GREMLIN Database
SSUD - Alkanesulfonate monooxygenase
UniProt: P40402 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 376 (308)
Sequences: 14430 (9165)
Seq/√Len: 522.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
234_E309_T5.5241.00
149_E154_K3.4071.00
35_Q66_E3.2791.00
234_E306_D3.0131.00
36_A39_R2.6101.00
36_A337_Y2.5961.00
131_D187_K2.5821.00
71_K102_L2.5011.00
233_T236_E2.4831.00
234_E238_W2.4801.00
38_D69_D2.4561.00
313_R316_E2.4391.00
207_E211_K2.3781.00
60_A72_F2.3641.00
183_E212_Q2.3591.00
308_Q346_L2.2931.00
64_A97_S2.2501.00
231_R236_E2.2151.00
306_D309_T2.1751.00
311_A346_L2.1711.00
128_E151_K2.1691.00
206_I222_F2.1661.00
182_I208_R2.1451.00
28_L98_D2.0831.00
339_F343_V2.0671.00
337_Y341_E2.0651.00
31_K35_Q2.0471.00
135_T188_H2.0091.00
211_K215_K2.0061.00
203_K207_E1.9811.00
208_R212_Q1.9661.00
35_Q39_R1.9601.00
213_A220_V1.9421.00
34_A63_L1.9351.00
122_S125_E1.9291.00
232_E342_L1.8991.00
40_L340_A1.8851.00
235_Q239_E1.8711.00
206_I210_K1.8671.00
242_E246_S1.8661.00
316_E319_A1.8561.00
142_Q169_H1.8541.00
94_D99_G1.8491.00
32_Q35_Q1.8381.00
186_A212_Q1.8191.00
315_A318_Q1.7711.00
31_K66_E1.7701.00
45_V70_L1.7401.00
334_E337_Y1.7301.00
125_E151_K1.7301.00
203_K319_A1.7161.00
64_A72_F1.7141.00
32_Q333_L1.6491.00
303_L310_I1.6371.00
90_T101_L1.6231.00
36_A333_L1.6201.00
63_L72_F1.6051.00
135_T139_R1.6021.00
204_E207_E1.5741.00
46_L73_L1.5681.00
36_A40_L1.5571.00
236_E240_A1.5541.00
183_E215_K1.5411.00
55_D89_M1.5251.00
138_R169_H1.5081.00
208_R211_K1.5001.00
31_K62_A1.4921.00
22_G25_A1.4921.00
334_E338_Y1.4811.00
34_A45_V1.4791.00
128_E152_H1.4591.00
212_Q215_K1.4471.00
147_S157_N1.4361.00
139_R143_G1.4211.00
230_A310_I1.4171.00
176_G192_Y1.3981.00
224_I322_I1.3851.00
232_E334_E1.3831.00
311_A315_A1.3831.00
342_L346_L1.3751.00
309_T312_D1.3741.00
183_E187_K1.3621.00
138_R188_H1.3571.00
125_E128_E1.3551.00
308_Q312_D1.3461.00
309_T313_R1.3311.00
39_R68_K1.3221.00
138_R172_I1.3211.00
135_T148_Y1.3131.00
111_P115_A1.2981.00
62_A65_G1.2971.00
329_G333_L1.2951.00
338_Y342_L1.2861.00
32_Q36_A1.2831.00
213_A218_R1.2751.00
34_A67_T1.2701.00
81_M89_M1.2691.00
28_L32_Q1.2661.00
288_L291_G1.2621.00
239_E242_E1.2461.00
145_T157_N1.2441.00
307_P338_Y1.2321.00
236_E239_E1.2281.00
25_A29_Y1.2241.00
90_T103_I1.2231.00
98_D165_Q1.2221.00
231_R237_A1.2141.00
55_D58_L1.2121.00
261_S264_D1.2121.00
312_D316_E1.2101.00
264_D267_G1.2071.00
229_I240_A1.2031.00
186_A216_E1.1991.00
131_D188_H1.1881.00
