GREMLIN Database
FEUB - Iron-uptake system permease protein FeuB
UniProt: P40410 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 334 (318)
Sequences: 13860 (9946)
Seq/√Len: 557.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
216_T275_D4.9731.00
71_A284_C3.7951.00
79_L208_A3.6611.00
107_C122_Y3.6521.00
21_S293_L3.5671.00
22_L63_A3.3691.00
72_A201_F3.2641.00
231_K234_T3.2581.00
67_L288_G3.1571.00
79_L239_A3.1091.00
66_A186_L2.9521.00
268_T286_L2.8841.00
65_G189_M2.7271.00
72_A246_L2.6431.00
72_A250_A2.6161.00
37_I51_D2.6141.00
22_L67_L2.4211.00
75_V284_C2.4011.00
222_D236_K2.3781.00
17_A289_I2.3691.00
102_F164_L2.3491.00
37_I40_T2.3351.00
18_I289_I2.2911.00
75_V205_I2.2771.00
69_I250_A2.2581.00
102_F161_L2.2361.00
78_A283_S2.1801.00
272_V282_C2.1481.00
27_L35_T2.1451.00
48_G51_D2.1431.00
216_T276_Y2.0941.00
69_I254_A2.0731.00
25_S63_A2.0651.00
62_R295_D2.0421.00
67_L292_T2.0171.00
68_L198_A1.9561.00
18_I67_L1.9511.00
200_F249_S1.9461.00
82_G276_Y1.9241.00
21_S289_I1.9091.00
34_S37_I1.8781.00
214_K235_I1.8431.00
105_T165_S1.8041.00
106_L110_L1.8021.00
80_M243_V1.7911.00
189_M193_F1.7831.00
217_A230_Q1.7581.00
45_F52_H1.7461.00
211_L214_K1.6951.00
11_L282_C1.6881.00
127_S248_G1.6801.00
207_M242_S1.6551.00
297_A301_I1.6051.00
260_V291_L1.6051.00
18_I285_I1.5741.00
36_D40_T1.5581.00
298_S309_I1.5521.00
49_N52_H1.5381.00
64_A194_L1.5381.00
234_T238_M1.5351.00
211_L238_M1.5161.00
104_I123_S1.5151.00
204_G246_L1.5131.00
14_S285_I1.4991.00
24_L27_L1.4981.00
39_F43_I1.4941.00
204_G245_I1.4821.00
297_A312_V1.4631.00
41_S56_W1.4541.00
52_H56_W1.4451.00
76_S246_L1.4441.00
131_A244_I1.4401.00
103_I122_Y1.4391.00
21_S292_T1.4371.00
268_T279_L1.4251.00
195_K199_P1.4101.00
195_K198_A1.4071.00
78_A279_L1.3961.00
24_L28_Y1.3951.00
101_A165_S1.3941.00
190_S193_F1.3871.00
14_S282_C1.3831.00
211_L235_I1.3721.00
10_I282_C1.3681.00
65_G253_L1.3601.00
186_L291_L1.3541.00
278_R281_P1.3191.00
204_G242_S1.3121.00
160_L318_V1.2981.00
25_S296_L1.2951.00
264_V290_F1.2881.00
97_S247_T1.2841.00
268_T282_C1.2771.00
299_R306_E1.2761.00
74_A264_V1.2721.00
199_P203_I1.2511.00
68_L194_L1.2461.00
207_M211_L1.2311.00
276_Y279_L1.2271.00
99_G126_G1.2211.00
211_L239_A1.2201.00
103_I126_G1.2141.00
130_G161_L1.2011.00
83_I239_A1.1931.00
78_A276_Y1.1881.00
101_A182_Y1.1851.00
132_V136_G1.1731.00
31_K54_I1.1651.00
235_I238_M1.1611.00
226_K233_K1.1581.00
105_T178_L1.1581.00
11_L278_R1.1531.00
264_V286_L1.1531.00
18_I288_G1.1501.00
234_T237_I1.1501.00
257_I291_L1.1351.00
221_G225_S1.1341.00
