GREMLIN Database
FEUA - Iron-uptake system-binding protein
UniProt: P40409 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 317 (276)
Sequences: 14256 (11064)
Seq/√Len: 666.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
154_M167_K4.1011.00
157_A166_A4.0121.00
150_K174_E3.9391.00
246_N279_K3.9181.00
162_K165_K3.4661.00
176_D308_K3.1971.00
158_Q163_E3.0611.00
279_K283_E3.0411.00
59_I66_M2.9871.00
42_E47_T2.8181.00
154_M170_I2.7431.00
165_K168_K2.6611.00
40_K47_T2.6201.00
178_K182_T2.5981.00
217_Y222_L2.5611.00
167_K171_A2.5031.00
171_A175_Q2.4861.00
110_K113_E2.4651.00
241_K244_E2.3601.00
43_Y48_Y2.3171.00
58_A111_I2.2361.00
214_S218_G2.1281.00
57_I160_T2.1041.00
69_A160_T2.0761.00
56_K77_Q2.0171.00
174_E178_K2.0051.00
270_E284_D1.9951.00
74_V160_T1.9951.00
192_K223_K1.9911.00
68_D153_M1.9831.00
175_Q179_E1.9761.00
74_V162_K1.9631.00
179_E183_K1.9441.00
248_D279_K1.9341.00
267_K271_K1.8671.00
168_K172_D1.8631.00
132_K135_T1.8391.00
176_D304_V1.8151.00
148_N151_E1.7891.00
38_K49_E1.7781.00
120_L156_L1.7721.00
278_L281_V1.7501.00
249_H287_Y1.7481.00
130_L134_S1.7331.00
40_K49_E1.6851.00
78_G114_M1.6641.00
249_H285_H1.6601.00
164_K168_K1.6411.00
178_K181_K1.6281.00
279_K282_K1.6161.00
172_D176_D1.6111.00
266_L270_E1.5821.00
131_Q135_T1.5781.00
106_P111_I1.5761.00
151_E154_M1.5451.00
58_A114_M1.5201.00
277_S282_K1.5121.00
165_K169_I1.5071.00
39_K158_Q1.4791.00
267_K270_E1.4751.00
98_E110_K1.4491.00
151_E155_L1.4441.00
107_N110_K1.4311.00
180_I311_A1.4191.00
127_E131_Q1.4051.00
191_S249_H1.4011.00
275_W281_V1.3981.00
150_K170_I1.3911.00
131_Q134_S1.3901.00
112_L136_A1.3881.00
239_L272_N1.3621.00
72_L162_K1.3501.00
59_I69_A1.3481.00
163_E167_K1.3451.00
250_I280_A1.3411.00
287_Y313_K1.3351.00
193_A222_L1.3241.00
182_T185_N1.3181.00
109_E240_E1.3171.00
58_A78_G1.3101.00
77_Q114_M1.3101.00
241_K245_M1.3041.00
194_L197_R1.3031.00
171_A174_E1.2971.00
176_D179_E1.2931.00
169_I172_D1.2871.00
175_Q178_K1.2821.00
226_N245_M1.2801.00
126_P129_T1.2751.00
308_K312_E1.2691.00
153_M166_A1.2641.00
202_N236_L1.2541.00
154_M174_E1.2501.00
108_I132_K1.2451.00
179_E182_T1.2391.00
225_P245_M1.2381.00
69_A74_V1.2351.00
309_A312_E1.2341.00
54_T117_D1.2241.00
155_L158_Q1.2231.00
170_I174_E1.2201.00
164_K167_K1.2011.00
50_V53_P1.1941.00
55_D117_D1.1911.00
88_D91_K1.1871.00
264_D267_K1.1761.00
304_V308_K1.1691.00
172_D175_Q1.1581.00
183_K311_A1.1501.00
190_D223_K1.1451.00
56_K115_K1.1401.00
180_I307_L1.1321.00
181_K219_D1.1241.00
55_D75_H1.1191.00
208_E218_G1.1191.00
38_K52_V1.1151.00
71_L169_I1.0951.00
57_I118_V1.0881.00
194_L247_P1.0761.00
181_K185_N1.0521.00
184_I187_K1.0411.00
43_Y46_K1.0371.00
81_S99_P1.0341.00
38_K51_T1.0331.00
43_Y130_L1.0201.00
38_K53_P1.0171.00
177_L181_K1.0171.00
37_E161_G1.0091.00
67_E302_S1.0081.00
177_L307_L1.0011.00
252_V288_V0.9981.00
155_L159_L0.9981.00
192_K248_D0.9891.00
290_S293_P0.9871.00
275_W278_L0.9861.00
268_D271_K0.9851.00
20_C23_K0.9841.00
129_T132_K0.9781.00
