GREMLIN Database
GLNL - Transcriptional regulatory protein GlnL
UniProt: P40759 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 314 (274)
Sequences: 9704 (8930)
Seq/√Len: 539.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_Q72_T3.5581.00
61_D64_E3.4671.00
13_R31_E3.3451.00
17_R31_E3.2941.00
13_R33_D3.0151.00
6_A38_V2.9651.00
231_R234_R2.9431.00
30_G48_I2.9251.00
66_I77_I2.8421.00
53_I65_T2.6781.00
275_E278_S2.6701.00
76_K124_E2.5491.00
2_R28_A2.5261.00
262_K270_S2.5191.00
34_D59_G2.4981.00
36_S59_G2.4661.00
67_R91_E2.4441.00
68_Q71_N2.3931.00
39_E68_Q2.3081.00
43_L69_I2.2861.00
138_V141_T2.1851.00
68_Q72_T2.1521.00
99_Y116_K2.0961.00
264_F268_V2.0921.00
38_V65_T2.0511.00
98_E120_R2.0241.00
227_A231_R2.0141.00
30_G46_K2.0061.00
32_A42_M1.9851.00
35_G60_R1.9671.00
51_L69_I1.9361.00
34_D37_Q1.9101.00
99_Y113_V1.8771.00
98_E117_V1.8771.00
33_D37_Q1.8521.00
66_I79_M1.8451.00
121_I125_H1.8171.00
4_F32_A1.8071.00
43_L48_I1.8011.00
76_K120_R1.7671.00
43_L73_Y1.6971.00
79_M97_I1.6691.00
78_V113_V1.6531.00
60_R68_Q1.6361.00
64_E67_R1.6231.00
259_Y263_F1.6181.00
141_T144_K1.6121.00
3_F27_E1.5871.00
42_M48_I1.5851.00
141_T145_A1.5671.00
78_V117_V1.5671.00
224_E252_S1.5611.00
232_I271_Q1.5591.00
55_L79_M1.5241.00
79_M92_A1.4991.00
239_S243_F1.4901.00
131_Q134_L1.4831.00
241_H245_S1.4661.00
87_E90_G1.4631.00
94_S99_Y1.4571.00
7_D13_R1.4311.00
138_V142_E1.4211.00
53_I79_M1.4151.00
56_L83_V1.4091.00
70_Q98_E1.4051.00
60_R64_E1.3991.00
51_L77_I1.3991.00
91_E94_S1.3831.00
274_K277_Q1.3831.00
127_I131_Q1.3541.00
40_G45_F1.3511.00
67_R71_N1.3451.00
66_I97_I1.3401.00
69_I77_I1.3401.00
127_I130_I1.3201.00
67_R95_L1.2891.00
137_L141_T1.2731.00
6_A51_L1.2701.00
39_E65_T1.2631.00
36_S40_G1.2551.00
35_G65_T1.2321.00
39_E60_R1.2311.00
32_A35_G1.2311.00
4_F43_L1.2311.00
12_V15_I1.2291.00
50_I118_K1.2291.00
86_K89_V1.2121.00
278_S282_K1.2101.00
55_L63_I1.2071.00
53_I77_I1.1941.00
90_G94_S1.1881.00
4_F30_G1.1861.00
64_E68_Q1.1841.00
105_I110_I1.1821.00
131_Q135_S1.1741.00
253_N256_F1.1741.00
9_D12_V1.1701.00
252_S256_F1.1661.00
19_I107_R1.1641.00
22_D26_G1.1621.00
129_A133_S1.1611.00
243_F264_F1.1491.00
134_L137_L1.1401.00
89_V93_Y1.1321.00
138_V144_K1.1291.00
113_V117_V1.1261.00
247_G260_A1.1191.00
51_L65_T1.1151.00
32_A38_V1.1131.00
56_L82_Q1.1081.00
256_F267_P1.1061.00
240_L243_F1.0981.00
118_K122_E1.0971.00
265_D268_V1.0901.00
7_D57_M1.0841.00
121_I124_E1.0741.00
42_M46_K1.0721.00
14_S17_R1.0671.00
76_K98_E1.0651.00
252_S255_K1.0641.00
123_L126_S1.0621.00
142_E145_A1.0591.00
239_S242_H1.0561.00
130_I134_L1.0551.00
57_M60_R1.0551.00
130_I133_S1.0531.00
52_L110_I1.0501.00
61_D91_E1.0471.00
14_S31_E1.0401.00
133_S137_L1.0361.00
43_L51_L1.0331.00
30_G42_M1.0311.00
63_I91_E1.0261.00
85_A88_M1.0261.00
43_L65_T1.0181.00
137_L144_K1.0151.00
17_R21_E1.0121.00
8_D54_D1.0071.00
50_I114_L1.0071.00
223_R226_K1.0061.00
