TGL - BACSU - GREMLIN Contacts

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TGL - Protein-glutamine gamma-glutamyltransferase

UniProt:	P40746	Sequences: MIIVSGQLLRPQDIENWQIDQDLNPLLKEMIETPVQFDYHSIAELMFELKLRMNIVAAAKTLHKSGAKFATFLKTYGNTTYWRVSPEGALELKYRMPPSKAIRDIAENGPFYAFECATAIVIIYYLALIDTIGEDKFNASFDRIILYDWHYEKLPIYTETGHHFFLGDCLYFKNPEFDPQKAQWRGENVILLGEDKYFAHGLGILNGKQIIDKLNSFRKKGALQSAYLLSQATRLDVPSLFRIVR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	245 (228)
Sequences:	137 (115)
Seq/√Len:	7.6

BACSU - TGL

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
66_G	109_G	4.314	0.98
170_L	189_V	4.046	0.97
97_P	138_N	3.942	0.96
169_C	190_I	3.669	0.95
67_A	114_F	3.613	0.94
126_L	130_D	3.462	0.93
77_G	90_L	3.430	0.92
75_T	84_V	3.419	0.92
95_R	120_I	3.046	0.87
173_K	185_R	2.905	0.84
77_G	84_V	2.842	0.83
62_L	65_S	2.602	0.76
118_T	122_I	2.500	0.73
75_T	90_L	2.473	0.73
121_V	237_V	2.267	0.65
56_V	123_I	2.162	0.62
121_V	148_D	2.159	0.61
158_T	233_T	2.107	0.60
30_M	234_R	1.924	0.52
58_A	126_L	1.912	0.52
177_F	185_R	1.910	0.52
84_V	90_L	1.857	0.50
176_E	222_A	1.853	0.49
51_L	128_L	1.836	0.49
90_L	181_K	1.835	0.49
58_A	123_I	1.803	0.47
190_I	210_I	1.781	0.47
171_Y	186_G	1.773	0.46
48_E	237_V	1.773	0.46
177_F	198_F	1.730	0.45
104_D	108_N	1.728	0.45
72_F	117_A	1.726	0.44
184_W	187_E	1.699	0.43
179_P	211_I	1.680	0.43
124_Y	169_C	1.668	0.42
45_L	102_I	1.650	0.41
123_I	192_L	1.637	0.41
184_W	203_G	1.635	0.41
169_C	210_I	1.582	0.39
62_L	202_L	1.562	0.38
37_F	77_G	1.561	0.38
114_F	132_I	1.534	0.37
187_E	203_G	1.511	0.36
81_Y	181_K	1.506	0.36
147_Y	227_Y	1.502	0.36
55_I	138_N	1.479	0.35
81_Y	101_A	1.458	0.34
61_T	75_T	1.449	0.34
148_D	198_F	1.444	0.34
59_A	102_I	1.434	0.33
90_L	146_L	1.416	0.33
184_W	197_Y	1.410	0.33
90_L	105_I	1.408	0.32
70_A	176_E	1.403	0.32
76_Y	113_A	1.390	0.32
81_Y	133_G	1.384	0.32
126_L	236_D	1.382	0.32
71_T	74_K	1.381	0.32
216_S	232_A	1.381	0.32
114_F	198_F	1.375	0.31
163_H	190_I	1.373	0.31
27_L	56_V	1.368	0.31
75_T	119_A	1.356	0.31
75_T	213_K	1.349	0.30
91_E	102_I	1.331	0.30
23_L	71_T	1.322	0.30
123_I	130_D	1.297	0.29
95_R	198_F	1.285	0.28
150_H	236_D	1.285	0.28
139_A	143_R	1.270	0.28
45_L	49_L	1.243	0.27
164_F	234_R	1.232	0.27
160_T	219_K	1.228	0.27
37_F	164_F	1.224	0.26
46_M	79_T	1.217	0.26
70_A	114_F	1.214	0.26
99_S	234_R	1.194	0.25
29_E	70_A	1.182	0.25
146_L	210_I	1.172	0.25
81_Y	182_A	1.170	0.25
184_W	202_L	1.169	0.25
70_A	113_A	1.166	0.25
113_A	165_F	1.164	0.25
90_L	122_I	1.157	0.24
98_P	208_K	1.156	0.24
37_F	227_Y	1.156	0.24
49_L	197_Y	1.137	0.24
65_S	120_I	1.133	0.24
83_R	93_K	1.132	0.24
148_D	151_Y	1.130	0.24
163_H	169_C	1.129	0.24
114_F	144_I	1.121	0.23
140_S	144_I	1.112	0.23
105_I	122_I	1.110	0.23
147_Y	150_H	1.108	0.23
62_L	236_D	1.095	0.23
195_D	206_N	1.095	0.23
23_L	30_M	1.094	0.23
94_Y	222_A	1.092	0.23
195_D	208_K	1.083	0.22
99_S	143_R	1.071	0.22
23_L	148_D	1.062	0.22
72_F	177_F	1.061	0.22
65_S	202_L	1.060	0.22
67_A	198_F	1.057	0.22
