FEUC - BACSU - GREMLIN Contacts

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FEUC - Iron-uptake system permease protein FeuC

UniProt:	P40411	Sequences: MAKKYALFIALILVVSYFSLTSGSFSVRPAELLSTLFQIDPNPQYEILLFDLRLPRVVMAAIIGLGLGIAGAVIQAITRNGLADPGILGINAGAGAGIVAFMLLFQGQKEVTSIAAAMGMPLFGLIGGLIAAILIYIFAWHRGNLDSGRIILVGIAINSGFSALSLFLSLKMDPQDYQMAMVWKNGSIWSANWTYITAVLPWMLLFIPILIGKSRLLDTIRFDEDTVRSLGISSNKEKTILLVACVAIISACVSVAGSMAFVGLIAPHISRRLAGVEHRYILPLSGLIGMLLVISADFAGKLFFQPAEVPAGIILAILGVPYFLYLLFKQKKGENA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	336 (318)
Sequences:	13808 (9813)
Seq/√Len:	550.3

ECOLI - FEPG FEPD FECC FECD BTUC FHUB
BACSU - FEUC FHUB FHUG YVRB YFME FEUB YCLN YFHA YFIZ YFMD YCLO
HALSA - Q9HMG0 Q9HMG7 BTUCA
SULSO - Q97ZU1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
218_D	277_E	4.264	1.00
65_L	286_G	3.700	1.00
101_F	123_F	3.621	1.00
15_V	295_S	3.497	1.00
73_V	210_L	3.413	1.00
16_S	57_V	3.362	1.00
233_S	236_K	3.193	1.00
66_G	203_M	3.044	1.00
73_V	241_L	3.005	1.00
61_A	290_M	2.931	1.00
60_A	188_I	2.811	1.00
270_S	288_I	2.791	1.00
31_E	45_Y	2.663	1.00
59_M	191_A	2.548	1.00
69_I	286_G	2.516	1.00
66_G	248_I	2.450	1.00
16_S	61_A	2.434	1.00
31_E	34_S	2.429	1.00
66_G	252_C	2.425	1.00
96_A	164_L	2.416	1.00
224_E	238_K	2.340	1.00
12_I	291_L	2.258	1.00
63_I	252_C	2.244	1.00
11_L	291_L	2.237	1.00
72_A	285_S	2.160	1.00
69_I	207_I	2.152	1.00
274_A	284_L	2.148	1.00
42_N	45_Y	2.134	1.00
21_T	29_P	2.122	1.00
61_A	294_I	2.083	1.00
12_I	61_A	2.070	1.00
63_I	256_A	2.063	1.00
216_L	237_E	2.051	1.00
202_W	251_A	2.033	1.00
62_I	200_L	1.967	1.00
28_R	31_E	1.964	1.00
96_A	161_F	1.941	1.00
30_A	34_S	1.932	1.00
100_A	104_L	1.917	1.00
56_R	297_D	1.888	1.00
76_A	278_H	1.858	1.00
213_K	216_L	1.855	1.00
74_I	245_C	1.845	1.00
15_V	291_L	1.834	1.00
219_T	232_I	1.831	1.00
218_D	278_H	1.811	1.00
19_S	57_V	1.793	1.00
99_V	165_S	1.790	1.00
209_I	244_A	1.766	1.00
39_I	46_E	1.722	1.00
206_F	248_I	1.690	1.00
191_A	195_Y	1.679	1.00
43_P	46_E	1.674	1.00
46_E	50_F	1.668	1.00
213_K	240_I	1.658	1.00
197_T	201_P	1.582	1.00
58_V	196_I	1.577	1.00
262_V	293_V	1.572	1.00
236_K	240_I	1.563	1.00
72_A	281_I	1.561	1.00
18_F	21_T	1.545	1.00
299_A	303_F	1.539	1.00
192_N	195_Y	1.533	1.00
128_G	250_S	1.532	1.00
98_I	124_G	1.516	1.00
213_K	237_E	1.508	1.00
12_I	287_L	1.500	1.00
35_T	50_F	1.492	1.00
132_A	246_V	1.489	1.00
206_F	247_A	1.487	1.00
5_Y	284_L	1.487	1.00
18_F	22_S	1.480	1.00
