GREMLIN Database
AROG - Protein AroA(G)
UniProt: P39912 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 358 (323)
Sequences: 1229 (725)
Seq/√Len: 40.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
131_Y176_R4.7931.00
207_I221_A4.7581.00
121_F347_L4.7581.00
326_D329_V4.6611.00
204_V257_I4.2441.00
108_D111_G3.8931.00
282_L286_T3.7711.00
298_T307_T3.3631.00
249_M256_I3.1671.00
148_I204_V3.1521.00
276_I307_T3.0271.00
108_D113_K2.9951.00
301_R342_E2.9061.00
175_K179_D2.8931.00
212_M236_A2.8101.00
189_I205_I2.7291.00
134_V173_I2.7241.00
139_A180_E2.5741.00
193_A220_A2.4821.00
175_K178_A2.4671.00
309_K349_E2.4601.00
98_R104_D2.4451.00
241_F282_L2.4411.00
144_Q344_E2.3901.00
137_V325_P2.3561.00
274_L292_V2.3521.00
119_Q354_V2.3091.00
279_V292_V2.2961.00
122_I148_I2.2661.00
187_S202_I2.2511.00
334_S337_Q2.2331.00
198_A202_I2.2121.00
96_V249_M2.2010.99
284_Q302_D2.1790.99
36_K40_A2.1760.99
281_I303_L2.1640.99
119_Q312_L2.1400.99
282_L290_V2.1380.99
178_A181_F2.1010.99
53_T64_G2.0120.99
307_T314_I1.9740.99
189_I207_I1.9530.99
128_V174_L1.9410.99
301_R339_A1.8970.98
135_A181_F1.8840.98
169_E172_Q1.8810.98
172_Q201_Y1.8280.98
173_I177_V1.8210.98
141_A146_I1.8100.98
168_V197_E1.8020.98
221_A228_V1.8010.98
225_K255_Q1.7630.97
178_A185_V1.7460.97
190_V216_E1.7440.97
223_A251_Q1.7390.97
194_H216_E1.7170.97
265_T273_T1.7000.97
192_P195_I1.6630.96
321_A346_W1.6230.96
122_I291_F1.5980.95
91_S99_K1.5810.95
135_A180_E1.5660.95
283_K317_D1.5520.95
130_S133_Q1.5390.94
96_V256_I1.5270.94
78_I85_L1.5170.94
107_V204_V1.5160.94
291_F318_G1.5060.94
267_E273_T1.4980.94
305_L349_E1.4860.93
277_S297_S1.4850.93
189_I195_I1.4630.93
339_A342_E1.4600.93
34_I39_E1.4340.92
343_F347_L1.4170.92
140_A144_Q1.3840.91
35_G38_K1.3680.90
187_S198_A1.3430.89
62_N65_P1.3400.89
196_E220_A1.3340.89
123_V146_I1.3320.89
104_D116_D1.3270.89
297_S307_T1.3240.89
106_I113_K1.3220.88
191_T216_E1.3100.88
92_K243_N1.3090.88
148_I186_I1.3070.88
168_V201_Y1.3050.88
46_F53_T1.3020.88
168_V172_Q1.2960.87
62_N66_F1.2890.87
47_D52_R1.2890.87
114_I204_V1.2760.87
309_K353_M1.2730.86
276_I292_V1.2640.86
209_A234_L1.2580.86
42_G82_G1.2550.86
114_I148_I1.2380.85
175_K201_Y1.2320.85
67_E72_Q1.2240.84
131_Y173_I1.2220.84
68_N72_Q1.2160.84
186_I229_L1.2150.84
131_Y135_A1.2100.84
220_A223_A1.2030.83
274_L279_V1.2030.83
344_E348_N1.1880.82
308_A320_M1.1850.82
164_Q219_K1.1820.82
195_I199_L1.1590.81
197_E201_Y1.1550.81
154_F197_E1.1400.80
221_A224_V1.1360.79
176_R180_E1.1350.79
276_I298_T1.1220.79
166_L173_I1.1220.79
238_I281_I1.1140.78
143_K344_E1.1130.78
195_I221_A1.1090.78
