GREMLIN Database
CWLO - Peptidoglycan DL-endopeptidase CwlO
UniProt: P40767 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 473 (393)
Sequences: 486 (449)
Seq/√Len: 22.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
363_G374_I5.3271.00
351_S442_L4.9171.00
267_K271_E4.6941.00
268_K272_A3.9001.00
351_S452_V3.8761.00
394_P399_T3.8451.00
344_E417_R3.5941.00
448_H451_S3.5671.00
364_G394_P3.5541.00
381_V420_L3.4871.00
266_I270_E3.2941.00
365_R374_I3.2541.00
357_S374_I3.2411.00
270_E274_K3.2091.00
381_V403_L3.1521.00
423_F433_G3.0211.00
353_I357_S2.6910.99
354_V442_L2.6750.99
271_E275_A2.6420.99
436_L452_V2.6090.99
265_L269_Q2.6030.99
241_L245_K2.5660.99
375_F383_W2.5160.98
263_A267_K2.4960.98
357_S365_R2.4490.98
411_S414_E2.4110.98
441_F455_M2.3810.98
415_M421_V2.3260.97
354_V449_G2.3030.97
238_A242_A2.2810.97
350_G442_L2.2640.97
124_R164_D2.2520.97
381_V434_I2.2200.96
357_S363_G2.1580.96
382_R394_P2.1490.95
269_Q273_Q2.1430.95
314_N320_S2.0900.95
102_K106_E2.0780.95
442_L452_V2.0130.94
417_R442_L1.9980.93
255_I258_E1.9670.93
263_A266_I1.9600.93
424_D428_T1.9400.92
283_D287_A1.9290.92
393_G402_T1.9080.92
328_S332_S1.8860.91
433_G436_L1.8840.91
95_K99_E1.8660.91
250_A253_A1.8600.90
319_G323_K1.8580.90
349_V353_I1.8360.90
421_V455_M1.7990.89
417_R436_L1.7990.89
251_E255_I1.7910.89
45_S53_A1.7350.87
392_L403_L1.7310.87
306_D316_S1.7160.86
315_S321_S1.7150.86
347_I436_L1.7050.86
381_V392_L1.6960.86
433_G441_F1.6460.84
207_D211_N1.6440.84
358_P374_I1.6340.84
364_G399_T1.6320.83
238_A241_L1.6150.83
240_E244_Q1.6140.83
329_N333_G1.6120.83
325_S329_N1.6110.83
360_K373_R1.6100.83
304_S310_N1.6090.83
310_N314_N1.5940.82
248_T252_Q1.5880.82
251_E254_R1.5810.81
295_S301_S1.5730.81
182_E186_N1.5610.81
252_Q255_I1.5590.80
393_G400_T1.5220.79
264_A271_E1.4880.77
245_K248_T1.4870.77
343_I347_I1.4830.77
380_F384_A1.4820.77
344_E348_S1.4660.76
318_N324_K1.4580.76
440_T452_V1.4570.76
313_S319_G1.4520.75
423_F464_F1.4510.75
242_A245_K1.4470.75
300_S305_S1.4160.74
404_V422_F1.4160.74
280_Q284_S1.4080.73
254_R257_K1.4060.73
403_L420_L1.4030.73
325_S330_S1.3990.73
309_S317_S1.3820.72
176_A180_D1.3720.71
382_R403_L1.3680.71
349_V352_S1.3650.71
312_S320_S1.3590.70
264_A268_K1.3490.70
424_D430_G1.3430.69
352_S380_F1.3280.69
308_S313_S1.3260.68
253_A257_K1.3260.68
317_S322_S1.3250.68
318_N322_S1.3230.68
305_S310_N1.3190.68
179_E183_A1.3180.68
353_I363_G1.3170.68
306_D309_S1.3150.68
308_S314_N1.3120.68
364_G382_R1.3000.67
324_K328_S1.2920.66
300_S306_D1.2910.66
344_E436_L1.2890.66