97_G	123_F	1.461	1.00
15_V	294_I	1.460	1.00
8_F	287_L	1.441	1.00
300_G	311_A	1.430	1.00
188_I	293_V	1.384	1.00
33_L	37_F	1.368	1.00
270_S	284_L	1.368	1.00
299_A	314_I	1.356	1.00
8_F	284_L	1.355	1.00
206_F	244_A	1.353	1.00
19_S	298_F	1.335	1.00
8_F	288_I	1.332	1.00
70_A	248_I	1.322	1.00
201_P	205_L	1.311	1.00
280_Y	283_P	1.305	1.00
131_A	161_F	1.301	1.00
213_K	241_L	1.279	1.00
209_I	213_K	1.277	1.00
95_G	165_S	1.263	1.00
59_M	255_V	1.258	1.00
270_S	281_I	1.253	1.00
197_T	200_L	1.251	1.00
160_G	320_V	1.244	1.00
266_A	292_L	1.229	1.00
12_I	290_M	1.229	1.00
44_Q	47_I	1.226	1.00
228_R	235_N	1.226	1.00
266_A	288_I	1.223	1.00
91_N	249_I	1.213	1.00
47_I	51_D	1.213	1.00
62_I	196_I	1.209	1.00
26_S	29_P	1.203	1.00
68_G	266_A	1.201	1.00
219_T	230_L	1.200	1.00
226_T	229_S	1.192	1.00
35_T	46_E	1.188	1.00
256_A	259_M	1.187	1.00
95_G	184_K	1.177	1.00
236_K	239_T	1.176	1.00
199_V	255_V	1.171	1.00
97_G	127_G	1.169	1.00
278_H	281_I	1.168	1.00
77_I	241_L	1.161	1.00
237_E	240_I	1.140	1.00
93_G	131_A	1.140	1.00
60_A	294_I	1.136	1.00
8_F	291_L	1.133	1.00
99_V	180_A	1.131	1.00
65_L	290_M	1.122	1.00
25_F	48_L	1.112	1.00
72_A	282_L	1.110	1.00
125_L	247_A	1.108	1.00
235_N	238_K	1.104	1.00
209_I	240_I	1.101	1.00
133_I	137_I	1.099	1.00
103_L	168_L	1.096	1.00
5_Y	280_Y	1.096	1.00
208_P	212_G	1.096	1.00
210_L	244_A	1.084	1.00
60_A	293_V	1.082	1.00
39_I	50_F	1.081	1.00
235_N	239_T	1.078	1.00
158_N	162_S	1.076	1.00
59_M	196_I	1.074	1.00
62_I	199_V	1.073	1.00
122_L	126_I	1.066	1.00
96_A	100_A	1.063	1.00
65_L	68_G	1.061	1.00
223_D	227_V	1.058	1.00
35_T	49_L	1.050	1.00
123_F	127_G	1.048	1.00
93_G	127_G	1.044	1.00
283_P	286_G	1.043	1.00
301_K	308_E	1.042	1.00
17_Y	21_T	1.039	1.00
199_V	203_M	1.032	1.00
58_V	193_W	1.022	1.00
21_T	32_L	1.022	1.00
22_S	302_L	1.021	1.00
135_I	157_I	1.020	1.00
300_G	314_I	1.014	1.00
72_A	278_H	1.004	1.00
280_Y	284_L	0.999	1.00
274_A	280_Y	0.997	1.00
217_L	241_L	0.996	1.00
140_W	235_N	0.993	1.00
174_P	178_Q	0.992	1.00
20_L	57_V	0.989	1.00
16_S	294_I	0.989	1.00
100_A	168_L	0.987	1.00
299_A	302_L	0.987	1.00
92_A	161_F	0.985	1.00
10_A	14_V	0.985	1.00
297_D	301_K	0.982	1.00
50_F	54_L	0.979	1.00
205_L	208_P	0.976	1.00
35_T	45_Y	0.971	1.00
291_L	295_S	0.970	1.00
116_A	119_G	0.967	1.00
206_F	251_A	0.967	1.00
259_M	293_V	0.965	1.00
35_T	39_I	0.957	1.00
237_E	241_L	0.954	1.00
91_N	258_S	0.952	1.00
15_V	298_F	0.952	1.00
57_V	298_F	0.948	1.00
266_A	270_S	0.947	1.00
