300_A0.5860.40
395_V407_E0.5830.39
56_Q177_L0.5830.39
378_F412_A0.5830.39
22_Y128_V0.5820.39
288_Y292_A0.5820.39
90_K115_T0.5810.39
13_V18_F0.5810.39
299_L302_F0.5800.39
173_K310_K0.5790.39
257_V279_M0.5780.39
148_I202_Y0.5780.39
244_N364_G0.5780.39
126_Y235_N0.5770.39
337_L341_L0.5750.39
289_I352_V0.5750.39
278_E357_E0.5740.39
284_M288_Y0.5720.38
221_A279_M0.5710.38
244_N381_L0.5710.38
338_F342_S0.5690.38
238_E380_D0.5690.38
133_N261_T0.5690.38
348_F372_E0.5690.38
281_H286_H0.5680.38
104_V141_S0.5680.38
338_F341_L0.5670.38
333_L340_V0.5670.38
184_V189_F0.5660.38
19_F26_S0.5650.38
37_G49_S0.5620.37
305_I334_L0.5610.37
217_I271_I0.5600.37
289_I385_G0.5600.37
286_H356_Q0.5570.37
56_Q363_Y0.5560.37
52_A259_W0.5550.37
63_F70_P0.5540.37
44_S48_P0.5540.37
378_F385_G0.5530.37
108_F181_L0.5530.37
91_W128_V0.5530.37
237_S261_T0.5530.37
145_D148_I0.5520.36
165_Y333_L0.5520.36
242_A396_K0.5520.36
198_I246_Y0.5510.36
13_V17_L0.5510.36
253_N347_P0.5500.36
15_Y19_F0.5500.36
134_I259_W0.5490.36
61_K136_T0.5480.36
195_P253_N0.5480.36
143_A212_E0.5480.36
211_K263_L0.5470.36
152_I308_L0.5460.36
135_S240_T0.5460.36
258_L271_I0.5460.36
215_S222_D0.5440.36
354_R361_D0.5440.36
71_L97_P0.5430.36
47_K359_K0.5420.35
254_K395_V0.5420.35
90_K122_D0.5400.35
35_V38_T0.5390.35
229_D252_A0.5380.35
128_V270_E0.5380.35
15_Y22_Y0.5380.35
247_V259_W0.5380.35
325_R330_A0.5380.35
222_D363_Y0.5370.35
200_P260_D0.5360.35
266_L274_I0.5350.35
57_Y374_A0.5340.35
23_F69_V0.5340.35
377_T384_T0.5330.35
86_K217_I0.5310.34
58_S62_N0.5310.34
196_V232_Y0.5310.34
315_L318_S0.5310.34
248_T287_V0.5310.34
255_R261_T0.5300.34
64_L71_L0.5280.34
259_W340_V0.5280.34
192_F196_V0.5270.34
186_F332_P0.5270.34
148_I275_M0.5260.34
254_K282_Y0.5250.34
16_G215_S0.5250.34
202_Y237_S0.5250.34
220_L405_I0.5240.34
107_V170_R0.5240.34
243_L407_E0.5230.34
240_T261_T0.5230.34
175_W368_T0.5230.34
10_L94_A0.5230.34
300_A316_T0.5220.34
34_A197_I0.5210.34
19_F73_W0.5200.33
246_Y274_I0.5200.33
89_K92_I0.5190.33
92_I323_E0.5180.33
153_S276_G0.5170.33
246_Y261_T0.5160.33
135_S138_T0.5160.33
151_W154_F0.5150.33
19_F22_Y0.5150.33
271_I346_T0.5150.33
16_G77_F0.5130.33
107_V323_E0.5130.33
88_I151_W0.5130.33
11_A14_L0.5130.33
153_S183_T0.5120.33
343_F347_P0.5110.33
166_W311_R0.5110.33
89_K320_F0.5100.33
149_S160_C0.5090.32
266_L271_I0.5090.32
291_L343_F0.5080.32
19_F324_G0.5080.32
130_L344_A0.5080.32
380_D384_T0.5080.32
184_V193_I0.5080.32
314_R319_M0.5070.32
205_F239_K0.5060.32
165_Y304_V0.5050.32
108_F157_F0.5050.32
147_V150_F0.5040.32
74_F355_Y0.5040.32
160_C373_A0.5010.32
392_P395_V0.5010.32
12_Y24_F0.5000.32
358_N401_S0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4aw6A 2 0.9648 100 0.191 Contact Map
4il3A 1 0.9695 100 0.199 Contact Map
3c37A 1 0.4648 100 0.722 Contact Map
3cqbA 4 0.2324 99.8 0.827 Contact Map
4qhjA 2 0.2394 97.5 0.927 Contact Map
4jiuA 1 0.2277 96.6 0.937 Contact Map
3dteA 2 0.3545 95.6 0.942 Contact Map
4jixA 2 0.2535 94.8 0.945 Contact Map
4o66A 2 0.1643 42.6 0.968 Contact Map
2kw0A 1 0.1643 29.7 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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