FEUB - BACSU - GREMLIN Contacts

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FEUB - Iron-uptake system permease protein FeuB

UniProt:	P40410	Sequences: MYSKQWTRIILITSPFAIALSLLLSILYGAKHLSTDIVFTSLIHFDPGNTDHQIIWHSRIPRAAGALLIGAALAVSGALMQGITRNYLASPSIMGVSDGSAFIITLCMVLLPQSSSIEMMIYSFIGSALGAVLVFGLAAMMPNGFTPVQLAIIGTVTSMLLSSLSAAMSIYFQISQDLSFWYSARLHQMSPDFLKLAAPFFLIGIIMAISLSKKVTAVSLGDDISKSLGQKKKTIKIMAMLSVIILTGSAVALAGKIAFVGLVVPHITRFLVGSDYSRLIPCSCILGGIFLTLCDLASRFINYPFETPIEVVTSIIGVPFFLYLIKRKGGEQNG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	334 (318)
Sequences:	13860 (9946)
Seq/√Len:	557.8

ECOLI - FEPG FECC FEPD BTUC FECD FHUB
BACSU - FEUB FHUB FHUG YVRB YFMD YFME YFIZ YFHA FEUC YCLN YCLO
HALSA - Q9HMG0 Q9HMG7 BTUCA
SULSO - Q97ZU1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
216_T	275_D	4.973	1.00
71_A	284_C	3.795	1.00
79_L	208_A	3.661	1.00
107_C	122_Y	3.652	1.00
21_S	293_L	3.567	1.00
22_L	63_A	3.369	1.00
72_A	201_F	3.264	1.00
231_K	234_T	3.258	1.00
67_L	288_G	3.157	1.00
79_L	239_A	3.109	1.00
66_A	186_L	2.952	1.00
268_T	286_L	2.884	1.00
65_G	189_M	2.727	1.00
72_A	246_L	2.643	1.00
72_A	250_A	2.616	1.00
37_I	51_D	2.614	1.00
22_L	67_L	2.421	1.00
75_V	284_C	2.401	1.00
222_D	236_K	2.378	1.00
17_A	289_I	2.369	1.00
102_F	164_L	2.349	1.00
37_I	40_T	2.335	1.00
18_I	289_I	2.291	1.00
75_V	205_I	2.277	1.00
69_I	250_A	2.258	1.00
102_F	161_L	2.236	1.00
78_A	283_S	2.180	1.00
272_V	282_C	2.148	1.00
27_L	35_T	2.145	1.00
48_G	51_D	2.143	1.00
216_T	276_Y	2.094	1.00
69_I	254_A	2.073	1.00
25_S	63_A	2.065	1.00
62_R	295_D	2.042	1.00
67_L	292_T	2.017	1.00
68_L	198_A	1.956	1.00
18_I	67_L	1.951	1.00
200_F	249_S	1.946	1.00
82_G	276_Y	1.924	1.00
21_S	289_I	1.909	1.00
34_S	37_I	1.878	1.00
214_K	235_I	1.843	1.00
105_T	165_S	1.804	1.00
106_L	110_L	1.802	1.00
80_M	243_V	1.791	1.00
189_M	193_F	1.783	1.00
217_A	230_Q	1.758	1.00
45_F	52_H	1.746	1.00
211_L	214_K	1.695	1.00
11_L	282_C	1.688	1.00
127_S	248_G	1.680	1.00
207_M	242_S	1.655	1.00
297_A	301_I	1.605	1.00
260_V	291_L	1.605	1.00
18_I	285_I	1.574	1.00
36_D	40_T	1.558	1.00
298_S	309_I	1.552	1.00
49_N	52_H	1.538	1.00
64_A	194_L	1.538	1.00
234_T	238_M	1.535	1.00
211_L	238_M	1.516	1.00
104_I	123_S	1.515	1.00
204_G	246_L	1.513	1.00
14_S	285_I	1.499	1.00
24_L	27_L	1.498	1.00
39_F	43_I	1.494	1.00
204_G	245_I	1.482	1.00
297_A	312_V	1.463	1.00
41_S	56_W	1.454	1.00
52_H	56_W	1.445	1.00
76_S	246_L	1.444	1.00
131_A	244_I	1.440	1.00
