GREMLIN Database
YHXD - Uncharacterized oxidoreductase YhxD
UniProt: P40398 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 299 (242)
Sequences: 89289 (59493)
Seq/√Len: 3824.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
156_Y164_F3.4081.00
182_S225_R2.8891.00
206_N210_G2.8011.00
156_Y160_E2.7641.00
113_D116_F2.6871.00
54_A133_V2.5331.00
185_T212_T2.5171.00
125_H176_Y2.4951.00
230_A289_V2.4531.00
178_P222_K2.4101.00
118_Q172_A2.3351.00
170_V215_L2.3051.00
133_V278_A2.2631.00
136_L185_T2.2351.00
65_R69_I2.2171.00
187_T209_I2.1541.00
235_W266_Q2.1461.00
81_N109_G2.1181.00
114_E152_T2.1061.00
77_D103_K2.0991.00
121_V173_A2.0791.00
90_A106_L2.0531.00
288_Q291_G2.0331.00
160_E164_F1.9811.00
85_E91_E1.9721.00
70_A272_D1.9711.00
272_D281_N1.9631.00
174_L219_L1.9451.00
65_R93_V1.9281.00
69_I96_L1.9101.00
60_D82_Y1.8881.00
65_R96_L1.8701.00
273_V290_Y1.8331.00
81_N120_L1.7871.00
67_A274_Y1.7701.00
70_A74_E1.7651.00
53_K77_D1.7521.00
105_V127_E1.7481.00
70_A275_V1.7451.00
265_G284_Y1.7441.00
212_T228_S1.7401.00
71_Y278_A1.6881.00
59_G80_I1.6721.00
109_G116_F1.6491.00
79_A124_S1.6451.00
162_N204_T1.6421.00
123_Q127_E1.6201.00
85_E108_P1.5561.00
79_A128_L1.5431.00
74_E275_V1.5431.00
63_I234_I1.5381.00
152_T168_W1.5231.00
48_K281_N1.4831.00
94_K98_E1.4821.00
134_L169_V1.4801.00
151_P154_Q1.4741.00
122_K126_H1.4631.00
166_L208_I1.4621.00
53_K130_G1.4251.00
70_A73_R1.4221.00
94_K106_L1.4171.00
119_D123_Q1.4151.00
159_F163_V1.4141.00
84_P89_D1.4121.00
77_D102_R1.4071.00
135_A186_T1.4031.00
107_I123_Q1.4011.00
61_S89_D1.3931.00
142_Q157_K1.3701.00
192_Y291_G1.3671.00
68_A80_I1.3491.00
123_Q126_H1.3481.00
109_G120_L1.3481.00
48_K74_E1.3461.00
164_F168_W1.3431.00
95_E99_A1.3221.00
235_W240_I1.3161.00
76_A133_V1.3131.00
118_Q122_K1.3131.00
54_A71_Y1.3101.00
117_C169_V1.2921.00
145_E154_Q1.2891.00
114_E168_W1.2831.00
163_V207_A1.2801.00
273_V292_I1.2771.00
229_V274_Y1.2691.00
91_E95_E1.2671.00
69_I100_E1.2351.00
134_L173_A1.2241.00
105_V128_L1.2241.00
215_L226_V1.2181.00
114_E118_Q1.2111.00
61_S237_P1.2041.00
148_E178_P1.2011.00
187_T228_S1.1951.00
71_Y76_A1.1931.00
73_R100_E1.1921.00
53_K79_A1.1911.00
116_F119_D1.1901.00
95_E98_E1.1671.00
79_A105_V1.1671.00
152_T164_F1.1651.00
82_Y90_A1.1511.00
51_G76_A1.1511.00
49_L76_A1.1481.00
136_L170_V1.1471.00
170_V183_I1.1441.00
155_I164_F1.1421.00
107_I120_L1.1371.00
209_I289_V1.1291.00
140_K161_V1.1291.00
131_L173_A1.1161.00
55_L120_L1.1021.00
182_S227_N1.0991.00
228_S289_V1.0901.00
54_A76_A1.0771.00
137_V186_T1.0721.00
70_A271_A1.0661.00
234_I265_G1.0581.00
69_I73_R1.0531.00
159_F164_F1.0491.00
146_N149_D1.0451.00
