GREMLIN Database
GLNK - Sensor histidine kinase GlnK
UniProt: P40758 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 410 (353)
Sequences: 15074 (13602)
Seq/√Len: 724.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
209_Y230_I3.7111.00
257_M294_Y3.6281.00
337_E396_V3.6111.00
331_M400_R3.2641.00
387_T398_A3.1971.00
376_K380_T3.1661.00
335_Q396_V3.0621.00
314_M339_N3.0301.00
344_S347_I2.9201.00
348_G388_F2.8701.00
338_D342_G2.8321.00
335_Q398_A2.8071.00
213_K231_H2.7421.00
294_Y382_L2.7341.00
388_F397_F2.7001.00
327_P333_E2.6981.00
256_Y293_E2.6961.00
323_R335_Q2.6741.00
284_Y323_R2.6621.00
333_E400_R2.6141.00
166_R170_T2.5951.00
375_V386_I2.5421.00
348_G390_N2.5111.00
302_I379_V2.4811.00
206_Y234_K2.4731.00
282_D321_S2.4231.00
379_V384_G2.3791.00
282_D319_M2.3521.00
333_E398_A2.3391.00
213_K228_G2.2261.00
323_R337_E2.2141.00
325_R333_E2.1761.00
258_R261_D2.1631.00
302_I378_I2.1521.00
389_D396_V2.1481.00
319_M339_N2.1371.00
284_Y321_S2.1311.00
379_V399_I2.1231.00
325_R335_Q2.0861.00
265_L300_L2.0541.00
254_R293_E2.0421.00
390_N395_V2.0231.00
345_E348_G2.0101.00
177_M181_V2.0021.00
314_M318_G1.9751.00
326_K403_V1.9661.00
318_G339_N1.9591.00
321_S337_E1.9561.00
166_R169_Q1.9501.00
334_F399_I1.9471.00
177_M180_I1.9251.00
302_I375_V1.9251.00
389_D398_A1.9221.00
343_I347_I1.9021.00
255_D296_V1.9021.00
385_D400_R1.8891.00
205_S234_K1.8601.00
352_F386_I1.8531.00
206_Y235_K1.8521.00
343_I351_V1.8091.00
350_I356_F1.7981.00
294_Y299_V1.7971.00
205_S230_I1.7481.00
350_I353_D1.7451.00
347_I350_I1.7351.00
256_Y291_H1.7301.00
219_L223_I1.7281.00
378_I382_L1.6981.00
280_Q319_M1.6931.00
220_S223_I1.6681.00
274_A311_V1.6181.00
212_M223_I1.6101.00
343_I395_V1.6091.00
209_Y231_H1.6021.00
295_H298_I1.5921.00
271_E275_E1.5861.00
270_N304_N1.5851.00
313_A357_T1.5821.00
380_T385_D1.5811.00
212_M227_A1.5721.00
185_Y189_V1.5691.00
170_T173_Q1.5621.00
390_N393_R1.5491.00
173_Q177_M1.5471.00
176_H179_M1.5271.00
347_I356_F1.5251.00
184_L187_E1.5161.00
208_L226_L1.5101.00
308_A312_E1.4941.00
314_M320_V1.4881.00
303_I334_F1.4741.00
176_H180_I1.4641.00
215_K223_I1.4591.00
231_H235_K1.4581.00
213_K224_L1.4551.00
169_Q173_Q1.4471.00
387_T400_R1.4371.00
210_R231_H1.4251.00
298_I301_S1.4051.00
353_D356_F1.3951.00
173_Q176_H1.3881.00
161_Y165_S1.3721.00
338_D394_G1.3571.00
327_P400_R1.3201.00
172_Q175_E1.3041.00
238_Q242_A1.3001.00
243_G298_I1.2891.00
179_M182_S1.2881.00
209_Y227_A1.2841.00
332_V403_V1.2771.00
351_V388_F1.2721.00
170_T174_H1.2611.00
260_S324_L1.2541.00
307_T322_L1.2431.00
352_F388_F1.2291.00
204_D208_L1.2271.00
206_Y238_Q1.2231.00
303_I307_T1.2091.00
298_I378_I1.2051.00
167_E170_T1.1951.00
347_I358_S1.1931.00
285_C324_L1.1901.00
352_F397_F1.1861.00
379_V401_L1.1641.00
197_T301_S1.1571.00
269_M304_N1.1541.00
299_V382_L1.1461.00
171_R175_E1.1461.00
209_Y213_K1.1421.00
