GREMLIN Database
GLCU - Glucose uptake protein GlcU
UniProt: P40420 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 287 (279)
Sequences: 316 (245)
Seq/√Len: 14.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_I190_V4.7421.00
120_V124_I4.4921.00
64_S184_Q4.4341.00
39_L189_V4.0171.00
39_L185_A3.5510.99
18_L253_I3.2240.99
35_T188_M3.1240.98
241_M277_A2.8820.97
94_M157_L2.5360.94
216_W270_I2.5000.93
74_N235_S2.4190.92
216_W230_V2.3140.90
61_G175_V2.2330.88
40_I190_V2.1740.87
137_D265_A2.1390.86
16_I219_G2.1380.86
100_S116_I2.0790.84
59_I63_V2.0440.83
267_A271_I2.0220.83
226_S230_V2.0140.82
20_N76_L2.0000.82
248_L270_I1.9990.82
167_V223_L1.9530.80
248_L252_F1.9400.80
13_W258_K1.9020.79
137_D262_Q1.8620.77
126_I137_D1.8460.76
181_L220_N1.8050.75
125_F128_V1.7820.74
30_Q72_Q1.7800.74
85_S123_L1.7510.72
237_S281_G1.7480.72
30_Q82_M1.7100.71
58_F61_G1.6840.69
44_V55_L1.6770.69
220_N223_L1.6670.69
188_M224_F1.6620.68
46_Y182_L1.6580.68
42_S224_F1.6460.67
216_W220_N1.6360.67
54_S141_K1.6260.67
51_P107_F1.6220.66
26_G63_V1.6160.66
90_I244_V1.6140.66
170_A175_V1.6090.66
152_G233_A1.6090.66
104_V127_I1.6090.66
90_I105_I1.6030.65
16_I34_T1.5990.65
88_M243_I1.5890.65
6_A238_L1.5540.63
42_S182_L1.5500.63
92_T247_T1.5480.63
6_A38_A1.5330.62
227_Q280_L1.5240.61
78_S87_T1.5190.61
79_I280_L1.5150.61
104_V120_V1.4850.59
81_L151_K1.4830.59
93_G96_L1.4510.57
152_G277_A1.4460.57
97_V127_I1.4430.57
120_V261_R1.4380.57
42_S185_A1.4210.56
97_V241_M1.4180.56
228_P252_F1.4140.55
207_I210_I1.3780.53
30_Q236_F1.3770.53
121_L124_I1.3670.53
124_I263_L1.3620.53
15_S219_G1.3570.52
3_L275_A1.3500.52
273_I280_L1.3470.52
170_A270_I1.3430.51
104_V244_V1.3370.51
108_R111_S1.3370.51
38_A216_W1.3370.51
72_Q96_L1.3350.51
195_L266_I1.3210.50
205_Y208_R1.3200.50
237_S280_L1.3160.50
260_K271_I1.3030.49
104_V116_I1.3020.49
74_N155_I1.2860.48
268_I271_I1.2800.48
264_I268_I1.2750.48
98_S164_L1.2740.48
137_D261_R1.2670.47
101_L104_V1.2630.47
12_F15_S1.2480.46
3_L238_L1.2480.46
167_V232_V1.2460.46
137_D259_T1.2430.46
100_S104_V1.2370.46
15_S18_L1.2350.45
204_K208_R1.2230.45
36_I189_V1.2230.45
23_L245_I1.2210.45
70_L192_G1.2190.45
13_W72_Q1.2090.44
101_L106_V1.2090.44
263_L266_I1.2040.44
273_I277_A1.2010.44
184_Q233_A1.1950.43
153_I218_G1.1890.43
181_L281_G1.1880.43
184_Q238_L1.1840.43
113_P117_T1.1840.43
109_E171_R1.1790.42
219_G242_G1.1780.42
125_F186_I1.1520.41
126_I214_L1.1490.41
47_F221_M1.1490.41
37_G92_T1.1380.40
187_G236_F1.1380.40
224_F235_S1.1380.40
91_S160_T1.1340.40
68_W224_F1.1300.40
93_G130_I1.1290.40
121_L182_L1.1250.40
135_L261_R1.1230.39
27_P34_T1.1230.39
78_S182_L1.1150.39
243_I274_I1.1130.39
104_V171_R1.1130.39
118_L185_A1.1120.39
113_P151_K1.1070.39
194_V214_L1.0940.38
42_S191_G1.0840.37
75_Q107_F1.0760.37
23_L26_G1.0760.37
102_F168_V1.0750.37
79_I262_Q1.0700.37
173_F235_S1.0580.36
176_S217_A1.0520.36
13_W30_Q1.0490.36
69_S123_L1.0400.35
16_I76_L1.0340.35
151_K261_R1.0310.35
127_I139_N1.0270.34