32_Q329_G1.1851.00
173_Y223_G1.1821.00
230_A307_P1.1731.00
47_L63_L1.1651.00
183_E208_R1.1511.00
221_R323_E1.1501.00
149_E156_E1.1491.00
34_A70_L1.1461.00
125_E152_H1.1341.00
38_D68_K1.1331.00
47_L60_A1.1311.00
132_E150_G1.1281.00
58_L61_S1.1261.00
216_E219_S1.1231.00
73_L102_L1.1231.00
331_P334_E1.1221.00
131_D135_T1.1181.00
187_K216_E1.1131.00
264_D268_Q1.1071.00
38_D67_T1.1061.00
139_R148_Y1.1011.00
183_E216_E1.1011.00
138_R190_D1.1011.00
139_R144_E1.0951.00
179_Q208_R1.0931.00
232_E236_E1.0921.00
285_S288_L1.0871.00
62_A96_I1.0821.00
35_Q68_K1.0801.00
136_V148_Y1.0791.00
62_A66_E1.0781.00
57_W89_M1.0681.00
86_A133_F1.0671.00
137_W141_L1.0601.00
105_V134_L1.0561.00
241_A245_I1.0531.00
136_V153_I1.0481.00
115_A156_E1.0471.00
180_A183_E1.0471.00
129_A132_E1.0461.00
230_A338_Y1.0391.00
262_R265_S1.0381.00
238_W242_E1.0291.00
265_S268_Q1.0231.00
199_P316_E1.0221.00
39_R337_Y1.0201.00
40_L336_A1.0191.00
253_I256_A1.0191.00
94_D168_P1.0151.00
93_L101_L1.0031.00
293_G296_R1.0001.00
236_E331_P0.9911.00
173_Y191_V0.9871.00
315_A319_A0.9831.00
155_V158_S0.9821.00
134_L188_H0.9811.00
305_G310_I0.9801.00
37_A336_A0.9751.00
241_A304_V0.9741.00
226_L303_L0.9731.00
144_E147_S0.9711.00
327_F339_F0.9641.00
212_Q216_E0.9591.00
109_G113_E0.9571.00
50_G54_E0.9531.00
228_V327_F0.9491.00
213_A219_S0.9471.00
103_I137_W0.9461.00
239_E243_R0.9431.00
136_V139_R0.9381.00
182_I186_A0.9371.00
58_L93_L0.9351.00
21_D29_Y0.9311.00
136_V155_V0.9311.00
85_L89_M0.9291.00
231_R240_A0.9291.00
24_T28_L0.9281.00
226_L314_I0.9281.00
258_A261_S0.9201.00
148_Y151_K0.9131.00
203_K320_L0.9131.00
44_G73_L0.9091.00
247_H250_D0.9091.00
184_A188_H0.9091.00
240_A338_Y0.9071.00
29_Y32_Q0.8901.00
243_R246_S0.8891.00
311_A343_V0.8871.00
29_Y329_G0.8851.00
335_E338_Y0.8751.00
193_L223_G0.8731.00
260_L265_S0.8731.00
42_Y340_A0.8681.00
232_E338_Y0.8671.00
235_Q238_W0.8661.00
39_R341_E0.8641.00
128_E180_A0.8641.00
182_I212_Q0.8621.00
94_D167_E0.8581.00
27_H96_I0.8571.00
261_S265_S0.8561.00
95_R165_Q0.8561.00
213_A216_E0.8531.00
336_A340_A0.8491.00
303_L313_R0.8461.00
95_R168_P0.8421.00
240_A331_P0.8401.00
230_A343_V0.8401.00
238_W299_A0.8391.00
204_E208_R0.8381.00
238_W241_A0.8371.00
64_A101_L0.8361.00
131_D184_A0.8351.00
177_S196_G0.8351.00
65_G97_S0.8341.00
138_R142_Q0.8321.00
140_L146_V0.8301.00
201_Q204_E0.8271.00
108_G113_E0.8271.00
221_R324_S0.8271.00
198_P201_Q0.8241.00
141_L170_P0.8191.00
262_R266_S0.8191.00
129_A133_F0.8191.00