305_N375_V1.1391.00
379_V386_I1.1341.00
302_I399_I1.1261.00
310_A320_V1.1231.00
263_L324_L1.1211.00
306_L399_I1.1201.00
260_S264_Q1.1141.00
204_D233_V1.1061.00
75_D79_G1.1041.00
267_I283_F1.1031.00
258_R291_H1.0951.00
175_E179_M1.0951.00
357_T365_T1.0931.00
208_L229_E1.0911.00
312_E359_K1.0891.00
262_L266_V1.0871.00
262_L294_Y1.0831.00
221_G224_L1.0811.00
384_G401_L1.0781.00
321_S339_N1.0701.00
174_H177_M1.0651.00
199_E242_A1.0511.00
175_E178_L1.0501.00
343_I348_G1.0501.00
388_F395_V1.0491.00
266_V307_T1.0451.00
182_S185_Y1.0381.00
157_V161_Y1.0361.00
183_N187_E1.0331.00
209_Y234_K1.0291.00
377_E380_T1.0211.00
331_M385_D1.0071.00
187_E191_L1.0001.00
169_Q172_Q1.0001.00
338_D395_V1.0001.00
265_L296_V0.9951.00
216_D223_I0.9921.00
254_R382_L0.9901.00
198_T237_N0.9891.00
273_Y276_A0.9871.00
216_D219_L0.9871.00
260_S285_C0.9851.00
219_L222_R0.9851.00
174_H178_L0.9801.00
184_L188_T0.9741.00
179_M183_N0.9731.00
229_E233_V0.9711.00
180_I184_L0.9701.00
224_L228_G0.9691.00
259_A334_F0.9691.00
178_L182_S0.9661.00
269_M300_L0.9651.00
228_G232_E0.9591.00
303_I336_V0.9561.00
206_Y231_H0.9531.00
239_R297_F0.9531.00
190_H194_T0.9501.00
351_V397_F0.9471.00
257_M296_V0.9471.00
198_T241_F0.9471.00
286_S289_G0.9461.00
207_Q211_E0.9441.00
270_N311_V0.9331.00
259_A332_V0.9261.00
247_L373_S0.9231.00
167_E171_R0.9201.00
343_I349_D0.9181.00
375_V379_V0.9161.00
322_L334_F0.9081.00
370_I374_Y0.9071.00
233_V236_D0.9041.00
266_V300_L0.8871.00
270_N307_T0.8871.00
306_L397_F0.8871.00
267_I271_E0.8841.00
387_T399_I0.8821.00
343_I390_N0.8781.00
290_E326_K0.8771.00
257_M262_L0.8731.00
343_I388_F0.8711.00
234_K238_Q0.8711.00
310_A336_V0.8701.00
270_N308_A0.8701.00
354_P377_E0.8671.00
313_A359_K0.8671.00
296_V300_L0.8631.00
327_P331_M0.8601.00
337_E391_Q0.8571.00
225_R229_E0.8561.00
289_G324_L0.8561.00
199_E238_Q0.8561.00
313_A341_P0.8541.00
384_G399_I0.8531.00
206_Y210_R0.8521.00
264_Q268_R0.8491.00
193_K354_P0.8451.00
384_G402_P0.8441.00
218_Q223_I0.8421.00
322_L336_V0.8391.00
158_L161_Y0.8391.00
60_E64_G0.8351.00
290_E332_V0.8351.00
267_I281_I0.8351.00
242_A246_K0.8351.00
286_S325_R0.8341.00
357_T367_S0.8331.00
134_P138_T0.8211.00
352_F376_K0.8181.00
263_L283_F0.8171.00
307_T320_V0.8171.00
277_L311_V0.8151.00
279_K283_F0.8141.00
264_Q283_F0.8141.00
56_R60_E0.8111.00
220_S224_L0.8111.00
211_E226_L0.8091.00
194_T244_L0.8071.00
197_T240_I0.8061.00
300_L304_N0.8041.00
249_S368_T0.8031.00
266_V270_N0.8031.00
189_V354_P0.8021.00
279_K314_M0.8011.00
183_N186_E0.8011.00
236_D300_L0.7991.00
171_R174_H0.7991.00
266_V304_N0.7941.00
262_L299_V0.7941.00
181_V184_L0.7901.00
377_E381_E0.7881.00
70_T74_Y0.7851.00
279_K311_V0.7851.00
331_M402_P0.7851.00
205_S209_Y0.7841.00
199_E245_S0.7821.00
168_K171_R0.7781.00
172_Q176_H0.7751.00
79_G82_F0.7741.00
208_L230_I0.7741.00
333_E387_T0.7691.00
324_L332_V0.7671.00