74_N159_S1.0250.34
110_W119_G1.0190.34
19_F215_I1.0180.34
238_L273_I1.0150.34
13_W68_W1.0130.34
156_L162_G1.0130.34
25_G33_G1.0030.33
152_G242_G1.0020.33
235_S270_I0.9920.33
11_L113_P0.9900.33
26_G88_M0.9760.32
181_L223_L0.9750.32
17_V79_I0.9730.32
95_Q110_W0.9720.32
9_P85_S0.9720.32
270_I277_A0.9710.32
75_Q156_L0.9660.31
15_S253_I0.9650.31
154_L158_V0.9650.31
105_I271_I0.9560.31
109_E278_V0.9520.31
103_G224_F0.9520.31
252_F263_L0.9490.31
17_V223_L0.9440.30
23_L208_R0.9430.30
8_L260_K0.9420.30
5_L11_L0.9390.30
170_A243_I0.9380.30
76_L216_W0.9360.30
108_R117_T0.9340.30
196_T206_A0.9330.30
33_G95_Q0.9300.30
159_S237_S0.9280.30
39_L259_T0.9220.29
206_A216_W0.9170.29
264_I275_A0.9150.29
21_V76_L0.9140.29
83_G103_G0.9070.29
152_G256_E0.9020.28
99_T155_I0.8990.28
61_G222_F0.8980.28
13_W17_V0.8930.28
6_A222_F0.8900.28
86_K122_A0.8890.28
53_L66_L0.8880.28
249_G256_E0.8850.28
92_T162_G0.8770.27
11_L77_K0.8700.27
10_A75_Q0.8660.27
8_L123_L0.8630.27
167_V237_S0.8610.27
31_T223_L0.8610.27
47_F124_I0.8580.27
37_G187_G0.8550.26
51_P96_L0.8540.26
148_N186_I0.8530.26
32_L268_I0.8520.26
26_G120_V0.8480.26
230_V270_I0.8470.26
32_L64_S0.8420.26
126_I154_L0.8420.26
96_L167_V0.8390.26
118_L151_K0.8370.26
68_W72_Q0.8340.26
24_G242_G0.8270.25
140_D182_L0.8250.25
185_A188_M0.8250.25
154_L257_K0.8250.25
21_V87_T0.8240.25
247_T273_I0.8240.25
47_F193_L0.8090.24
92_T184_Q0.8070.24
105_I154_L0.8030.24
85_S251_I0.7980.24
11_L90_I0.7970.24
44_V113_P0.7940.24
216_W242_G0.7890.24
236_F250_G0.7890.24
108_R116_I0.7870.24
71_G75_Q0.7870.24
175_V235_S0.7840.23
15_S61_G0.7820.23
37_G162_G0.7820.23
168_V216_W0.7740.23
11_L197_Y0.7700.23
219_G246_S0.7690.23
140_D264_I0.7670.23
220_N280_L0.7670.23
40_I62_I0.7660.23
18_L249_G0.7580.22
235_S277_A0.7560.22
20_N31_T0.7560.22
224_F266_I0.7540.22
17_V222_F0.7540.22
43_I138_K0.7530.22
159_S220_N0.7520.22
207_I281_G0.7480.22
75_Q160_T0.7470.22
6_A122_A0.7450.22
105_I124_I0.7440.22
23_L243_I0.7440.22
73_A123_L0.7400.22
170_A223_L0.7380.22
171_R232_V0.7380.22
214_L218_G0.7360.22
47_F271_I0.7350.22
128_V271_I0.7350.22
75_Q91_S0.7350.22
69_S126_I0.7340.22
130_I232_V0.7330.21
103_G176_S0.7310.21
22_K37_G0.7280.21
13_W188_M0.7270.21
8_L27_P0.7210.21
216_W223_L0.7190.21
117_T211_L0.7190.21
114_I117_T0.7130.21
107_F245_I0.7120.21
209_N266_I0.7100.21
4_L210_I0.7080.21
168_V181_L0.7070.21
21_V280_L0.7050.20
126_I261_R0.7050.20
35_T224_F0.7030.20
78_S165_V0.7030.20
79_I137_D0.7010.20
63_V174_N0.6970.20
220_N224_F0.6930.20
111_S253_I0.6930.20
2_D229_R0.6920.20
233_A259_T0.6910.20
30_Q160_T0.6890.20
107_F246_S0.6890.20
101_L204_K0.6890.20
41_V192_G0.6880.20
11_L198_R0.6850.20
96_L245_I0.6820.20
66_L157_L0.6800.20
63_V66_L0.6780.20
96_L262_Q0.6770.19
22_K25_G0.6740.19
41_V181_L0.6740.19
124_I186_I0.6730.19
132_L244_V0.6710.19
4_L190_V0.6700.19
30_Q76_L0.6690.19
28_Y199_H0.6690.19
93_G246_S0.6680.19
46_Y226_S0.6620.19
68_W188_M0.6610.19
87_T104_V0.6610.19
126_I265_A0.6600.19
91_S162_G0.6600.19
