GREMLIN Database
CHED - Chemoreceptor glutamine deamidase CheD
UniProt: P40404 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 166 (147)
Sequences: 1466 (1123)
Seq/√Len: 92.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
122_K135_E5.4431.00
49_V73_A3.6991.00
81_L86_C3.4631.00
93_A130_I3.1701.00
118_V137_T2.8291.00
51_V70_A2.7761.00
38_L93_A2.3731.00
145_I154_L2.3451.00
41_K92_K2.1241.00
95_L121_I2.1231.00
51_V121_I2.1181.00
80_M83_E1.9961.00
34_V118_V1.9711.00
66_R76_T1.9141.00
18_I84_A1.9061.00
123_E127_L1.8641.00
39_Y92_K1.8641.00
100_E112_K1.8271.00
112_K115_P1.8251.00
46_A149_P1.8111.00
95_L132_I1.7771.00
37_V48_L1.7481.00
82_I88_K1.7391.00
94_K134_S1.6601.00
40_D90_A1.5921.00
92_K133_I1.5791.00
42_E90_A1.5751.00
47_G77_T1.5711.00
43_K90_A1.5471.00
16_V77_T1.5191.00
136_D158_T1.5041.00
70_A121_I1.4991.00
38_L130_I1.4881.00
74_V124_Q1.4471.00
19_A46_A1.4430.99
39_Y147_F1.3620.99
70_A120_A1.3280.99
78_I128_F1.3230.99
75_Q79_D1.3120.99
75_Q124_Q1.2900.99
46_A152_C1.2880.99
79_D83_E1.2820.99
88_K128_F1.2780.99
34_V137_T1.2590.99
81_L91_L1.2440.98
93_A125_L1.2370.98
125_L130_I1.2310.98
87_R90_A1.2290.98
41_K90_A1.2200.98
39_Y44_Q1.2190.98
118_V138_G1.1980.98
119_L123_E1.1830.98
148_E153_M1.1820.98
18_I45_T1.1750.98
115_P119_L1.1730.98
120_A124_Q1.1710.98
19_A23_D1.1630.98
38_L91_L1.1630.98
136_D156_I1.1590.98
24_T148_E1.1220.97
26_R146_E1.1170.97
79_D128_F1.1140.97
96_A154_L1.0980.97
76_T79_D1.0980.97
148_E151_S1.0950.97
37_V147_F1.0940.97
93_A131_P1.0930.97
75_Q128_F1.0920.97
95_L137_T1.0760.96
16_V80_M1.0660.96
86_C91_L1.0620.96
109_D112_K1.0610.96
46_A147_F1.0580.96
56_S72_T1.0570.96
67_A76_T1.0400.95
37_V152_C1.0330.95
76_T80_M1.0230.95
124_Q128_F1.0210.95
95_L122_K1.0160.95
49_V70_A1.0080.95
122_K137_T1.0080.95
24_T146_E1.0000.94
122_K132_I0.9950.94
56_S71_D0.9870.94
82_I91_L0.9840.94
145_I156_I0.9740.94
40_D86_C0.9620.93
148_E155_H0.9570.93
41_K152_C0.9560.93
35_G145_I0.9520.93
123_E126_S0.9260.92
8_V24_T0.9150.91
79_D82_I0.8940.90
34_V70_A0.8870.90
17_K80_M0.8860.90
46_A81_L0.8840.90
78_I91_L0.8800.90
146_E154_L0.8750.89
80_M84_A0.8730.89
20_R84_A0.8580.88
8_V26_R0.8570.88
96_A145_I0.8520.88
28_S160_K0.8450.88
86_C90_A0.8430.87
95_L135_E0.8400.87
16_V76_T0.8290.87
19_A149_P0.8260.86
43_K46_A0.8170.86
22_P150_K0.8100.85
11_V48_L0.8100.85
130_I133_I0.8080.85
11_V144_T0.8050.85
124_Q127_L0.8050.85
42_E87_R0.8040.85
56_S60_K0.7970.84
116_R119_L0.7940.84
37_V92_K0.7930.84