333_L337_Y0.8151.00
20_S23_R0.8091.00
207_E321_G0.8061.00
174_F185_A0.8051.00
132_E151_K0.8021.00
32_Q39_R0.8001.00
312_D315_A0.8001.00
60_A64_A0.7991.00
254_A257_Q0.7971.00
246_S250_D0.7951.00
28_L31_K0.7931.00
174_F181_G0.7931.00
340_A344_F0.7921.00
242_E245_I0.7911.00
254_A258_A0.7821.00
263_Y266_S0.7811.00
91_S164_P0.7771.00
259_A262_R0.7761.00
94_D169_H0.7691.00
145_T159_N0.7671.00
183_E211_K0.7641.00
263_Y267_G0.7631.00
209_V220_V0.7501.00
110_D113_E0.7501.00
33_V336_A0.7481.00
23_R26_D0.7461.00
94_D164_P0.7451.00
294_L298_G0.7421.00
255_K259_A0.7401.00
240_A243_R0.7381.00
228_V339_F0.7381.00
60_A74_V0.7381.00
253_I257_Q0.7321.00
61_S65_G0.7321.00
210_K214_A0.7321.00
131_D180_A0.7301.00
26_D29_Y0.7281.00
125_E129_A0.7271.00
194_T205_K0.7261.00
102_L173_Y0.7251.00
139_R146_V0.7231.00
192_Y209_V0.7211.00
127_Y180_A0.7191.00
60_A93_L0.7181.00
315_A347_L0.7171.00
257_Q262_R0.7171.00
243_R247_H0.7171.00
139_R142_Q0.7141.00
158_S162_F0.7091.00
134_L174_F0.7071.00
124_D180_A0.7071.00
260_L263_Y0.7061.00
50_G53_C0.7041.00
64_A93_L0.7041.00
179_Q212_Q0.7031.00
206_I209_V0.6991.00
77_R108_G0.6941.00
294_L297_G0.6911.00
133_F137_W0.6901.00
315_A346_L0.6881.00
147_S156_E0.6861.00
233_T237_A0.6851.00
83_P136_V0.6851.00
47_L59_T0.6851.00
76_V106_V0.6841.00
76_V86_A0.6811.00
82_Q85_L0.6791.00
185_A192_Y0.6791.00
31_K63_L0.6761.00
72_F97_S0.6751.00
228_V303_L0.6751.00
107_A126_R0.6741.00
200_E203_K0.6741.00
209_V213_A0.6711.00
287_N290_A0.6711.00
60_A101_L0.6701.00
179_Q183_E0.6701.00
132_E136_V0.6691.00
289_W292_I0.6681.00
229_I241_A0.6661.00
33_V333_L0.6661.00
174_F184_A0.6641.00
112_Y115_A0.6621.00
199_P203_K0.6591.00
37_A70_L0.6541.00
232_E307_P0.6531.00
86_A137_W0.6521.00
83_P133_F0.6511.00
105_V172_I0.6491.00
287_N291_G0.6481.00
210_K323_E0.6481.00
135_T138_R0.6461.00
46_L75_A0.6461.00
330_Y333_L0.6461.00
27_H62_A0.6461.00
255_K260_L0.6451.00
182_I192_Y0.6451.00
129_A153_I0.6451.00
259_A264_D0.6431.00
44_G324_S0.6411.00
81_M85_L0.6411.00
28_L68_K0.6401.00
187_K212_Q0.6391.00
237_A241_A0.6381.00
263_Y268_Q0.6371.00
135_T187_K0.6351.00
256_A261_S0.6331.00
36_A340_A0.6321.00
149_E152_H0.6311.00
160_L163_P0.6311.00
84_S140_L0.6281.00
238_W304_V0.6251.00
258_A262_R0.6231.00
74_V101_L0.6221.00
136_V140_L0.6221.00
261_S266_S0.6201.00
262_R268_Q0.6201.00
31_K65_G0.6191.00
78_P86_A0.6171.00
73_L173_Y0.6171.00
90_T141_L0.6151.00
260_L264_D0.6141.00
29_Y33_V0.6141.00
42_Y344_F0.6121.00
132_E148_Y0.6111.00
