GREMLIN Database
IOLX - scyllo-inositol 2-dehydrogenase (NAD(+))
UniProt: P40332 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 342 (311)
Sequences: 25722 (19227)
Seq/√Len: 1090.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_Y86_K3.0901.00
81_G109_A2.8091.00
128_R182_D2.7961.00
85_I113_K2.7691.00
6_R31_K2.7001.00
194_S221_E2.6741.00
147_K249_T2.6621.00
40_K44_E2.6331.00
135_D138_R2.6291.00
89_E113_K2.5971.00
108_K312_T2.5801.00
193_T223_D2.4191.00
85_I89_E2.3961.00
75_T83_M2.3931.00
8_A62_V2.3541.00
81_G106_E2.3541.00
85_I109_A2.3471.00
137_K141_D2.3341.00
93_Q120_I2.2941.00
218_T321_A2.1971.00
88_A119_V2.1941.00
34_C56_S2.1691.00
58_D61_E2.1341.00
138_R142_A2.1261.00
79_T83_M2.0891.00
323_N327_N2.0751.00
296_E300_N2.0371.00
112_E116_E2.0301.00
81_G85_I1.9751.00
84_I96_V1.9441.00
135_D139_R1.9391.00
115_K309_I1.9311.00
29_G299_R1.9161.00
17_Y49_E1.9111.00
70_A294_F1.8771.00
88_A114_V1.8491.00
113_K117_T1.8421.00
108_K112_E1.8391.00
108_K316_E1.8231.00
82_D86_K1.8231.00
44_E48_R1.8221.00
75_T79_T1.8111.00
54_K65_D1.7751.00
93_Q119_V1.7661.00
89_E117_T1.7541.00
8_A68_I1.7401.00
145_I248_G1.7101.00
104_L319_I1.6951.00
39_L42_R1.6931.00
222_F228_G1.6841.00
71_V87_A1.6771.00
7_C70_A1.6751.00
30_A295_A1.6741.00
84_I110_A1.6541.00
103_S106_E1.6421.00
63_L87_A1.6031.00
68_I92_K1.5901.00
57_E61_E1.5781.00
121_C308_D1.5751.00
191_E313_I1.5731.00
23_L72_I1.5611.00
64_E90_N1.5571.00
124_G290_E1.5281.00
89_E116_E1.5151.00
136_A253_I1.5131.00
193_T221_E1.5101.00
137_K186_Y1.5091.00
199_G325_F1.5091.00
313_I316_E1.4981.00
120_I301_G1.4871.00
139_R144_E1.4841.00
59_P86_K1.4811.00
45_Q49_E1.4621.00
111_S308_D1.4551.00
111_S312_T1.4431.00
27_V292_Q1.4331.00
191_E223_D1.4321.00
113_K116_E1.4321.00
102_L106_E1.4291.00
61_E64_E1.4261.00
81_G110_A1.4201.00
56_S65_D1.4151.00
185_R191_E1.4091.00
149_I249_T1.3961.00
60_Y64_E1.3861.00
40_K57_E1.3811.00
88_A117_T1.3731.00
86_K89_E1.3611.00
152_K245_E1.3591.00
188_L226_A1.3461.00
185_R313_I1.3461.00
6_R33_V1.3451.00
56_S62_V1.3371.00
101_T107_S1.3331.00
101_T110_A1.3311.00
43_A55_W1.3211.00
245_E254_F1.3081.00
61_E65_D1.2961.00
296_E302_K1.2911.00
6_R69_D1.2741.00
107_S312_T1.2721.00
293_H297_C1.2671.00
104_L316_E1.2631.00
86_K90_N1.2611.00
104_L108_K1.2601.00
198_H221_E1.2531.00
12_L35_V1.2441.00
36_G59_P1.2351.00
145_I251_G1.2341.00
45_Q48_R1.2001.00
73_I83_M1.1961.00
185_R222_F1.1961.00
181_Y317_V1.1951.00
192_I222_F1.1921.00
148_P246_V1.1891.00
