GREMLIN Database
FEUC - Iron-uptake system permease protein FeuC
UniProt: P40411 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 336 (318)
Sequences: 13808 (9813)
Seq/√Len: 550.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
218_D277_E4.2641.00
65_L286_G3.7001.00
101_F123_F3.6211.00
15_V295_S3.4971.00
73_V210_L3.4131.00
16_S57_V3.3621.00
233_S236_K3.1931.00
66_G203_M3.0441.00
73_V241_L3.0051.00
61_A290_M2.9311.00
60_A188_I2.8111.00
270_S288_I2.7911.00
31_E45_Y2.6631.00
59_M191_A2.5481.00
69_I286_G2.5161.00
66_G248_I2.4501.00
16_S61_A2.4341.00
31_E34_S2.4291.00
66_G252_C2.4251.00
96_A164_L2.4161.00
224_E238_K2.3401.00
12_I291_L2.2581.00
63_I252_C2.2441.00
11_L291_L2.2371.00
72_A285_S2.1601.00
69_I207_I2.1521.00
274_A284_L2.1481.00
42_N45_Y2.1341.00
21_T29_P2.1221.00
61_A294_I2.0831.00
12_I61_A2.0701.00
63_I256_A2.0631.00
216_L237_E2.0511.00
202_W251_A2.0331.00
62_I200_L1.9671.00
28_R31_E1.9641.00
96_A161_F1.9411.00
30_A34_S1.9321.00
100_A104_L1.9171.00
56_R297_D1.8881.00
76_A278_H1.8581.00
213_K216_L1.8551.00
74_I245_C1.8451.00
15_V291_L1.8341.00
219_T232_I1.8311.00
218_D278_H1.8111.00
19_S57_V1.7931.00
99_V165_S1.7901.00
209_I244_A1.7661.00
39_I46_E1.7221.00
206_F248_I1.6901.00
191_A195_Y1.6791.00
43_P46_E1.6741.00
46_E50_F1.6681.00
213_K240_I1.6581.00
197_T201_P1.5821.00
58_V196_I1.5771.00
262_V293_V1.5721.00
236_K240_I1.5631.00
72_A281_I1.5611.00
18_F21_T1.5451.00
299_A303_F1.5391.00
192_N195_Y1.5331.00
128_G250_S1.5321.00
98_I124_G1.5161.00
213_K237_E1.5081.00
12_I287_L1.5001.00
35_T50_F1.4921.00
132_A246_V1.4891.00
206_F247_A1.4871.00
5_Y284_L1.4871.00
18_F22_S1.4801.00
97_G123_F1.4611.00
15_V294_I1.4601.00
8_F287_L1.4411.00
300_G311_A1.4301.00
188_I293_V1.3841.00
33_L37_F1.3681.00
270_S284_L1.3681.00
299_A314_I1.3561.00
8_F284_L1.3551.00
206_F244_A1.3531.00
19_S298_F1.3351.00
8_F288_I1.3321.00
70_A248_I1.3221.00
201_P205_L1.3111.00
280_Y283_P1.3051.00
131_A161_F1.3011.00
213_K241_L1.2791.00
209_I213_K1.2771.00
95_G165_S1.2631.00
59_M255_V1.2581.00
270_S281_I1.2531.00
197_T200_L1.2511.00
160_G320_V1.2441.00
266_A292_L1.2291.00
12_I290_M1.2291.00
44_Q47_I1.2261.00
228_R235_N1.2261.00
266_A288_I1.2231.00
91_N249_I1.2131.00
47_I51_D1.2131.00
62_I196_I1.2091.00
26_S29_P1.2031.00
68_G266_A1.2011.00
219_T230_L1.2001.00
226_T229_S1.1921.00
35_T46_E1.1881.00
256_A259_M1.1871.00
95_G184_K1.1771.00
236_K239_T1.1761.00
199_V255_V1.1711.00
97_G127_G1.1691.00
278_H281_I1.1681.00
77_I241_L1.1611.00
237_E240_I1.1401.00
93_G131_A1.1401.00