255_I259_Q1.2790.66
443_N451_S1.2790.66
433_G442_L1.2670.65
364_G383_W1.2620.65
433_G443_N1.2570.64
314_N322_S1.2570.64
296_S300_S1.2550.64
265_L268_K1.2530.64
357_S373_R1.2350.63
245_K249_E1.2320.63
343_I417_R1.2280.62
320_S324_K1.2280.62
171_Q174_D1.2270.62
318_N323_K1.2250.62
348_S351_S1.2230.62
315_S327_G1.2220.62
420_L434_I1.2110.61
252_Q256_K1.2100.61
314_N318_N1.2100.61
411_S415_M1.2010.61
100_I103_L1.1990.60
54_K58_L1.1950.60
309_S315_S1.1890.60
259_Q263_A1.1860.60
353_I365_R1.1850.60
421_V433_G1.1820.59
298_D303_N1.1790.59
146_S149_D1.1770.59
349_V375_F1.1610.58
415_M423_F1.1560.58
200_E204_K1.1560.58
321_S324_K1.1540.57
349_V387_S1.1450.57
323_K326_S1.1380.56
154_A158_S1.1220.55
394_P401_D1.1140.55
326_S332_S1.1140.55
450_V455_M1.1130.55
303_N311_G1.1130.55
305_S309_S1.1050.54
315_S319_G1.1030.54
117_R174_D1.1010.54
253_A256_K1.0930.53
303_N317_S1.0900.53
301_S307_N1.0820.53
267_K274_K1.0780.52
310_N316_S1.0700.52
315_S318_N1.0660.51
211_N254_R1.0650.51
327_G330_S1.0590.51
353_I380_F1.0590.51
352_S357_S1.0520.50
311_G315_S1.0490.50
98_E101_K1.0460.50
279_T284_S1.0460.50
310_N322_S1.0440.50
421_V464_F1.0350.49
443_N453_D1.0300.49
309_S319_G1.0300.49
447_S450_V1.0280.49
297_S303_N1.0260.49
359_Y376_D1.0230.48
381_V385_Y1.0230.48
392_L432_V1.0210.48
349_V383_W1.0180.48
361_F374_I1.0160.48
238_A245_K1.0140.48
348_S442_L1.0140.48
365_R373_R1.0130.48
250_A254_R1.0120.48
137_Y157_V1.0090.48
68_I216_L1.0070.47
241_L244_Q1.0060.47
399_T402_T1.0040.47
244_Q247_N1.0010.47
300_S318_N0.9990.47
129_Q132_G0.9960.47
316_S321_S0.9960.47
380_F450_V0.9960.47
213_K217_F0.9930.46
299_D308_S0.9900.46
114_I171_Q0.9810.46
353_I384_A0.9720.45
443_N456_S0.9610.44
235_K246_A0.9600.44
380_F394_P0.9590.44
124_R147_F0.9570.44
172_E175_K0.9530.44
300_S308_S0.9500.43
282_D286_T0.9480.43
177_K181_S0.9480.43
143_G153_R0.9430.43
212_E216_L0.9410.43
307_N313_S0.9380.43
279_T282_D0.9310.42
83_S87_E0.9300.42
52_E230_A0.9250.42
382_R392_L0.9240.42
259_Q271_E0.9240.42
410_V414_E0.9210.42
418_G431_H0.9160.41
306_D313_S0.9150.41
117_R129_Q0.9130.41
264_A267_K0.9070.41
403_L424_D0.9000.40
412_A421_V0.9000.40
309_S313_S0.8990.40
238_A248_T0.8990.40
297_S307_N0.8980.40
299_D302_D0.8940.40
302_D313_S0.8940.40
349_V384_A0.8930.40
237_E248_T0.8900.39
111_E115_E0.8890.39
242_A246_A0.8800.39
384_A388_A0.8790.39
410_V416_K0.8780.39
48_A51_I0.8780.39
325_S328_S0.8750.38
410_V435_Y0.8730.38
279_T283_D0.8730.38
440_T454_S0.8700.38
366_T433_G0.8690.38
346_A388_A0.8680.38
422_F450_V0.8660.38
