GREMLIN Database
RSBU - Phosphoserine phosphatase RsbU
UniProt: P40399 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 335 (262)
Sequences: 6684 (4467)
Seq/√Len: 275.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
217_Q260_D4.2591.00
182_H258_Q3.4091.00
268_M332_R3.3611.00
184_S258_Q3.3471.00
286_L313_S3.3451.00
264_E267_D3.3321.00
187_L221_A3.2881.00
149_N208_Y3.0341.00
232_S239_Y2.9621.00
232_S267_D2.9011.00
219_T260_D2.8301.00
270_V330_V2.8201.00
217_Q262_H2.8101.00
147_S212_N2.6481.00
219_T258_Q2.5731.00
233_Q267_D2.4371.00
169_I204_I2.3751.00
123_D332_R2.3721.00
147_S210_N2.3171.00
286_L290_D2.2201.00
229_F240_D2.1821.00
76_V79_G2.0741.00
205_T225_H2.0651.00
126_A139_Y2.0641.00
183_P221_A2.0471.00
240_D292_Q2.0041.00
76_V80_Y1.9761.00
149_N210_N1.8601.00
150_I209_A1.8471.00
150_I331_L1.8041.00
146_E214_D1.8011.00
83_A86_E1.7911.00
209_A218_F1.7871.00
152_I273_S1.7441.00
303_A330_V1.7211.00
302_S305_E1.7101.00
87_H90_L1.7041.00
69_S72_F1.7041.00
207_F220_Y1.6301.00
129_V315_L1.6171.00
307_V330_V1.5911.00
240_D288_R1.5891.00
232_S235_D1.5571.00
294_L313_S1.5461.00
322_L326_F1.5451.00
144_D147_S1.5321.00
127_I304_Q1.4941.00
301_S305_E1.4911.00
218_F261_Q1.4831.00
72_F76_V1.4781.00
82_M86_E1.4701.00
218_F269_I1.4701.00
80_Y83_A1.4701.00
79_G83_A1.4461.00
105_A109_Q1.4431.00
140_H174_D1.4361.00
270_V295_I1.4341.00
297_E313_S1.4301.00
206_M248_L1.4291.00
216_H333_R1.4201.00
298_H309_N1.4111.00
205_T247_V1.3921.00
177_P186_V1.3911.00
220_Y241_L1.3781.00
293_K297_E1.3751.00
308_K312_D1.3531.00
241_L261_Q1.3531.00
73_L76_V1.3491.00
229_F292_Q1.3341.00
69_S73_L1.3321.00
229_F238_F1.3191.00
212_N215_K1.3121.00
92_G95_Q1.3031.00
270_V328_L1.3031.00
172_A193_V1.2951.00
298_H306_M1.2951.00
314_L326_F1.2931.00
215_K262_H1.2921.00
123_D303_A1.2791.00
151_A173_M1.2751.00
179_T189_N1.2741.00
301_S309_N1.2611.00
232_S264_E1.2591.00
177_P208_Y1.2551.00
282_E290_D1.2491.00
207_F222_S1.2411.00
191_N251_S1.2291.00
127_I308_K1.2081.00
222_S244_K1.2041.00
152_I327_T1.2031.00
94_Q98_K1.1961.00
280_R323_H1.1791.00
220_Y259_F1.1741.00
191_N195_E1.1731.00
183_P208_Y1.1721.00
132_K158_K1.1671.00
111_L167_S1.1651.00
280_R285_F1.1621.00
185_Q188_K1.1591.00
127_I311_Y1.1561.00
287_E290_D1.1541.00
80_Y84_Y1.1531.00
156_I203_F1.1371.00
209_A271_L1.1291.00
98_K133_Q1.1231.00
278_E285_F1.1171.00
294_L309_N1.1141.00
268_M330_V1.1081.00
268_M303_A1.1071.00
192_R253_D1.0961.00
86_E89_T1.0931.00
173_M190_L1.0891.00
239_Y261_Q1.0851.00
76_V83_A1.0811.00
124_I141_F1.0711.00
137_D274_D1.0671.00
238_F292_Q1.0631.00
294_L298_H1.0581.00
77_M80_Y1.0551.00
170_K174_D1.0531.00
84_Y88_Q1.0511.00
186_V208_Y1.0431.00
294_L310_I1.0411.00
73_L79_G1.0321.00
80_Y86_E1.0301.00
309_N313_S1.0301.00
207_F228_G1.0261.00
79_G87_H1.0221.00
277_T291_L1.0181.00
187_L206_M1.0181.00
146_E213_M1.0171.00
