GREMLIN Database
SSUA - Putative aliphatic sulfonates-binding protein
UniProt: P40400 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 332 (301)
Sequences: 14008 (10436)
Seq/√Len: 601.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
250_H253_E3.3691.00
105_K223_T3.2071.00
246_W250_H3.1711.00
137_K165_T3.1231.00
60_E238_K3.0591.00
225_F229_H3.0461.00
223_T227_E2.9121.00
103_D223_T2.8841.00
55_D242_K2.8811.00
134_K163_D2.8671.00
309_D312_D2.7931.00
60_E242_K2.7571.00
224_K228_E2.7521.00
234_V238_K2.6841.00
139_A183_V2.6831.00
32_E65_K2.6691.00
256_D266_K2.5361.00
32_E63_K2.5111.00
53_F240_F2.4541.00
34_R65_K2.4431.00
252_D270_E2.4221.00
129_D132_G2.4121.00
292_Q296_D2.3721.00
245_V249_E2.2951.00
190_E194_S2.1641.00
30_L63_K2.1611.00
229_H232_E2.1571.00
50_K253_E2.1531.00
160_S163_D2.1131.00
296_D300_R2.0851.00
18_C21_N2.0401.00
36_G84_L2.0361.00
49_E260_D2.0241.00
128_Q132_G2.0111.00
266_K270_E1.9951.00
221_V226_S1.9661.00
299_F307_K1.9641.00
136_K184_D1.9531.00
52_W242_K1.9501.00
147_F151_Y1.9221.00
86_F221_V1.9021.00
169_L177_A1.8541.00
256_D260_D1.8091.00
155_D300_R1.8071.00
231_D235_R1.7801.00
52_W239_V1.7451.00
52_W246_W1.7451.00
270_E274_K1.7381.00
265_D268_V1.7111.00
241_N245_V1.7051.00
221_V233_V1.6801.00
18_C22_G1.6771.00
253_E256_D1.6681.00
207_N210_S1.6651.00
131_K157_V1.6491.00
159_L163_D1.6331.00
50_K246_W1.5791.00
225_F233_V1.5631.00
137_K167_I1.5371.00
246_W253_E1.5291.00
288_V292_Q1.5201.00
86_F233_V1.5141.00
247_Q254_A1.5001.00
106_E218_F1.5001.00
98_Q223_T1.4961.00
235_R239_V1.4921.00
138_I185_A1.4871.00
154_L159_L1.4801.00
198_M271_N1.4701.00
51_G54_E1.4591.00
255_A270_E1.4571.00
105_K315_D1.4471.00
296_D307_K1.4421.00
259_S266_K1.4371.00
226_S233_V1.4271.00
89_V220_L1.4251.00
131_K134_K1.4151.00
133_L185_A1.4151.00
225_F232_E1.4141.00
86_F236_F1.4141.00
230_P234_V1.4041.00
52_W55_D1.4011.00
108_G237_L1.3741.00
288_V311_K1.3701.00
271_N274_K1.3671.00
47_A243_A1.3511.00
122_N181_G1.3481.00
15_L18_C1.3411.00
137_K184_D1.3251.00
34_R67_V1.3231.00
60_E235_R1.3201.00
75_Q87_S1.3161.00
74_P77_E1.2981.00
55_D60_E1.2911.00
78_G83_K1.2871.00
69_F78_G1.2861.00
130_V153_A1.2801.00
174_A186_W1.2791.00
154_L164_V1.2671.00
82_D224_K1.2651.00
48_K54_E1.2601.00
43_P244_V1.2551.00
47_A53_F1.2461.00
130_V157_V1.2351.00
297_F301_T1.2331.00
289_K293_E1.2301.00
231_D234_V1.2281.00
31_K229_H1.2271.00
252_D256_D1.2261.00
46_I246_W1.2251.00