60_A294_I1.1361.00
8_F291_L1.1331.00
99_V180_A1.1311.00
65_L290_M1.1221.00
25_F48_L1.1121.00
72_A282_L1.1101.00
125_L247_A1.1081.00
235_N238_K1.1041.00
209_I240_I1.1011.00
133_I137_I1.0991.00
103_L168_L1.0961.00
5_Y280_Y1.0961.00
208_P212_G1.0961.00
210_L244_A1.0841.00
60_A293_V1.0821.00
39_I50_F1.0811.00
235_N239_T1.0781.00
158_N162_S1.0761.00
59_M196_I1.0741.00
62_I199_V1.0731.00
122_L126_I1.0661.00
96_A100_A1.0631.00
65_L68_G1.0611.00
223_D227_V1.0581.00
35_T49_L1.0501.00
123_F127_G1.0481.00
93_G127_G1.0441.00
283_P286_G1.0431.00
301_K308_E1.0421.00
17_Y21_T1.0391.00
199_V203_M1.0321.00
58_V193_W1.0221.00
21_T32_L1.0221.00
22_S302_L1.0211.00
135_I157_I1.0201.00
300_G314_I1.0141.00
72_A278_H1.0041.00
280_Y284_L0.9991.00
274_A280_Y0.9971.00
217_L241_L0.9961.00
140_W235_N0.9931.00
174_P178_Q0.9921.00
20_L57_V0.9891.00
16_S294_I0.9891.00
100_A168_L0.9871.00
299_A302_L0.9871.00
92_A161_F0.9851.00
10_A14_V0.9851.00
297_D301_K0.9821.00
50_F54_L0.9791.00
205_L208_P0.9761.00
35_T45_Y0.9711.00
291_L295_S0.9701.00
116_A119_G0.9671.00
206_F251_A0.9671.00
259_M293_V0.9651.00
35_T39_I0.9571.00
237_E241_L0.9541.00
91_N258_S0.9521.00
15_V298_F0.9521.00
57_V298_F0.9481.00
266_A270_S0.9471.00
34_S38_Q0.9431.00
321_P325_Y0.9321.00
9_I13_L0.9321.00
130_I134_L0.9311.00
34_S39_I0.9241.00
304_F307_A0.9151.00
198_A201_P0.9091.00
201_P204_L0.9091.00
90_I128_G0.9081.00
252_C256_A0.9041.00
62_I203_M0.9001.00
316_A321_P0.8981.00
17_Y29_P0.8981.00
193_W196_I0.8921.00
173_D176_D0.8911.00
281_I285_S0.8891.00
46_E51_D0.8861.00
273_L288_I0.8811.00
96_A165_S0.8801.00
32_L49_L0.8791.00
277_E280_Y0.8781.00
232_I237_E0.8771.00
225_D228_R0.8721.00
239_T243_V0.8711.00
94_A128_G0.8691.00
295_S299_A0.8631.00
40_D43_P0.8591.00
224_E228_R0.8571.00
34_S37_F0.8541.00
13_L17_Y0.8471.00
65_L207_I0.8381.00
70_A245_C0.8371.00
96_A168_L0.8361.00
126_I130_I0.8351.00
23_G53_R0.8351.00
218_D279_R0.8341.00
136_Y239_T0.8341.00
322_Y325_Y0.8331.00
180_A184_K0.8311.00
167_F171_K0.8311.00
300_G310_P0.8271.00
194_T197_T0.8221.00
209_I212_G0.8211.00
71_G267_P0.8201.00
57_V294_I0.8181.00
9_I287_L0.8181.00
98_I120_M0.8171.00
271_R281_I0.8111.00
27_V49_L0.8101.00
175_Q179_M0.8101.00
21_T26_S0.8091.00
86_G91_N0.8091.00
102_M120_M0.8081.00
234_S238_K0.8051.00
125_L129_L0.8041.00
213_K244_A0.8001.00
13_L16_S0.7951.00
101_F120_M0.7931.00
242_L246_V0.7921.00
195_Y255_V0.7921.00
66_G70_A0.7911.00
270_S274_A0.7871.00
32_L35_T0.7871.00
54_L193_W0.7851.00
214_S279_R0.7811.00
317_I321_P0.7791.00
93_G161_F0.7791.00