154_D278_E1.0131.00
277_T288_R1.0041.00
220_Y261_Q1.0021.00
125_G330_V1.0021.00
274_D324_D1.0011.00
232_S237_T0.9991.00
72_F79_G0.9951.00
146_E212_N0.9941.00
154_D324_D0.9901.00
89_T93_I0.9861.00
152_I329_I0.9811.00
191_N256_Y0.9791.00
129_V311_Y0.9761.00
191_N253_D0.9681.00
191_N249_G0.9611.00
308_K311_Y0.9611.00
140_H170_K0.9601.00
80_Y87_H0.9561.00
78_I81_G0.9561.00
182_H185_Q0.9541.00
83_A87_H0.9481.00
289_P293_K0.9461.00
149_N186_V0.9431.00
90_L94_Q0.9401.00
150_I329_I0.9361.00
125_G307_V0.9351.00
82_M85_Q0.9311.00
92_G96_E0.9311.00
153_A206_M0.9261.00
203_F250_I0.9191.00
274_D278_E0.9171.00
176_L186_V0.9171.00
231_Y238_F0.9151.00
238_F296_E0.9141.00
151_A208_Y0.9101.00
183_P258_Q0.9061.00
172_A175_S0.9051.00
188_K255_D0.9011.00
93_I96_E0.9001.00
305_E309_N0.8981.00
269_I331_L0.8931.00
286_L294_L0.8921.00
154_D158_K0.8881.00
150_I218_F0.8741.00
152_I207_F0.8691.00
209_A220_Y0.8611.00
99_S102_E0.8581.00
292_Q296_E0.8571.00
154_D274_D0.8561.00
108_Q166_M0.8501.00
155_V225_H0.8411.00
223_A256_Y0.8401.00
93_I97_I0.8361.00
137_D154_D0.8351.00
183_P187_L0.8341.00
304_Q308_K0.8311.00
290_D293_K0.8200.99
148_I213_M0.8160.99
79_G84_Y0.8150.99
76_V87_H0.8150.99
272_F277_T0.8090.99
153_A204_I0.8090.99
144_D213_M0.8030.99
230_Y267_D0.8030.99
276_V326_F0.8010.99
166_M171_Y0.7980.99
122_L333_R0.7970.99
176_L190_L0.7940.99
127_I307_V0.7870.99
245_G256_Y0.7860.99
75_E79_G0.7830.99
98_K102_E0.7790.99
293_K296_E0.7780.99
211_Y216_H0.7770.99
303_A332_R0.7760.99
69_S75_E0.7750.99
81_G85_Q0.7720.99
230_Y241_L0.7710.99
263_L333_R0.7710.99
191_N250_I0.7660.99
211_Y218_F0.7630.99
138_Y153_A0.7590.99
125_G303_A0.7580.99
216_H265_K0.7500.99
74_I78_I0.7490.99
123_D302_S0.7480.99
273_S327_T0.7470.99
79_G86_E0.7460.99
272_F276_V0.7430.99
81_G84_Y0.7410.99
268_M306_M0.7400.99
116_V141_F0.7400.99
237_T296_E0.7390.99
276_V314_L0.7330.99
169_I194_V0.7310.99
246_L254_Y0.7270.99
222_S225_H0.7250.99
158_K274_D0.7240.99
76_V84_Y0.7220.99
222_S228_G0.7210.99
291_L310_I0.7210.99
309_N312_D0.7210.99
86_E90_L0.7190.99
94_Q97_I0.7180.99
231_Y295_I0.7180.99
295_I306_M0.7170.99
281_T284_G0.7140.99
279_C282_E0.7140.99
184_S188_K0.7120.98
307_V328_L0.7100.98
138_Y206_M0.7060.98
153_A169_I0.7050.98
137_D325_D0.7050.98
69_S79_G0.6960.98
224_G228_G0.6940.98
138_Y166_M0.6930.98
230_Y269_I0.6920.98
125_G304_Q0.6910.98
272_F291_L0.6890.98
104_A134_M0.6870.98
151_A206_M0.6870.98
87_H91_R0.6820.98
226_E272_F0.6820.98
173_M206_M0.6810.98
70_L73_L0.6810.98
158_K204_I0.6790.98
305_E308_K0.6780.98
123_D304_Q0.6750.98
276_V328_L0.6750.98
90_L158_K0.6750.98
143_K148_I0.6710.98
244_K257_K0.6710.98
164_L167_S0.6690.98
210_N219_T0.6690.98
247_V250_I0.6680.98
74_I81_G0.6670.98
230_Y263_L0.6660.98
279_C314_L0.6640.98
245_G257_K0.6640.98
229_F295_I0.6630.98
298_H301_S0.6620.98
116_V126_A0.6620.98
170_K197_N0.6610.98