206_Y210_V0.9741.00
194_L205_I0.9731.00
195_V217_Y0.9701.00
193_A197_R0.9621.00
157_A170_I0.9591.00
173_Y219_D0.9561.00
69_A76_P0.9531.00
223_K227_E0.9451.00
43_Y47_T0.9451.00
76_P97_A0.9431.00
215_T218_G0.9431.00
154_M158_Q0.9341.00
144_H147_S0.9321.00
156_L160_T0.9301.00
193_A217_Y0.9291.00
70_K76_P0.9181.00
72_L169_I0.9161.00
176_D180_I0.9151.00
210_V214_S0.9121.00
191_S285_H0.9101.00
53_P162_K0.9071.00
119_I137_G0.9041.00
75_H162_K0.9041.00
69_A120_L0.9011.00
141_P159_L0.8991.00
226_N241_K0.8951.00
15_L18_A0.8941.00
281_V286_V0.8901.00
307_L311_A0.8871.00
45_D134_S0.8871.00
57_I69_A0.8861.00
193_A196_I0.8861.00
168_K171_A0.8841.00
94_T97_A0.8831.00
166_A170_I0.8831.00
37_E52_V0.8811.00
194_L198_I0.8751.00
176_D305_R0.8711.00
273_P276_K0.8681.00
50_V54_T0.8651.00
68_D156_L0.8611.00
242_L278_L0.8591.00
120_L159_L0.8581.00
215_T219_D0.8551.00
89_M92_D0.8491.00
270_E286_V0.8471.00
279_K285_H0.8471.00
54_T118_V0.8451.00
53_P161_G0.8381.00
173_Y177_L0.8341.00
265_A268_D0.8311.00
118_V159_L0.8261.00
60_T119_I0.8241.00
116_P119_I0.8231.00
86_F89_M0.8231.00
37_E53_P0.8211.00
78_G101_G0.8191.00
305_R309_A0.8171.00
70_K94_T0.8161.00
59_I76_P0.8111.00
176_D311_A0.8061.00
237_S245_M0.8031.00
16_T19_A0.8001.00
79_A97_A0.7981.00
195_V253_Q0.7971.00
276_K281_V0.7961.00
87_P92_D0.7951.00
156_L159_L0.7941.00
152_N155_L0.7931.00
52_V55_D0.7911.00
138_T141_P0.7871.00
88_D92_D0.7851.00
184_I311_A0.7801.00
169_I173_Y0.7781.00
150_K154_M0.7761.00
142_V155_L0.7751.00
154_M157_A0.7731.00
251_F310_A0.7711.00
80_I83_S0.7611.00
92_D95_D0.7611.00
72_L160_T0.7611.00
167_K170_I0.7611.00
229_K245_M0.7591.00
243_S278_L0.7571.00
191_S222_L0.7571.00
251_F287_Y0.7551.00
123_T143_S0.7531.00
39_K50_V0.7531.00
72_L165_K0.7521.00
20_C24_N0.7521.00
205_I226_N0.7511.00
243_S277_S0.7511.00
72_L157_A0.7501.00
264_D268_D0.7501.00
50_V139_T0.7491.00
226_N229_K0.7451.00
252_V286_V0.7451.00
111_I133_I0.7421.00
71_L153_M0.7411.00
206_Y234_Q0.7291.00
65_S120_L0.7281.00
119_I136_A0.7251.00
304_V307_L0.7211.00
177_L219_D0.7191.00
293_P309_A0.7171.00
73_D162_K0.7161.00
183_K186_D0.7161.00
93_I96_K0.7131.00
160_T163_E0.7061.00
208_E227_E0.7041.00
194_L242_L0.7041.00
56_K117_D0.7041.00
102_E105_E0.7031.00
272_N276_K0.7021.00
141_P155_L0.6991.00
86_F90_F0.6971.00
187_K190_D0.6961.00
18_A21_G0.6951.00
302_S305_R0.6941.00
243_S247_P0.6931.00
112_L138_T0.6931.00
153_M169_I0.6901.00
87_P90_F0.6901.00
58_A116_P0.6881.00
79_A99_P0.6861.00
72_L153_M0.6831.00
73_D165_K0.6801.00
150_K177_L0.6781.00
128_K131_Q0.6741.00
212_F215_T0.6721.00
180_I184_I0.6691.00
196_I250_I0.6671.00
290_S309_A0.6641.00
72_L166_A0.6581.00
208_E229_K0.6551.00
93_I97_A0.6531.00
149_W173_Y0.6491.00
195_V213_N0.6491.00
204_Y236_L0.6481.00
100_T114_M0.6441.00
196_I199_R0.6411.00
238_S241_K0.6391.00
289_N294_L0.6361.00
253_Q289_N0.6361.00
109_E112_L0.6341.00
303_K307_L0.6341.00
121_A141_P0.6341.00
67_E298_G0.6331.00
269_L272_N0.6291.00
154_M163_E0.6291.00
190_D194_L0.6281.00