188_T251_E0.7671.00
348_G352_F0.7651.00
168_K172_Q0.7631.00
146_S150_I0.7621.00
324_L334_F0.7581.00
212_M230_I0.7581.00
263_L322_L0.7571.00
274_A320_V0.7551.00
197_T201_V0.7541.00
181_V185_Y0.7491.00
263_L303_I0.7481.00
254_R294_Y0.7421.00
342_G395_V0.7421.00
156_S160_L0.7401.00
348_G397_F0.7391.00
345_E391_Q0.7321.00
330_S403_V0.7291.00
60_E63_G0.7281.00
180_I183_N0.7271.00
160_L163_T0.7271.00
57_V61_L0.7261.00
153_S156_S0.7231.00
267_I322_L0.7161.00
200_K204_D0.7151.00
86_Y91_S0.7141.00
306_L375_V0.7131.00
191_L195_L0.7121.00
159_K163_T0.7091.00
204_D229_E0.7091.00
343_I397_F0.7081.00
72_I76_Q0.7071.00
213_K227_A0.7071.00
243_G301_S0.7061.00
223_I227_A0.7041.00
57_V60_E0.7021.00
301_S304_N0.6981.00
342_G394_G0.6971.00
150_I157_V0.6951.00
313_A365_T0.6941.00
299_V401_L0.6941.00
237_N240_I0.6911.00
228_G231_H0.6911.00
141_A145_I0.6891.00
246_K301_S0.6881.00
262_L300_L0.6881.00
196_K200_K0.6811.00
274_A281_I0.6811.00
232_E265_L0.6811.00
120_E123_V0.6771.00
156_S159_K0.6771.00
159_K162_E0.6761.00
216_D220_S0.6751.00
287_I290_E0.6751.00
223_I226_L0.6741.00
263_L266_V0.6741.00
261_D265_L0.6731.00
162_E165_S0.6731.00
202_T241_F0.6711.00
301_S378_I0.6691.00
268_R271_E0.6691.00
161_Y164_Q0.6681.00
372_L375_V0.6661.00
87_A91_S0.6651.00
182_S186_E0.6651.00
230_I234_K0.6651.00
98_F101_R0.6641.00
136_K140_I0.6641.00
157_V162_E0.6641.00
341_P365_T0.6641.00
72_I75_D0.6641.00
208_L211_E0.6611.00
131_V135_E0.6611.00
386_I397_F0.6611.00
189_V377_E0.6591.00
91_S95_A0.6591.00
267_I307_T0.6581.00
143_I147_H0.6551.00
59_L63_G0.6511.00
57_V64_G0.6491.00
298_I382_L0.6491.00
312_E357_T0.6491.00
237_N241_F0.6491.00
357_T366_P0.6481.00
178_L181_V0.6461.00
226_L229_E0.6451.00
335_Q389_D0.6421.00
199_E237_N0.6391.00
69_L73_L0.6371.00
306_L379_V0.6371.00
373_S377_E0.6371.00
120_E124_Q0.6371.00
247_L251_E0.6361.00
58_F62_W0.6361.00
198_T244_L0.6351.00
200_K207_Q0.6331.00
203_N207_Q0.6331.00
298_I381_E0.6311.00
73_L77_A0.6301.00
203_N208_L0.6301.00
155_Y159_K0.6301.00
180_I188_T0.6261.00
302_I306_L0.6231.00
315_D318_G0.6191.00
69_L79_G0.6191.00
229_E232_E0.6191.00
239_R243_G0.6191.00
102_P105_L0.6181.00
262_L265_L0.6181.00
189_V193_K0.6171.00
306_L386_I0.6171.00
280_Q283_F0.6171.00
361_D366_P0.6161.00
90_F94_K0.6161.00
198_T201_V0.6141.00
351_V373_S0.6141.00
227_A230_I0.6131.00
195_L201_V0.6121.00
169_Q177_M0.6121.00
374_Y378_I0.6121.00
122_T125_F0.6111.00
121_L124_Q0.6101.00
304_N308_A0.6081.00
314_M317_E0.6041.00
51_A54_I0.6041.00
302_I382_L0.6031.00
54_I58_F0.6021.00
75_D78_S0.6021.00
71_P75_D0.6011.00
116_S120_E0.5991.00
49_G60_E0.5991.00
70_T75_D0.5971.00
117_D120_E0.5951.00
345_E390_N0.5931.00
91_S94_K0.5921.00
101_R105_L0.5881.00
61_L65_G0.5881.00
254_R383_E0.5871.00
68_G71_P0.5861.00
309_N371_G0.5841.00
49_G52_V0.5841.00
191_L194_T0.5821.00
136_K139_D0.5811.00