211_I214_S0.7721.00
204_L208_P0.7711.00
224_E234_S0.7701.00
56_R301_K0.7691.00
262_V315_L0.7681.00
302_L305_Q0.7661.00
293_V315_L0.7651.00
303_F306_P0.7651.00
178_Q181_M0.7641.00
278_H283_P0.7631.00
119_G122_L0.7601.00
90_I132_A0.7581.00
203_M252_C0.7571.00
137_I140_W0.7561.00
68_G72_A0.7551.00
199_V251_A0.7551.00
129_L250_S0.7511.00
22_S26_S0.7501.00
227_V234_S0.7491.00
202_W206_F0.7481.00
287_L291_L0.7441.00
14_V17_Y0.7431.00
304_F309_V0.7431.00
128_G246_V0.7431.00
210_L241_L0.7421.00
74_I88_L0.7411.00
84_D87_I0.7391.00
56_R308_E0.7371.00
216_L232_I0.7361.00
136_Y235_N0.7351.00
100_A105_F0.7351.00
38_Q46_E0.7341.00
325_Y329_K0.7331.00
92_A95_G0.7321.00
12_I16_S0.7311.00
118_M122_L0.7311.00
272_R326_L0.7291.00
131_A135_I0.7281.00
103_L172_M0.7251.00
69_I210_L0.7241.00
43_P47_I0.7241.00
251_A254_S0.7241.00
27_V45_Y0.7241.00
212_G216_L0.7241.00
78_T151_I0.7231.00
270_S273_L0.7231.00
100_A164_L0.7201.00
65_L203_M0.7171.00
12_I294_I0.7161.00
67_L262_V0.7141.00
129_L246_V0.7111.00
290_M294_I0.7101.00
68_G286_G0.7101.00
47_I50_F0.7031.00
207_I211_I0.7021.00
59_M199_V0.7011.00
135_I139_A0.7001.00
120_M123_F0.6971.00
20_L54_L0.6971.00
58_V62_I0.6951.00
293_V311_A0.6951.00
138_F153_V0.6951.00
42_N46_E0.6951.00
174_P177_Y0.6931.00
102_M179_M0.6911.00
132_A242_L0.6911.00
99_V169_S0.6891.00
8_F12_I0.6851.00
220_I234_S0.6831.00
19_S301_K0.6771.00
25_F29_P0.6771.00
199_V202_W0.6771.00
140_W143_G0.6771.00
47_I52_L0.6741.00
70_A249_I0.6721.00
29_P33_L0.6721.00
296_A314_I0.6721.00
251_A255_V0.6711.00
200_L204_L0.6711.00
40_D46_E0.6711.00
269_I288_I0.6701.00
259_M311_A0.6671.00
101_F119_G0.6661.00
27_V35_T0.6651.00
95_G258_S0.6591.00
25_F28_R0.6581.00
140_W145_L0.6581.00
188_I311_A0.6551.00
69_I282_L0.6541.00
269_I272_R0.6521.00
193_W197_T0.6521.00
76_A221_R0.6511.00
292_L318_L0.6511.00
279_R283_P0.6511.00
28_R45_Y0.6481.00
169_S181_M0.6461.00
228_R234_S0.6451.00
262_V292_L0.6411.00
267_P285_S0.6371.00
54_L58_V0.6361.00
202_W247_A0.6351.00
166_L183_W0.6351.00
73_V244_A0.6321.00
92_A158_N0.6321.00
166_L170_L0.6301.00
30_A33_L0.6301.00
84_D263_G0.6271.00
286_G290_M0.6261.00
162_S184_K0.6251.00
22_S298_F0.6251.00
265_I269_I0.6251.00
176_D179_M0.6241.00
292_L296_A0.6231.00
181_M184_K0.6221.00
218_D283_P0.6211.00
91_N94_A0.6181.00
126_I129_L0.6181.00
146_D149_R0.6171.00
265_I323_F0.6171.00
203_M207_I0.6171.00
63_I188_I0.6161.00
295_S298_F0.6151.00
148_G151_I0.6151.00
97_G101_F0.6141.00
206_F210_L0.6141.00
162_S166_L0.6101.00
14_V18_F0.6101.00
264_L326_L0.6091.00
