GREMLIN Database
BGLH - Aryl-phospho-beta-D-glucosidase BglH
UniProt: P40740 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 469 (440)
Sequences: 6788 (4229)
Seq/√Len: 201.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_G104_E4.3301.00
384_Q453_K4.1021.00
114_D166_K3.6031.00
110_D166_K3.1991.00
399_A409_L3.1821.00
76_A119_H3.1281.00
69_K115_E3.0601.00
110_D162_R2.9481.00
127_I159_V2.9231.00
451_K455_F2.8911.00
115_E118_K2.8671.00
103_E107_R2.8651.00
107_R111_D2.7831.00
63_D66_H2.7761.00
103_E162_R2.7531.00
306_Y395_H2.7061.00
93_F158_T2.6961.00
398_E401_E2.6861.00
241_T246_D2.6301.00
157_K161_K2.6151.00
29_E66_H2.5731.00
16_G80_F2.4551.00
392_L414_S2.3781.00
73_A119_H2.3221.00
350_R405_D2.3211.00
354_N405_D2.2961.00
146_R290_D2.2691.00
150_E214_L2.2551.00
390_N394_D2.2421.00
219_G228_I2.2311.00
42_N59_H2.2101.00
217_K221_D2.2041.00
113_F163_Y2.1841.00
436_Y450_I2.1571.00
64_F108_F2.1531.00
386_D453_K2.1451.00
69_K111_D2.1231.00
82_A413_T2.1121.00
72_I112_L2.0581.00
122_E168_K2.0501.00
64_F83_F2.0361.00
459_Q463_A2.0131.00
87_I125_V1.9981.00
378_E382_T1.9501.00
117_L166_K1.9431.00
39_V134_L1.9201.00
153_E218_A1.9071.00
104_E107_R1.8791.00
271_G275_R1.8781.00
72_I119_H1.8751.00
157_K218_A1.8741.00
85_T113_F1.8741.00
289_G292_E1.8561.00
206_H269_Y1.8361.00
27_Y34_L1.8271.00
35_S90_T1.8061.00
219_G226_S1.7981.00
350_R401_E1.7941.00
26_A29_E1.7891.00
157_K222_I1.7871.00
34_L39_V1.7871.00
110_D114_D1.7771.00
214_L293_L1.7761.00
238_Y351_I1.7591.00
14_W465_N1.7171.00
115_E119_H1.7061.00
223_I226_S1.7031.00
18_V23_V1.6941.00
114_D117_L1.6861.00
122_E169_Y1.6731.00
286_M291_E1.6681.00
347_K398_E1.6491.00
73_A115_E1.6411.00
85_T112_L1.6321.00
116_L121_I1.6261.00
113_F117_L1.6201.00
353_L407_V1.6051.00
460_Q463_A1.5961.00
140_Y151_F1.5961.00
110_D163_Y1.5941.00
135_G139_N1.5881.00
350_R354_N1.5841.00
268_A295_K1.5841.00
306_Y348_G1.5811.00
355_T359_R1.5721.00
153_E214_L1.5621.00
266_R361_Q1.5591.00
72_I115_E1.5501.00
365_F410_I1.5471.00
171_M231_M1.5411.00
13_L82_A1.5411.00
68_Y111_D1.5361.00
21_N58_Y1.5271.00
148_V151_F1.5221.00
160_F219_G1.4951.00
205_A260_F1.4931.00
82_A124_V1.4571.00
165_H223_I1.4501.00
438_D446_T1.4481.00
259_F273_M1.4461.00
18_V83_F1.4461.00
67_R70_E1.4421.00
72_I116_L1.4341.00
33_G96_G1.4281.00
144_K200_A1.4271.00
369_N412_Y1.4241.00
75_F80_F1.4181.00
349_L399_A1.4131.00
171_M301_Y1.4111.00
93_F101_P1.4061.00
261_S302_I1.4031.00
106_L158_T1.4031.00
357_Y362_K1.4011.00
95_N98_E1.3981.00
141_G145_N1.3801.00
218_A221_D1.3711.00
77_E455_F1.3701.00
414_S434_F1.3681.00
39_V139_N1.3631.00
85_T125_V1.3621.00
254_E272_Y1.3611.00
43_G51_S1.3611.00
124_V413_T1.3461.00
339_E374_V1.3411.00
63_D67_R1.3331.00
26_A66_H1.3221.00
460_Q464_T1.3131.00
168_K225_D1.3111.00
