GREMLIN Database
YISR - Uncharacterized HTH-type transcriptional regulator YisR
UniProt: P40331 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 287 (236)
Sequences: 32506 (27587)
Seq/√Len: 1795.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
223_V231_R3.3141.00
238_K271_E3.2981.00
190_Q232_V3.0501.00
246_D254_T3.0251.00
234_M271_E3.0151.00
200_K210_Q2.8401.00
236_E239_R2.8371.00
188_Y192_H2.6981.00
192_H195_E2.6731.00
231_R270_I2.6071.00
267_F278_Y2.4441.00
240_L254_T2.3151.00
237_A263_F2.3131.00
185_A213_V2.2811.00
217_M228_Y2.0761.00
198_T201_D2.0681.00
240_L255_V2.0181.00
47_Y54_S1.9641.00
246_D250_V1.9571.00
193_Y232_V1.9251.00
273_I281_I1.9221.00
226_A230_N1.8361.00
47_Y56_S1.8271.00
189_L229_T1.8081.00
185_A206_L1.8001.00
186_A221_L1.7951.00
240_L246_D1.7831.00
188_Y205_A1.7731.00
247_K250_V1.7261.00
182_A221_L1.7101.00
260_P264_S1.7031.00
234_M270_I1.7021.00
49_T54_S1.7011.00
266_L269_Q1.6921.00
202_L225_P1.6571.00
199_I214_S1.6381.00
159_L162_E1.6341.00
238_K278_Y1.6301.00
239_R243_S1.6271.00
232_V236_E1.6231.00
223_V227_Q1.6181.00
187_R191_E1.6171.00
212_Y216_C1.6161.00
241_L248_M1.6051.00
45_T56_S1.6031.00
43_Q82_S1.5981.00
236_E240_L1.5901.00
58_E61_E1.5761.00
188_Y197_T1.5651.00
42_K84_Y1.5231.00
213_V225_P1.5081.00
249_G260_P1.4981.00
190_Q228_Y1.4771.00
210_Q214_S1.4711.00
273_I277_E1.4641.00
49_T72_Y1.4641.00
179_E220_V1.4561.00
225_P229_T1.4541.00
212_Y215_R1.4491.00
262_Y266_L1.4401.00
250_V253_E1.4221.00
193_Y236_E1.4181.00
249_G253_E1.4061.00
208_Y212_Y1.4031.00
237_A255_V1.3971.00
47_Y74_T1.3941.00
276_I280_K1.3921.00
186_A190_Q1.3901.00
36_F67_P1.3861.00
257_M266_L1.3781.00
250_V254_T1.3781.00
201_D205_A1.3731.00
45_T58_E1.3721.00
136_A140_E1.3601.00
194_K254_T1.3591.00
211_D215_R1.3421.00
214_S225_P1.3351.00
251_I255_V1.3181.00
236_E255_V1.3131.00
231_R235_T1.3131.00
158_I165_L1.3091.00
158_I162_E1.3021.00
162_E166_H1.2991.00
230_N266_L1.2931.00
200_K204_L1.2921.00
261_T264_S1.2921.00
51_N69_L1.2721.00
224_T227_Q1.2581.00
189_L232_V1.2371.00
195_E201_D1.2341.00
244_T279_R1.2261.00
232_V235_T1.2151.00
208_Y213_V1.2121.00
238_K242_S1.1911.00
155_R159_L1.1911.00
264_S274_S1.1891.00
158_I161_E1.1881.00
185_A202_L1.1861.00
209_H212_Y1.1751.00
181_V208_Y1.1721.00
125_R128_K1.1701.00
196_K258_E1.1551.00
264_S276_I1.1491.00
137_Q141_K1.1451.00
66_S69_L1.1311.00
42_K82_S1.1191.00
235_T238_K1.1071.00
180_R184_E1.0971.00
125_R129_V1.0931.00
246_D251_I1.0911.00
43_Q59_G1.0911.00
265_K269_Q1.0781.00
197_T202_L1.0741.00
216_C219_Q1.0721.00
199_I225_P1.0691.00
277_E280_K1.0571.00
181_V216_C1.0511.00