146_P161_L0.6590.19
173_F277_A0.6570.19
83_G92_T0.6560.19
109_E276_A0.6550.19
63_V134_S0.6540.19
16_I107_F0.6540.19
167_V220_N0.6540.19
53_L82_M0.6530.19
177_G189_V0.6520.19
72_Q188_M0.6520.19
125_F271_I0.6500.19
30_Q188_M0.6500.19
59_I189_V0.6490.19
12_F16_I0.6470.18
56_R124_I0.6470.18
25_G162_G0.6470.18
177_G234_T0.6440.18
115_A123_L0.6430.18
239_S277_A0.6390.18
16_I232_V0.6390.18
125_F255_R0.6380.18
132_L265_A0.6350.18
137_D235_S0.6340.18
166_Y183_P0.6310.18
67_F165_V0.6290.18
20_N79_I0.6270.18
219_G233_A0.6250.18
43_I108_R0.6230.18
159_S224_F0.6230.18
170_A237_S0.6230.18
31_T242_G0.6200.18
101_L275_A0.6180.18
118_L121_L0.6160.17
111_S116_I0.6160.17
51_P91_S0.6150.17
75_Q159_S0.6150.17
63_V218_G0.6120.17
53_L58_F0.6120.17
257_K275_A0.6120.17
107_F276_A0.6110.17
46_Y94_M0.6090.17
223_L237_S0.6050.17
124_I128_V0.6030.17
124_I194_V0.6000.17
26_G248_L0.5990.17
167_V170_A0.5990.17
93_G188_M0.5970.17
138_K275_A0.5970.17
180_A224_F0.5970.17
186_I203_N0.5950.17
16_I216_W0.5940.17
186_I239_S0.5930.17
141_K275_A0.5910.17
87_T246_S0.5860.17
169_V225_I0.5850.16
133_T273_I0.5830.16
5_L55_L0.5830.16
102_F169_V0.5800.16
154_L271_I0.5750.16
198_R208_R0.5750.16
259_T262_Q0.5740.16
96_L99_T0.5730.16
33_G110_W0.5730.16
167_V216_W0.5720.16
48_F211_L0.5710.16
64_S251_I0.5680.16
159_S185_A0.5670.16
113_P139_N0.5660.16
113_P253_I0.5630.16
160_T189_V0.5630.16
24_G238_L0.5620.16
121_L275_A0.5620.16
54_S117_T0.5600.16
227_Q230_V0.5570.16
129_G276_A0.5560.16
39_L239_S0.5560.16
9_P14_G0.5530.16
23_L205_Y0.5500.15
236_F239_S0.5500.15
91_S95_Q0.5490.15
69_S81_L0.5490.15
46_Y51_P0.5490.15
210_I218_G0.5480.15
104_V233_A0.5470.15
49_V221_M0.5460.15
32_L131_I0.5460.15
89_P110_W0.5460.15
6_A152_G0.5460.15
120_V264_I0.5440.15
235_S238_L0.5440.15
82_M273_I0.5430.15
33_G75_Q0.5410.15
126_I178_W0.5380.15
191_G217_A0.5380.15
5_L210_I0.5380.15
241_M250_G0.5350.15
147_S217_A0.5350.15
158_V206_A0.5340.15
11_L105_I0.5340.15
12_F219_G0.5330.15
31_T80_Q0.5320.15
175_V180_A0.5300.15
44_V49_V0.5290.15
11_L146_P0.5270.15
166_Y220_N0.5260.15
117_T204_K0.5220.15
135_L222_F0.5220.15
35_T239_S0.5220.15
173_F212_P0.5210.15
235_S280_L0.5190.15
260_K274_I0.5190.15
208_R275_A0.5180.15
271_I278_V0.5170.14
22_K202_F0.5120.14
222_F225_I0.5110.14
13_W222_F0.5100.14
39_L267_A0.5080.14
123_L232_V0.5070.14
25_G100_S0.5070.14
29_S168_V0.5040.14
30_Q187_G0.5030.14
20_N212_P0.5010.14
237_S270_I0.5010.14
92_T273_I0.5000.14
77_K193_L0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.2683 97.1 0.927 Contact Map
3b5dA 2 0.3554 97 0.929 Contact Map
3o7qA 1 0.8049 58.5 0.962 Contact Map
2gfpA 2 0.7909 38.9 0.967 Contact Map
2cfqA 1 0.8293 34.2 0.968 Contact Map
4j05A 3 0.8955 23.7 0.97 Contact Map
1pw4A 1 0.5122 23.5 0.97 Contact Map
3wdoA 1 0.7979 23.4 0.97 Contact Map
4p6vB 1 0.6028 17.7 0.972 Contact Map
4rngA 2 0.2892 17.4 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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