SSUA - BACSU - GREMLIN Contacts

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SSUA - Putative aliphatic sulfonates-binding protein

UniProt:	P40400	Sequences: MKKGLIVLVAVIFLLAGCGANGASGDHKQLKEIRIGIQQSLSPLLIAKEKGWFEDAFEKEGIKVKWVEFQSGPPQFEGLAADKLDFSQVGNSPVIAGQAAGIDFKEIGLSQDGLKANGILVNQNSGIQDVKGLKGKKIAVAKGSSGFDFLYKALDQVGLSANDVTIIQLQPDEAASAFENGSVDAWSIWEPYLSLETMKHGAKILVNGESTDLYSPGFTLVRTKFSEEHPDEVVRFLKVFNKAVVWQKEHLDEAADLYSDIKDLDKKVVENVLKNTEPLNEIISDDIVKAQQETADFQFRTKAIDKKIDVKDVVDNTFIKKALEEHSSGGDQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	332 (301)
Sequences:	14008 (10436)
Seq/√Len:	601.5

ECOLI - SSUA TAUA
BACSU - SSUA YTLA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
250_H	253_E	3.369	1.00
105_K	223_T	3.207	1.00
246_W	250_H	3.171	1.00
137_K	165_T	3.123	1.00
60_E	238_K	3.059	1.00
225_F	229_H	3.046	1.00
223_T	227_E	2.912	1.00
103_D	223_T	2.884	1.00
55_D	242_K	2.881	1.00
134_K	163_D	2.867	1.00
309_D	312_D	2.793	1.00
60_E	242_K	2.757	1.00
224_K	228_E	2.752	1.00
234_V	238_K	2.684	1.00
139_A	183_V	2.683	1.00
32_E	65_K	2.669	1.00
256_D	266_K	2.536	1.00
32_E	63_K	2.511	1.00
53_F	240_F	2.454	1.00
34_R	65_K	2.443	1.00
252_D	270_E	2.422	1.00
129_D	132_G	2.412	1.00
292_Q	296_D	2.372	1.00
245_V	249_E	2.295	1.00
190_E	194_S	2.164	1.00
30_L	63_K	2.161	1.00
229_H	232_E	2.157	1.00
50_K	253_E	2.153	1.00
160_S	163_D	2.113	1.00
296_D	300_R	2.085	1.00
18_C	21_N	2.040	1.00
36_G	84_L	2.036	1.00
49_E	260_D	2.024	1.00
128_Q	132_G	2.011	1.00
266_K	270_E	1.995	1.00
221_V	226_S	1.966	1.00
299_F	307_K	1.964	1.00
136_K	184_D	1.953	1.00
52_W	242_K	1.950	1.00
147_F	151_Y	1.922	1.00
86_F	221_V	1.902	1.00
169_L	177_A	1.854	1.00
256_D	260_D	1.809	1.00
155_D	300_R	1.807	1.00
231_D	235_R	1.780	1.00
52_W	239_V	1.745	1.00
52_W	246_W	1.745	1.00
270_E	274_K	1.738	1.00
265_D	268_V	1.711	1.00
241_N	245_V	1.705	1.00
221_V	233_V	1.680	1.00
18_C	22_G	1.677	1.00
253_E	256_D	1.668	1.00
207_N	210_S	1.665	1.00
131_K	157_V	1.649	1.00
159_L	163_D	1.633	1.00
50_K	246_W	1.579	1.00
225_F	233_V	1.563	1.00
137_K	167_I	1.537	1.00
246_W	253_E	1.529	1.00
288_V	292_Q	1.520	1.00
86_F	233_V	1.514	1.00
247_Q	254_A	1.500	1.00
106_E	218_F	1.500	1.00
98_Q	223_T	1.496	1.00
235_R	239_V	1.492	1.00
138_I	185_A	1.487	1.00
154_L	159_L	1.480	1.00
198_M	271_N	1.470	1.00
51_G	54_E	1.459	1.00