34_S	38_Q	0.943	1.00
321_P	325_Y	0.932	1.00
9_I	13_L	0.932	1.00
130_I	134_L	0.931	1.00
34_S	39_I	0.924	1.00
304_F	307_A	0.915	1.00
198_A	201_P	0.909	1.00
201_P	204_L	0.909	1.00
90_I	128_G	0.908	1.00
252_C	256_A	0.904	1.00
62_I	203_M	0.900	1.00
316_A	321_P	0.898	1.00
17_Y	29_P	0.898	1.00
193_W	196_I	0.892	1.00
173_D	176_D	0.891	1.00
281_I	285_S	0.889	1.00
46_E	51_D	0.886	1.00
273_L	288_I	0.881	1.00
96_A	165_S	0.880	1.00
32_L	49_L	0.879	1.00
277_E	280_Y	0.878	1.00
232_I	237_E	0.877	1.00
225_D	228_R	0.872	1.00
239_T	243_V	0.871	1.00
94_A	128_G	0.869	1.00
295_S	299_A	0.863	1.00
40_D	43_P	0.859	1.00
224_E	228_R	0.857	1.00
34_S	37_F	0.854	1.00
13_L	17_Y	0.847	1.00
65_L	207_I	0.838	1.00
70_A	245_C	0.837	1.00
96_A	168_L	0.836	1.00
126_I	130_I	0.835	1.00
23_G	53_R	0.835	1.00
218_D	279_R	0.834	1.00
136_Y	239_T	0.834	1.00
322_Y	325_Y	0.833	1.00
180_A	184_K	0.831	1.00
167_F	171_K	0.831	1.00
300_G	310_P	0.827	1.00
194_T	197_T	0.822	1.00
209_I	212_G	0.821	1.00
71_G	267_P	0.820	1.00
57_V	294_I	0.818	1.00
9_I	287_L	0.818	1.00
98_I	120_M	0.817	1.00
271_R	281_I	0.811	1.00
27_V	49_L	0.810	1.00
175_Q	179_M	0.810	1.00
21_T	26_S	0.809	1.00
86_G	91_N	0.809	1.00
102_M	120_M	0.808	1.00
234_S	238_K	0.805	1.00
125_L	129_L	0.804	1.00
213_K	244_A	0.800	1.00
13_L	16_S	0.795	1.00
101_F	120_M	0.793	1.00
242_L	246_V	0.792	1.00
195_Y	255_V	0.792	1.00
66_G	70_A	0.791	1.00
270_S	274_A	0.787	1.00
32_L	35_T	0.787	1.00
54_L	193_W	0.785	1.00
214_S	279_R	0.781	1.00
317_I	321_P	0.779	1.00
93_G	161_F	0.779	1.00
211_I	214_S	0.772	1.00
204_L	208_P	0.771	1.00
224_E	234_S	0.770	1.00
56_R	301_K	0.769	1.00
262_V	315_L	0.768	1.00
302_L	305_Q	0.766	1.00
293_V	315_L	0.765	1.00
303_F	306_P	0.765	1.00
178_Q	181_M	0.764	1.00
278_H	283_P	0.763	1.00
119_G	122_L	0.760	1.00
90_I	132_A	0.758	1.00
203_M	252_C	0.757	1.00
137_I	140_W	0.756	1.00
68_G	72_A	0.755	1.00
199_V	251_A	0.755	1.00
129_L	250_S	0.751	1.00
22_S	26_S	0.750	1.00
227_V	234_S	0.749	1.00
202_W	206_F	0.748	1.00
287_L	291_L	0.744	1.00
14_V	17_Y	0.743	1.00
304_F	309_V	0.743	1.00
128_G	246_V	0.743	1.00
210_L	241_L	0.742	1.00
74_I	88_L	0.741	1.00
84_D	87_I	0.739	1.00
56_R	308_E	0.737	1.00
216_L	232_I	0.736	1.00
136_Y	235_N	0.735	1.00
100_A	105_F	0.735	1.00
38_Q	46_E	0.734	1.00
325_Y	329_K	0.733	1.00
92_A	95_G	0.732	1.00
12_I	16_S	0.731	1.00
118_M	122_L	0.731	1.00
272_R	326_L	0.729	1.00
131_A	135_I	0.728	1.00
103_L	172_M	0.725	1.00