87_I159_V1.3101.00
230_C264_Q1.3091.00
268_A274_K1.3081.00
457_W461_V1.3061.00
451_K456_N1.2901.00
353_L399_A1.2891.00
169_Y227_K1.2821.00
396_L399_A1.2781.00
268_A361_Q1.2551.00
134_L138_K1.2531.00
173_F211_A1.2471.00
97_D151_F1.2401.00
456_N459_Q1.2311.00
287_A290_D1.2291.00
197_K200_A1.2251.00
150_E153_E1.2241.00
377_V450_I1.2201.00
87_I92_I1.2191.00
146_R207_H1.2191.00
291_E294_L1.2181.00
173_F208_Q1.2141.00
394_D397_I1.2121.00
393_R397_I1.2111.00
73_A77_E1.2111.00
147_K150_E1.2101.00
179_V208_Q1.2061.00
75_F435_I1.1901.00
354_N407_V1.1871.00
106_L162_R1.1801.00
382_T453_K1.1771.00
64_F112_L1.1691.00
143_W148_V1.1631.00
68_Y115_E1.1611.00
195_E200_A1.1591.00
127_I152_Y1.1581.00
62_I418_I1.1581.00
110_D165_H1.1551.00
132_M148_V1.1521.00
357_Y408_E1.1491.00
262_D359_R1.1471.00
160_F215_A1.1421.00
134_L139_N1.1391.00
26_A30_G1.1341.00
400_R404_A1.1301.00
239_P247_V1.1291.00
27_Y32_K1.1241.00
97_D140_Y1.1231.00
156_A215_A1.1221.00
18_V85_T1.1221.00
33_G135_G1.1201.00
239_P250_A1.1201.00
458_Y462_I1.1131.00
9_P403_I1.1101.00
262_D266_R1.1091.00
161_K222_I1.1091.00
439_R447_F1.1001.00
153_E215_A1.1001.00
160_F228_I1.0931.00
244_P247_V1.0901.00
219_G223_I1.0901.00
378_E384_Q1.0891.00
400_R403_I1.0871.00
147_K151_F1.0811.00
244_P248_F1.0771.00
237_T253_N1.0761.00
106_L110_D1.0721.00
347_K351_I1.0691.00
77_E451_K1.0691.00
113_F125_V1.0681.00
113_F166_K1.0681.00
95_N135_G1.0671.00
240_M313_S1.0591.00
216_V220_H1.0591.00
234_A352_T1.0571.00
110_D117_L1.0571.00
8_F403_I1.0551.00
153_E157_K1.0531.00
219_G224_P1.0471.00
214_L218_A1.0471.00
401_E404_A1.0451.00
245_E347_K1.0361.00
140_Y147_K1.0351.00
8_F400_R1.0341.00
349_L409_L1.0321.00
33_G94_P1.0311.00
254_E258_L1.0301.00
248_F252_E1.0291.00
390_N393_R1.0281.00
254_E273_M1.0281.00
218_A222_I1.0281.00
101_P158_T1.0271.00
156_A218_A1.0241.00
381_G450_I1.0231.00
340_W372_G1.0201.00
67_R448_N1.0191.00
207_H210_V1.0191.00
288_E291_E1.0191.00
245_E314_T1.0171.00
60_N439_R1.0161.00
337_S343_Q1.0101.00
246_D314_T1.0071.00
377_V381_G1.0061.00
349_L366_I1.0051.00
16_G75_F1.0041.00
92_I158_T1.0021.00
338_S371_L1.0011.00
60_N447_F0.9981.00
217_K297_H0.9921.00
268_A271_G0.9901.00
438_D448_N0.9891.00
164_Q226_S0.9791.00
243_K247_V0.9791.00
247_V250_A0.9781.00
275_R278_A0.9781.00
389_I457_W0.9781.00
32_K90_T0.9771.00
159_V163_Y0.9771.00
151_F154_R0.9741.00
158_T162_R0.9721.00
331_K335_L0.9711.00
336_K387_Y0.9700.99
23_V64_F0.9700.99
124_V169_Y0.9690.99
124_V365_F0.9690.99
146_R287_A0.9670.99
11_G410_I0.9670.99
251_M254_E0.9600.99
253_N312_A0.9580.99
132_M142_G0.9540.99
81_K465_N0.9520.99
336_K394_D0.9470.99
13_L124_V0.9440.99
157_K223_I0.9440.99
248_F251_M0.9390.99
149_I214_L0.9390.99
160_F226_S0.9370.99
374_V429_K0.9330.99
56_N429_K0.9290.99
373_A387_Y0.9260.99