293_H305_I1.1821.00
73_I84_I1.1801.00
41_G44_E1.1801.00
87_A94_I1.1761.00
91_G117_T1.1741.00
109_A112_E1.1731.00
152_K231_E1.1671.00
36_G62_V1.1641.00
111_S309_I1.1531.00
47_A55_W1.1531.00
243_R254_F1.1471.00
62_V68_I1.1411.00
59_P83_M1.1411.00
100_L107_S1.1301.00
29_G292_Q1.1261.00
88_A113_K1.1261.00
66_P92_K1.1261.00
307_T310_D1.1251.00
5_V299_R1.1071.00
7_C30_A1.1041.00
292_Q296_E1.1021.00
76_P79_T1.0981.00
319_I323_N1.0961.00
95_F124_G1.0901.00
34_C62_V1.0891.00
156_R159_G1.0891.00
95_F290_E1.0811.00
5_V70_A1.0761.00
59_P63_L1.0741.00
323_N326_R1.0711.00
295_A299_R1.0711.00
196_S219_Y1.0671.00
109_A113_K1.0661.00
112_E115_K1.0631.00
93_Q301_G1.0571.00
185_R310_D1.0551.00
320_A323_N1.0521.00
139_R142_A1.0481.00
184_A228_G1.0471.00
111_S115_K1.0441.00
67_G92_K1.0431.00
107_S315_L1.0431.00
63_L86_K1.0421.00
133_Y186_Y1.0371.00
151_Y188_L1.0281.00
5_V298_V1.0221.00
34_C68_I1.0191.00
85_I110_A1.0181.00
293_H302_K1.0071.00
138_R141_D1.0061.00
145_I253_I1.0001.00
10_L83_M0.9961.00
106_E109_A0.9921.00
151_Y228_G0.9891.00
96_V121_C0.9871.00
154_F158_Q0.9751.00
43_A57_E0.9741.00
26_S288_C0.9721.00
63_L90_N0.9711.00
129_F293_H0.9681.00
101_T106_E0.9651.00
29_G296_E0.9611.00
105_E108_K0.9551.00
320_A324_S0.9541.00
293_H296_E0.9501.00
93_Q298_V0.9481.00
155_T159_G0.9481.00
128_R310_D0.9471.00
42_R45_Q0.9461.00
288_C292_Q0.9371.00
65_D68_I0.9371.00
148_P248_G0.9361.00
289_L292_Q0.9291.00
296_E301_G0.9221.00
136_A255_I0.9221.00
110_A121_C0.9181.00
100_L308_D0.9181.00
134_A305_I0.9151.00
19_H72_I0.9141.00
126_M286_A0.9131.00
254_F264_T0.9111.00
83_M86_K0.9101.00
145_I148_P0.9091.00
56_S61_E0.9091.00
105_E109_A0.9071.00
155_T158_Q0.9061.00
84_I94_I0.9021.00
148_P188_L0.8991.00
192_I220_I0.8931.00
43_A47_A0.8911.00
309_I313_I0.8901.00
104_L312_T0.8901.00
12_L37_D0.8891.00
35_V46_V0.8811.00
100_L121_C0.8811.00
44_E55_W0.8771.00
144_E267_S0.8761.00
322_T326_R0.8721.00
122_Q294_F0.8711.00
81_G101_T0.8701.00
21_K49_E0.8681.00
198_H227_A0.8651.00
114_V117_T0.8551.00
72_I291_L0.8491.00
217_L229_D0.8481.00
41_G45_Q0.8481.00
19_H22_N0.8441.00
40_K43_A0.8421.00
44_E47_A0.8381.00
96_V100_L0.8381.00
37_D43_A0.8361.00
79_T82_D0.8351.00
88_A94_I0.8311.00
73_I87_A0.8261.00
108_K111_S0.8231.00
181_Y318_G0.8231.00
316_E320_A0.8211.00
267_S270_G0.8201.00
33_V67_G0.8161.00
146_G251_G0.8131.00
40_K55_W0.8121.00
102_L169_S0.8081.00
146_G248_G0.8071.00
120_I298_V0.8071.00
8_A34_C0.8051.00
152_K229_D0.8051.00
