GLCU - BACSU - GREMLIN Contacts

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GLCU - Glucose uptake protein GlcU

UniProt:	P40420	Sequences: MDLLLALLPALFWGSIVLFNVKLGGGPYSQTLGTTIGALIVSIVIYFFVQPVLSLRIFIVGIVSGLFWSLGQANQLKSIQLMGVSKTMPISTGMQLVSTSLFGVIVFREWSTPIAITLGVLALIFIIVGIILTSLEDKNDKKEGEPSNLKKGILILLVSTLGYLVYVVVARLFNVSGWSALLPQAIGMVVGGLVLTYRHKPFNKYAIRNILPGLIWAGGNMFLFISQPRVGVATSFSLSQMGIVISTLGGIFILREKKTKRQLIAIAIGIILIIAAAVFLGIAKTNS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	287 (279)
Sequences:	316 (245)
Seq/√Len:	14.6

BACSU - GLCU

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
62_I	190_V	4.742	1.00
120_V	124_I	4.492	1.00
64_S	184_Q	4.434	1.00
39_L	189_V	4.017	1.00
39_L	185_A	3.551	0.99
18_L	253_I	3.224	0.99
35_T	188_M	3.124	0.98
241_M	277_A	2.882	0.97
94_M	157_L	2.536	0.94
216_W	270_I	2.500	0.93
74_N	235_S	2.419	0.92
216_W	230_V	2.314	0.90
61_G	175_V	2.233	0.88
40_I	190_V	2.174	0.87
137_D	265_A	2.139	0.86
16_I	219_G	2.138	0.86
100_S	116_I	2.079	0.84
59_I	63_V	2.044	0.83
267_A	271_I	2.022	0.83
226_S	230_V	2.014	0.82
20_N	76_L	2.000	0.82
248_L	270_I	1.999	0.82
167_V	223_L	1.953	0.80
248_L	252_F	1.940	0.80
13_W	258_K	1.902	0.79
137_D	262_Q	1.862	0.77
126_I	137_D	1.846	0.76
181_L	220_N	1.805	0.75
125_F	128_V	1.782	0.74
30_Q	72_Q	1.780	0.74
85_S	123_L	1.751	0.72
237_S	281_G	1.748	0.72
30_Q	82_M	1.710	0.71
58_F	61_G	1.684	0.69
44_V	55_L	1.677	0.69
220_N	223_L	1.667	0.69
188_M	224_F	1.662	0.68
46_Y	182_L	1.658	0.68
42_S	224_F	1.646	0.67
216_W	220_N	1.636	0.67
54_S	141_K	1.626	0.67
51_P	107_F	1.622	0.66
26_G	63_V	1.616	0.66
90_I	244_V	1.614	0.66
170_A	175_V	1.609	0.66
152_G	233_A	1.609	0.66
104_V	127_I	1.609	0.66
90_I	105_I	1.603	0.65
16_I	34_T	1.599	0.65
88_M	243_I	1.589	0.65
6_A	238_L	1.554	0.63
42_S	182_L	1.550	0.63
92_T	247_T	1.548	0.63
6_A	38_A	1.533	0.62
227_Q	280_L	1.524	0.61
78_S	87_T	1.519	0.61
79_I	280_L	1.515	0.61
104_V	120_V	1.485	0.59
81_L	151_K	1.483	0.59
93_G	96_L	1.451	0.57
152_G	277_A	1.446	0.57
97_V	127_I	1.443	0.57
120_V	261_R	1.438	0.57
42_S	185_A	1.421	0.56
97_V	241_M	1.418	0.56
228_P	252_F	1.414	0.55
207_I	210_I	1.378	0.53
30_Q	236_F	1.377	0.53
121_L	124_I	1.367	0.53
124_I	263_L	1.362	0.53
15_S	219_G	1.357	0.52
3_L	275_A	1.350	0.52
273_I	280_L	1.347	0.52
170_A	270_I	1.343	0.51
104_V	244_V	1.337	0.51
108_R	111_S	1.337	0.51
38_A	216_W	1.337	0.51
72_Q	96_L	1.335	0.51
195_L	266_I	1.321	0.50
205_Y	208_R	1.320	0.50
237_S	280_L	1.316	0.50
260_K	271_I	1.303	0.49
104_V	116_I	1.302	0.49
74_N	155_I	1.286	0.48
268_I	271_I	1.280	0.48
264_I	268_I	1.275	0.48
98_S	164_L	1.274	0.48
137_D	261_R	1.267	0.47
101_L	104_V	1.263	0.47
12_F	15_S	1.248	0.46