14_S286_L1.1281.00
41_S52_H1.1241.00
102_F106_L1.1221.00
14_S289_I1.1181.00
134_V157_T1.1171.00
295_D299_R1.1121.00
224_I227_S1.1081.00
68_L197_A1.1071.00
53_Q57_H1.1061.00
78_A280_I1.0941.00
115_S118_E1.0931.00
71_A74_A1.0871.00
32_H35_T1.0831.00
124_F245_I1.0811.00
197_A253_L1.0801.00
233_K236_K1.0781.00
56_W60_I1.0681.00
65_G194_L1.0621.00
297_A300_F1.0601.00
121_I125_I1.0591.00
66_A291_L1.0521.00
129_L133_L1.0491.00
109_V168_M1.0471.00
289_I293_L1.0441.00
64_A191_P1.0431.00
204_G249_S1.0421.00
21_S296_L1.0391.00
208_A242_S1.0381.00
197_A201_F1.0371.00
254_A257_I1.0351.00
45_F56_W1.0351.00
314_S319_P1.0331.00
22_L292_T1.0321.00
207_M238_M1.0321.00
66_A292_T1.0241.00
50_T53_Q1.0231.00
26_I63_A1.0151.00
217_A228_L1.0071.00
9_I12_I0.9991.00
122_Y126_G0.9981.00
63_A296_L0.9981.00
139_A233_K0.9941.00
276_Y281_P0.9881.00
71_A288_G0.9881.00
38_V55_I0.9781.00
223_D226_K0.9721.00
281_P284_C0.9711.00
28_Y300_F0.9701.00
272_V278_R0.9681.00
264_V268_T0.9641.00
203_I206_I0.9631.00
167_A171_Y0.9601.00
99_G130_G0.9561.00
23_L27_L0.9501.00
206_I210_S0.9491.00
41_S55_I0.9421.00
106_L168_M0.9411.00
16_F20_L0.9351.00
98_D161_L0.9331.00
233_K237_I0.9321.00
15_P19_A0.9311.00
191_P194_L0.9311.00
158_S162_S0.9291.00
27_L38_V0.9191.00
77_G265_P0.9181.00
278_R282_C0.9141.00
97_S256_K0.9111.00
41_S45_F0.9081.00
23_L35_T0.9061.00
298_S308_P0.9061.00
298_S312_V0.9061.00
196_L199_P0.9051.00
135_F233_K0.9041.00
279_L283_S0.8951.00
293_L297_A0.8931.00
230_Q235_I0.8891.00
102_F165_S0.8861.00
102_F168_M0.8861.00
130_G134_V0.8851.00
104_I119_M0.8831.00
29_G59_R0.8831.00
320_F323_Y0.8831.00
235_I239_A0.8791.00
302_N305_F0.8791.00
72_A76_S0.8771.00
41_S51_D0.8761.00
139_A142_P0.8721.00
109_V172_F0.8711.00
215_V239_A0.8701.00
68_L201_F0.8681.00
98_D101_A0.8611.00
71_A205_I0.8611.00
250_A254_A0.8601.00
9_I13_T0.8551.00
271_L286_L0.8531.00
199_P202_L0.8511.00
92_S97_S0.8441.00
33_L55_I0.8381.00
40_T43_I0.8381.00
62_R299_R0.8341.00
212_S277_S0.8301.00
108_M119_M0.8281.00
211_L242_S0.8281.00
139_A144_G0.8221.00
208_A239_A0.8201.00
127_S244_I0.8201.00
76_S243_V0.8201.00
19_A23_L0.8181.00
202_L206_I0.8171.00
301_I304_P0.8161.00
63_A292_T0.8151.00
216_T277_S0.8151.00
96_V127_S0.8141.00
46_D49_N0.8131.00
40_T44_H0.8111.00
52_H57_H0.8091.00
319_P323_Y0.8061.00
178_L182_Y0.8041.00
10_I14_S0.7991.00
291_L313_T0.7981.00
10_I13_T0.7941.00
176_Q179_S0.7921.00
62_R306_E0.7921.00
38_V41_S0.7921.00
207_M210_S0.7881.00
105_T169_S0.7861.00
222_D226_K0.7861.00
222_D232_K0.7821.00
300_F303_Y0.7811.00