8_A36_G0.8041.00
77_T175_D0.8031.00
151_Y246_V0.8031.00
114_V121_C0.8011.00
84_I88_A0.7991.00
192_I317_V0.7991.00
167_K211_G0.7981.00
297_C300_N0.7961.00
170_G174_I0.7951.00
140_I248_G0.7911.00
96_V110_A0.7901.00
31_K53_E0.7901.00
245_E252_S0.7851.00
297_C302_K0.7841.00
153_G244_A0.7831.00
37_D42_R0.7801.00
114_V119_V0.7791.00
197_G321_A0.7781.00
7_C23_L0.7761.00
134_A138_R0.7761.00
172_I232_A0.7731.00
196_S324_S0.7731.00
297_C304_P0.7731.00
120_I297_C0.7731.00
65_D92_K0.7721.00
185_R314_N0.7721.00
27_V30_A0.7711.00
21_K26_S0.7681.00
17_Y45_Q0.7641.00
107_S111_S0.7601.00
6_R68_I0.7591.00
122_Q297_C0.7531.00
151_Y184_A0.7531.00
10_L75_T0.7511.00
15_L74_V0.7501.00
54_K67_G0.7491.00
303_T307_T0.7481.00
243_R256_G0.7481.00
47_A52_I0.7461.00
10_L59_P0.7461.00
16_G74_V0.7451.00
220_I228_G0.7441.00
70_A93_Q0.7421.00
147_K224_S0.7391.00
192_I223_D0.7361.00
19_H291_L0.7361.00
29_G295_A0.7361.00
114_V308_D0.7361.00
46_V49_E0.7321.00
23_L291_L0.7301.00
171_G213_V0.7281.00
88_A121_C0.7281.00
312_T316_E0.7271.00
250_E268_A0.7231.00
153_G180_D0.7221.00
123_V311_A0.7181.00
141_D189_G0.7171.00
33_V68_I0.7171.00
294_F298_V0.7141.00
184_A222_F0.7141.00
198_H219_Y0.7081.00
9_V20_A0.7031.00
33_V65_D0.7031.00
125_F178_I0.7031.00
100_L123_V0.7021.00
19_H23_L0.7021.00
173_F318_G0.6971.00
219_Y227_A0.6961.00
62_V65_D0.6951.00
127_R130_D0.6941.00
8_A71_V0.6941.00
80_H96_V0.6851.00
178_I314_N0.6821.00
15_L287_Y0.6811.00
175_D234_R0.6801.00
154_F157_D0.6781.00
293_H304_P0.6781.00
81_G113_K0.6781.00
12_L43_A0.6761.00
133_Y183_I0.6751.00
213_V322_T0.6751.00
188_L222_F0.6741.00
267_S271_S0.6731.00
308_D311_A0.6721.00
134_A289_L0.6711.00
88_A110_A0.6701.00
10_L36_G0.6691.00
147_K250_E0.6691.00
267_S272_S0.6681.00
177_S180_D0.6671.00
194_S198_H0.6671.00
150_Y227_A0.6641.00
16_G21_K0.6611.00
23_L30_A0.6591.00
200_R221_E0.6571.00
214_D235_T0.6551.00
315_L319_I0.6551.00
247_I252_S0.6521.00
287_Y290_E0.6511.00
6_R67_G0.6511.00
218_T230_V0.6501.00
82_D109_A0.6491.00
91_G119_V0.6491.00
177_S232_A0.6461.00
85_I88_A0.6461.00
7_C295_A0.6441.00
96_V123_V0.6431.00
128_R186_Y0.6431.00
15_L19_H0.6421.00
137_K187_L0.6391.00
154_F159_G0.6381.00
33_V54_K0.6381.00
221_E227_A0.6371.00
310_D313_I0.6361.00
158_Q161_P0.6351.00
222_F226_A0.6351.00
92_K119_V0.6331.00
95_F122_Q0.6311.00
20_A32_L0.6291.00
233_S236_S0.6251.00
125_F182_D0.6241.00
7_C72_I0.6231.00
182_D314_N0.6221.00
70_A298_V0.6211.00
98_K179_H0.6211.00