216_C220_V1.0441.00
274_S277_E1.0391.00
137_Q140_E1.0351.00
157_Q161_E1.0351.00
31_R71_H1.0291.00
230_N269_Q1.0281.00
37_D71_H1.0171.00
203_S210_Q1.0161.00
155_R162_E1.0101.00
194_K236_E1.0101.00
33_F71_H0.9921.00
161_E165_L0.9901.00
188_Y206_L0.9891.00
276_I279_R0.9831.00
259_D265_K0.9781.00
201_D204_L0.9751.00
186_A228_Y0.9731.00
240_L251_I0.9711.00
206_L213_V0.9561.00
189_L225_P0.9481.00
30_K70_E0.9441.00
181_V206_L0.9421.00
183_W187_R0.9391.00
199_I210_Q0.9381.00
248_M251_I0.9351.00
266_L270_I0.9301.00
264_S268_K0.9301.00
140_E144_D0.9261.00
120_G124_P0.9191.00
129_V132_P0.9181.00
184_E205_A0.9151.00
165_L169_K0.9111.00
202_L205_A0.9041.00
227_Q230_N0.8991.00
227_Q231_R0.8971.00
143_I147_A0.8971.00
233_R255_V0.8921.00
46_L81_T0.8851.00
241_L251_I0.8841.00
211_D214_S0.8831.00
230_N270_I0.8831.00
238_K267_F0.8791.00
226_A262_Y0.8781.00
184_E187_R0.8761.00
188_Y202_L0.8761.00
162_E165_L0.8731.00
217_M225_P0.8721.00
49_T52_E0.8701.00
271_E278_Y0.8681.00
234_M266_L0.8651.00
262_Y265_K0.8611.00
50_E53_T0.8511.00
268_K274_S0.8461.00
41_V46_L0.8451.00
277_E281_I0.8421.00
196_K201_D0.8411.00
244_T251_I0.8321.00
241_L279_R0.8301.00
193_Y229_T0.8251.00
46_L57_V0.8201.00
184_E206_L0.8181.00
208_Y216_C0.8181.00
49_T74_T0.8071.00
217_M221_L0.8061.00
183_W186_A0.8061.00
193_Y197_T0.8041.00
33_F37_D0.8031.00
182_A216_C0.8021.00
141_K145_Y0.8021.00
90_E94_E0.7921.00
252_A260_P0.7901.00
192_H205_A0.7811.00
45_T76_G0.7811.00
123_L126_K0.7761.00
193_Y255_V0.7701.00
47_Y76_G0.7671.00
36_F64_L0.7651.00
39_I85_W0.7651.00
30_K72_Y0.7611.00
268_K277_E0.7591.00
134_F166_H0.7561.00
237_A240_L0.7561.00
242_S278_Y0.7551.00
40_Y62_Y0.7551.00
253_E258_E0.7531.00
214_S218_Q0.7511.00
186_A217_M0.7491.00
226_A229_T0.7491.00
227_Q270_I0.7451.00
154_L157_Q0.7451.00
182_A185_A0.7431.00
48_I63_I0.7351.00
185_A188_Y0.7341.00
182_A220_V0.7301.00
192_H201_D0.7291.00
81_T85_W0.7291.00
215_R219_Q0.7251.00
134_F137_Q0.7221.00
259_D262_Y0.7191.00
273_I278_Y0.7191.00
46_L56_S0.7181.00
128_K132_P0.7171.00
228_Y232_V0.7161.00
178_K219_Q0.7111.00
185_A217_M0.7101.00
214_S224_T0.7071.00
185_A189_L0.7041.00
234_M263_F0.7041.00
37_D87_H0.7021.00
251_I279_R0.6981.00
214_S226_A0.6961.00
155_R165_L0.6901.00
182_A186_A0.6811.00
153_P157_Q0.6801.00
141_K159_L0.6801.00
189_L228_Y0.6781.00
185_A225_P0.6781.00
179_E216_C0.6761.00
155_R158_I0.6741.00
121_L125_R0.6731.00
122_A125_R0.6731.00
121_L124_P0.6721.00
261_T274_S0.6691.00
235_T270_I0.6681.00
181_V184_E0.6671.00
197_T201_D0.6671.00
134_F138_Q0.6661.00
138_Q141_K0.6641.00
258_E262_Y0.6641.00
141_K162_E0.6631.00