85_Q89_T0.6600.98
294_L297_E0.6590.98
212_N217_Q0.6570.97
225_H228_G0.6560.97
141_F148_I0.6540.97
158_K278_E0.6530.97
80_Y91_R0.6520.97
124_I331_L0.6510.97
191_N252_Q0.6490.97
155_V166_M0.6460.97
138_Y204_I0.6460.97
231_Y299_M0.6440.97
279_C286_L0.6420.97
226_E277_T0.6410.97
69_S76_V0.6410.97
246_L250_I0.6390.97
80_Y90_L0.6380.97
107_V164_L0.6370.97
221_A245_G0.6360.97
280_R284_G0.6350.97
184_S221_A0.6340.97
226_E288_R0.6340.97
233_Q266_G0.6310.97
175_S193_V0.6290.97
315_L319_D0.6290.97
76_V81_G0.6270.97
147_S219_T0.6270.97
89_T92_G0.6270.97
158_K162_A0.6260.97
230_Y239_Y0.6260.97
143_K213_M0.6230.97
113_G140_H0.6200.96
108_Q112_L0.6190.96
137_D324_D0.6190.96
172_A176_L0.6120.96
228_G241_L0.6120.96
73_L83_A0.6100.96
161_P202_M0.6100.96
240_D295_I0.6090.96
160_I164_L0.6090.96
152_I271_L0.6060.96
128_S327_T0.6040.96
72_F77_M0.6010.96
231_Y268_M0.5960.96
158_K324_D0.5950.96
141_F329_I0.5900.95
75_E83_A0.5880.95
142_V177_P0.5850.95
288_R292_Q0.5840.95
189_N192_R0.5820.95
122_L211_Y0.5820.95
263_L267_D0.5810.95
216_H262_H0.5810.95
73_L77_M0.5790.95
282_E318_Q0.5780.95
188_K192_R0.5780.95
251_S254_Y0.5760.95
72_F89_T0.5750.95
216_H263_L0.5720.94
72_F80_Y0.5710.94
243_A259_F0.5700.94
264_E333_R0.5700.94
119_E148_I0.5650.94
225_H272_F0.5620.94
153_A166_M0.5600.94
233_Q264_E0.5580.94
71_D74_I0.5570.94
77_M83_A0.5540.93
225_H273_S0.5530.93
270_V310_I0.5530.93
104_A108_Q0.5510.93
221_A258_Q0.5470.93
167_S171_Y0.5460.93
169_I190_L0.5440.93
108_Q134_M0.5440.93
140_H151_A0.5420.93
166_M204_I0.5420.93
232_S238_F0.5400.93
124_I150_I0.5400.93
76_V91_R0.5390.93
144_D210_N0.5370.92
131_A322_L0.5370.92
72_F75_E0.5360.92
79_G82_M0.5360.92
117_P141_F0.5350.92
69_S77_M0.5320.92
315_L322_L0.5310.92
270_V307_V0.5310.92
173_M186_V0.5280.92
152_I166_M0.5270.92
93_I98_K0.5260.92
192_R254_Y0.5240.91
241_L269_I0.5230.91
277_T285_F0.5220.91
225_H278_E0.5210.91
211_Y263_L0.5200.91
236_N296_E0.5200.91
138_Y170_K0.5200.91
76_V86_E0.5190.91
111_L170_K0.5160.91
104_A164_L0.5140.91
158_K323_H0.5140.91
75_E80_Y0.5130.91
97_I101_I0.5120.91
91_R95_Q0.5120.91
95_Q98_K0.5120.91
84_Y87_H0.5120.91
101_I105_A0.5120.91
156_I198_V0.5090.90
159_G202_M0.5080.90
72_F83_A0.5080.90
154_D205_T0.5080.90
209_A331_L0.5050.90
244_K247_V0.5050.90
238_F295_I0.5050.90
276_V310_I0.5020.90
176_L179_T0.5020.90
111_L164_L0.5020.90
289_P292_Q0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3eq2A 2 0.9313 100 0.375 Contact Map
3ke6A 2 0.6657 100 0.382 Contact Map
3f79A 2 0.7015 100 0.393 Contact Map
3pu9A 2 0.6478 100 0.493 Contact Map
3t91A 3 0.6358 100 0.509 Contact Map
3zt9A 1 0.5672 100 0.549 Contact Map
3w42A 1 0.5881 100 0.567 Contact Map
2j82A 1 0.5761 100 0.633 Contact Map
2jfrA 1 0.5821 100 0.637 Contact Map
3rnrA 2 0.5403 100 0.646 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0097 seconds.