87_A164_P0.6091.00
206_I320_L0.6081.00
51_R88_R0.6081.00
71_K171_P0.6071.00
210_K321_G0.6041.00
33_V329_G0.6031.00
159_N163_P0.6031.00
148_Y153_I0.6011.00
262_R267_G0.6001.00
311_A347_L0.5981.00
174_F189_T0.5960.99
27_H31_K0.5960.99
222_F322_I0.5940.99
43_T69_D0.5930.99
57_W90_T0.5920.99
210_K213_A0.5900.99
179_Q204_E0.5860.99
230_A339_F0.5850.99
223_G326_I0.5830.99
230_A306_D0.5790.99
225_R326_I0.5780.99
182_I209_V0.5770.99
123_H126_R0.5750.99
223_G324_S0.5740.99
187_K215_K0.5730.99
227_H328_S0.5730.99
228_V310_I0.5720.99
231_R338_Y0.5720.99
38_D70_L0.5700.99
44_G326_I0.5700.99
81_M86_A0.5620.99
255_K265_S0.5620.99
67_T70_L0.5620.99
40_L333_L0.5610.99
237_A306_D0.5610.99
61_S97_S0.5610.99
62_A97_S0.5600.99
107_A130_T0.5580.99
245_I248_L0.5570.99
94_D97_S0.5570.99
43_T71_K0.5560.99
165_Q168_P0.5530.99
45_V63_L0.5520.99
256_A259_A0.5520.99
210_K222_F0.5510.99
59_T92_T0.5510.99
250_D253_I0.5500.99
55_D92_T0.5480.99
91_S95_R0.5480.99
292_I296_R0.5470.99
307_P341_E0.5470.99
258_A266_S0.5460.99
49_T81_M0.5440.99
307_P342_L0.5400.99
21_D25_A0.5390.99
186_A213_A0.5390.99
191_V221_R0.5360.99
30_F33_V0.5340.99
67_T100_R0.5330.99
209_V222_F0.5320.99
103_I172_I0.5310.99
258_A264_D0.5290.99
61_S93_L0.5280.99
293_G297_G0.5280.99
171_P221_R0.5270.99
58_L92_T0.5260.99
105_V137_W0.5260.99
141_L172_I0.5200.99
25_A28_L0.5190.99
233_T306_D0.5190.99
202_V205_K0.5180.99
58_L62_A0.5180.99
303_L317_Y0.5170.99
114_L119_L0.5170.99
109_G112_Y0.5160.99
286_P289_W0.5160.99
224_I317_Y0.5140.99
173_Y324_S0.5140.99
322_I325_F0.5130.98
297_G300_G0.5130.98
104_N175_G0.5120.98
257_Q265_S0.5120.98
142_Q168_P0.5100.98
91_S163_P0.5080.98
177_S205_K0.5080.98
28_L65_G0.5080.98
329_G335_E0.5070.98
60_A97_S0.5060.98
332_H335_E0.5060.98
197_E201_Q0.5060.98
231_R234_E0.5050.98
132_E135_T0.5050.98
292_I295_V0.5030.98
257_Q261_S0.5020.98
285_S290_A0.5020.98
255_K258_A0.5020.98
240_A334_E0.5020.98
199_P320_L0.5000.98
115_A118_G0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3sdoA 2 0.9867 100 0.219 Contact Map
1tvlA 2 0.9176 100 0.221 Contact Map
3b9oA 2 0.9707 100 0.233 Contact Map
1nqkA 4 0.9122 100 0.235 Contact Map
3raoA 2 0.8803 100 0.267 Contact Map
2wgkA 2 0.8803 100 0.28 Contact Map
1ezwA 3 0.8617 100 0.281 Contact Map
2i7gA 2 0.8617 100 0.282 Contact Map
1lucA 1 0.8218 100 0.285 Contact Map
1z69A 4 0.8484 100 0.296 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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