148_I184_A1.1060.78
122_I186_I1.1050.77
263_I273_T1.1020.77
36_K57_N1.0950.77
242_I286_T1.0920.77
249_M254_D1.0750.76
140_A340_I1.0670.75
279_V314_I1.0640.75
122_I184_A1.0590.74
140_A341_P1.0580.74
134_V177_V1.0580.74
174_L185_V1.0510.74
274_L307_T1.0470.74
338_M346_W1.0420.73
202_I205_I1.0400.73
178_A182_D1.0320.72
107_V257_I1.0310.72
309_K350_L1.0300.72
141_A183_L1.0250.72
173_I176_R1.0040.70
168_V200_D0.9980.70
199_L205_I0.9940.70
56_N63_D0.9930.70
209_A332_S0.9920.69
69_S72_Q0.9910.69
64_G68_N0.9900.69
276_I297_S0.9870.69
147_K184_A0.9870.69
221_A251_Q0.9860.69
178_A184_A0.9790.68
166_L169_E0.9750.68
323_V343_F0.9730.68
197_E200_D0.9710.68
92_K239_S0.9650.67
269_A281_I0.9640.67
114_I120_R0.9610.67
70_T90_H0.9600.67
308_A319_V0.9580.67
345_K349_E0.9560.67
238_I278_A0.9540.66
107_V255_Q0.9490.66
121_F343_F0.9460.66
298_T303_L0.9370.65
42_G46_F0.9350.65
230_L248_I0.9340.65
42_G66_F0.9340.65
135_A177_V0.9280.64
149_L177_V0.9200.64
216_E219_K0.9160.63
56_N65_P0.9150.63
46_F51_E0.9100.63
189_I221_A0.9060.62
44_N47_D0.9050.62
112_E120_R0.9010.62
110_K184_A0.9000.62
301_R328_S0.8950.61
75_F78_I0.8940.61
38_K81_A0.8920.61
269_A285_E0.8900.61
133_Q173_I0.8880.61
40_A47_D0.8870.61
105_T287_H0.8870.61
199_L202_I0.8860.61
148_I320_M0.8840.60
219_K251_Q0.8840.60
56_N62_N0.8830.60
177_V181_F0.8730.59
175_K181_F0.8700.59
248_I253_N0.8700.59
224_V251_Q0.8620.58
190_V194_H0.8610.58
44_N48_P0.8590.58
195_I224_V0.8570.58
64_G67_E0.8560.58
40_A44_N0.8550.58
187_S207_I0.8540.58
39_E64_G0.8540.58
109_I114_I0.8500.57
137_V340_I0.8480.57
195_I205_I0.8470.57
135_A178_A0.8440.57
38_K82_G0.8430.57
65_P100_K0.8420.57
117_G354_V0.8410.57
43_V53_T0.8400.56
349_E352_P0.8400.56
303_L306_P0.8380.56
56_N100_K0.8380.56
175_K202_I0.8360.56
189_I198_A0.8320.56
51_E66_F0.8290.55
61_N90_H0.8280.55
130_S166_L0.8250.55
47_D53_T0.8210.55
139_A143_K0.8200.55
120_R148_I0.8130.54
146_I347_L0.8130.54
305_L321_A0.8120.54
54_M63_D0.8120.54
292_V311_A0.8120.54
67_E70_T0.8110.54
199_L225_K0.8060.53
123_V323_V0.8050.53
191_T236_A0.8020.53
237_T264_R0.8010.53
144_Q340_I0.8000.53
118_Q147_K0.7990.53
134_V149_L0.7940.52
45_R80_K0.7920.52
136_E325_P0.7910.52
142_K183_L0.7880.52
93_A285_E0.7820.51
306_P311_A0.7820.51
209_A308_A0.7790.51
234_L266_Y0.7780.51
133_Q137_V0.7780.51
352_P355_K0.7770.51
142_K180_E0.7760.51
200_D276_I0.7740.50
167_G194_H0.7730.50
42_G64_G0.7730.50
116_D120_R0.7730.50
43_V55_L0.7690.50
325_P337_Q0.7690.50
47_D50_R0.7650.50
108_D112_E0.7600.49
190_V257_I0.7560.49
205_I224_V0.7560.49
43_V47_D0.7560.49
277_S311_A0.7550.49