69_I	210_L	0.724	1.00
43_P	47_I	0.724	1.00
251_A	254_S	0.724	1.00
27_V	45_Y	0.724	1.00
212_G	216_L	0.724	1.00
78_T	151_I	0.723	1.00
270_S	273_L	0.723	1.00
100_A	164_L	0.720	1.00
65_L	203_M	0.717	1.00
12_I	294_I	0.716	1.00
67_L	262_V	0.714	1.00
129_L	246_V	0.711	1.00
290_M	294_I	0.710	1.00
68_G	286_G	0.710	1.00
47_I	50_F	0.703	1.00
207_I	211_I	0.702	1.00
59_M	199_V	0.701	1.00
135_I	139_A	0.700	1.00
120_M	123_F	0.697	1.00
20_L	54_L	0.697	1.00
58_V	62_I	0.695	1.00
293_V	311_A	0.695	1.00
138_F	153_V	0.695	1.00
42_N	46_E	0.695	1.00
174_P	177_Y	0.693	1.00
102_M	179_M	0.691	1.00
132_A	242_L	0.691	1.00
99_V	169_S	0.689	1.00
8_F	12_I	0.685	1.00
220_I	234_S	0.683	1.00
19_S	301_K	0.677	1.00
25_F	29_P	0.677	1.00
199_V	202_W	0.677	1.00
140_W	143_G	0.677	1.00
47_I	52_L	0.674	1.00
70_A	249_I	0.672	1.00
29_P	33_L	0.672	1.00
296_A	314_I	0.672	1.00
251_A	255_V	0.671	1.00
200_L	204_L	0.671	1.00
40_D	46_E	0.671	1.00
269_I	288_I	0.670	1.00
259_M	311_A	0.667	1.00
101_F	119_G	0.666	1.00
27_V	35_T	0.665	1.00
95_G	258_S	0.659	1.00
25_F	28_R	0.658	1.00
140_W	145_L	0.658	1.00
188_I	311_A	0.655	1.00
69_I	282_L	0.654	1.00
269_I	272_R	0.652	1.00
193_W	197_T	0.652	1.00
76_A	221_R	0.651	1.00
292_L	318_L	0.651	1.00
279_R	283_P	0.651	1.00
28_R	45_Y	0.648	1.00
169_S	181_M	0.646	1.00
228_R	234_S	0.645	1.00
262_V	292_L	0.641	1.00
267_P	285_S	0.637	1.00
54_L	58_V	0.636	1.00
202_W	247_A	0.635	1.00
166_L	183_W	0.635	1.00
73_V	244_A	0.632	1.00
92_A	158_N	0.632	1.00
166_L	170_L	0.630	1.00
30_A	33_L	0.630	1.00
84_D	263_G	0.627	1.00
286_G	290_M	0.626	1.00
162_S	184_K	0.625	1.00
22_S	298_F	0.625	1.00
265_I	269_I	0.625	1.00
176_D	179_M	0.624	1.00
292_L	296_A	0.623	1.00
181_M	184_K	0.622	1.00
218_D	283_P	0.621	1.00
91_N	94_A	0.618	1.00
126_I	129_L	0.618	1.00
146_D	149_R	0.617	1.00
265_I	323_F	0.617	1.00
203_M	207_I	0.617	1.00
63_I	188_I	0.616	1.00
295_S	298_F	0.615	1.00
148_G	151_I	0.615	1.00
97_G	101_F	0.614	1.00
206_F	210_L	0.614	1.00
162_S	166_L	0.610	1.00
14_V	18_F	0.610	1.00
264_L	326_L	0.609	1.00
134_L	137_I	0.607	1.00
153_V	156_A	0.607	1.00
283_P	287_L	0.606	1.00
7_L	11_L	0.605	1.00
139_A	153_V	0.605	1.00
20_L	49_L	0.604	1.00
269_I	292_L	0.603	1.00
29_P	32_L	0.602	1.00
188_I	256_A	0.602	1.00
137_I	141_H	0.601	1.00
49_L	54_L	0.599	1.00
212_G	215_R	0.599	1.00
65_L	69_I	0.597	1.00
300_G	308_E	0.597	1.00
241_L	245_C	0.597	1.00
265_I	322_Y	0.596	1.00
216_L	219_T	0.595	1.00
101_F	105_F	0.592	1.00