70_A	74_K	1.044	0.21
44_E	101_A	1.043	0.21
16_N	36_Q	1.040	0.21
134_E	207_G	1.038	0.21
161_G	235_L	1.026	0.21
178_D	181_K	1.023	0.21
37_F	46_M	1.018	0.21
123_I	198_F	1.002	0.20
190_I	240_L	0.995	0.20
29_E	114_F	0.991	0.20
120_I	198_F	0.990	0.20
56_V	209_Q	0.988	0.20
119_A	149_W	0.982	0.20
54_N	91_E	0.979	0.20
75_T	184_W	0.978	0.19
73_L	150_H	0.976	0.19
117_A	233_T	0.964	0.19
109_G	155_P	0.962	0.19
87_E	91_E	0.961	0.19
120_I	127_A	0.960	0.19
193_G	219_K	0.950	0.19
59_A	191_L	0.949	0.19
30_M	164_F	0.946	0.19
135_D	197_Y	0.933	0.18
30_M	49_L	0.932	0.18
94_Y	190_I	0.930	0.18
77_G	173_K	0.928	0.18
19_I	196_K	0.926	0.18
32_E	169_C	0.926	0.18
72_F	240_L	0.925	0.18
56_V	210_I	0.916	0.18
71_T	76_Y	0.914	0.18
121_V	150_H	0.911	0.18
80_T	113_A	0.905	0.18
14_I	57_A	0.901	0.18
55_I	101_A	0.898	0.18
79_T	158_T	0.888	0.17
183_Q	236_D	0.887	0.17
75_T	197_Y	0.886	0.17
68_K	190_I	0.876	0.17
185_R	192_L	0.876	0.17
44_E	234_R	0.874	0.17
182_A	195_D	0.873	0.17
133_G	189_V	0.869	0.17
65_S	183_Q	0.867	0.17
21_Q	101_A	0.864	0.17
114_F	148_D	0.863	0.17
26_L	138_N	0.858	0.17
58_A	130_D	0.852	0.17
161_G	234_R	0.851	0.17
61_T	73_L	0.849	0.16
186_G	192_L	0.846	0.16
171_Y	192_L	0.846	0.16
94_Y	140_S	0.843	0.16
219_K	230_S	0.841	0.16
77_G	146_L	0.838	0.16
118_T	240_L	0.835	0.16
51_L	184_W	0.829	0.16
63_H	106_A	0.826	0.16
87_E	224_Q	0.823	0.16
27_L	210_I	0.819	0.16
109_G	241_F	0.816	0.16
190_I	193_G	0.816	0.16
62_L	123_I	0.815	0.16
68_K	210_I	0.808	0.16
90_L	126_L	0.807	0.16
81_Y	196_K	0.805	0.16
84_V	183_Q	0.802	0.15
89_A	169_C	0.800	0.15
123_I	127_A	0.797	0.15
105_I	146_L	0.797	0.15
158_T	232_A	0.796	0.15
41_S	227_Y	0.788	0.15
41_S	44_E	0.786	0.15
74_K	144_I	0.785	0.15
47_F	211_I	0.781	0.15
76_Y	239_S	0.774	0.15
109_G	195_D	0.772	0.15
54_N	130_D	0.765	0.15
61_T	93_K	0.763	0.15
98_P	138_N	0.762	0.15
106_A	126_L	0.761	0.15
111_F	144_I	0.758	0.15
101_A	212_D	0.756	0.15
101_A	196_K	0.755	0.15
143_R	205_L	0.755	0.15
33_T	36_Q	0.746	0.14
42_I	95_R	0.745	0.14
118_T	146_L	0.740	0.14
24_N	36_Q	0.737	0.14
23_L	53_M	0.735	0.14
36_Q	209_Q	0.728	0.14
16_N	106_A	0.728	0.14
143_R	152_E	0.724	0.14
156_I	213_K	0.717	0.14
61_T	194_E	0.711	0.14
153_K	232_A	0.711	0.14
67_A	193_G	0.706	0.14
204_I	225_S	0.704	0.14
73_L	113_A	0.704	0.14
58_A	236_D	0.701	0.13
117_A	146_L	0.698	0.13
124_Y	235_L	0.697	0.13
27_L	42_I	0.696	0.13
123_I	189_V	0.695	0.13
42_I	208_K	0.694	0.13
61_T	225_S	0.692	0.13
15_E	24_N	0.686	0.13
62_L	66_G	0.685	0.13
93_K	179_P	0.682	0.13
198_F	211_I	0.682	0.13
37_F	102_I	0.678	0.13
123_I	210_I	0.677	0.13
35_V	42_I	0.669	0.13
76_Y	93_K	0.668	0.13
76_Y	86_P	0.665	0.13
203_G	226_A	0.663	0.13
38_D	148_D	0.662	0.13
100_K	237_V	0.655	0.13
189_V	210_I	0.653	0.13
59_A	113_A	0.653	0.13
58_A	189_V	0.652	0.13
71_T	197_Y	0.651	0.13
110_P	155_P	0.650	0.13
118_T	177_F	0.649	0.13
134_E	208_K	0.647	0.12
35_V	207_G	0.645	0.12
170_L	191_L	0.645	0.12
51_L	241_F	0.644	0.12
179_P	221_G	0.643	0.12