92_E96_L1.0401.00
212_T226_V1.0371.00
112_S157_K1.0311.00
52_R280_E1.0281.00
79_A107_I1.0211.00
142_Q154_Q1.0121.00
66_A268_V1.0111.00
150_L200_D1.0051.00
67_A135_A1.0031.00
80_I104_A0.9991.00
66_A69_I0.9981.00
91_E94_K0.9961.00
114_E171_K0.9931.00
186_T274_Y0.9931.00
53_K128_L0.9841.00
263_R269_E0.9821.00
276_F285_V0.9791.00
98_E103_K0.9771.00
276_F282_S0.9741.00
111_L165_S0.9661.00
77_D105_V0.9531.00
253_G257_P0.9371.00
107_I127_E0.9371.00
153_E157_K0.9291.00
52_R132_D0.9281.00
182_S283_S0.9251.00
86_E91_E0.9221.00
115_S119_D0.9221.00
140_K157_K0.9221.00
112_S160_E0.9191.00
70_A268_V0.9151.00
97_I104_A0.9111.00
170_V211_F0.9061.00
92_E95_E0.9011.00
176_Y179_E0.9001.00
63_I67_A0.8971.00
85_E106_L0.8971.00
166_L185_T0.8961.00
135_A274_Y0.8921.00
119_D122_K0.8921.00
89_D92_E0.8911.00
167_Y211_F0.8861.00
72_A102_R0.8811.00
124_S128_L0.8631.00
202_A210_G0.8611.00
94_K104_A0.8561.00
72_A97_I0.8491.00
285_V290_Y0.8451.00
201_Y205_K0.8381.00
268_V272_D0.8371.00
191_G209_I0.8341.00
93_V96_L0.8261.00
108_P116_F0.8221.00
162_N205_K0.8201.00
237_P240_I0.8191.00
67_A271_A0.8151.00
105_V123_Q0.8121.00
66_A267_P0.8091.00
61_S84_P0.8071.00
115_S118_Q0.8071.00
152_T171_K0.8061.00
96_L100_E0.8021.00
209_I228_S0.8001.00
147_I219_L0.7981.00
97_I102_R0.7971.00
254_Q257_P0.7951.00
72_A104_A0.7931.00
192_Y230_A0.7931.00
170_V185_T0.7891.00
71_Y275_V0.7891.00
66_A271_A0.7881.00
109_G117_C0.7821.00
172_A175_P0.7811.00
159_F204_T0.7801.00
59_G81_N0.7791.00
199_L218_Q0.7761.00
152_T156_Y0.7761.00
188_S201_Y0.7731.00
61_S65_R0.7731.00
65_R92_E0.7691.00
77_D128_L0.7631.00
194_P210_G0.7571.00
148_E219_L0.7531.00
55_L131_L0.7531.00
55_L81_N0.7521.00
184_I278_A0.7521.00
159_F203_A0.7501.00
114_E172_A0.7491.00
155_I167_Y0.7471.00
131_L176_Y0.7451.00
154_Q157_K0.7421.00
183_I226_V0.7401.00
261_L286_T0.7381.00
273_V276_F0.7331.00
125_H179_E0.7281.00
136_L169_V0.7231.00
57_T169_V0.7161.00
177_L180_G0.7161.00
259_A284_Y0.7141.00
147_I215_L0.7121.00
69_I97_I0.7121.00
202_A206_N0.7041.00
166_L170_V0.7021.00
253_G256_T0.6991.00
180_G225_R0.6981.00
184_I274_Y0.6961.00
158_T204_T0.6961.00
244_Q248_N0.6921.00
125_H130_G0.6901.00
134_L183_I0.6881.00
74_E281_N0.6811.00
192_Y209_I0.6771.00
286_T295_G0.6771.00
130_G176_Y0.6731.00
199_L211_F0.6731.00
122_K176_Y0.6671.00
90_A108_P0.6671.00
121_V172_A0.6641.00
197_M218_Q0.6641.00
244_Q247_E0.6611.00
117_C168_W0.6591.00
60_D90_A0.6581.00
163_V203_A0.6571.00
71_Y274_Y0.6551.00
173_A177_L0.6551.00
178_P219_L0.6541.00
71_Y133_V0.6511.00
245_P248_N0.6461.00
140_K238_L0.6461.00
82_Y85_E0.6451.00
219_L222_K0.6431.00
53_K124_S0.6401.00
121_V169_V0.6401.00