162_D239_S0.7550.49
312_L354_V0.7390.47
313_A353_M0.7380.47
130_S331_L0.7350.47
305_L345_K0.7350.47
130_S332_S0.7350.47
109_I204_V0.7340.47
112_E148_I0.7310.46
199_L224_V0.7300.46
58_I89_D0.7290.46
57_N63_D0.7290.46
134_V332_S0.7280.46
276_I311_A0.7270.46
135_A139_A0.7260.46
297_S332_S0.7250.46
140_A344_E0.7240.46
239_S335_A0.7230.46
112_E147_K0.7220.46
136_E139_A0.7210.46
146_I149_L0.7200.45
177_V183_L0.7190.45
149_L183_L0.7150.45
89_D94_L0.7130.45
40_A43_V0.7130.45
298_T337_Q0.7080.44
225_K251_Q0.7070.44
68_N90_H0.7070.44
204_V228_V0.7050.44
167_G190_V0.7050.44
195_I198_A0.7030.44
54_M65_P0.6980.43
131_Y177_V0.6980.43
159_S243_N0.6960.43
176_R179_D0.6910.43
267_E270_T0.6900.43
63_D85_L0.6890.43
338_M342_E0.6890.43
58_I94_L0.6860.42
45_R48_P0.6800.42
161_Y246_E0.6780.42
308_A346_W0.6750.41
130_S137_V0.6740.41
192_P216_E0.6740.41
346_W350_L0.6710.41
40_A107_V0.6710.41
77_E86_Q0.6700.41
92_K162_D0.6690.41
238_I282_L0.6690.41
348_N351_K0.6680.41
83_L86_Q0.6670.41
131_Y134_V0.6660.41
42_G80_K0.6660.41
207_I266_Y0.6650.41
135_A176_R0.6640.40
175_K185_V0.6640.40
142_K248_I0.6630.40
345_K348_N0.6620.40
209_A320_M0.6600.40
93_A269_A0.6590.40
119_Q353_M0.6590.40
137_V140_A0.6560.40
35_G82_G0.6560.40
281_I286_T0.6550.40
312_L350_L0.6550.40
270_T277_S0.6540.40
281_I300_R0.6530.39
189_I199_L0.6520.39
142_K181_F0.6520.39
114_I122_I0.6490.39
118_Q143_K0.6480.39
166_L170_G0.6480.39
37_A41_Q0.6460.39
172_Q197_E0.6460.39
70_T88_E0.6440.39
41_Q80_K0.6440.39
281_I285_E0.6430.39
66_F89_D0.6430.39
225_K253_N0.6400.38
129_E260_E0.6380.38
277_S280_P0.6370.38
52_R59_I0.6360.38
122_I204_V0.6330.38
62_N68_N0.6330.38
179_D201_Y0.6320.38
58_I62_N0.6320.38
60_E88_E0.6300.37
109_I112_E0.6290.37
144_Q321_A0.6270.37
185_V190_V0.6260.37
33_E292_V0.6250.37
277_S298_T0.6250.37
251_Q254_D0.6250.37
170_G267_E0.6250.37
105_T110_K0.6230.37
157_R296_H0.6220.37
239_S244_A0.6210.37
300_R303_L0.6170.36
281_I284_Q0.6150.36
54_M62_N0.6130.36
56_N220_A0.6120.36
46_F64_G0.6120.36
264_R273_T0.6100.36
109_I255_Q0.6090.36
101_K105_T0.6090.36
190_V221_A0.6060.35
43_V46_F0.6050.35
238_I269_A0.6050.35
225_K254_D0.6030.35
127_A331_L0.6020.35
301_R305_L0.6000.35
191_T194_H0.5990.35
295_T346_W0.5980.35
45_R49_V0.5980.35
267_E278_A0.5970.35
198_A216_E0.5930.34
97_S235_A0.5920.34
39_E42_G0.5910.34
284_Q303_L0.5900.34
263_I267_E0.5900.34
109_I148_I0.5890.34
215_F250_S0.5890.34
215_F243_N0.5860.34
98_R284_Q0.5860.34
185_V202_I0.5860.34
102_P177_V0.5860.34
137_V173_I0.5850.34
97_S167_G0.5830.33
270_T273_T0.5820.33
347_L350_L0.5810.33
168_V171_L0.5810.33
257_I282_L0.5790.33