103_I	122_Y	1.439	1.00
21_S	292_T	1.437	1.00
268_T	279_L	1.425	1.00
195_K	199_P	1.410	1.00
195_K	198_A	1.407	1.00
78_A	279_L	1.396	1.00
24_L	28_Y	1.395	1.00
101_A	165_S	1.394	1.00
190_S	193_F	1.387	1.00
14_S	282_C	1.383	1.00
211_L	235_I	1.372	1.00
10_I	282_C	1.368	1.00
65_G	253_L	1.360	1.00
186_L	291_L	1.354	1.00
278_R	281_P	1.319	1.00
204_G	242_S	1.312	1.00
160_L	318_V	1.298	1.00
25_S	296_L	1.295	1.00
264_V	290_F	1.288	1.00
97_S	247_T	1.284	1.00
268_T	282_C	1.277	1.00
299_R	306_E	1.276	1.00
74_A	264_V	1.272	1.00
199_P	203_I	1.251	1.00
68_L	194_L	1.246	1.00
207_M	211_L	1.231	1.00
276_Y	279_L	1.227	1.00
99_G	126_G	1.221	1.00
211_L	239_A	1.220	1.00
103_I	126_G	1.214	1.00
130_G	161_L	1.201	1.00
83_I	239_A	1.193	1.00
78_A	276_Y	1.188	1.00
101_A	182_Y	1.185	1.00
132_V	136_G	1.173	1.00
31_K	54_I	1.165	1.00
235_I	238_M	1.161	1.00
226_K	233_K	1.158	1.00
105_T	178_L	1.158	1.00
11_L	278_R	1.153	1.00
264_V	286_L	1.153	1.00
18_I	288_G	1.150	1.00
234_T	237_I	1.150	1.00
257_I	291_L	1.135	1.00
221_G	225_S	1.134	1.00
14_S	286_L	1.128	1.00
41_S	52_H	1.124	1.00
102_F	106_L	1.122	1.00
14_S	289_I	1.118	1.00
134_V	157_T	1.117	1.00
295_D	299_R	1.112	1.00
224_I	227_S	1.108	1.00
68_L	197_A	1.107	1.00
53_Q	57_H	1.106	1.00
78_A	280_I	1.094	1.00
115_S	118_E	1.093	1.00
71_A	74_A	1.087	1.00
32_H	35_T	1.083	1.00
124_F	245_I	1.081	1.00
197_A	253_L	1.080	1.00
233_K	236_K	1.078	1.00
56_W	60_I	1.068	1.00
65_G	194_L	1.062	1.00
297_A	300_F	1.060	1.00
121_I	125_I	1.059	1.00
66_A	291_L	1.052	1.00
129_L	133_L	1.049	1.00
109_V	168_M	1.047	1.00
289_I	293_L	1.044	1.00
64_A	191_P	1.043	1.00
204_G	249_S	1.042	1.00
21_S	296_L	1.039	1.00
208_A	242_S	1.038	1.00
197_A	201_F	1.037	1.00
254_A	257_I	1.035	1.00
45_F	56_W	1.035	1.00
314_S	319_P	1.033	1.00
22_L	292_T	1.032	1.00
207_M	238_M	1.032	1.00
66_A	292_T	1.024	1.00
50_T	53_Q	1.023	1.00
26_I	63_A	1.015	1.00
217_A	228_L	1.007	1.00
9_I	12_I	0.999	1.00
122_Y	126_G	0.998	1.00
63_A	296_L	0.998	1.00
139_A	233_K	0.994	1.00
276_Y	281_P	0.988	1.00
71_A	288_G	0.988	1.00
38_V	55_I	0.978	1.00
223_D	226_K	0.972	1.00
281_P	284_C	0.971	1.00
28_Y	300_F	0.970	1.00
272_V	278_R	0.968	1.00
264_V	268_T	0.964	1.00
203_I	206_I	0.963	1.00
167_A	171_Y	0.960	1.00
99_G	130_G	0.956	1.00
23_L	27_L	0.950	1.00
206_I	210_S	0.949	1.00
41_S	55_I	0.942	1.00
106_L	168_M	0.941	1.00
16_F	20_L	0.935	1.00
98_D	161_L	0.933	1.00
233_K	237_I	0.932	1.00
15_P	19_A	0.931	1.00
191_P	194_L	0.931	1.00