119_E123_L0.9941.00
37_Q40_G0.9941.00
2_R30_G0.9921.00
226_K230_Q0.9801.00
52_L78_V0.9741.00
111_V115_Q0.9671.00
126_S129_A0.9611.00
134_L138_V0.9591.00
12_V82_Q0.9561.00
196_Q199_S0.9541.00
40_G44_Q0.9541.00
5_I16_L0.9511.00
66_I95_L0.9491.00
219_T223_R0.9461.00
53_I66_I0.9441.00
253_N257_E0.9421.00
251_F254_P0.9371.00
137_L143_R0.9371.00
251_F255_K0.9361.00
5_I13_R0.9321.00
264_F272_K0.9311.00
138_V143_R0.9291.00
199_S202_Q0.9281.00
139_N143_R0.9271.00
115_Q119_E0.9261.00
69_I73_Y0.9231.00
155_L159_G0.9231.00
160_T164_S0.9171.00
91_E95_L0.9101.00
75_G124_E0.9061.00
271_Q274_K0.9001.00
2_R48_I0.9001.00
172_G176_D0.8991.00
137_L140_R0.8971.00
269_V273_M0.8961.00
35_G57_M0.8841.00
146_R150_K0.8831.00
208_A212_L0.8811.00
56_L61_D0.8791.00
229_E271_Q0.8731.00
266_F269_V0.8731.00
23_E26_G0.8701.00
54_D103_K0.8691.00
156_K160_T0.8651.00
234_R237_I0.8571.00
63_I92_A0.8561.00
89_V109_E0.8481.00
176_D180_V0.8461.00
271_Q275_E0.8441.00
254_P257_E0.8421.00
126_S130_I0.8411.00
132_H135_S0.8411.00
106_N109_E0.8411.00
36_S60_R0.8411.00
158_A162_L0.8401.00
2_R46_K0.8401.00
55_L92_A0.8391.00
139_N142_E0.8381.00
6_A35_G0.8321.00
137_L142_E0.8291.00
156_K159_G0.8241.00
150_K154_G0.8231.00
27_E50_I0.8201.00
6_A65_T0.8181.00
135_S139_N0.8171.00
136_R140_R0.8141.00
65_T69_I0.8141.00
23_E111_V0.8131.00
228_S271_Q0.8121.00
232_I272_K0.8121.00
109_E113_V0.8111.00
112_T116_K0.8071.00
10_R14_S0.8061.00
229_E267_P0.8041.00
82_Q104_P0.8011.00
159_G163_L0.7981.00
39_E44_Q0.7941.00
159_G162_L0.7921.00
55_L88_M0.7911.00
167_G171_E0.7851.00
137_L145_A0.7841.00
128_G131_Q0.7841.00
32_A37_Q0.7811.00
5_I17_R0.7761.00
268_V271_Q0.7721.00
56_L85_A0.7701.00
224_E243_F0.7681.00
153_S159_G0.7671.00
250_D254_P0.7661.00
129_A132_H0.7641.00
123_L127_I0.7631.00
122_E125_H0.7621.00
265_D269_V0.7561.00
223_R228_S0.7531.00
14_S18_Q0.7521.00
151_S155_L0.7481.00
4_F38_V0.7451.00
219_T222_N0.7441.00
234_R242_H0.7441.00
225_M260_A0.7421.00
119_E122_E0.7411.00
109_E112_T0.7371.00
207_V211_K0.7351.00
75_G128_G0.7331.00
90_G93_Y0.7301.00
16_L80_I0.7301.00
169_M172_G0.7281.00
54_D81_S0.7281.00
135_S138_V0.7271.00
20_I114_L0.7261.00
236_I239_S0.7231.00
27_E118_K0.7221.00
128_G132_H0.7211.00
202_Q206_Q0.7191.00
176_D179_A0.7191.00
260_A263_F0.7151.00
183_Y187_H0.7141.00
150_K153_S0.7131.00
49_D121_I0.7121.00
270_S274_K0.7101.00
140_R143_R0.7051.00
268_V272_K0.7051.00
125_H128_G0.7041.00
105_I109_E0.7041.00
140_R144_K0.7031.00
4_F42_M0.7031.00
83_V88_M0.7011.00
153_S156_K0.7001.00
116_K120_R0.6991.00
184_L187_H0.6981.00
255_K258_T0.6981.00
174_A178_M0.6951.00
124_E128_G0.6941.00
138_V145_A0.6891.00
10_R13_R0.6891.00
223_R227_A0.6891.00
4_F48_I0.6871.00
264_F269_V0.6861.00
84_E89_V0.6841.00
60_R65_T0.6811.00
132_H136_R0.6811.00
66_I70_Q0.6791.00
104_P109_E0.6781.00
152_D156_K0.6731.00
56_L88_M0.6731.00
222_N225_M0.6711.00
246_L278_S0.6701.00
69_I72_T0.6691.00