216_V228_I0.9250.99
141_G144_K0.9240.99
431_R439_R0.9160.99
180_L204_A0.9150.99
93_F98_E0.9140.99
98_E135_G0.9090.99
107_R110_D0.9070.99
265_A362_K0.9050.99
70_E73_A0.9030.99
229_G303_G0.9030.99
357_Y361_Q0.9010.99
198_L280_N0.9010.99
156_A160_F0.8980.99
193_E196_N0.8860.99
162_R166_K0.8860.99
237_T250_A0.8860.99
340_W430_K0.8840.99
377_V382_T0.8840.99
215_A218_A0.8840.99
73_A76_A0.8820.99
111_D114_D0.8810.99
242_S247_V0.8780.99
418_I437_V0.8770.99
106_L159_V0.8770.99
331_K337_S0.8760.99
80_F417_P0.8730.99
461_V465_N0.8700.99
165_H226_S0.8690.99
276_Y280_N0.8670.99
336_K390_N0.8670.99
217_K293_L0.8660.99
108_F112_L0.8650.99
75_F121_I0.8650.99
117_L123_P0.8640.99
262_D360_Y0.8640.99
371_L387_Y0.8620.99
229_G301_Y0.8600.99
110_D113_F0.8590.99
372_G430_K0.8560.99
251_M272_Y0.8540.99
155_Y159_V0.8490.99
403_I409_L0.8460.99
52_M55_L0.8460.99
232_I261_S0.8460.99
212_S216_V0.8450.99
31_G102_N0.8450.99
289_G293_L0.8430.99
128_S132_M0.8430.99
227_K363_P0.8420.99
164_Q223_I0.8410.99
140_Y148_V0.8400.99
349_L398_E0.8380.99
97_D139_N0.8340.98
95_N100_E0.8340.98
347_K401_E0.8300.98
172_T230_C0.8270.98
171_M303_G0.8260.98
309_S343_Q0.8250.98
345_D348_G0.8250.98
456_N460_Q0.8240.98
149_I210_V0.8230.98
275_R279_E0.8230.98
173_F179_V0.8230.98
214_L217_K0.8220.98
14_W396_L0.8210.98
304_F364_L0.8190.98
128_S131_E0.8180.98
354_N358_D0.8160.98
7_R10_E0.8150.98
144_K195_E0.8140.98
7_R400_R0.8120.98
383_I450_I0.8090.98
240_M246_D0.8080.98
386_D390_N0.8070.98
397_I401_E0.7990.98
309_S348_G0.7990.98
96_G135_G0.7980.98
258_L359_R0.7970.98
77_E459_Q0.7960.98
92_I159_V0.7950.98
80_F458_Y0.7940.98
172_T212_S0.7910.98
350_R398_E0.7890.98
178_V233_A0.7880.98
308_M343_Q0.7870.98
23_V62_I0.7860.98
453_K456_N0.7860.98
20_A88_A0.7850.98
199_N203_Q0.7850.98
309_S345_D0.7850.98
36_T132_M0.7850.98
234_A304_F0.7820.98
97_D135_G0.7780.98
68_Y72_I0.7770.98
357_Y407_V0.7760.98
101_P106_L0.7750.98
158_T161_K0.7700.97
138_K184_F0.7660.97
88_A131_E0.7630.97
243_K246_D0.7630.97
353_L409_L0.7620.97
192_E195_E0.7590.97
32_K35_S0.7560.97
271_G274_K0.7540.97
251_M355_T0.7510.97
344_I373_A0.7500.97
145_N151_F0.7490.97
60_N63_D0.7470.97
103_E110_D0.7460.97
375_D378_E0.7450.97
13_L122_E0.7450.97
237_T312_A0.7440.97
76_A120_H0.7440.97
354_N357_Y0.7410.97
362_K408_E0.7370.97
28_N34_L0.7360.97
152_Y156_A0.7330.97
332_N335_L0.7330.97
265_A299_V0.7330.97
105_G108_F0.7320.97
182_A188_G0.7310.97
265_A302_I0.7300.96
435_I451_K0.7300.96
9_P408_E0.7290.96
58_Y61_G0.7280.96
78_M451_K0.7270.96
27_Y59_H0.7250.96
172_T228_I0.7230.96
97_D154_R0.7200.96
164_Q222_I0.7190.96
420_L432_Y0.7180.96
117_L168_K0.7170.96
123_P168_K0.7170.96
209_F264_Q0.7170.96
177_N233_A0.7160.96
150_E154_R0.7160.96
248_F347_K0.7160.96
236_T351_I0.7150.96
364_L407_V0.7140.96