244_Q252_Q0.8610.38
249_E252_Q0.8610.38
400_T404_V0.8570.37
75_I420_L0.8570.37
251_E258_E0.8530.37
172_E415_M0.8520.37
312_S316_S0.8480.37
237_E245_K0.8470.37
306_D320_S0.8440.36
302_D308_S0.8440.36
307_N321_S0.8430.36
347_I442_L0.8430.36
315_S322_S0.8430.36
304_S322_S0.8420.36
282_D287_A0.8400.36
415_M436_L0.8310.36
93_N192_V0.8290.36
305_S311_G0.8290.36
307_N315_S0.8240.35
317_S320_S0.8160.35
224_Q227_T0.8130.35
339_N342_G0.8080.34
312_S321_S0.8070.34
423_F426_Y0.8050.34
375_F422_F0.8050.34
327_G331_N0.8010.34
231_I235_K0.8000.34
366_T375_F0.7980.34
304_S314_N0.7980.34
400_T432_V0.7970.34
96_T188_K0.7950.33
305_S313_S0.7940.33
121_L153_R0.7940.33
104_K167_L0.7920.33
308_S311_G0.7910.33
304_S312_S0.7890.33
403_L433_G0.7890.33
105_K410_V0.7870.33
445_N448_H0.7870.33
305_S308_S0.7850.33
297_S313_S0.7850.33
317_S326_S0.7840.33
244_Q248_T0.7830.33
310_N318_N0.7820.33
310_N328_S0.7810.33
235_K238_A0.7800.32
353_I450_V0.7780.32
423_F427_K0.7770.32
393_G432_V0.7760.32
354_V447_S0.7740.32
316_S319_G0.7730.32
308_S312_S0.7670.32
312_S315_S0.7660.32
296_S303_N0.7650.32
316_S320_S0.7620.31
190_K334_G0.7620.31
415_M455_M0.7610.31
426_Y430_G0.7610.31
298_D314_N0.7590.31
286_T295_S0.7580.31
317_S327_G0.7580.31
385_Y388_A0.7570.31
96_T103_L0.7560.31
224_Q228_A0.7530.31
144_S147_F0.7530.31
221_K231_I0.7530.31
318_N321_S0.7520.31
302_D310_N0.7520.31
312_S318_N0.7500.31
301_S305_S0.7490.31
400_T450_V0.7490.31
270_E273_Q0.7480.31
326_S330_S0.7470.31
364_G375_F0.7470.31
268_K271_E0.7470.31
316_S322_S0.7460.30
252_Q258_E0.7460.30
295_S298_D0.7450.30
402_T405_G0.7440.30
364_G402_T0.7420.30
100_I185_L0.7400.30
310_N327_G0.7400.30
47_V51_I0.7360.30
208_K212_E0.7360.30
375_F450_V0.7360.30
107_I423_F0.7360.30
162_D347_I0.7340.30
446_T449_G0.7330.30
52_E63_E0.7320.30
296_S299_D0.7320.30
385_Y390_V0.7310.30
319_G322_S0.7300.30
230_A233_E0.7290.29
309_S320_S0.7280.29
357_S442_L0.7280.29
103_L189_L0.7270.29
280_Q283_D0.7260.29
75_I381_V0.7240.29
311_G326_S0.7240.29
226_K230_A0.7230.29
110_T129_Q0.7210.29
343_I441_F0.7180.29
448_H453_D0.7170.29
220_A224_Q0.7160.29
304_S311_G0.7160.29
305_S314_N0.7150.29
144_S233_E0.7130.29
310_N324_K0.7120.29
445_N449_G0.7110.28
355_G379_S0.7080.28
298_D302_D0.7040.28
302_D305_S0.7030.28
329_N332_S0.7030.28
118_N121_L0.7020.28
439_G455_M0.7010.28
346_A360_K0.7000.28
105_K108_K0.6990.28
297_S302_D0.6960.28
357_S375_F0.6950.28
298_D308_S0.6950.28
432_V435_Y0.6940.28
297_S301_S0.6940.28
241_L248_T0.6930.27
332_S336_V0.6900.27
145_T465_K0.6890.27