96_L99_A0.6401.00
284_Y294_G0.6391.00
66_A70_A0.6321.00
145_E149_D0.6321.00
117_C172_A0.6311.00
82_Y108_P0.6301.00
243_G247_E0.6271.00
103_K127_E0.6251.00
209_I230_A0.6241.00
271_A275_V0.6231.00
185_T226_V0.6231.00
206_N213_V0.6221.00
57_T137_V0.6211.00
177_L181_A0.6201.00
227_N277_L0.6201.00
139_G162_N0.6191.00
51_G77_D0.6191.00
114_E153_E0.6181.00
164_F167_Y0.6171.00
140_K204_T0.6141.00
243_G246_T0.6131.00
62_G236_T0.6111.00
285_V292_I0.6111.00
98_E101_G0.6061.00
190_E202_A0.6061.00
234_I270_L0.6061.00
70_A281_N0.6051.00
269_E283_S0.6021.00
83_L110_D0.6001.00
263_R283_S0.6001.00
214_G218_Q0.5971.00
280_E283_S0.5931.00
233_P239_Q0.5921.00
91_E106_L0.5921.00
74_E279_S0.5901.00
174_L178_P0.5881.00
167_Y171_K0.5861.00
56_V68_A0.5861.00
166_L169_V0.5851.00
187_T230_A0.5851.00
86_E89_D0.5831.00
82_Y106_L0.5831.00
155_I200_D0.5821.00
209_I213_V0.5821.00
157_K160_E0.5821.00
265_G294_G0.5811.00
221_S262_N0.5801.00
122_K172_A0.5781.00
81_N111_L0.5771.00
80_I93_V0.5761.00
59_G68_A0.5761.00
174_L222_K0.5741.00
72_A103_K0.5741.00
272_D283_S0.5691.00
120_L169_V0.5671.00
80_I106_L0.5651.00
69_I93_V0.5641.00
122_K125_H0.5601.00
69_I268_V0.5591.00
220_A286_T0.5561.00
168_W172_A0.5551.00
54_A278_A0.5551.00
142_Q145_E0.5541.00
256_T264_A0.5471.00
112_S161_V0.5471.00
90_A94_K0.5461.00
279_S282_S0.5451.00
82_Y89_D0.5451.00
118_Q175_P0.5451.00
124_S127_E0.5441.00
61_S82_Y0.5441.00
101_G104_A0.5431.00
206_N209_I0.5411.00
270_L292_I0.5401.00
193_N296_I0.5391.00
202_A214_G0.5361.00
199_L214_G0.5351.00
220_A261_L0.5341.00
52_R76_A0.5321.00
124_S129_G0.5311.00
121_V125_H0.5301.00
52_R180_G0.5291.00
86_E92_E0.5291.00
73_R268_V0.5271.00
81_N124_S0.5241.00
136_L166_L0.5241.00
240_I244_Q0.5231.00
64_G137_V0.5201.00
216_G287_S0.5191.00
68_A97_I0.5181.00
91_E98_E0.5171.00
93_V97_I0.5161.00
161_V165_S0.5161.00
155_I203_A0.5131.00
162_N201_Y0.5121.00
141_Q238_L0.5121.00
266_Q269_E0.5101.00
203_A211_F0.5091.00
155_I159_F0.5081.00
155_I163_V0.5071.00
210_G213_V0.5061.00
179_E222_K0.5051.00
285_V288_Q0.5051.00
55_L124_S0.5041.00
111_L138_A0.5021.00
118_Q171_K0.5021.00
273_V285_V0.5021.00
216_G286_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vl8A 4 0.8294 100 0.225 Contact Map
3wtcA 4 0.8361 100 0.237 Contact Map
2ae2A 4 0.8462 100 0.24 Contact Map
3r3sA 4 0.9766 100 0.24 Contact Map
4is2A 3 0.7057 100 0.24 Contact Map
1iy8A 4 0.8361 100 0.24 Contact Map
4nbvA 4 0.8161 100 0.241 Contact Map
1zemA 4 0.8261 100 0.242 Contact Map
4bmnA 4 0.806 100 0.242 Contact Map
4nimA 4 0.7525 100 0.242 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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