376_K379_E0.7100.96
11_G465_N0.7100.96
247_V251_M0.7090.96
205_A259_F0.7080.96
207_H287_A0.7080.96
125_V167_V0.7060.96
144_K204_A0.7030.96
14_W81_K0.7010.96
268_A291_E0.7000.96
402_A407_V0.7000.96
160_F222_I0.6980.95
71_D449_R0.6980.95
67_R447_F0.6950.95
273_M277_L0.6930.95
178_V182_A0.6930.95
231_M305_S0.6910.95
52_M56_N0.6910.95
18_V418_I0.6900.95
192_E196_N0.6900.95
116_L120_H0.6870.95
209_F294_L0.6850.95
378_E381_G0.6840.95
34_L42_N0.6820.95
30_G65_Y0.6800.95
396_L461_V0.6770.95
117_L122_E0.6770.95
26_A65_Y0.6760.95
146_R289_G0.6760.95
396_L414_S0.6750.95
206_H286_M0.6750.95
377_V380_D0.6750.95
389_I453_K0.6740.95
377_V383_I0.6740.95
347_K350_R0.6730.94
434_F458_Y0.6680.94
116_L119_H0.6680.94
23_V420_L0.6640.94
363_P408_E0.6630.94
291_E295_K0.6630.94
211_A215_A0.6620.94
124_V171_M0.6620.94
159_V170_W0.6620.94
213_A294_L0.6620.94
238_Y309_S0.6620.94
161_K218_A0.6610.94
339_E373_A0.6610.94
243_K314_T0.6590.94
58_Y426_A0.6580.94
157_K221_D0.6580.94
95_N139_N0.6570.94
78_M434_F0.6560.94
267_G295_K0.6540.94
72_I121_I0.6540.94
27_Y88_A0.6530.94
304_F356_L0.6530.94
422_S432_Y0.6520.94
85_T116_L0.6510.93
401_E405_D0.6490.93
288_E292_E0.6470.93
382_T450_I0.6470.93
306_Y349_L0.6460.93
156_A159_V0.6450.93
353_L402_A0.6430.93
275_R401_E0.6420.93
232_I260_F0.6410.93
305_S367_V0.6410.93
146_R210_V0.6410.93
302_I362_K0.6410.93
461_V464_T0.6400.93
84_R174_N0.6380.93
81_K122_E0.6370.93
196_N199_N0.6370.93
199_N283_E0.6360.93
149_I211_A0.6360.93
436_Y452_K0.6340.93
13_L81_K0.6340.93
75_F417_P0.6340.93
447_F451_K0.6330.92
17_A413_T0.6320.92
93_F97_D0.6310.92
258_L355_T0.6300.92
113_F167_V0.6280.92
152_Y173_F0.6270.92
8_F465_N0.6260.92
216_V299_V0.6230.92
93_F100_E0.6210.92
69_K73_A0.6200.92
382_T456_N0.6190.92
234_A257_T0.6190.92
202_Y277_L0.6170.92
421_V439_R0.6160.91
234_A261_S0.6160.91
167_V170_W0.6150.91
34_L134_L0.6150.91
315_D318_E0.6140.91
128_S179_V0.6130.91
213_A298_T0.6130.91
386_D389_I0.6120.91
259_F277_L0.6120.91
93_F154_R0.6120.91
399_A403_I0.6120.91
278_A281_N0.6110.91
136_L151_F0.6110.91
313_S328_G0.6110.91
254_E355_T0.6100.91
340_W425_T0.6100.91
36_T138_K0.6090.91
144_K203_Q0.6080.91
106_L163_Y0.6080.91
436_Y448_N0.6060.91
249_A253_N0.6060.91
339_E430_K0.6060.91
293_L297_H0.6050.91
96_G136_L0.6030.91
273_M276_Y0.6020.91
287_A291_E0.6020.91
227_K410_I0.6010.90
15_G413_T0.6000.90
241_T313_S0.6000.90
61_G447_F0.5980.90
234_A356_L0.5970.90
117_L120_H0.5970.90
154_R158_T0.5970.90
127_I160_F0.5940.90
365_F411_G0.5940.90
87_I113_F0.5930.90
11_G403_I0.5930.90
81_K462_I0.5920.90
69_K72_I0.5920.90
203_Q207_H0.5910.90
240_M311_A0.5900.90
364_L409_L0.5880.89
169_Y365_F0.5870.89
41_P421_V0.5840.89
420_L423_A0.5820.89
222_I226_S0.5820.89
111_D115_E0.5810.89
331_K334_Y0.5790.89
34_L90_T0.5780.89
18_V417_P0.5770.89