255_A	270_E	1.457	1.00
105_K	315_D	1.447	1.00
296_D	307_K	1.442	1.00
259_S	266_K	1.437	1.00
226_S	233_V	1.427	1.00
89_V	220_L	1.425	1.00
131_K	134_K	1.415	1.00
133_L	185_A	1.415	1.00
225_F	232_E	1.414	1.00
86_F	236_F	1.414	1.00
230_P	234_V	1.404	1.00
52_W	55_D	1.401	1.00
108_G	237_L	1.374	1.00
288_V	311_K	1.370	1.00
271_N	274_K	1.367	1.00
47_A	243_A	1.351	1.00
122_N	181_G	1.348	1.00
15_L	18_C	1.341	1.00
137_K	184_D	1.325	1.00
34_R	67_V	1.323	1.00
60_E	235_R	1.320	1.00
75_Q	87_S	1.316	1.00
74_P	77_E	1.298	1.00
55_D	60_E	1.291	1.00
78_G	83_K	1.287	1.00
69_F	78_G	1.286	1.00
130_V	153_A	1.280	1.00
174_A	186_W	1.279	1.00
154_L	164_V	1.267	1.00
82_D	224_K	1.265	1.00
48_K	54_E	1.260	1.00
43_P	244_V	1.255	1.00
47_A	53_F	1.246	1.00
130_V	157_V	1.235	1.00
297_F	301_T	1.233	1.00
289_K	293_E	1.230	1.00
231_D	234_V	1.228	1.00
31_K	229_H	1.227	1.00
252_D	256_D	1.226	1.00
46_I	246_W	1.225	1.00
128_Q	203_K	1.213	1.00
140_V	166_I	1.210	1.00
118_G	193_L	1.194	1.00
222_R	225_F	1.189	1.00
170_Q	173_E	1.184	1.00
267_K	270_E	1.183	1.00
60_E	239_V	1.141	1.00
183_V	186_W	1.140	1.00
122_N	125_S	1.131	1.00
105_K	226_S	1.127	1.00
46_I	257_L	1.123	1.00
79_L	87_S	1.116	1.00
107_I	221_V	1.114	1.00
53_F	64_V	1.105	1.00
195_L	199_K	1.098	1.00
152_K	155_D	1.074	1.00
127_I	136_K	1.071	1.00
52_W	60_E	1.070	1.00
11_V	14_L	1.065	1.00
122_N	178_F	1.065	1.00
251_L	255_A	1.061	1.00
121_V	125_S	1.060	1.00
107_I	233_V	1.059	1.00
177_A	183_V	1.041	1.00
245_V	248_K	1.038	1.00
49_E	257_L	1.034	1.00
34_R	85_D	1.031	1.00
80_A	102_I	1.021	1.00
255_A	266_K	1.019	1.00
123_Q	203_K	1.016	1.00
152_K	156_Q	1.016	1.00
150_L	166_I	1.005	1.00
34_R	84_L	1.004	1.00
50_K	257_L	1.000	1.00
62_I	235_R	0.999	1.00
232_E	235_R	0.995	1.00
256_D	259_S	0.992	1.00
176_S	179_E	0.990	1.00
267_K	271_N	0.972	1.00
295_A	307_K	0.972	1.00
251_L	274_K	0.971	1.00
29_Q	229_H	0.971	1.00
176_S	180_N	0.971	1.00
295_A	308_I	0.969	1.00
134_K	159_L	0.962	1.00
253_E	257_L	0.960	1.00
36_G	69_F	0.957	1.00
175_A	179_E	0.953	1.00
119_I	187_S	0.953	1.00
121_V	205_L	0.952	1.00
86_F	107_I	0.950	1.00
46_I	50_K	0.950	1.00
78_G	84_L	0.945	1.00
221_V	225_F	0.942	1.00
94_V	220_L	0.931	1.00
12_I	15_L	0.930	1.00
53_F	239_V	0.929	1.00
289_K	292_Q	0.927	1.00
107_I	237_L	0.923	1.00
99_A	305_D	0.918	1.00
79_L	220_L	0.915	1.00