134_L137_I0.6071.00
153_V156_A0.6071.00
283_P287_L0.6061.00
7_L11_L0.6051.00
139_A153_V0.6051.00
20_L49_L0.6041.00
269_I292_L0.6031.00
29_P32_L0.6021.00
188_I256_A0.6021.00
137_I141_H0.6011.00
49_L54_L0.5991.00
212_G215_R0.5991.00
65_L69_I0.5971.00
300_G308_E0.5971.00
241_L245_C0.5971.00
265_I322_Y0.5961.00
216_L219_T0.5951.00
101_F105_F0.5921.00
15_V18_F0.5901.00
60_A311_A0.5901.00
328_F331_K0.5891.00
249_I253_V0.5891.00
130_I133_I0.5871.00
102_M180_A0.5871.00
74_I83_A0.5871.00
18_F298_F0.5851.00
16_S20_L0.5800.99
215_R218_D0.5800.99
32_L37_F0.5800.99
269_I322_Y0.5790.99
104_L107_G0.5790.99
240_I244_A0.5770.99
32_L36_L0.5770.99
59_M63_I0.5760.99
194_T198_A0.5740.99
5_Y9_I0.5730.99
132_A136_Y0.5730.99
19_S294_I0.5730.99
92_A162_S0.5720.99
288_I291_L0.5720.99
68_G289_G0.5720.99
73_V245_C0.5710.99
131_A157_I0.5690.99
5_Y287_L0.5680.99
240_I243_V0.5680.99
246_V250_S0.5680.99
300_G303_F0.5660.99
297_D308_E0.5660.99
136_Y140_W0.5630.99
220_I237_E0.5610.99
17_Y33_L0.5600.99
250_S254_S0.5590.99
72_A270_S0.5580.99
74_I90_I0.5580.99
79_R224_E0.5570.99
78_T81_G0.5560.99
198_A202_W0.5560.99
59_M256_A0.5550.99
196_I200_L0.5520.99
139_A145_L0.5490.99
218_D221_R0.5490.99
90_I135_I0.5480.99
205_L209_I0.5480.99
198_A251_A0.5470.99
298_F302_L0.5470.99
105_F108_Q0.5440.99
233_S240_I0.5410.99
108_Q116_A0.5380.99
233_S239_T0.5380.99
31_E38_Q0.5370.99
25_F45_Y0.5360.99
21_T33_L0.5350.99
36_L49_L0.5330.99
120_M124_G0.5310.99
93_G157_I0.5290.99
127_G131_A0.5280.99
16_S58_V0.5280.99
169_S184_K0.5260.99
169_S180_A0.5260.99
217_L278_H0.5250.99
153_V157_I0.5250.99
7_L10_A0.5250.99
26_S30_A0.5240.99
98_I123_F0.5240.99
270_S285_S0.5240.99
196_I199_V0.5200.99
207_I286_G0.5200.99
117_A121_P0.5190.99
31_E35_T0.5170.99
169_S177_Y0.5170.99
294_I298_F0.5150.99
94_A124_G0.5140.99
172_M176_D0.5140.99
207_I210_L0.5120.99
203_M208_P0.5090.99
39_I42_N0.5080.99
325_Y328_F0.5080.99
10_A13_L0.5080.99
12_I57_V0.5060.99
160_G164_L0.5060.99
170_L185_N0.5030.99
83_A90_I0.5000.98
268_H271_R0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nq2A 2 0.9137 100 0.183 Contact Map
4g1uA 2 0.875 100 0.195 Contact Map
2qi9A 2 0.9315 100 0.198 Contact Map
2m20A 2 0.0804 10.7 0.967 Contact Map
3rlfF 1 0.369 8.1 0.969 Contact Map
2xq2A 2 0.5625 8 0.969 Contact Map
3mktA 1 0.9196 8 0.969 Contact Map
2nr9A 2 0.5 6.5 0.97 Contact Map
2l9uA 2 0.0923 5.8 0.971 Contact Map
4tquM 1 0.4018 5.7 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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