420_L432_V0.6860.27
275_A279_T0.6860.27
400_T429_N0.6840.27
63_E121_L0.6820.27
436_L440_T0.6810.27
231_I238_A0.6800.27
100_I107_I0.6760.27
259_Q269_Q0.6760.27
108_K194_A0.6750.26
137_Y141_L0.6730.26
240_E243_N0.6730.26
178_L185_L0.6730.26
75_I110_T0.6730.26
243_N247_N0.6700.26
310_N320_S0.6700.26
394_P402_T0.6700.26
415_M432_V0.6690.26
227_T238_A0.6680.26
359_Y378_S0.6680.26
263_A272_A0.6660.26
107_I121_L0.6640.26
280_Q301_S0.6640.26
56_K162_D0.6620.26
67_K71_E0.6610.26
263_A270_E0.6610.26
301_S311_G0.6600.26
424_D441_F0.6590.26
359_Y377_C0.6590.26
313_S318_N0.6590.26
142_L390_V0.6580.26
318_N327_G0.6580.26
117_R121_L0.6570.26
229_K301_S0.6570.26
304_S316_S0.6550.25
203_Q207_D0.6540.25
350_G428_T0.6540.25
44_Q241_L0.6540.25
315_S320_S0.6540.25
286_T294_A0.6520.25
435_Y440_T0.6510.25
271_E274_K0.6490.25
421_V427_K0.6480.25
436_L442_L0.6470.25
121_L171_Q0.6440.25
300_S304_S0.6440.25
383_W387_S0.6430.25
323_K327_G0.6430.25
403_L447_S0.6390.25
385_Y401_D0.6390.25
302_D307_N0.6380.25
313_S329_N0.6370.24
431_H437_G0.6370.24
418_G437_G0.6370.24
423_F441_F0.6360.24
313_S317_S0.6350.24
313_S316_S0.6330.24
111_E114_I0.6330.24
249_E253_A0.6320.24
328_S333_G0.6320.24
327_G333_G0.6320.24
324_K327_G0.6320.24
125_V132_G0.6310.24
417_R452_V0.6300.24
404_V436_L0.6300.24
303_N309_S0.6290.24
410_V436_L0.6260.24
258_E271_E0.6260.24
299_D309_S0.6260.24
361_F399_T0.6250.24
296_S306_D0.6240.24
62_Q416_K0.6240.24
279_T286_T0.6240.24
423_F430_G0.6230.24
316_S324_K0.6220.24
346_A392_L0.6220.24
331_N335_T0.6210.24
353_I374_I0.6200.24
423_F455_M0.6200.24
237_E242_A0.6180.24
97_K160_I0.6180.24
363_G366_T0.6180.24
366_T450_V0.6160.23
329_N334_G0.6150.23
227_T231_I0.6140.23
303_N308_S0.6140.23
303_N313_S0.6050.23
357_S366_T0.6050.23
366_T383_W0.6040.23
311_G321_S0.6020.23
377_C431_H0.6020.23
377_C418_G0.6020.23
47_V50_S0.6010.23
343_I388_A0.6010.23
299_D311_G0.6000.23
236_S241_L0.5990.23
59_T65_Q0.5980.23
153_R166_D0.5970.23
54_K57_E0.5970.23
384_A387_S0.5940.22
104_K108_K0.5940.22
303_N314_N0.5930.22
330_S336_V0.5930.22
50_S53_A0.5900.22
421_V443_N0.5900.22
374_I444_D0.5900.22
427_K430_G0.5900.22
168_I181_S0.5890.22
313_S323_K0.5890.22
352_S450_V0.5890.22
118_N171_Q0.5880.22
220_A227_T0.5880.22
167_L414_E0.5880.22
346_A406_R0.5880.22
441_F447_S0.5870.22
53_A190_K0.5870.22
309_S318_N0.5870.22
113_R174_D0.5860.22
304_S321_S0.5840.22
268_K273_Q0.5840.22
309_S323_K0.5830.22
330_S334_G0.5830.22
236_S239_S0.5830.22
419_D431_H0.5820.22
295_S300_S0.5800.22
362_G376_D0.5790.22