14_L	17_G	0.913	1.00
124_N	181_G	0.908	1.00
293_E	296_D	0.908	1.00
191_P	194_S	0.907	1.00
72_G	93_P	0.900	1.00
121_V	185_A	0.894	1.00
244_V	248_K	0.888	1.00
142_K	168_Q	0.885	1.00
82_D	222_R	0.883	1.00
35_I	64_V	0.882	1.00
296_D	299_F	0.879	1.00
120_L	193_L	0.876	1.00
299_F	306_K	0.876	1.00
239_V	242_K	0.873	1.00
153_A	157_V	0.873	1.00
179_E	199_K	0.866	1.00
98_Q	313_V	0.865	1.00
10_A	13_F	0.865	1.00
235_R	238_K	0.862	1.00
19_G	22_G	0.859	1.00
287_I	290_A	0.855	1.00
224_K	227_E	0.854	1.00
16_A	19_G	0.847	1.00
46_I	243_A	0.844	1.00
46_I	247_Q	0.843	1.00
47_A	52_W	0.841	1.00
226_S	230_P	0.839	1.00
103_D	224_K	0.835	1.00
31_K	34_R	0.832	1.00
9_V	12_I	0.832	1.00
54_E	63_K	0.832	1.00
61_G	235_R	0.828	1.00
138_I	164_V	0.827	1.00
7_V	13_F	0.826	1.00
190_E	193_L	0.825	1.00
71_S	74_P	0.824	1.00
223_T	226_S	0.822	1.00
240_F	244_V	0.822	1.00
119_I	185_A	0.822	1.00
225_F	228_E	0.816	1.00
52_W	243_A	0.815	1.00
295_A	299_F	0.813	1.00
16_A	20_A	0.809	1.00
178_F	183_V	0.807	1.00
86_F	232_E	0.807	1.00
285_D	289_K	0.805	1.00
204_I	207_N	0.805	1.00
151_Y	161_A	0.800	1.00
246_W	254_A	0.799	1.00
225_F	230_P	0.798	1.00
122_N	126_G	0.798	1.00
105_K	227_E	0.797	1.00
201_G	204_I	0.796	1.00
219_T	236_F	0.795	1.00
246_W	249_E	0.795	1.00
90_G	93_P	0.794	1.00
127_I	132_G	0.791	1.00
227_E	230_P	0.791	1.00
31_K	232_E	0.790	1.00
31_K	35_I	0.787	1.00
173_E	176_S	0.784	1.00
152_K	293_E	0.773	1.00
236_F	240_F	0.773	1.00
282_I	285_D	0.772	1.00
62_I	232_E	0.768	1.00
76_F	97_G	0.766	1.00
255_A	273_L	0.765	1.00
118_G	204_I	0.762	1.00
292_Q	310_V	0.761	1.00
177_A	182_S	0.761	1.00
213_L	216_P	0.760	1.00
238_K	242_K	0.758	1.00
233_V	237_L	0.757	1.00
150_L	154_L	0.757	1.00
285_D	288_V	0.756	1.00
286_D	289_K	0.755	1.00
89_V	94_V	0.754	1.00
8_L	14_L	0.753	1.00
51_G	55_D	0.750	1.00
85_D	222_R	0.749	1.00
269_V	272_V	0.749	1.00
33_I	225_F	0.746	1.00
143_G	147_F	0.744	1.00
11_V	15_L	0.743	1.00
154_L	157_V	0.740	1.00
295_A	310_V	0.740	1.00
91_N	291_Q	0.739	1.00
46_I	254_A	0.739	1.00
150_L	187_S	0.738	1.00
147_F	166_I	0.734	1.00
39_Q	68_E	0.732	1.00
142_K	147_F	0.732	1.00
155_D	301_T	0.731	1.00
42_S	258_Y	0.730	1.00
103_D	222_R	0.720	1.00
310_V	314_V	0.720	1.00
126_G	203_K	0.720	1.00
194_S	198_M	0.719	1.00
198_M	268_V	0.719	1.00
192_Y	196_E	0.717	1.00
257_L	260_D	0.717	1.00