275_D278_R0.7791.00
269_R279_L0.7781.00
315_I319_P0.7771.00
15_P285_I0.7751.00
40_T45_F0.7731.00
100_S127_S0.7731.00
74_A284_C0.7691.00
225_S232_K0.7691.00
128_A248_G0.7681.00
33_L51_D0.7641.00
18_I22_L0.7611.00
134_V138_A0.7611.00
84_T151_A0.7601.00
268_T271_L0.7581.00
20_L23_L0.7581.00
267_I286_L0.7571.00
71_A201_F0.7561.00
25_S299_R0.7561.00
107_C119_M0.7551.00
18_I292_T0.7541.00
135_F237_I0.7531.00
216_T281_P0.7511.00
74_A78_A0.7491.00
200_F204_G0.7481.00
125_I129_L0.7461.00
268_T272_V0.7461.00
31_K34_S0.7411.00
90_S93_I0.7401.00
75_V208_A0.7401.00
139_A145_F0.7391.00
80_M94_M0.7381.00
285_I289_I0.7331.00
136_G139_A0.7331.00
19_A22_L0.7301.00
240_M244_I0.7301.00
73_L260_V0.7301.00
290_F294_C0.7291.00
237_I241_L0.7271.00
201_F250_A0.7251.00
172_F175_S0.7211.00
60_I191_P0.7191.00
124_F128_A0.7191.00
232_K236_K0.7191.00
101_A256_K0.7151.00
295_D306_E0.7151.00
27_L32_H0.7131.00
46_D52_H0.7121.00
260_V313_T0.7121.00
131_A240_M0.7121.00
64_A68_L0.7081.00
193_F253_L0.7051.00
31_K35_T0.7021.00
249_S253_L0.6941.00
106_L111_L0.6941.00
44_H52_H0.6891.00
65_G197_A0.6861.00
118_E121_I0.6861.00
197_A249_S0.6861.00
26_I55_I0.6831.00
257_I309_I0.6831.00
198_A202_L0.6821.00
82_G219_S0.6751.00
179_S182_Y0.6751.00
173_Q177_D0.6741.00
302_N307_T0.6701.00
75_V280_I0.6671.00
20_L24_L0.6661.00
294_C312_V0.6661.00
262_L324_L0.6651.00
270_F324_L0.6651.00
10_I271_L0.6641.00
106_L164_L0.6641.00
265_P283_S0.6631.00
209_I212_S0.6621.00
108_M177_D0.6621.00
131_A135_F0.6611.00
277_S281_P0.6591.00
323_Y327_R0.6591.00
226_K232_K0.6561.00
138_A153_I0.6551.00
249_S252_A0.6521.00
53_Q58_S0.6511.00
76_S247_T0.6491.00
35_T38_V0.6481.00
216_T219_S0.6441.00
128_A244_I0.6441.00
204_G208_A0.6441.00
210_S214_K0.6411.00
90_S261_G0.6401.00
96_V131_A0.6391.00
28_Y32_H0.6361.00
69_I186_L0.6361.00
14_S18_I0.6351.00
38_V42_L0.6341.00
192_D195_K0.6341.00
60_I64_A0.6321.00
33_L41_S0.6311.00
267_I270_F0.6291.00
288_G292_T0.6281.00
214_K230_Q0.6281.00
126_G130_G0.6261.00
243_V248_G0.6251.00
200_F245_I0.6221.00
99_G161_L0.6211.00
119_M122_Y0.6211.00
97_S100_S0.6201.00
267_I290_F0.6181.00
273_G281_P0.6181.00
23_L39_F0.6171.00
84_T87_Y0.6161.00
71_A75_V0.6161.00
79_L242_S0.6151.00
284_C288_G0.6141.00
218_V232_K0.6131.00
135_F139_A0.6131.00
49_N53_Q0.6111.00
197_A200_F0.6111.00
36_D39_F0.6111.00
139_A143_N0.6101.00
53_Q56_W0.6091.00
80_M89_A0.6081.00
169_S179_S0.6081.00
66_A309_I0.6071.00
148_V151_A0.6051.00
263_V321_F0.6041.00
103_I107_C0.6021.00
290_F316_I0.6011.00
26_I60_I0.6011.00
166_A181_W0.6001.00