185_V205_I0.5770.33
127_A228_V0.5750.33
241_F278_A0.5740.33
308_A350_L0.5720.33
139_A181_F0.5720.33
66_F69_S0.5690.32
133_Q332_S0.5670.32
322_E337_Q0.5660.32
239_S267_E0.5660.32
276_I337_Q0.5660.32
79_F84_E0.5650.32
239_S268_T0.5610.32
239_S269_A0.5600.32
222_G251_Q0.5570.31
120_R147_K0.5570.31
127_A209_A0.5560.31
101_K254_D0.5560.31
239_S282_L0.5560.31
301_R337_Q0.5560.31
148_I183_L0.5550.31
127_A332_S0.5550.31
65_P89_D0.5540.31
114_I257_I0.5540.31
157_R299_G0.5530.31
34_I53_T0.5530.31
325_P340_I0.5530.31
149_L270_T0.5520.31
240_E267_E0.5510.31
122_I229_L0.5500.31
109_I184_A0.5490.31
171_L175_K0.5470.31
138_A183_L0.5470.31
141_A347_L0.5470.31
127_A190_V0.5470.31
158_T215_F0.5450.30
195_I207_I0.5440.30
209_A213_Q0.5440.30
295_T304_L0.5440.30
236_A244_A0.5430.30
207_I226_K0.5430.30
276_I280_P0.5430.30
91_S285_E0.5430.30
172_Q179_D0.5410.30
221_A225_K0.5410.30
166_L331_L0.5390.30
41_Q45_R0.5390.30
198_A205_I0.5370.30
41_Q48_P0.5370.30
123_V321_A0.5360.30
127_A154_F0.5360.30
235_A272_N0.5360.30
143_K312_L0.5360.30
127_A157_R0.5340.30
241_F258_L0.5340.30
228_V248_I0.5330.30
113_K118_Q0.5310.29
300_R342_E0.5290.29
276_I281_I0.5290.29
351_K354_V0.5280.29
169_E173_I0.5280.29
65_P94_L0.5280.29
329_V335_A0.5270.29
277_S307_T0.5270.29
209_A241_F0.5250.29
132_E139_A0.5250.29
36_K39_E0.5230.29
67_E89_D0.5210.29
264_R267_E0.5210.29
92_K190_V0.5200.29
77_E83_L0.5200.29
194_H303_L0.5190.28
103_E291_F0.5180.28
322_E332_S0.5170.28
127_A272_N0.5170.28
269_A272_N0.5170.28
129_E263_I0.5160.28
272_N298_T0.5160.28
213_Q343_F0.5150.28
136_E140_A0.5130.28
58_I88_E0.5130.28
81_A88_E0.5120.28
313_A317_D0.5120.28
205_I221_A0.5110.28
193_A196_E0.5110.28
69_S90_H0.5110.28
341_P344_E0.5100.28
189_I216_E0.5080.28
220_A283_K0.5060.27
248_I256_I0.5060.27
95_L137_V0.5060.27
110_K185_V0.5060.27
128_V183_L0.5050.27
267_E277_S0.5050.27
45_R76_K0.5050.27
100_K340_I0.5030.27
67_E71_I0.5030.27
109_I241_F0.5030.27
180_E291_F0.5020.27
143_K335_A0.5010.27
276_I314_I0.5010.27
172_Q302_D0.5000.27
235_A263_I0.5000.27
297_S337_Q0.5000.27
223_A341_P0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vr6A 4 0.9441 100 0.36 Contact Map
3nvtA 4 0.9693 100 0.416 Contact Map
1vs1A 4 0.757 100 0.508 Contact Map
4c1lA 4 0.7318 100 0.508 Contact Map
4lu0A 4 0.676 100 0.54 Contact Map
2qkfA 4 0.676 100 0.549 Contact Map
1o60A 4 0.7011 100 0.552 Contact Map
3tmlA 4 0.6648 100 0.552 Contact Map
3fs2A 4 0.6844 100 0.553 Contact Map
3tqkA 2 0.7458 100 0.555 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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