243_A	247_Q	0.716	1.00
275_N	278_P	0.714	1.00
85_D	225_F	0.712	1.00
41_L	45_L	0.710	1.00
94_V	106_E	0.708	1.00
239_V	243_A	0.706	1.00
264_L	269_V	0.705	1.00
179_E	201_G	0.705	1.00
248_K	251_L	0.705	1.00
272_V	276_T	0.703	1.00
292_Q	295_A	0.703	1.00
123_Q	201_G	0.702	1.00
17_G	21_N	0.702	1.00
139_A	174_A	0.702	1.00
197_T	271_N	0.701	1.00
13_F	16_A	0.698	1.00
271_N	275_N	0.696	1.00
178_F	186_W	0.695	1.00
212_D	215_S	0.693	1.00
91_N	218_F	0.690	1.00
95_I	295_A	0.685	1.00
17_G	20_A	0.684	1.00
45_L	49_E	0.682	1.00
288_V	314_V	0.679	1.00
35_I	236_F	0.672	1.00
62_I	239_V	0.671	1.00
119_I	133_L	0.669	1.00
274_K	278_P	0.664	1.00
259_S	269_V	0.663	1.00
10_A	14_L	0.663	1.00
29_Q	232_E	0.662	1.00
148_D	297_F	0.661	1.00
138_I	150_L	0.661	1.00
109_L	112_D	0.661	1.00
178_F	202_A	0.661	1.00
193_L	197_T	0.659	1.00
30_L	229_H	0.659	1.00
252_D	255_A	0.659	1.00
198_M	267_K	0.657	1.00
79_L	84_L	0.657	1.00
206_V	210_S	0.656	1.00
151_Y	166_I	0.655	1.00
121_V	126_G	0.650	1.00
7_V	10_A	0.649	1.00
290_A	293_E	0.646	1.00
153_A	211_T	0.646	1.00
100_A	305_D	0.646	1.00
195_L	198_M	0.645	1.00
86_F	225_F	0.642	1.00
6_I	18_C	0.642	1.00
274_K	277_E	0.638	1.00
110_S	219_T	0.637	1.00
219_T	240_F	0.635	1.00
54_E	60_E	0.632	1.00
77_E	81_A	0.626	1.00
106_E	291_Q	0.626	1.00
197_T	204_I	0.626	1.00
97_G	104_F	0.624	1.00
188_I	192_Y	0.624	1.00
299_F	304_I	0.624	1.00
134_K	160_S	0.623	1.00
275_N	279_L	0.621	1.00
252_D	274_K	0.621	1.00
286_D	291_Q	0.620	1.00
200_H	204_I	0.618	1.00
241_N	244_V	0.613	1.00
47_A	50_K	0.613	1.00
30_L	65_K	0.613	1.00
177_A	180_N	0.612	1.00
45_L	48_K	0.611	1.00
12_I	16_A	0.610	1.00
251_L	254_A	0.607	1.00
139_A	169_L	0.607	1.00
114_L	214_Y	0.605	1.00
98_Q	312_D	0.604	1.00
229_H	233_V	0.603	1.00
252_D	266_K	0.602	1.00
43_P	47_A	0.601	1.00
246_W	257_L	0.601	1.00
221_V	236_F	0.601	1.00
281_E	285_D	0.600	1.00
76_F	89_V	0.597	1.00
6_I	13_F	0.596	1.00
91_N	294_T	0.593	1.00
268_V	272_V	0.590	1.00
284_S	287_I	0.590	1.00
137_K	182_S	0.589	1.00
126_G	136_K	0.588	1.00
62_I	236_F	0.588	1.00
139_A	186_W	0.588	1.00
134_K	154_L	0.587	1.00
79_L	222_R	0.587	1.00
200_H	203_K	0.587	1.00
107_I	226_S	0.585	1.00
136_K	185_A	0.585	1.00
115_K	209_E	0.584	1.00
137_K	183_V	0.584	1.00
55_D	61_G	0.580	1.00
152_K	297_F	0.579	1.00
208_G	211_T	0.579	1.00
120_L	204_I	0.576	1.00