96_A156_I0.7840.83
71_D124_Q0.7840.83
45_T86_C0.7820.83
100_E111_M0.7550.81
49_V74_V0.7440.80
36_L95_L0.7320.79
13_I49_V0.7290.79
19_A25_I0.7270.78
36_L121_I0.7190.78
28_S73_A0.7090.77
11_V17_K0.7060.76
36_L51_V0.7060.76
98_G114_G0.7060.76
81_L149_P0.6990.76
55_D71_D0.6980.76
44_Q150_K0.6970.76
55_D101_M0.6920.75
49_V77_T0.6900.75
17_K25_I0.6830.74
51_V74_V0.6760.73
20_R23_D0.6740.73
59_S109_D0.6730.73
92_K131_P0.6730.73
136_D143_R0.6730.73
146_E155_H0.6710.73
13_I51_V0.6700.73
92_K147_F0.6690.73
100_E115_P0.6670.72
141_S158_T0.6670.72
25_I48_L0.6630.72
82_I87_R0.6600.71
12_G142_G0.6490.70
144_T157_R0.6470.70
32_S117_N0.6390.69
47_G86_C0.6350.69
16_V67_A0.6350.69
72_T76_T0.6320.68
125_L131_P0.6250.67
59_S145_I0.6240.67
13_I28_S0.6240.67
89_F127_L0.6220.67
100_E139_G0.6170.66
11_V146_E0.6130.66
103_K111_M0.6110.66
37_V49_V0.6100.65
55_D58_L0.6080.65
141_S159_V0.6070.65
99_S141_S0.6000.64
53_L68_K0.6000.64
147_F154_L0.5970.64
25_I149_P0.5960.64
39_Y133_I0.5950.64
67_A73_A0.5940.63
70_A77_T0.5930.63
13_I27_T0.5890.63
18_I77_T0.5810.62
40_D85_G0.5800.62
30_L35_G0.5800.62
8_V145_I0.5790.61
45_T84_A0.5770.61
37_V154_L0.5760.61
34_V51_V0.5720.61
88_K126_S0.5700.60
42_E89_F0.5670.60
48_L145_I0.5660.60
68_K142_G0.5610.59
77_T85_G0.5580.59
17_K35_G0.5560.58
93_A133_I0.5540.58
75_Q147_F0.5530.58
94_K154_L0.5490.57
123_E131_P0.5460.57
20_R45_T0.5440.57
54_P116_R0.5400.56
14_A112_K0.5310.55
57_T69_Y0.5300.55
21_F110_L0.5260.54
13_I52_M0.5250.54
119_L126_S0.5250.54
125_L132_I0.5250.54
92_K152_C0.5240.54
14_A104_F0.5220.54
47_G128_F0.5220.54
52_M71_D0.5220.54
9_I23_D0.5210.54
58_L63_E0.5160.53
54_P118_V0.5160.53
8_V146_E0.5150.53
40_D47_G0.5140.53
15_D27_T0.5120.52
83_E110_L0.5110.52
79_D88_K0.5110.52
41_K149_P0.5110.52
35_G96_A0.5090.52
18_I81_L0.5090.52
74_V120_A0.5070.52
25_I86_C0.5050.51
141_S160_K0.5040.51
42_E123_E0.5030.51
52_M113_I0.5020.51
78_I130_I0.5020.51
30_L53_L0.5010.51
75_Q78_I0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2f9zC 1 0.9036 100 0.088 Contact Map
1xfjA 1 0.8735 20.9 0.944 Contact Map
3al5A 2 0.5663 16.7 0.946 Contact Map
3g3tA 1 0.3614 15.1 0.947 Contact Map
3ba3A 2 0.3072 12.8 0.949 Contact Map
2nu8B 2 0.8494 11.8 0.95 Contact Map
4o1jA 4 0.8976 11.7 0.95 Contact Map
1t8hA 1 0.8373 11.4 0.95 Contact Map
1c1yB 1 0.4578 10.6 0.951 Contact Map
3v4cA 2 0.241 9.8 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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