16_L110_I0.6671.00
175_H179_A0.6671.00
86_K90_G0.6661.00
225_M228_S0.6651.00
52_L114_L0.6621.00
93_Y97_I0.6591.00
6_A32_A0.6581.00
70_Q76_K0.6561.00
108_I112_T0.6541.00
162_L165_E0.6541.00
158_A164_S0.6531.00
53_I69_I0.6531.00
251_F256_F0.6521.00
225_M229_E0.6501.00
18_Q22_D0.6501.00
275_E279_K0.6491.00
155_L158_A0.6471.00
53_I57_M0.6471.00
80_I83_V0.6461.00
107_R111_V0.6451.00
124_E127_I0.6441.00
98_E116_K0.6411.00
8_D81_S0.6391.00
161_F165_E0.6391.00
233_R275_E0.6381.00
195_K199_S0.6361.00
80_I105_I0.6351.00
157_E161_F0.6341.00
8_D57_M0.6321.00
139_N145_A0.6321.00
246_L249_T0.6261.00
6_A57_M0.6261.00
6_A53_I0.6251.00
157_E162_L0.6201.00
79_M98_E0.6191.00
251_F257_E0.6171.00
176_D181_L0.6171.00
134_L144_K0.6151.00
153_S157_E0.6151.00
135_S141_T0.6151.00
20_I111_V0.6121.00
263_F266_F0.6111.00
221_V225_M0.6111.00
70_Q95_L0.6101.00
35_G39_E0.6091.00
54_D57_M0.6091.00
9_D82_Q0.6081.00
241_H244_A0.6061.00
224_E227_A0.6031.00
35_G38_V0.6021.00
224_E228_S0.6011.00
92_A97_I0.5991.00
8_D82_Q0.5991.00
55_L61_D0.5981.00
133_S136_R0.5971.00
225_M256_F0.5941.00
114_L118_K0.5931.00
248_T251_F0.5911.00
35_G61_D0.5911.00
63_I88_M0.5901.00
84_E102_H0.5901.00
9_D56_L0.5901.00
136_R139_N0.5891.00
81_S103_K0.5881.00
171_E176_D0.5870.99
253_N258_T0.5850.99
122_E126_S0.5850.99
131_Q141_T0.5830.99
92_A100_F0.5790.99
113_V116_K0.5720.99
79_M95_L0.5690.99
90_G109_E0.5670.99
79_M89_V0.5640.99
167_G170_G0.5620.99
69_I74_S0.5580.99
170_G174_A0.5580.99
204_F236_I0.5580.99
27_E114_L0.5560.99
55_L66_I0.5550.99
116_K119_E0.5520.99
250_D253_N0.5500.99
161_F164_S0.5500.99
27_E115_Q0.5490.99
242_H245_S0.5490.99
77_I98_E0.5480.99
220_E247_G0.5460.99
35_G59_G0.5450.99
152_D155_L0.5450.99
214_T217_S0.5450.99
151_S154_G0.5420.99
47_Q73_Y0.5410.99
55_L83_V0.5400.99
169_M176_D0.5370.99
3_F22_D0.5360.99
57_M65_T0.5350.99
215_G218_Q0.5350.99
80_I89_V0.5320.99
3_F52_L0.5320.99
170_G173_G0.5310.99
111_V114_L0.5280.99
134_L141_T0.5260.99
233_R237_I0.5260.99
115_Q118_K0.5240.99
277_Q281_A0.5230.99
146_R151_S0.5220.99
44_Q73_Y0.5170.99
34_D57_M0.5160.99
221_V260_A0.5130.99
76_K117_V0.5120.99
54_D82_Q0.5110.99
76_K121_I0.5100.99
187_H191_E0.5090.99
254_P258_T0.5090.99
7_D103_K0.5060.99
271_Q277_Q0.5060.99
89_V97_I0.5050.98
247_G252_S0.5050.98
205_T209_V0.5050.98
206_Q233_R0.5040.98
5_I52_L0.5030.98
146_R152_D0.5010.98
151_S156_K0.5010.98
84_E87_E0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yioA 1 0.621 100 0.517 Contact Map
4g97A 1 0.4045 100 0.527 Contact Map
3n0rA 1 0.379 100 0.529 Contact Map
4b09A 2 0.6115 100 0.537 Contact Map
4gvpA 1 0.6369 100 0.538 Contact Map
1s8nA 1 0.5892 100 0.541 Contact Map
4ldzA 2 0.6115 99.9 0.544 Contact Map
2oqrA 2 0.6401 99.9 0.544 Contact Map
3q9sA 1 0.6115 99.9 0.546 Contact Map
3breA 4 0.9331 99.9 0.546 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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