96_A	100_A	0.575	1.00
293_E	297_F	0.572	1.00
146_G	189_W	0.571	1.00
63_K	66_W	0.571	1.00
151_Y	155_D	0.570	1.00
237_L	241_N	0.569	1.00
161_A	166_I	0.568	1.00
118_G	121_V	0.567	1.00
135_G	163_D	0.567	1.00
87_S	220_L	0.566	1.00
299_F	302_K	0.565	1.00
194_S	197_T	0.564	1.00
268_V	271_N	0.564	1.00
106_E	286_D	0.564	1.00
74_P	78_G	0.562	1.00
230_P	233_V	0.562	1.00
96_A	99_A	0.561	1.00
6_I	10_A	0.561	1.00
89_V	93_P	0.559	1.00
85_D	229_H	0.558	1.00
43_P	243_A	0.558	1.00
44_L	240_F	0.557	1.00
120_L	188_I	0.557	1.00
76_F	220_L	0.557	1.00
48_K	66_W	0.555	0.99
181_G	184_D	0.554	0.99
78_G	81_A	0.554	0.99
53_F	62_I	0.554	0.99
212_D	216_P	0.553	0.99
31_K	62_I	0.552	0.99
242_K	245_V	0.550	0.99
131_K	159_L	0.548	0.99
269_V	273_L	0.547	0.99
295_A	304_I	0.546	0.99
108_G	219_T	0.546	0.99
111_Q	217_G	0.545	0.99
205_L	208_G	0.544	0.99
67_V	78_G	0.544	0.99
151_Y	301_T	0.541	0.99
117_N	121_V	0.540	0.99
258_Y	269_V	0.536	0.99
47_A	239_V	0.535	0.99
175_A	178_F	0.534	0.99
308_I	313_V	0.534	0.99
230_P	315_D	0.532	0.99
35_I	86_F	0.531	0.99
9_V	14_L	0.529	0.99
84_L	87_S	0.528	0.99
17_G	22_G	0.528	0.99
129_D	157_V	0.526	0.99
302_K	305_D	0.526	0.99
250_H	254_A	0.524	0.99
115_K	207_N	0.524	0.99
202_A	205_L	0.524	0.99
9_V	13_F	0.521	0.99
125_S	128_Q	0.520	0.99
69_F	75_Q	0.520	0.99
47_A	240_F	0.520	0.99
273_L	277_E	0.519	0.99
39_Q	45_L	0.518	0.99
190_E	275_N	0.517	0.99
290_A	294_T	0.517	0.99
108_G	111_Q	0.516	0.99
8_L	16_A	0.516	0.99
155_D	161_A	0.515	0.99
6_I	14_L	0.514	0.99
174_A	177_A	0.513	0.99
255_A	259_S	0.510	0.99
155_D	160_S	0.510	0.99
197_T	275_N	0.509	0.99
94_V	218_F	0.509	0.99
292_Q	311_K	0.505	0.99
16_A	22_G	0.504	0.99
197_T	200_H	0.504	0.99
18_C	28_K	0.503	0.99
48_K	63_K	0.503	0.99
21_N	27_H	0.501	0.99
99_A	306_K	0.501	0.99
264_L	268_V	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3qslA	1	0.9277	100	0.299	Contact Map
2g29A	1	0.9066	100	0.321	Contact Map
3un6A	1	0.8584	100	0.324	Contact Map
4nmyA	1	0.8614	100	0.331	Contact Map
2x26A	1	0.8976	100	0.34	Contact Map
2de3A	1	0.8705	100	0.342	Contact Map
2i49A	1	0.9006	100	0.359	Contact Map
3ix1A	2	0.8614	100	0.363	Contact Map
3uifA	1	0.9066	100	0.394	Contact Map
2x7qA	1	0.8705	100	0.396	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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