158_S	162_S	0.929	1.00
27_L	38_V	0.919	1.00
77_G	265_P	0.918	1.00
278_R	282_C	0.914	1.00
97_S	256_K	0.911	1.00
41_S	45_F	0.908	1.00
23_L	35_T	0.906	1.00
298_S	308_P	0.906	1.00
298_S	312_V	0.906	1.00
196_L	199_P	0.905	1.00
135_F	233_K	0.904	1.00
279_L	283_S	0.895	1.00
293_L	297_A	0.893	1.00
230_Q	235_I	0.889	1.00
102_F	165_S	0.886	1.00
102_F	168_M	0.886	1.00
130_G	134_V	0.885	1.00
104_I	119_M	0.883	1.00
29_G	59_R	0.883	1.00
320_F	323_Y	0.883	1.00
235_I	239_A	0.879	1.00
302_N	305_F	0.879	1.00
72_A	76_S	0.877	1.00
41_S	51_D	0.876	1.00
139_A	142_P	0.872	1.00
109_V	172_F	0.871	1.00
215_V	239_A	0.870	1.00
68_L	201_F	0.868	1.00
98_D	101_A	0.861	1.00
71_A	205_I	0.861	1.00
250_A	254_A	0.860	1.00
9_I	13_T	0.855	1.00
271_L	286_L	0.853	1.00
199_P	202_L	0.851	1.00
92_S	97_S	0.844	1.00
33_L	55_I	0.838	1.00
40_T	43_I	0.838	1.00
62_R	299_R	0.834	1.00
212_S	277_S	0.830	1.00
108_M	119_M	0.828	1.00
211_L	242_S	0.828	1.00
139_A	144_G	0.822	1.00
208_A	239_A	0.820	1.00
127_S	244_I	0.820	1.00
76_S	243_V	0.820	1.00
19_A	23_L	0.818	1.00
202_L	206_I	0.817	1.00
301_I	304_P	0.816	1.00
63_A	292_T	0.815	1.00
216_T	277_S	0.815	1.00
96_V	127_S	0.814	1.00
46_D	49_N	0.813	1.00
40_T	44_H	0.811	1.00
52_H	57_H	0.809	1.00
319_P	323_Y	0.806	1.00
178_L	182_Y	0.804	1.00
10_I	14_S	0.799	1.00
291_L	313_T	0.798	1.00
10_I	13_T	0.794	1.00
176_Q	179_S	0.792	1.00
62_R	306_E	0.792	1.00
38_V	41_S	0.792	1.00
207_M	210_S	0.788	1.00
105_T	169_S	0.786	1.00
222_D	226_K	0.786	1.00
222_D	232_K	0.782	1.00
300_F	303_Y	0.781	1.00
275_D	278_R	0.779	1.00
269_R	279_L	0.778	1.00
315_I	319_P	0.777	1.00
15_P	285_I	0.775	1.00
40_T	45_F	0.773	1.00
100_S	127_S	0.773	1.00
74_A	284_C	0.769	1.00
225_S	232_K	0.769	1.00
128_A	248_G	0.768	1.00
33_L	51_D	0.764	1.00
18_I	22_L	0.761	1.00
134_V	138_A	0.761	1.00
84_T	151_A	0.760	1.00
268_T	271_L	0.758	1.00
20_L	23_L	0.758	1.00
267_I	286_L	0.757	1.00
71_A	201_F	0.756	1.00
25_S	299_R	0.756	1.00
107_C	119_M	0.755	1.00
18_I	292_T	0.754	1.00
135_F	237_I	0.753	1.00
216_T	281_P	0.751	1.00
74_A	78_A	0.749	1.00
200_F	204_G	0.748	1.00
125_I	129_L	0.746	1.00
268_T	272_V	0.746	1.00
31_K	34_S	0.741	1.00
90_S	93_I	0.740	1.00
75_V	208_A	0.740	1.00
139_A	145_F	0.739	1.00
80_M	94_M	0.738	1.00
285_I	289_I	0.733	1.00
136_G	139_A	0.733	1.00
19_A	22_L	0.730	1.00
240_M	244_I	0.730	1.00
73_L	260_V	0.730	1.00
290_F	294_C	0.729	1.00
237_I	241_L	0.727	1.00
201_F	250_A	0.725	1.00
172_F	175_S	0.721	1.00