128_Q203_K1.2131.00
140_V166_I1.2101.00
118_G193_L1.1941.00
222_R225_F1.1891.00
170_Q173_E1.1841.00
267_K270_E1.1831.00
60_E239_V1.1411.00
183_V186_W1.1401.00
122_N125_S1.1311.00
105_K226_S1.1271.00
46_I257_L1.1231.00
79_L87_S1.1161.00
107_I221_V1.1141.00
53_F64_V1.1051.00
195_L199_K1.0981.00
152_K155_D1.0741.00
127_I136_K1.0711.00
52_W60_E1.0701.00
11_V14_L1.0651.00
122_N178_F1.0651.00
251_L255_A1.0611.00
121_V125_S1.0601.00
107_I233_V1.0591.00
177_A183_V1.0411.00
245_V248_K1.0381.00
49_E257_L1.0341.00
34_R85_D1.0311.00
80_A102_I1.0211.00
255_A266_K1.0191.00
123_Q203_K1.0161.00
152_K156_Q1.0161.00
150_L166_I1.0051.00
34_R84_L1.0041.00
50_K257_L1.0001.00
62_I235_R0.9991.00
232_E235_R0.9951.00
256_D259_S0.9921.00
176_S179_E0.9901.00
267_K271_N0.9721.00
295_A307_K0.9721.00
251_L274_K0.9711.00
29_Q229_H0.9711.00
176_S180_N0.9711.00
295_A308_I0.9691.00
134_K159_L0.9621.00
253_E257_L0.9601.00
36_G69_F0.9571.00
175_A179_E0.9531.00
119_I187_S0.9531.00
121_V205_L0.9521.00
86_F107_I0.9501.00
46_I50_K0.9501.00
78_G84_L0.9451.00
221_V225_F0.9421.00
94_V220_L0.9311.00
12_I15_L0.9301.00
53_F239_V0.9291.00
289_K292_Q0.9271.00
107_I237_L0.9231.00
99_A305_D0.9181.00
79_L220_L0.9151.00
14_L17_G0.9131.00
124_N181_G0.9081.00
293_E296_D0.9081.00
191_P194_S0.9071.00
72_G93_P0.9001.00
121_V185_A0.8941.00
244_V248_K0.8881.00
142_K168_Q0.8851.00
82_D222_R0.8831.00
35_I64_V0.8821.00
296_D299_F0.8791.00
120_L193_L0.8761.00
299_F306_K0.8761.00
239_V242_K0.8731.00
153_A157_V0.8731.00
179_E199_K0.8661.00
98_Q313_V0.8651.00
10_A13_F0.8651.00
235_R238_K0.8621.00
19_G22_G0.8591.00
287_I290_A0.8551.00
224_K227_E0.8541.00
16_A19_G0.8471.00
46_I243_A0.8441.00
46_I247_Q0.8431.00
47_A52_W0.8411.00
226_S230_P0.8391.00
103_D224_K0.8351.00
31_K34_R0.8321.00
9_V12_I0.8321.00
54_E63_K0.8321.00
61_G235_R0.8281.00
138_I164_V0.8271.00
7_V13_F0.8261.00
190_E193_L0.8251.00
71_S74_P0.8241.00
223_T226_S0.8221.00
240_F244_V0.8221.00
119_I185_A0.8221.00
225_F228_E0.8161.00
52_W243_A0.8151.00
295_A299_F0.8131.00
16_A20_A0.8091.00
178_F183_V0.8071.00
86_F232_E0.8071.00
285_D289_K0.8051.00
204_I207_N0.8051.00
151_Y161_A0.8001.00
246_W254_A0.7991.00
225_F230_P0.7981.00
122_N126_G0.7981.00
105_K227_E0.7971.00
201_G204_I0.7961.00
219_T236_F0.7951.00
246_W249_E0.7951.00
90_G93_P0.7941.00
127_I132_G0.7911.00
227_E230_P0.7911.00
31_K232_E0.7901.00
31_K35_I0.7871.00
173_E176_S0.7841.00