247_T251_V0.6001.00
137_L153_I0.5991.00
215_V276_Y0.5981.00
35_T39_F0.5971.00
89_A96_V0.5971.00
22_L26_I0.5961.00
30_A304_P0.5951.00
153_I156_V0.5901.00
80_M96_V0.5881.00
268_T283_S0.5871.00
48_G52_H0.5871.00
34_S51_D0.5861.00
248_G252_A0.5861.00
108_M178_L0.5851.00
292_T296_L0.5841.00
293_L296_L0.5831.00
191_P195_K0.5821.00
262_L265_P0.5821.00
18_I63_A0.5811.00
326_K329_G0.5811.00
117_I121_I0.5801.00
13_T17_A0.5791.00
74_A287_G0.5770.99
124_F127_S0.5770.99
175_S178_L0.5770.99
166_A170_I0.5760.99
83_I243_V0.5750.99
214_K217_A0.5740.99
170_I311_V0.5730.99
196_L249_S0.5730.99
104_I122_Y0.5710.99
12_I16_F0.5710.99
100_S123_S0.5690.99
127_S131_A0.5670.99
169_S182_Y0.5670.99
162_S182_Y0.5640.99
296_L300_F0.5630.99
203_I207_M0.5630.99
260_V290_F0.5590.99
174_I177_D0.5530.99
205_I209_I0.5530.99
37_I44_H0.5530.99
231_K238_M0.5510.99
238_M242_S0.5510.99
216_T279_L0.5500.99
22_L64_A0.5500.99
298_S306_E0.5470.99
186_L309_I0.5460.99
98_D162_S0.5450.99
201_F206_I0.5440.99
96_V134_V0.5430.99
90_S256_K0.5430.99
244_I248_G0.5420.99
194_L198_A0.5420.99
263_V320_F0.5420.99
267_I320_F0.5410.99
11_L15_P0.5410.99
146_T149_Q0.5400.99
291_L309_I0.5380.99
64_A198_A0.5380.99
38_V43_I0.5370.99
27_L39_F0.5370.99
65_G69_I0.5360.99
55_I60_I0.5350.99
13_T16_F0.5330.99
186_L254_A0.5320.99
129_L132_V0.5310.99
78_A268_T0.5280.99
257_I313_T0.5270.99
25_S292_T0.5250.99
300_F304_P0.5250.99
75_V201_F0.5250.99
138_A150_L0.5230.99
162_S166_A0.5220.99
210_S213_K0.5210.99
209_I280_I0.5210.99
16_F19_A0.5200.99
99_G157_T0.5190.99
153_I157_T0.5190.99
96_V185_R0.5170.99
239_A243_V0.5160.99
98_D158_S0.5150.99
24_L296_L0.5140.99
298_S301_I0.5140.99
10_I272_V0.5100.99
90_S313_T0.5100.99
163_S263_V0.5100.99
298_S304_P0.5090.99
115_S120_M0.5080.99
213_K216_T0.5070.99
78_A82_G0.5060.99
176_Q182_Y0.5060.99
295_D304_P0.5060.99
281_P285_I0.5050.99
258_A263_V0.5050.99
142_P145_F0.5040.99
167_A311_V0.5040.99
169_S175_S0.5030.99
298_S307_T0.5020.99
161_L164_L0.5020.99
85_R221_G0.5010.99
133_L136_G0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nq2A 2 0.9162 100 0.183 Contact Map
4g1uA 2 0.8802 100 0.19 Contact Map
2qi9A 2 0.9431 100 0.2 Contact Map
2m20A 2 0.0838 13.8 0.966 Contact Map
2cfqA 1 0.8743 13.5 0.966 Contact Map
3wdoA 1 0.8713 11.8 0.967 Contact Map
1pw4A 1 0.8802 11.8 0.967 Contact Map
2b2hA 3 0.6138 7.7 0.969 Contact Map
2xq2A 2 0.6826 7.5 0.969 Contact Map
4z7fA 2 0.476 7 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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