60_I	191_P	0.719	1.00
124_F	128_A	0.719	1.00
232_K	236_K	0.719	1.00
101_A	256_K	0.715	1.00
295_D	306_E	0.715	1.00
27_L	32_H	0.713	1.00
46_D	52_H	0.712	1.00
260_V	313_T	0.712	1.00
131_A	240_M	0.712	1.00
64_A	68_L	0.708	1.00
193_F	253_L	0.705	1.00
31_K	35_T	0.702	1.00
249_S	253_L	0.694	1.00
106_L	111_L	0.694	1.00
44_H	52_H	0.689	1.00
65_G	197_A	0.686	1.00
118_E	121_I	0.686	1.00
197_A	249_S	0.686	1.00
26_I	55_I	0.683	1.00
257_I	309_I	0.683	1.00
198_A	202_L	0.682	1.00
82_G	219_S	0.675	1.00
179_S	182_Y	0.675	1.00
173_Q	177_D	0.674	1.00
302_N	307_T	0.670	1.00
75_V	280_I	0.667	1.00
20_L	24_L	0.666	1.00
294_C	312_V	0.666	1.00
262_L	324_L	0.665	1.00
270_F	324_L	0.665	1.00
10_I	271_L	0.664	1.00
106_L	164_L	0.664	1.00
265_P	283_S	0.663	1.00
209_I	212_S	0.662	1.00
108_M	177_D	0.662	1.00
131_A	135_F	0.661	1.00
277_S	281_P	0.659	1.00
323_Y	327_R	0.659	1.00
226_K	232_K	0.656	1.00
138_A	153_I	0.655	1.00
249_S	252_A	0.652	1.00
53_Q	58_S	0.651	1.00
76_S	247_T	0.649	1.00
35_T	38_V	0.648	1.00
216_T	219_S	0.644	1.00
128_A	244_I	0.644	1.00
204_G	208_A	0.644	1.00
210_S	214_K	0.641	1.00
90_S	261_G	0.640	1.00
96_V	131_A	0.639	1.00
28_Y	32_H	0.636	1.00
69_I	186_L	0.636	1.00
14_S	18_I	0.635	1.00
38_V	42_L	0.634	1.00
192_D	195_K	0.634	1.00
60_I	64_A	0.632	1.00
33_L	41_S	0.631	1.00
267_I	270_F	0.629	1.00
288_G	292_T	0.628	1.00
214_K	230_Q	0.628	1.00
126_G	130_G	0.626	1.00
243_V	248_G	0.625	1.00
200_F	245_I	0.622	1.00
99_G	161_L	0.621	1.00
119_M	122_Y	0.621	1.00
97_S	100_S	0.620	1.00
267_I	290_F	0.618	1.00
273_G	281_P	0.618	1.00
23_L	39_F	0.617	1.00
84_T	87_Y	0.616	1.00
71_A	75_V	0.616	1.00
79_L	242_S	0.615	1.00
284_C	288_G	0.614	1.00
218_V	232_K	0.613	1.00
135_F	139_A	0.613	1.00
49_N	53_Q	0.611	1.00
197_A	200_F	0.611	1.00
36_D	39_F	0.611	1.00
139_A	143_N	0.610	1.00
53_Q	56_W	0.609	1.00
80_M	89_A	0.608	1.00
169_S	179_S	0.608	1.00
66_A	309_I	0.607	1.00
148_V	151_A	0.605	1.00
263_V	321_F	0.604	1.00
103_I	107_C	0.602	1.00
290_F	316_I	0.601	1.00
26_I	60_I	0.601	1.00
166_A	181_W	0.600	1.00
247_T	251_V	0.600	1.00
137_L	153_I	0.599	1.00
215_V	276_Y	0.598	1.00
35_T	39_F	0.597	1.00
89_A	96_V	0.597	1.00
22_L	26_I	0.596	1.00
30_A	304_P	0.595	1.00
153_I	156_V	0.590	1.00
80_M	96_V	0.588	1.00
268_T	283_S	0.587	1.00
48_G	52_H	0.587	1.00
34_S	51_D	0.586	1.00
248_G	252_A	0.586	1.00
108_M	178_L	0.585	1.00
292_T	296_L	0.584	1.00
293_L	296_L	0.583	1.00
191_P	195_K	0.582	1.00
262_L	265_P	0.582	1.00