173_F216_A0.6211.00
202_L214_D0.6211.00
39_L44_E0.6201.00
46_V50_L0.6191.00
191_E316_E0.6181.00
125_F314_N0.6171.00
182_D186_Y0.6161.00
203_N214_D0.6141.00
187_L246_V0.6101.00
120_I303_T0.6101.00
185_R317_V0.6091.00
197_G218_T0.6091.00
179_H182_D0.6081.00
17_Y42_R0.6051.00
126_M287_Y0.6051.00
84_I121_C0.6041.00
27_V295_A0.6031.00
140_I246_V0.6021.00
56_S66_P0.6021.00
71_V92_K0.6011.00
14_R18_Y0.6001.00
17_Y50_L0.6001.00
157_D160_A0.5921.00
122_Q293_H0.5911.00
17_Y21_K0.5911.00
215_Q233_S0.5901.00
60_Y82_D0.5901.00
153_G184_A0.5871.00
181_Y321_A0.5831.00
263_V266_L0.5801.00
59_P87_A0.5731.00
199_G216_A0.5731.00
219_Y229_D0.5731.00
314_N318_G0.5721.00
148_P226_A0.5671.00
72_I95_F0.5661.00
82_D85_I0.5651.00
150_Y247_I0.5611.00
220_I230_V0.5581.00
69_D299_R0.5571.00
197_G216_A0.5571.00
196_S221_E0.5571.00
184_A230_V0.5561.00
73_I80_H0.5551.00
127_R182_D0.5551.00
140_I187_L0.5541.00
16_G46_V0.5541.00
35_V55_W0.5501.00
134_A186_Y0.5481.00
136_A187_L0.5471.00
38_P75_T0.5471.00
13_G74_V0.5471.00
30_A70_A0.5471.00
159_G162_P0.5461.00
17_Y46_V0.5461.00
15_L97_E0.5431.00
144_E147_K0.5421.00
160_A164_E0.5401.00
267_S273_F0.5401.00
5_V30_A0.5361.00
122_Q290_E0.5351.00
84_I114_V0.5351.00
173_F218_T0.5331.00
318_G322_T0.5311.00
103_S319_I0.5311.00
296_E299_R0.5301.00
78_S102_L0.5291.00
111_S114_V0.5281.00
266_L271_S0.5271.00
156_R161_P0.5271.00
174_I319_I0.5251.00
12_L46_V0.5241.00
21_K25_T0.5231.00
20_A46_V0.5221.00
155_T160_A0.5221.00
270_G273_F0.5211.00
89_E109_A0.5191.00
36_G56_S0.5181.00
156_R160_A0.5181.00
120_I294_F0.5161.00
10_L73_I0.5141.00
143_G147_K0.5101.00
75_T80_H0.5101.00
36_G57_E0.5091.00
159_G163_A0.5091.00
97_E124_G0.5081.00
172_I213_V0.5071.00
9_V72_I0.5071.00
74_V97_E0.5061.00
151_Y244_A0.5051.00
19_H97_E0.5051.00
131_P289_L0.5041.00
13_G16_G0.5041.00
48_R55_W0.5031.00
9_V32_L0.5031.00
169_S212_D0.5031.00
129_F306_V0.5021.00
35_V43_A0.5011.00
285_E288_C0.5001.00
200_R215_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3euwA 4 0.9678 100 0.202 Contact Map
4mkxA 4 0.9737 100 0.205 Contact Map
1h6dA 8 0.9883 100 0.209 Contact Map
3ceaA 4 0.9795 100 0.21 Contact Map
3ezyA 4 0.9737 100 0.214 Contact Map
3dtyA 4 0.962 100 0.224 Contact Map
2nvwA 3 0.9444 100 0.224 Contact Map
3v5nA 4 0.9181 100 0.225 Contact Map
3db2A 2 0.9591 100 0.23 Contact Map
1zh8A 2 0.9181 100 0.231 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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