GREMLIN Database
CHEC - CheY-P phosphatase CheC
UniProt: P40403 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 209 (192)
Sequences: 1502 (1220)
Seq/√Len: 88.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
144_P149_D4.9821.00
8_K11_Q4.6811.00
36_R94_E4.2221.00
146_V149_D3.8961.00
141_P146_V3.3091.00
146_V151_F3.2961.00
141_P149_D3.1491.00
109_D112_S3.1411.00
64_V82_I3.0551.00
17_E20_N2.7161.00
149_D153_A2.6661.00
114_S118_E2.6431.00
118_E122_I2.3541.00
71_M75_L2.3151.00
20_N43_P2.3061.00
141_P144_P2.2861.00
151_F154_V2.2101.00
20_N24_G2.1951.00
27_A198_F2.0261.00
114_S121_N2.0241.00
144_P154_V1.9141.00
118_E121_N1.8951.00
193_P197_S1.8851.00
128_L131_L1.8751.00
75_L201_L1.8481.00
120_G125_G1.8171.00
68_F78_S1.8001.00
166_G169_A1.7411.00
71_M191_M1.6901.00
121_N126_S1.6321.00
125_G129_T1.6051.00
144_P150_M1.5691.00
129_T133_D1.5681.00
147_S152_G1.5491.00
123_L126_S1.5331.00
121_N128_L1.5061.00
40_M43_P1.4750.99
37_K91_F1.4530.99
122_I135_T1.4470.99
121_N135_T1.3900.99
17_E24_G1.3830.99
70_R142_S1.3720.99
168_H201_L1.3670.99
53_L78_S1.3570.99
115_A121_N1.3130.99
71_M77_G1.3050.99
30_M33_L1.2920.99
168_H172_V1.2860.99
77_G172_V1.2770.98
17_E21_I1.2650.98
118_E135_T1.2550.98
38_I190_F1.2550.98
24_G28_S1.2520.98
93_R103_I1.2330.98
114_S127_Y1.2290.98
118_E125_G1.2180.98
200_K203_V1.2080.98
140_Y146_V1.1820.98
124_A127_Y1.1790.97
27_A84_P1.1790.97
188_H197_S1.1760.97
19_G172_V1.1710.97
13_D21_I1.1650.97
81_F187_A1.1650.97
28_S32_Q1.1520.97
92_I95_L1.1200.97
82_I94_E1.1170.96
122_I128_L1.1160.96
144_P151_F1.1100.96
121_N125_G1.1000.96
122_I131_L1.0960.96
118_E127_Y1.0910.96
31_A96_I1.0830.96
111_M114_S1.0770.96
40_M67_I1.0730.96
46_K86_F1.0730.96
24_G43_P1.0700.96
118_E126_S1.0640.95
128_L141_P1.0530.95
23_A31_A1.0500.95
16_R198_F1.0330.95
65_A88_A1.0250.94
57_F83_M1.0210.94
36_R179_Q1.0160.94
69_L169_A1.0050.94
19_G22_G1.0040.94
41_E175_S0.9980.93
144_P147_S0.9940.93
111_M122_I0.9770.93
82_I191_M0.9760.93
126_S131_L0.9760.93
31_A50_F0.9750.93
33_L97_G0.9710.93
128_L134_L0.9650.92
93_R101_F0.9590.92
116_L122_I0.9560.92
121_N129_T0.9520.92
114_S129_T0.9490.92
23_A40_M0.9430.91
122_I127_Y0.9390.91
30_M78_S0.9360.91
111_M119_L0.9320.91
95_L119_L0.9310.91
150_M153_A0.9280.91
28_S40_M0.9260.91
134_L159_L0.9230.91
169_A173_D0.9150.90
171_V200_K0.9010.89
80_F158_G0.8980.89
108_E114_S0.8970.89
111_M118_E0.8940.89
119_L122_I0.8910.89
8_K68_F0.8890.89
91_F179_Q0.8840.89
10_E27_A0.8820.88
169_A178_D0.8750.88
27_A96_I0.8750.88
118_E123_L0.8720.88
38_I45_A0.8700.88
182_Q200_K0.8600.87
165_V201_L0.8550.87
118_E144_P0.8410.86
178_D196_D0.8390.86
11_Q87_Q0.8370.86
121_N127_Y0.8330.85
33_L50_F0.8310.85
115_A118_E0.8270.85
8_K48_L0.8210.85
177_F184_E0.8190.84
79_M124_A0.8180.84
130_A134_L0.8080.84
83_M91_F0.8050.83
178_D190_F0.8000.83
53_L58_G0.7990.83
179_Q182_Q0.7980.83
35_N61_D0.7960.83
74_D137_L0.7950.83
70_R78_S0.7940.83
18_V66_S0.7940.83
126_S144_P0.7930.82
123_L201_L0.7910.82
123_L130_A0.7810.81
110_H122_I0.7770.81
144_P155_I0.7760.81
21_I24_G0.7740.81
114_S193_P0.7740.81
11_Q175_S0.7690.80
91_F122_I0.7650.80
114_S132_A0.7640.80
111_M120_G0.7630.80
48_L72_E0.7620.80
69_L78_S0.7600.80