133_Q136_A0.6631.00
166_H170_E0.6621.00
202_L213_V0.6571.00
245_N251_I0.6551.00
124_P128_K0.6431.00
193_Y233_R0.6391.00
223_V228_Y0.6371.00
234_M257_M0.6351.00
155_R169_K0.6331.00
261_T265_K0.6301.00
190_Q236_E0.6291.00
43_Q80_A0.6271.00
188_Y201_D0.6271.00
57_V63_I0.6241.00
39_I65_L0.6231.00
35_V87_H0.6231.00
134_F141_K0.6221.00
260_P263_F0.6191.00
152_L155_R0.6181.00
218_Q224_T0.6161.00
65_L71_H0.6151.00
178_K181_V0.6151.00
133_Q137_Q0.6131.00
39_I83_Y0.6111.00
141_K144_D0.6101.00
199_I226_A0.6081.00
156_K167_L0.6001.00
180_R220_V0.5991.00
179_E183_W0.5981.00
197_T233_R0.5981.00
128_K131_R0.5941.00
61_E128_K0.5921.00
202_L206_L0.5901.00
41_V81_T0.5881.00
259_D269_Q0.5861.00
92_R95_F0.5861.00
154_L158_I0.5861.00
138_Q159_L0.5841.00
247_K251_I0.5811.00
267_F273_I0.5811.00
235_T271_E0.5771.00
221_L228_Y0.5751.00
36_F39_I0.5721.00
41_V57_V0.5681.00
168_Q172_F0.5681.00
32_V70_E0.5671.00
27_T74_T0.5671.00
237_A251_I0.5671.00
94_E98_K0.5661.00
40_Y139_F0.5641.00
229_T233_R0.5631.00
199_I211_D0.5631.00
230_N262_Y0.5611.00
185_A205_A0.5611.00
124_P129_V0.5611.00
150_S153_P0.5591.00
123_L127_G0.5591.00
178_K220_V0.5571.00
46_L73_G0.5571.00
263_F275_P0.5501.00
119_Y123_L0.5491.00
143_I146_S0.5481.00
230_N234_M0.5451.00
204_L207_H0.5451.00
155_R166_H0.5441.00
50_E65_L0.5401.00
176_S179_E0.5401.00
51_N70_E0.5381.00
42_K140_E0.5381.00
203_S206_L0.5371.00
137_Q144_D0.5371.00
182_A213_V0.5371.00
90_E93_Y0.5371.00
41_V83_Y0.5371.00
131_R134_F0.5351.00
39_I48_I0.5341.00
241_L278_Y0.5331.00
138_Q142_L0.5311.00
192_H197_T0.5281.00
248_M276_I0.5281.00
154_L165_L0.5281.00
120_G123_L0.5271.00
144_D148_E0.5261.00
239_R242_S0.5251.00
41_V44_G0.5241.00
154_L161_E0.5241.00
142_L145_Y0.5221.00
149_N152_L0.5221.00
240_L243_S0.5221.00
152_L156_K0.5211.00
197_T229_T0.5201.00
132_P136_A0.5201.00
230_N257_M0.5201.00
182_A206_L0.5191.00
145_Y169_K0.5181.00
187_R190_Q0.5171.00
266_L271_E0.5161.00
189_L197_T0.5151.00
227_Q269_Q0.5121.00
119_Y122_A0.5101.00
263_F267_F0.5081.00
83_Y87_H0.5051.00
48_I57_V0.5051.00
235_T239_R0.5041.00
252_A257_M0.5031.00
166_H169_K0.5001.00
127_G131_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gbgA 1 0.8815 100 0.231 Contact Map
3oouA 1 0.3659 100 0.469 Contact Map
1bl0A 1 0.3833 100 0.47 Contact Map
3mn2A 1 0.3693 100 0.475 Contact Map
3oioA 1 0.3902 100 0.475 Contact Map
3w6vA 1 0.3798 100 0.478 Contact Map
3mklA 1 0.3868 100 0.478 Contact Map
2k9sA 1 0.3693 100 0.482 Contact Map
3lsgA 2 0.3554 100 0.491 Contact Map
1d5yA 1 0.3833 99.9 0.497 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0086 seconds.