62_W65_G0.5811.00
257_M299_V0.5801.00
253_L295_H0.5791.00
153_S157_V0.5771.00
147_H151_V0.5741.00
152_M159_K0.5741.00
75_D82_F0.5731.00
354_P373_S0.5731.00
119_V123_V0.5721.00
111_M115_V0.5711.00
274_A279_K0.5711.00
286_S290_E0.5701.00
258_R289_G0.5701.00
166_R173_Q0.5701.00
251_E354_P0.5681.00
104_M107_F0.5651.00
326_K330_S0.5631.00
249_S305_N0.5621.00
113_E117_D0.5621.00
351_V356_F0.5591.00
144_A147_H0.5581.00
299_V303_I0.5571.00
74_Y79_G0.5561.00
158_L162_E0.5521.00
203_N206_Y0.5511.00
274_A277_L0.5511.00
264_Q267_I0.5511.00
260_S289_G0.5501.00
288_E326_K0.5501.00
245_S248_I0.5491.00
341_P395_V0.5491.00
160_L164_Q0.5481.00
61_L66_H0.5481.00
123_V126_L0.5481.00
55_F58_F0.5481.00
156_S163_T0.5471.00
244_L248_I0.5471.00
231_H234_K0.5461.00
215_K219_L0.5461.00
139_D143_I0.5451.00
306_L336_V0.5451.00
361_D365_T0.5451.00
55_F60_E0.5431.00
149_F152_M0.5421.00
125_F128_F0.5421.00
297_F300_L0.5421.00
215_K220_S0.5411.00
272_K276_A0.5401.00
152_M156_S0.5401.00
399_I402_P0.5401.00
379_V385_D0.5391.00
334_F401_L0.5381.00
92_I95_A0.5381.00
212_M226_L0.5371.00
76_Q79_G0.5361.00
210_R214_G0.5361.00
74_Y78_S0.5361.00
286_S324_L0.5351.00
338_D341_P0.5341.00
216_D224_L0.5331.00
208_L233_V0.5331.00
281_I322_L0.5331.00
274_A278_G0.5311.00
62_W66_H0.5311.00
148_T151_V0.5311.00
148_T152_M0.5311.00
221_G225_R0.5301.00
339_N393_R0.5301.00
195_L199_E0.5291.00
250_N377_E0.5281.00
355_G370_I0.5281.00
63_G67_N0.5271.00
307_T311_V0.5271.00
101_R104_M0.5261.00
190_H193_K0.5261.00
94_K98_F0.5261.00
245_S249_S0.5251.00
359_K365_T0.5231.00
222_R226_L0.5231.00
69_L72_I0.5211.00
151_V155_Y0.5201.00
85_T88_C0.5201.00
245_S368_T0.5191.00
197_T200_K0.5181.00
266_V269_M0.5171.00
88_C91_S0.5171.00
203_N233_V0.5151.00
204_D207_Q0.5151.00
112_I116_S0.5151.00
295_H382_L0.5151.00
131_V134_P0.5151.00
52_V60_E0.5151.00
193_K197_T0.5151.00
140_I144_A0.5141.00
71_P74_Y0.5131.00
60_E65_G0.5121.00
148_T156_S0.5111.00
225_R228_G0.5101.00
270_N273_Y0.5091.00
238_Q241_F0.5091.00
379_V382_L0.5091.00
330_S402_P0.5081.00
123_V127_I0.5071.00
285_C289_G0.5071.00
122_T127_I0.5061.00
120_E125_F0.5061.00
311_V320_V0.5061.00
235_K238_Q0.5050.99
102_P106_G0.5050.99
57_V62_W0.5040.99
62_W67_N0.5040.99
86_Y89_L0.5040.99
236_D240_I0.5030.99
340_G395_V0.5020.99
284_Y325_R0.5020.99
52_V59_L0.5000.99
97_R100_E0.5000.99
119_V125_F0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.6537 100 0.425 Contact Map
4q20A 2 0.5488 100 0.436 Contact Map
3d36A 2 0.5341 100 0.449 Contact Map
3jz3A 2 0.3805 100 0.45 Contact Map
3a0rA 2 0.8049 100 0.452 Contact Map
2c2aA 2 0.5585 100 0.454 Contact Map
4bixA 2 0.5463 100 0.455 Contact Map
4mpcA 2 0.7049 100 0.457 Contact Map
2q8gA 2 0.7439 100 0.468 Contact Map
4gczA 2 0.8829 100 0.473 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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