152_K293_E0.7731.00
236_F240_F0.7731.00
282_I285_D0.7721.00
62_I232_E0.7681.00
76_F97_G0.7661.00
255_A273_L0.7651.00
118_G204_I0.7621.00
292_Q310_V0.7611.00
177_A182_S0.7611.00
213_L216_P0.7601.00
238_K242_K0.7581.00
233_V237_L0.7571.00
150_L154_L0.7571.00
285_D288_V0.7561.00
286_D289_K0.7551.00
89_V94_V0.7541.00
8_L14_L0.7531.00
51_G55_D0.7501.00
85_D222_R0.7491.00
269_V272_V0.7491.00
33_I225_F0.7461.00
143_G147_F0.7441.00
11_V15_L0.7431.00
154_L157_V0.7401.00
295_A310_V0.7401.00
91_N291_Q0.7391.00
46_I254_A0.7391.00
150_L187_S0.7381.00
147_F166_I0.7341.00
39_Q68_E0.7321.00
142_K147_F0.7321.00
155_D301_T0.7311.00
42_S258_Y0.7301.00
103_D222_R0.7201.00
310_V314_V0.7201.00
126_G203_K0.7201.00
194_S198_M0.7191.00
198_M268_V0.7191.00
192_Y196_E0.7171.00
257_L260_D0.7171.00
243_A247_Q0.7161.00
275_N278_P0.7141.00
85_D225_F0.7121.00
41_L45_L0.7101.00
94_V106_E0.7081.00
239_V243_A0.7061.00
264_L269_V0.7051.00
179_E201_G0.7051.00
248_K251_L0.7051.00
272_V276_T0.7031.00
292_Q295_A0.7031.00
123_Q201_G0.7021.00
17_G21_N0.7021.00
139_A174_A0.7021.00
197_T271_N0.7011.00
13_F16_A0.6981.00
271_N275_N0.6961.00
178_F186_W0.6951.00
212_D215_S0.6931.00
91_N218_F0.6901.00
95_I295_A0.6851.00
17_G20_A0.6841.00
45_L49_E0.6821.00
288_V314_V0.6791.00
35_I236_F0.6721.00
62_I239_V0.6711.00
119_I133_L0.6691.00
274_K278_P0.6641.00
259_S269_V0.6631.00
10_A14_L0.6631.00
29_Q232_E0.6621.00
148_D297_F0.6611.00
138_I150_L0.6611.00
109_L112_D0.6611.00
178_F202_A0.6611.00
193_L197_T0.6591.00
30_L229_H0.6591.00
252_D255_A0.6591.00
198_M267_K0.6571.00
79_L84_L0.6571.00
206_V210_S0.6561.00
151_Y166_I0.6551.00
121_V126_G0.6501.00
7_V10_A0.6491.00
290_A293_E0.6461.00
153_A211_T0.6461.00
100_A305_D0.6461.00
195_L198_M0.6451.00
86_F225_F0.6421.00
6_I18_C0.6421.00
274_K277_E0.6381.00
110_S219_T0.6371.00
219_T240_F0.6351.00
54_E60_E0.6321.00
77_E81_A0.6261.00
106_E291_Q0.6261.00
197_T204_I0.6261.00
97_G104_F0.6241.00
188_I192_Y0.6241.00
299_F304_I0.6241.00
134_K160_S0.6231.00
275_N279_L0.6211.00
252_D274_K0.6211.00
286_D291_Q0.6201.00
200_H204_I0.6181.00
241_N244_V0.6131.00
47_A50_K0.6131.00
30_L65_K0.6131.00
177_A180_N0.6121.00
45_L48_K0.6111.00
12_I16_A0.6101.00
251_L254_A0.6071.00
139_A169_L0.6071.00
114_L214_Y0.6051.00
98_Q312_D0.6041.00
229_H233_V0.6031.00
252_D266_K0.6021.00
43_P47_A0.6011.00
246_W257_L0.6011.00
221_V236_F0.6011.00
281_E285_D0.6001.00
76_F89_V0.5971.00
6_I13_F0.5961.00