92_I106_L0.5770.89
76_A118_K0.5770.89
53_T425_T0.5760.89
417_P435_I0.5760.89
74_L435_I0.5760.89
79_G459_Q0.5750.88
8_F14_W0.5750.88
324_G327_L0.5740.88
149_I153_E0.5740.88
213_A297_H0.5730.88
258_L262_D0.5720.88
217_K298_T0.5700.88
381_G448_N0.5700.88
114_D165_H0.5700.88
78_M455_F0.5680.88
239_P246_D0.5680.88
64_F75_F0.5680.88
23_V83_F0.5660.88
54_S429_K0.5660.88
98_E154_R0.5650.88
53_T56_N0.5650.88
95_N151_F0.5640.87
338_S372_G0.5620.87
363_P410_I0.5620.87
252_E314_T0.5620.87
261_S356_L0.5620.87
229_G365_F0.5600.87
74_L418_I0.5600.87
365_F413_T0.5590.87
217_K220_H0.5570.87
421_V428_M0.5570.87
36_T128_S0.5560.87
356_L364_L0.5550.87
212_S264_Q0.5540.87
202_Y280_N0.5540.87
235_T310_M0.5540.87
41_P58_Y0.5530.86
416_G420_L0.5520.86
164_Q224_P0.5510.86
26_A32_K0.5500.86
135_G138_K0.5500.86
27_Y42_N0.5500.86
80_F121_I0.5490.86
307_Y368_E0.5490.86
83_F116_L0.5490.86
135_G151_F0.5480.86
18_V64_F0.5480.86
431_R436_Y0.5480.86
175_E307_Y0.5470.86
60_N66_H0.5450.86
28_N59_H0.5450.86
389_I393_R0.5390.85
11_G81_K0.5390.85
231_M301_Y0.5380.85
210_V293_L0.5380.85
41_P52_M0.5350.85
127_I156_A0.5350.85
253_N256_K0.5350.85
338_S373_A0.5330.84
184_F195_E0.5330.84
351_I354_N0.5300.84
114_D118_K0.5290.84
184_F204_A0.5290.84
53_T429_K0.5280.84
335_L343_Q0.5280.84
238_Y345_D0.5270.84
367_V410_I0.5270.84
337_S341_G0.5260.84
64_F72_I0.5250.84
116_L123_P0.5240.83
124_V410_I0.5240.83
172_T215_A0.5230.83
193_E197_K0.5220.83
383_I436_Y0.5220.83
75_F83_F0.5210.83
210_V294_L0.5210.83
77_E456_N0.5210.83
371_L375_D0.5200.83
143_W173_F0.5200.83
136_L148_V0.5190.83
52_M421_V0.5190.83
313_S330_V0.5180.83
286_M289_G0.5180.83
67_R446_T0.5180.83
194_G197_K0.5170.83
392_L396_L0.5150.82
246_D249_A0.5150.82
126_T231_M0.5150.82
440_D448_N0.5130.82
64_F68_Y0.5120.82
30_G102_N0.5110.82
44_I51_S0.5110.82
435_I455_F0.5100.82
216_V297_H0.5100.82
261_S265_A0.5090.82
98_E101_P0.5090.82
397_I400_R0.5090.82
258_L272_Y0.5090.82
18_V420_L0.5080.81
21_N41_P0.5080.81
216_V219_G0.5070.81
140_Y145_N0.5050.81
392_L458_Y0.5050.81
37_A423_A0.5040.81
303_G367_V0.5040.81
37_A40_S0.5040.81
398_E405_D0.5030.81
32_K131_E0.5030.81
266_R360_Y0.5030.81
278_A283_E0.5020.81
338_S341_G0.5020.81
286_M290_D0.5010.81
456_N463_A0.5010.81
39_V43_G0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v02A 2 0.9552 100 0.112 Contact Map
2dgaA 5 0.9616 100 0.114 Contact Map
3ptmA 1 0.9552 100 0.115 Contact Map
2jf7A 5 0.9424 100 0.118 Contact Map
1v08A 2 0.9574 100 0.118 Contact Map
3wq5A 1 0.9552 100 0.119 Contact Map
1cbgA 2 0.9574 100 0.121 Contact Map
3w53A 1 0.9574 100 0.122 Contact Map
3f5lA 2 0.9531 100 0.126 Contact Map
4iplA 2 0.9574 100 0.127 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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