87_E	93_K	0.643	0.12
89_A	161_G	0.641	0.12
121_V	182_A	0.640	0.12
17_W	124_Y	0.634	0.12
140_S	177_F	0.626	0.12
132_I	144_I	0.626	0.12
124_Y	142_D	0.623	0.12
30_M	44_E	0.621	0.12
128_L	165_F	0.619	0.12
48_E	235_L	0.618	0.12
19_I	48_E	0.618	0.12
71_T	80_T	0.617	0.12
33_T	53_M	0.615	0.12
122_I	235_L	0.614	0.12
41_S	51_L	0.614	0.12
37_F	49_L	0.612	0.12
147_Y	233_T	0.611	0.12
91_E	101_A	0.610	0.12
66_G	71_T	0.608	0.12
162_H	195_D	0.608	0.12
62_L	189_V	0.604	0.12
118_T	131_T	0.604	0.12
58_A	147_Y	0.604	0.12
32_E	225_S	0.601	0.12
28_K	59_A	0.599	0.12
44_E	54_N	0.599	0.12
156_I	177_F	0.598	0.12
22_D	138_N	0.598	0.12
41_S	45_L	0.596	0.12
169_C	235_L	0.595	0.12
67_A	91_E	0.595	0.12
193_G	205_L	0.594	0.12
49_L	124_Y	0.593	0.12
63_H	189_V	0.590	0.12
43_A	135_D	0.590	0.12
134_E	138_N	0.589	0.12
152_E	239_S	0.588	0.11
106_A	221_G	0.585	0.11
18_Q	56_V	0.583	0.11
123_I	235_L	0.583	0.11
48_E	52_R	0.582	0.11
32_E	107_E	0.582	0.11
231_Q	238_P	0.581	0.11
62_L	184_W	0.581	0.11
103_R	126_L	0.580	0.11
151_Y	184_W	0.580	0.11
62_L	222_A	0.580	0.11
190_I	198_F	0.579	0.11
206_N	241_F	0.577	0.11
61_T	95_R	0.574	0.11
23_L	232_A	0.572	0.11
106_A	223_L	0.572	0.11
68_K	120_I	0.572	0.11
127_A	156_I	0.572	0.11
129_I	147_Y	0.569	0.11
114_F	185_R	0.568	0.11
172_F	207_G	0.568	0.11
90_L	145_I	0.566	0.11
131_T	180_Q	0.565	0.11
138_N	141_F	0.564	0.11
185_R	234_R	0.564	0.11
222_A	234_R	0.562	0.11
216_S	233_T	0.560	0.11
57_A	176_E	0.560	0.11
70_A	185_R	0.558	0.11
38_D	81_Y	0.550	0.11
30_M	165_F	0.550	0.11
59_A	70_A	0.549	0.11
123_I	209_Q	0.549	0.11
19_I	177_F	0.548	0.11
85_S	89_A	0.545	0.11
19_I	202_L	0.542	0.11
24_N	91_E	0.541	0.11
67_A	135_D	0.540	0.11
74_K	180_Q	0.538	0.11
89_A	231_Q	0.537	0.11
80_T	120_I	0.536	0.11
60_K	94_Y	0.534	0.11
133_G	185_R	0.532	0.11
62_L	159_E	0.532	0.11
60_K	209_Q	0.526	0.11
55_I	124_Y	0.523	0.10
83_R	206_N	0.523	0.10
150_H	155_P	0.521	0.10
39_Y	67_A	0.520	0.10
121_V	156_I	0.520	0.10
108_N	204_I	0.518	0.10
59_A	111_F	0.518	0.10
172_F	210_I	0.517	0.10
180_Q	229_L	0.515	0.10
42_I	110_P	0.514	0.10
89_A	166_L	0.514	0.10
89_A	235_L	0.514	0.10
79_T	131_T	0.512	0.10
101_A	138_N	0.510	0.10
114_F	147_Y	0.510	0.10
62_L	210_I	0.509	0.10
119_A	186_G	0.509	0.10
119_A	171_Y	0.509	0.10
151_Y	173_K	0.509	0.10
191_L	222_A	0.508	0.10
101_A	132_I	0.508	0.10
86_P	230_S	0.505	0.10
136_K	234_R	0.503	0.10
54_N	185_R	0.503	0.10
183_Q	230_S	0.501	0.10
173_K	183_Q	0.500	0.10

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2jtxA	1	0.1633	31.6	0.973	Contact Map
4bb7A	2	0.3143	29.7	0.973	Contact Map
4dpzX	1	0.2612	24.5	0.974	Contact Map
2if6A	1	0.298	22.9	0.975	Contact Map
4dotA	1	0.249	19.1	0.976	Contact Map
3lrxA	3	0.2408	18.6	0.976	Contact Map
2k1gA	1	0.502	18.4	0.976	Contact Map
4q95A	3	0.3184	17.9	0.976	Contact Map
4hz9A	1	0.4776	17.6	0.976	Contact Map
3kw0A	3	0.4286	17.4	0.976	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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