3_L	238_L	1.248	0.46
167_V	232_V	1.246	0.46
137_D	259_T	1.243	0.46
100_S	104_V	1.237	0.46
15_S	18_L	1.235	0.45
204_K	208_R	1.223	0.45
36_I	189_V	1.223	0.45
23_L	245_I	1.221	0.45
70_L	192_G	1.219	0.45
13_W	72_Q	1.209	0.44
101_L	106_V	1.209	0.44
263_L	266_I	1.204	0.44
273_I	277_A	1.201	0.44
184_Q	233_A	1.195	0.43
153_I	218_G	1.189	0.43
181_L	281_G	1.188	0.43
184_Q	238_L	1.184	0.43
113_P	117_T	1.184	0.43
109_E	171_R	1.179	0.42
219_G	242_G	1.178	0.42
125_F	186_I	1.152	0.41
126_I	214_L	1.149	0.41
47_F	221_M	1.149	0.41
37_G	92_T	1.138	0.40
187_G	236_F	1.138	0.40
224_F	235_S	1.138	0.40
91_S	160_T	1.134	0.40
68_W	224_F	1.130	0.40
93_G	130_I	1.129	0.40
121_L	182_L	1.125	0.40
135_L	261_R	1.123	0.39
27_P	34_T	1.123	0.39
78_S	182_L	1.115	0.39
243_I	274_I	1.113	0.39
104_V	171_R	1.113	0.39
118_L	185_A	1.112	0.39
113_P	151_K	1.107	0.39
194_V	214_L	1.094	0.38
42_S	191_G	1.084	0.37
75_Q	107_F	1.076	0.37
23_L	26_G	1.076	0.37
102_F	168_V	1.075	0.37
79_I	262_Q	1.070	0.37
173_F	235_S	1.058	0.36
176_S	217_A	1.052	0.36
13_W	30_Q	1.049	0.36
69_S	123_L	1.040	0.35
16_I	76_L	1.034	0.35
151_K	261_R	1.031	0.35
127_I	139_N	1.027	0.34
74_N	159_S	1.025	0.34
110_W	119_G	1.019	0.34
19_F	215_I	1.018	0.34
238_L	273_I	1.015	0.34
13_W	68_W	1.013	0.34
156_L	162_G	1.013	0.34
25_G	33_G	1.003	0.33
152_G	242_G	1.002	0.33
235_S	270_I	0.992	0.33
11_L	113_P	0.990	0.33
26_G	88_M	0.976	0.32
181_L	223_L	0.975	0.32
17_V	79_I	0.973	0.32
95_Q	110_W	0.972	0.32
9_P	85_S	0.972	0.32
270_I	277_A	0.971	0.32
75_Q	156_L	0.966	0.31
15_S	253_I	0.965	0.31
154_L	158_V	0.965	0.31
105_I	271_I	0.956	0.31
109_E	278_V	0.952	0.31
103_G	224_F	0.952	0.31
252_F	263_L	0.949	0.31
17_V	223_L	0.944	0.30
23_L	208_R	0.943	0.30
8_L	260_K	0.942	0.30
5_L	11_L	0.939	0.30
170_A	243_I	0.938	0.30
76_L	216_W	0.936	0.30
108_R	117_T	0.934	0.30
196_T	206_A	0.933	0.30
33_G	95_Q	0.930	0.30
159_S	237_S	0.928	0.30
39_L	259_T	0.922	0.29
206_A	216_W	0.917	0.29
264_I	275_A	0.915	0.29
21_V	76_L	0.914	0.29
83_G	103_G	0.907	0.29
152_G	256_E	0.902	0.28
99_T	155_I	0.899	0.28
61_G	222_F	0.898	0.28
13_W	17_V	0.893	0.28
6_A	222_F	0.890	0.28
86_K	122_A	0.889	0.28
53_L	66_L	0.888	0.28
249_G	256_E	0.885	0.28
92_T	162_G	0.877	0.27
11_L	77_K	0.870	0.27
10_A	75_Q	0.866	0.27
8_L	123_L	0.863	0.27
167_V	237_S	0.861	0.27
31_T	223_L	0.861	0.27
47_F	124_I	0.858	0.27
37_G	187_G	0.855	0.26
51_P	96_L	0.854	0.26
148_N	186_I	0.853	0.26
32_L	268_I	0.852	0.26
26_G	120_V	0.848	0.26
230_V	270_I	0.847	0.26
32_L	64_S	0.842	0.26
126_I	154_L	0.842	0.26
96_L	167_V	0.839	0.26
118_L	151_K	0.837	0.26
68_W	72_Q	0.834	0.26
24_G	242_G	0.827	0.25
140_D	182_L	0.825	0.25
185_A	188_M	0.825	0.25