91_N294_T0.5931.00
268_V272_V0.5901.00
284_S287_I0.5901.00
137_K182_S0.5891.00
126_G136_K0.5881.00
62_I236_F0.5881.00
139_A186_W0.5881.00
134_K154_L0.5871.00
79_L222_R0.5871.00
200_H203_K0.5871.00
107_I226_S0.5851.00
136_K185_A0.5851.00
115_K209_E0.5841.00
137_K183_V0.5841.00
55_D61_G0.5801.00
152_K297_F0.5791.00
208_G211_T0.5791.00
120_L204_I0.5761.00
96_A100_A0.5751.00
293_E297_F0.5721.00
146_G189_W0.5711.00
63_K66_W0.5711.00
151_Y155_D0.5701.00
237_L241_N0.5691.00
161_A166_I0.5681.00
118_G121_V0.5671.00
135_G163_D0.5671.00
87_S220_L0.5661.00
299_F302_K0.5651.00
194_S197_T0.5641.00
268_V271_N0.5641.00
106_E286_D0.5641.00
74_P78_G0.5621.00
230_P233_V0.5621.00
96_A99_A0.5611.00
6_I10_A0.5611.00
89_V93_P0.5591.00
85_D229_H0.5581.00
43_P243_A0.5581.00
44_L240_F0.5571.00
120_L188_I0.5571.00
76_F220_L0.5571.00
48_K66_W0.5550.99
181_G184_D0.5540.99
78_G81_A0.5540.99
53_F62_I0.5540.99
212_D216_P0.5530.99
31_K62_I0.5520.99
242_K245_V0.5500.99
131_K159_L0.5480.99
269_V273_L0.5470.99
295_A304_I0.5460.99
108_G219_T0.5460.99
111_Q217_G0.5450.99
205_L208_G0.5440.99
67_V78_G0.5440.99
151_Y301_T0.5410.99
117_N121_V0.5400.99
258_Y269_V0.5360.99
47_A239_V0.5350.99
175_A178_F0.5340.99
308_I313_V0.5340.99
230_P315_D0.5320.99
35_I86_F0.5310.99
9_V14_L0.5290.99
84_L87_S0.5280.99
17_G22_G0.5280.99
129_D157_V0.5260.99
302_K305_D0.5260.99
250_H254_A0.5240.99
115_K207_N0.5240.99
202_A205_L0.5240.99
9_V13_F0.5210.99
125_S128_Q0.5200.99
69_F75_Q0.5200.99
47_A240_F0.5200.99
273_L277_E0.5190.99
39_Q45_L0.5180.99
190_E275_N0.5170.99
290_A294_T0.5170.99
108_G111_Q0.5160.99
8_L16_A0.5160.99
155_D161_A0.5150.99
6_I14_L0.5140.99
174_A177_A0.5130.99
255_A259_S0.5100.99
155_D160_S0.5100.99
197_T275_N0.5090.99
94_V218_F0.5090.99
292_Q311_K0.5050.99
16_A22_G0.5040.99
197_T200_H0.5040.99
18_C28_K0.5030.99
48_K63_K0.5030.99
21_N27_H0.5010.99
99_A306_K0.5010.99
264_L268_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qslA 1 0.9277 100 0.299 Contact Map
2g29A 1 0.9066 100 0.321 Contact Map
3un6A 1 0.8584 100 0.324 Contact Map
4nmyA 1 0.8614 100 0.331 Contact Map
2x26A 1 0.8976 100 0.34 Contact Map
2de3A 1 0.8705 100 0.342 Contact Map
2i49A 1 0.9006 100 0.359 Contact Map
3ix1A 2 0.8614 100 0.363 Contact Map
3uifA 1 0.9066 100 0.394 Contact Map
2x7qA 1 0.8705 100 0.396 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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