15_V	18_F	0.590	1.00
60_A	311_A	0.590	1.00
328_F	331_K	0.589	1.00
249_I	253_V	0.589	1.00
130_I	133_I	0.587	1.00
102_M	180_A	0.587	1.00
74_I	83_A	0.587	1.00
18_F	298_F	0.585	1.00
16_S	20_L	0.580	0.99
215_R	218_D	0.580	0.99
32_L	37_F	0.580	0.99
269_I	322_Y	0.579	0.99
104_L	107_G	0.579	0.99
240_I	244_A	0.577	0.99
32_L	36_L	0.577	0.99
59_M	63_I	0.576	0.99
194_T	198_A	0.574	0.99
5_Y	9_I	0.573	0.99
132_A	136_Y	0.573	0.99
19_S	294_I	0.573	0.99
92_A	162_S	0.572	0.99
288_I	291_L	0.572	0.99
68_G	289_G	0.572	0.99
73_V	245_C	0.571	0.99
131_A	157_I	0.569	0.99
5_Y	287_L	0.568	0.99
240_I	243_V	0.568	0.99
246_V	250_S	0.568	0.99
300_G	303_F	0.566	0.99
297_D	308_E	0.566	0.99
136_Y	140_W	0.563	0.99
220_I	237_E	0.561	0.99
17_Y	33_L	0.560	0.99
250_S	254_S	0.559	0.99
72_A	270_S	0.558	0.99
74_I	90_I	0.558	0.99
79_R	224_E	0.557	0.99
78_T	81_G	0.556	0.99
198_A	202_W	0.556	0.99
59_M	256_A	0.555	0.99
196_I	200_L	0.552	0.99
139_A	145_L	0.549	0.99
218_D	221_R	0.549	0.99
90_I	135_I	0.548	0.99
205_L	209_I	0.548	0.99
198_A	251_A	0.547	0.99
298_F	302_L	0.547	0.99
105_F	108_Q	0.544	0.99
233_S	240_I	0.541	0.99
108_Q	116_A	0.538	0.99
233_S	239_T	0.538	0.99
31_E	38_Q	0.537	0.99
25_F	45_Y	0.536	0.99
21_T	33_L	0.535	0.99
36_L	49_L	0.533	0.99
120_M	124_G	0.531	0.99
93_G	157_I	0.529	0.99
127_G	131_A	0.528	0.99
16_S	58_V	0.528	0.99
169_S	184_K	0.526	0.99
169_S	180_A	0.526	0.99
217_L	278_H	0.525	0.99
153_V	157_I	0.525	0.99
7_L	10_A	0.525	0.99
26_S	30_A	0.524	0.99
98_I	123_F	0.524	0.99
270_S	285_S	0.524	0.99
196_I	199_V	0.520	0.99
207_I	286_G	0.520	0.99
117_A	121_P	0.519	0.99
31_E	35_T	0.517	0.99
169_S	177_Y	0.517	0.99
294_I	298_F	0.515	0.99
94_A	124_G	0.514	0.99
172_M	176_D	0.514	0.99
207_I	210_L	0.512	0.99
203_M	208_P	0.509	0.99
39_I	42_N	0.508	0.99
325_Y	328_F	0.508	0.99
10_A	13_L	0.508	0.99
12_I	57_V	0.506	0.99
160_G	164_L	0.506	0.99
170_L	185_N	0.503	0.99
83_A	90_I	0.500	0.98
268_H	271_R	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2nq2A	2	0.9137	100	0.183	Contact Map
4g1uA	2	0.875	100	0.195	Contact Map
2qi9A	2	0.9315	100	0.198	Contact Map
2m20A	2	0.0804	10.7	0.967	Contact Map
3rlfF	1	0.369	8.1	0.969	Contact Map
2xq2A	2	0.5625	8	0.969	Contact Map
3mktA	1	0.9196	8	0.969	Contact Map
2nr9A	2	0.5	6.5	0.97	Contact Map
2l9uA	2	0.0923	5.8	0.971	Contact Map
4tquM	1	0.4018	5.7	0.971	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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