154_L	257_K	0.825	0.25
21_V	87_T	0.824	0.25
247_T	273_I	0.824	0.25
47_F	193_L	0.809	0.24
92_T	184_Q	0.807	0.24
105_I	154_L	0.803	0.24
85_S	251_I	0.798	0.24
11_L	90_I	0.797	0.24
44_V	113_P	0.794	0.24
216_W	242_G	0.789	0.24
236_F	250_G	0.789	0.24
108_R	116_I	0.787	0.24
71_G	75_Q	0.787	0.24
175_V	235_S	0.784	0.23
15_S	61_G	0.782	0.23
37_G	162_G	0.782	0.23
168_V	216_W	0.774	0.23
11_L	197_Y	0.770	0.23
219_G	246_S	0.769	0.23
140_D	264_I	0.767	0.23
220_N	280_L	0.767	0.23
40_I	62_I	0.766	0.23
18_L	249_G	0.758	0.22
235_S	277_A	0.756	0.22
20_N	31_T	0.756	0.22
224_F	266_I	0.754	0.22
17_V	222_F	0.754	0.22
43_I	138_K	0.753	0.22
159_S	220_N	0.752	0.22
207_I	281_G	0.748	0.22
75_Q	160_T	0.747	0.22
6_A	122_A	0.745	0.22
105_I	124_I	0.744	0.22
23_L	243_I	0.744	0.22
73_A	123_L	0.740	0.22
170_A	223_L	0.738	0.22
171_R	232_V	0.738	0.22
214_L	218_G	0.736	0.22
47_F	271_I	0.735	0.22
128_V	271_I	0.735	0.22
75_Q	91_S	0.735	0.22
69_S	126_I	0.734	0.22
130_I	232_V	0.733	0.21
103_G	176_S	0.731	0.21
22_K	37_G	0.728	0.21
13_W	188_M	0.727	0.21
8_L	27_P	0.721	0.21
216_W	223_L	0.719	0.21
117_T	211_L	0.719	0.21
114_I	117_T	0.713	0.21
107_F	245_I	0.712	0.21
209_N	266_I	0.710	0.21
4_L	210_I	0.708	0.21
168_V	181_L	0.707	0.21
21_V	280_L	0.705	0.20
126_I	261_R	0.705	0.20
35_T	224_F	0.703	0.20
78_S	165_V	0.703	0.20
79_I	137_D	0.701	0.20
63_V	174_N	0.697	0.20
220_N	224_F	0.693	0.20
111_S	253_I	0.693	0.20
2_D	229_R	0.692	0.20
233_A	259_T	0.691	0.20
30_Q	160_T	0.689	0.20
107_F	246_S	0.689	0.20
101_L	204_K	0.689	0.20
41_V	192_G	0.688	0.20
11_L	198_R	0.685	0.20
96_L	245_I	0.682	0.20
66_L	157_L	0.680	0.20
63_V	66_L	0.678	0.20
96_L	262_Q	0.677	0.19
22_K	25_G	0.674	0.19
41_V	181_L	0.674	0.19
124_I	186_I	0.673	0.19
132_L	244_V	0.671	0.19
4_L	190_V	0.670	0.19
30_Q	76_L	0.669	0.19
28_Y	199_H	0.669	0.19
93_G	246_S	0.668	0.19
46_Y	226_S	0.662	0.19
68_W	188_M	0.661	0.19
87_T	104_V	0.661	0.19
126_I	265_A	0.660	0.19
91_S	162_G	0.660	0.19
146_P	161_L	0.659	0.19
173_F	277_A	0.657	0.19
83_G	92_T	0.656	0.19
109_E	276_A	0.655	0.19
63_V	134_S	0.654	0.19
16_I	107_F	0.654	0.19
167_V	220_N	0.654	0.19
53_L	82_M	0.653	0.19
177_G	189_V	0.652	0.19
72_Q	188_M	0.652	0.19
125_F	271_I	0.650	0.19
30_Q	188_M	0.650	0.19
59_I	189_V	0.649	0.19
12_F	16_I	0.647	0.18
56_R	124_I	0.647	0.18
25_G	162_G	0.647	0.18
177_G	234_T	0.644	0.18
115_A	123_L	0.643	0.18
239_S	277_A	0.639	0.18
16_I	232_V	0.639	0.18
125_F	255_R	0.638	0.18
132_L	265_A	0.635	0.18
137_D	235_S	0.634	0.18
166_Y	183_P	0.631	0.18
67_F	165_V	0.629	0.18
20_N	79_I	0.627	0.18
219_G	233_A	0.625	0.18
43_I	108_R	0.623	0.18
159_S	224_F	0.623	0.18
170_A	237_S	0.623	0.18
31_T	242_G	0.620	0.18
101_L	275_A	0.618	0.18