214_D221_K0.5790.22
304_S318_N0.5780.22
259_Q267_K0.5750.21
65_Q144_S0.5750.21
320_S326_S0.5750.21
156_A185_L0.5740.21
129_Q171_Q0.5730.21
53_A58_L0.5720.21
385_Y393_G0.5720.21
235_K239_S0.5720.21
163_A228_A0.5710.21
56_K101_K0.5710.21
360_K364_G0.5700.21
62_Q141_L0.5700.21
56_K66_S0.5690.21
362_G419_D0.5680.21
303_N315_S0.5680.21
430_G433_G0.5670.21
71_E142_L0.5670.21
300_S312_S0.5670.21
392_L420_L0.5660.21
311_G323_K0.5660.21
382_R386_A0.5660.21
197_A200_E0.5650.21
376_D379_S0.5610.21
295_S304_S0.5610.21
61_L64_N0.5580.21
306_D322_S0.5580.21
330_S333_G0.5580.21
331_N438_N0.5570.21
319_G336_V0.5570.21
306_D311_G0.5560.21
394_P450_V0.5540.20
346_A433_G0.5530.20
307_N311_G0.5530.20
107_I110_T0.5520.20
91_E145_T0.5510.20
61_L65_Q0.5490.20
57_E110_T0.5490.20
302_D306_D0.5470.20
357_S450_V0.5470.20
375_F455_M0.5460.20
297_S300_S0.5440.20
385_Y420_L0.5420.20
110_T117_R0.5420.20
297_S318_N0.5420.20
286_T301_S0.5400.20
400_T407_G0.5390.20
124_R185_L0.5360.20
413_S434_I0.5360.20
106_E181_S0.5350.20
346_A414_E0.5320.20
59_T63_E0.5320.20
298_D304_S0.5310.19
422_F447_S0.5310.19
297_S305_S0.5300.19
294_A301_S0.5290.19
107_I178_L0.5290.19
287_A309_S0.5290.19
319_G325_S0.5280.19
349_V364_G0.5280.19
346_A385_Y0.5280.19
44_Q47_V0.5280.19
376_D431_H0.5260.19
376_D418_G0.5260.19
320_S323_K0.5260.19
354_V432_V0.5240.19
65_Q89_K0.5240.19
359_Y419_D0.5230.19
141_L154_A0.5220.19
343_I424_D0.5210.19
281_T326_S0.5210.19
117_R171_Q0.5200.19
204_K391_N0.5200.19
82_T89_K0.5190.19
399_T433_G0.5190.19
143_G147_F0.5190.19
322_S325_S0.5180.19
304_S308_S0.5170.19
198_K208_K0.5150.19
376_D419_D0.5150.19
82_T206_L0.5140.19
112_A239_S0.5130.19
309_S312_S0.5110.19
308_S318_N0.5100.19
68_I107_I0.5100.19
400_T428_T0.5100.19
303_N310_N0.5090.19
309_S314_N0.5070.18
164_D360_K0.5070.18
304_S324_K0.5070.18
412_A433_G0.5070.18
338_S342_G0.5070.18
373_R442_L0.5040.18
303_N307_N0.5040.18
326_S334_G0.5030.18
403_L432_V0.5010.18
385_Y392_L0.5010.18
415_M464_F0.5010.18
267_K272_A0.5000.18
296_S318_N0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q4gX 1 0.3636 100 0.416 Contact Map
4cgkA 3 0.723 100 0.668 Contact Map
3pbiA 1 0.3805 100 0.677 Contact Map
2k1gA 1 0.2622 100 0.678 Contact Map
4lj1A 1 0.2579 100 0.681 Contact Map
4xcmA 2 0.4038 100 0.702 Contact Map
2hbwA 1 0.3848 100 0.708 Contact Map
4hpeA 1 0.5856 100 0.708 Contact Map
3npfA 2 0.4017 100 0.711 Contact Map
3h41A 1 0.4207 100 0.712 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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