18_I	63_A	0.581	1.00
326_K	329_G	0.581	1.00
117_I	121_I	0.580	1.00
13_T	17_A	0.579	1.00
74_A	287_G	0.577	0.99
124_F	127_S	0.577	0.99
175_S	178_L	0.577	0.99
166_A	170_I	0.576	0.99
83_I	243_V	0.575	0.99
214_K	217_A	0.574	0.99
170_I	311_V	0.573	0.99
196_L	249_S	0.573	0.99
104_I	122_Y	0.571	0.99
12_I	16_F	0.571	0.99
100_S	123_S	0.569	0.99
127_S	131_A	0.567	0.99
169_S	182_Y	0.567	0.99
162_S	182_Y	0.564	0.99
296_L	300_F	0.563	0.99
203_I	207_M	0.563	0.99
260_V	290_F	0.559	0.99
174_I	177_D	0.553	0.99
205_I	209_I	0.553	0.99
37_I	44_H	0.553	0.99
231_K	238_M	0.551	0.99
238_M	242_S	0.551	0.99
216_T	279_L	0.550	0.99
22_L	64_A	0.550	0.99
298_S	306_E	0.547	0.99
186_L	309_I	0.546	0.99
98_D	162_S	0.545	0.99
201_F	206_I	0.544	0.99
96_V	134_V	0.543	0.99
90_S	256_K	0.543	0.99
244_I	248_G	0.542	0.99
194_L	198_A	0.542	0.99
263_V	320_F	0.542	0.99
267_I	320_F	0.541	0.99
11_L	15_P	0.541	0.99
146_T	149_Q	0.540	0.99
291_L	309_I	0.538	0.99
64_A	198_A	0.538	0.99
38_V	43_I	0.537	0.99
27_L	39_F	0.537	0.99
65_G	69_I	0.536	0.99
55_I	60_I	0.535	0.99
13_T	16_F	0.533	0.99
186_L	254_A	0.532	0.99
129_L	132_V	0.531	0.99
78_A	268_T	0.528	0.99
257_I	313_T	0.527	0.99
25_S	292_T	0.525	0.99
300_F	304_P	0.525	0.99
75_V	201_F	0.525	0.99
138_A	150_L	0.523	0.99
162_S	166_A	0.522	0.99
210_S	213_K	0.521	0.99
209_I	280_I	0.521	0.99
16_F	19_A	0.520	0.99
99_G	157_T	0.519	0.99
153_I	157_T	0.519	0.99
96_V	185_R	0.517	0.99
239_A	243_V	0.516	0.99
98_D	158_S	0.515	0.99
24_L	296_L	0.514	0.99
298_S	301_I	0.514	0.99
10_I	272_V	0.510	0.99
90_S	313_T	0.510	0.99
163_S	263_V	0.510	0.99
298_S	304_P	0.509	0.99
115_S	120_M	0.508	0.99
213_K	216_T	0.507	0.99
78_A	82_G	0.506	0.99
176_Q	182_Y	0.506	0.99
295_D	304_P	0.506	0.99
281_P	285_I	0.505	0.99
258_A	263_V	0.505	0.99
142_P	145_F	0.504	0.99
167_A	311_V	0.504	0.99
169_S	175_S	0.503	0.99
298_S	307_T	0.502	0.99
161_L	164_L	0.502	0.99
85_R	221_G	0.501	0.99
133_L	136_G	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2nq2A	2	0.9162	100	0.183	Contact Map
4g1uA	2	0.8802	100	0.19	Contact Map
2qi9A	2	0.9431	100	0.2	Contact Map
2m20A	2	0.0838	13.8	0.966	Contact Map
2cfqA	1	0.8743	13.5	0.966	Contact Map
3wdoA	1	0.8713	11.8	0.967	Contact Map
1pw4A	1	0.8802	11.8	0.967	Contact Map
2b2hA	3	0.6138	7.7	0.969	Contact Map
2xq2A	2	0.6826	7.5	0.969	Contact Map
4z7fA	2	0.476	7	0.97	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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