118_L	121_L	0.616	0.17
111_S	116_I	0.616	0.17
51_P	91_S	0.615	0.17
75_Q	159_S	0.615	0.17
63_V	218_G	0.612	0.17
53_L	58_F	0.612	0.17
257_K	275_A	0.612	0.17
107_F	276_A	0.611	0.17
46_Y	94_M	0.609	0.17
223_L	237_S	0.605	0.17
124_I	128_V	0.603	0.17
124_I	194_V	0.600	0.17
26_G	248_L	0.599	0.17
167_V	170_A	0.599	0.17
93_G	188_M	0.597	0.17
138_K	275_A	0.597	0.17
180_A	224_F	0.597	0.17
186_I	203_N	0.595	0.17
16_I	216_W	0.594	0.17
186_I	239_S	0.593	0.17
141_K	275_A	0.591	0.17
87_T	246_S	0.586	0.17
169_V	225_I	0.585	0.16
133_T	273_I	0.583	0.16
5_L	55_L	0.583	0.16
102_F	169_V	0.580	0.16
154_L	271_I	0.575	0.16
198_R	208_R	0.575	0.16
259_T	262_Q	0.574	0.16
96_L	99_T	0.573	0.16
33_G	110_W	0.573	0.16
167_V	216_W	0.572	0.16
48_F	211_L	0.571	0.16
64_S	251_I	0.568	0.16
159_S	185_A	0.567	0.16
113_P	139_N	0.566	0.16
113_P	253_I	0.563	0.16
160_T	189_V	0.563	0.16
24_G	238_L	0.562	0.16
121_L	275_A	0.562	0.16
54_S	117_T	0.560	0.16
227_Q	230_V	0.557	0.16
129_G	276_A	0.556	0.16
39_L	239_S	0.556	0.16
9_P	14_G	0.553	0.16
23_L	205_Y	0.550	0.15
236_F	239_S	0.550	0.15
91_S	95_Q	0.549	0.15
69_S	81_L	0.549	0.15
46_Y	51_P	0.549	0.15
210_I	218_G	0.548	0.15
104_V	233_A	0.547	0.15
49_V	221_M	0.546	0.15
32_L	131_I	0.546	0.15
89_P	110_W	0.546	0.15
6_A	152_G	0.546	0.15
120_V	264_I	0.544	0.15
235_S	238_L	0.544	0.15
82_M	273_I	0.543	0.15
33_G	75_Q	0.541	0.15
126_I	178_W	0.538	0.15
191_G	217_A	0.538	0.15
5_L	210_I	0.538	0.15
241_M	250_G	0.535	0.15
147_S	217_A	0.535	0.15
158_V	206_A	0.534	0.15
11_L	105_I	0.534	0.15
12_F	219_G	0.533	0.15
31_T	80_Q	0.532	0.15
175_V	180_A	0.530	0.15
44_V	49_V	0.529	0.15
11_L	146_P	0.527	0.15
166_Y	220_N	0.526	0.15
117_T	204_K	0.522	0.15
135_L	222_F	0.522	0.15
35_T	239_S	0.522	0.15
173_F	212_P	0.521	0.15
235_S	280_L	0.519	0.15
260_K	274_I	0.519	0.15
208_R	275_A	0.518	0.15
271_I	278_V	0.517	0.14
22_K	202_F	0.512	0.14
222_F	225_I	0.511	0.14
13_W	222_F	0.510	0.14
39_L	267_A	0.508	0.14
123_L	232_V	0.507	0.14
25_G	100_S	0.507	0.14
29_S	168_V	0.504	0.14
30_Q	187_G	0.503	0.14
20_N	212_P	0.501	0.14
237_S	270_I	0.501	0.14
92_T	273_I	0.500	0.14
77_K	193_L	0.500	0.14

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2i68A	2	0.2683	97.1	0.927	Contact Map
3b5dA	2	0.3554	97	0.929	Contact Map
3o7qA	1	0.8049	58.5	0.962	Contact Map
2gfpA	2	0.7909	38.9	0.967	Contact Map
2cfqA	1	0.8293	34.2	0.968	Contact Map
4j05A	3	0.8955	23.7	0.97	Contact Map
1pw4A	1	0.5122	23.5	0.97	Contact Map
3wdoA	1	0.7979	23.4	0.97	Contact Map
4p6vB	1	0.6028	17.7	0.972	Contact Map
4rngA	2	0.2892	17.4	0.972	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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