10_E194_D0.7590.80
52_E55_D0.7580.80
118_E129_T0.7560.79
76_T196_D0.7550.79
27_A38_I0.7540.79
116_L120_G0.7520.79
147_S150_M0.7480.79
101_F110_H0.7480.79
121_N134_L0.7480.79
86_F91_F0.7480.79
143_V174_T0.7460.78
17_E43_P0.7400.78
122_I126_S0.7370.78
127_Y135_T0.7360.78
76_T80_F0.7310.77
108_E118_E0.7300.77
18_V42_V0.7260.77
88_A169_A0.7260.77
117_H198_F0.7240.76
92_I96_I0.7190.76
146_V155_I0.7090.75
159_L162_L0.7090.75
32_Q203_V0.7090.75
29_A33_L0.7070.75
50_F135_T0.7050.74
13_D40_M0.7020.74
109_D116_L0.6990.74
155_I159_L0.6990.74
144_P148_L0.6980.74
14_I28_S0.6960.73
149_D154_V0.6940.73
127_Y130_A0.6930.73
120_G132_A0.6910.73
115_A126_S0.6910.73
110_H121_N0.6880.73
190_F193_P0.6870.73
22_G192_L0.6840.72
112_S118_E0.6820.72
7_I102_D0.6810.72
71_M165_V0.6790.72
66_S154_V0.6780.72
196_D201_L0.6780.72
34_L192_L0.6740.71
103_I109_D0.6740.71
109_D119_L0.6700.71
46_K80_F0.6660.70
166_G170_I0.6640.70
127_Y131_L0.6640.70
22_G202_F0.6620.70
14_I196_D0.6590.69
14_I198_F0.6580.69
46_K56_F0.6570.69
28_S31_A0.6570.69
58_G61_D0.6540.69
48_L52_E0.6400.67
121_N124_A0.6370.67
64_V151_F0.6370.67
100_D110_H0.6350.67
70_R147_S0.6320.66
26_S72_E0.6300.66
82_I87_Q0.6300.66
58_G152_G0.6270.66
111_M116_L0.6260.65
139_L149_D0.6240.65
159_L170_I0.6230.65
108_E117_H0.6230.65
15_L172_V0.6180.64
92_I197_S0.6170.64
121_N133_D0.6150.64
42_V81_F0.6150.64
86_F196_D0.6110.64
56_F83_M0.6110.64
109_D123_L0.6100.63
7_I12_M0.6090.63
162_L170_I0.6080.63
113_S117_H0.6070.63
87_Q91_F0.6050.63
114_S122_I0.6020.62
165_V179_Q0.6000.62
165_V203_V0.5980.62
174_T190_F0.5960.62
120_G123_L0.5960.62
146_V152_G0.5890.61
89_E103_I0.5880.61
21_I25_H0.5870.61
84_P171_V0.5820.60
167_E170_I0.5800.60
100_D133_D0.5800.60
44_F173_D0.5790.59
93_R112_S0.5750.59
9_E199_E0.5710.58
63_P99_P0.5710.58
115_A119_L0.5700.58
38_I145_E0.5690.58
141_P148_L0.5680.58
50_F58_G0.5680.58
134_L154_V0.5620.57
121_N144_P0.5620.57
40_M81_F0.5610.57
35_N99_P0.5590.57
9_E111_M0.5570.57
126_S133_D0.5560.56
63_P165_V0.5530.56
109_D113_S0.5530.56
118_E133_D0.5510.56
49_S203_V0.5460.55
71_M171_V0.5450.55
123_L139_L0.5420.55
63_P182_Q0.5420.55
39_D186_K0.5420.55
24_G67_I0.5420.55
103_I112_S0.5370.54
111_M125_G0.5370.54
174_T187_A0.5360.54
83_M195_Y0.5330.53
122_I132_A0.5320.53
85_F88_A0.5270.52
124_A133_D0.5250.52
23_A95_L0.5250.52
114_S128_L0.5200.52
100_D160_M0.5190.51
74_D196_D0.5190.51
139_L146_V0.5160.51
69_L85_F0.5160.51
35_N184_E0.5120.50
60_A165_V0.5110.50
41_E196_D0.5110.50
13_D16_R0.5100.50
183_Q201_L0.5100.50
122_I133_D0.5100.50
132_A139_L0.5100.50
23_A174_T0.5080.50
23_A193_P0.5070.50
110_H114_S0.5060.50
132_A144_P0.5020.49
89_E108_E0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qtaA 2 0.9474 100 0.286 Contact Map
1xkrA 1 0.9617 100 0.329 Contact Map
4hynA 1 0.9426 100 0.423 Contact Map
4fhrA 1 0.8708 100 0.445 Contact Map
4gc8A 1 0.8756 99.9 0.466 Contact Map
1squA 2 0.7321 99.8 0.59 Contact Map
3hm4A 2 0.7321 99.8 0.593 Contact Map
3h2dA 2 0.7321 99.8 0.596 Contact Map
3hzhB 1 0.7321 99.7 0.625 Contact Map
3uswA 1 0.6507 49.1 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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