172_D304_V0.6271.00
216_L307_L0.6261.00
181_K220_L0.6261.00
134_S139_T0.6251.00
58_A100_T0.6231.00
108_I129_T0.6211.00
222_L249_H0.6211.00
39_K52_V0.6181.00
302_S306_F0.6171.00
133_I139_T0.6161.00
294_L297_G0.6161.00
59_I65_S0.6151.00
254_F288_V0.6151.00
194_L225_P0.6141.00
66_M79_A0.6121.00
127_E130_L0.6121.00
108_I111_I0.6111.00
173_Y176_D0.6111.00
193_A198_I0.6111.00
41_I50_V0.6101.00
295_A298_G0.6101.00
98_E114_M0.6081.00
196_I272_N0.6061.00
108_I136_A0.6061.00
58_A77_Q0.6051.00
62_S122_S0.6041.00
37_E51_T0.5981.00
69_A156_L0.5951.00
87_P91_K0.5951.00
304_V311_A0.5951.00
65_S156_L0.5951.00
50_V159_L0.5951.00
197_R200_Q0.5941.00
250_I275_W0.5931.00
170_I173_Y0.5931.00
50_V118_V0.5931.00
62_S65_S0.5921.00
118_V141_P0.5921.00
266_L288_V0.5861.00
58_A119_I0.5861.00
112_L240_E0.5841.00
150_K173_Y0.5821.00
214_S224_A0.5791.00
145_I148_N0.5771.00
272_N275_W0.5761.00
294_L306_F0.5741.00
209_Q214_S0.5731.00
205_I237_S0.5721.00
239_L275_W0.5721.00
255_S291_V0.5711.00
125_F129_T0.5711.00
149_W303_K0.5711.00
38_K50_V0.5711.00
237_S242_L0.5701.00
217_Y220_L0.5631.00
309_A313_K0.5611.00
306_F310_A0.5611.00
66_M70_K0.5611.00
180_I220_L0.5601.00
37_E40_K0.5591.00
110_K114_M0.5591.00
220_L311_A0.5581.00
44_L155_L0.5581.00
214_S227_E0.5581.00
60_T106_P0.5581.00
209_Q232_K0.5571.00
308_K311_A0.5571.00
180_I183_K0.5571.00
19_A22_S0.5551.00
249_H253_Q0.5541.00
54_T160_T0.5531.00
153_M170_I0.5511.00
53_P117_D0.5511.00
293_P305_R0.5501.00
242_L245_M0.5491.00
226_N237_S0.5481.00
206_Y214_S0.5481.00
76_P79_A0.5471.00
150_K219_D0.5461.00
65_S68_D0.5451.00
60_T121_A0.5441.00
68_D71_L0.5431.00
137_G140_I0.5431.00
154_M166_A0.5421.00
39_K53_P0.5411.00
70_K90_F0.5411.00
247_P250_I0.5381.00
193_A251_F0.5381.00
297_G300_A0.5361.00
220_L307_L0.5361.00
72_L156_L0.5351.00
192_K249_H0.5351.00
85_K89_M0.5351.00
243_S274_I0.5341.00
144_H148_N0.5341.00
19_A23_K0.5321.00
305_R308_K0.5311.00
174_E177_L0.5311.00
94_T98_E0.5281.00
17_A20_C0.5281.00
149_W153_M0.5260.99
147_S151_E0.5250.99
78_G100_T0.5240.99
265_A269_L0.5230.99
45_D130_L0.5230.99
130_L140_I0.5220.99
294_L309_A0.5200.99
91_K95_D0.5190.99
181_K184_I0.5190.99
177_L180_I0.5170.99
180_I304_V0.5130.99
275_W286_V0.5110.99
190_D193_A0.5090.99
278_L282_K0.5090.99
292_D296_Q0.5090.99
307_L312_E0.5070.99
70_K93_I0.5070.99
142_V156_L0.5060.99
119_I133_I0.5050.99
86_F91_K0.5050.99
37_E54_T0.5050.99
183_K187_K0.5040.99
45_D127_E0.5040.99
41_I155_L0.5040.99
128_K132_K0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n01A 1 0.877 100 0.234 Contact Map
3tlkA 1 0.858 100 0.249 Contact Map
3tnyA 1 0.8707 100 0.251 Contact Map
4mlzA 1 0.8612 100 0.258 Contact Map
3lhsA 1 0.8738 100 0.262 Contact Map
2wi8A 2 0.8833 100 0.263 Contact Map
4mx8A 1 0.8833 100 0.272 Contact Map
2x4lA 1 0.8454 100 0.276 Contact Map
3tefA 1 0.8549 100 0.282 Contact Map
4mdyA 1 0.8423 100 0.285 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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