AROG - BACSU - GREMLIN Contacts

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AROG - Protein AroA(G)

UniProt:	P39912	Sequences: MSNTELELLRQKADELNLQILKLINERGNVVKEIGKAKEAQGVNRFDPVRERTMLNNIIENNDGPFENSTIQHIFKEIFKAGLELQEEDHSKALLVSRKKKPEDTIVDIKGEKIGDGQQRFIVGPCAVESYEQVAEVAAAAKKQGIKILRGGAFKPRTSPYDFQGLGVEGLQILKRVADEFDLAVISEIVTPAHIEEALDYIDVIQIGARNMQNFELLKAAGAVKKPVLLKRGLAATISEFINAAEYIMSQGNDQIILCERGIRTYETATRNTLDISAVPILKQETHLPVFVDVTHSTGRRDLLLPTAKAALAIGADGVMAEVHPDPSVALSDSAQQMAIPEFEKWLNELKPMVKVNA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	358 (323)
Sequences:	1229 (725)
Seq/√Len:	40.3

ECOLI - KDSA
BACSU - AROG
SULSO - Q980J0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
131_Y	176_R	4.793	1.00
207_I	221_A	4.758	1.00
121_F	347_L	4.758	1.00
326_D	329_V	4.661	1.00
204_V	257_I	4.244	1.00
108_D	111_G	3.893	1.00
282_L	286_T	3.771	1.00
298_T	307_T	3.363	1.00
249_M	256_I	3.167	1.00
148_I	204_V	3.152	1.00
276_I	307_T	3.027	1.00
108_D	113_K	2.995	1.00
301_R	342_E	2.906	1.00
175_K	179_D	2.893	1.00
212_M	236_A	2.810	1.00
189_I	205_I	2.729	1.00
134_V	173_I	2.724	1.00
139_A	180_E	2.574	1.00
193_A	220_A	2.482	1.00
175_K	178_A	2.467	1.00
309_K	349_E	2.460	1.00
98_R	104_D	2.445	1.00
241_F	282_L	2.441	1.00
144_Q	344_E	2.390	1.00
137_V	325_P	2.356	1.00
274_L	292_V	2.352	1.00
119_Q	354_V	2.309	1.00
279_V	292_V	2.296	1.00
122_I	148_I	2.266	1.00
187_S	202_I	2.251	1.00
334_S	337_Q	2.233	1.00
198_A	202_I	2.212	1.00
96_V	249_M	2.201	0.99
284_Q	302_D	2.179	0.99
36_K	40_A	2.176	0.99
281_I	303_L	2.164	0.99
119_Q	312_L	2.140	0.99
282_L	290_V	2.138	0.99
178_A	181_F	2.101	0.99
53_T	64_G	2.012	0.99
307_T	314_I	1.974	0.99
189_I	207_I	1.953	0.99
128_V	174_L	1.941	0.99
301_R	339_A	1.897	0.98
135_A	181_F	1.884	0.98
169_E	172_Q	1.881	0.98
172_Q	201_Y	1.828	0.98
173_I	177_V	1.821	0.98
141_A	146_I	1.810	0.98
168_V	197_E	1.802	0.98
221_A	228_V	1.801	0.98
225_K	255_Q	1.763	0.97
178_A	185_V	1.746	0.97
190_V	216_E	1.744	0.97
223_A	251_Q	1.739	0.97
194_H	216_E	1.717	0.97
265_T	273_T	1.700	0.97
192_P	195_I	1.663	0.96
321_A	346_W	1.623	0.96
122_I	291_F	1.598	0.95
91_S	99_K	1.581	0.95
135_A	180_E	1.566	0.95
283_K	317_D	1.552	0.95
130_S	133_Q	1.539	0.94
96_V	256_I	1.527	0.94
78_I	85_L	1.517	0.94
107_V	204_V	1.516	0.94
291_F	318_G	1.506	0.94
267_E	273_T	1.498	0.94
305_L	349_E	1.486	0.93
277_S	297_S	1.485	0.93
189_I	195_I	1.463	0.93
339_A	342_E	1.460	0.93
34_I	39_E	1.434	0.92
343_F	347_L	1.417	0.92
140_A	144_Q	1.384	0.91
35_G	38_K	1.368	0.90
187_S	198_A	1.343	0.89
62_N	65_P	1.340	0.89
196_E	220_A	1.334	0.89
123_V	146_I	1.332	0.89
104_D	116_D	1.327	0.89
297_S	307_T	1.324	0.89
106_I	113_K	1.322	0.88
191_T	216_E	1.310	0.88
92_K	243_N	1.309	0.88
148_I	186_I	1.307	0.88
168_V	201_Y	1.305	0.88
46_F	53_T	1.302	0.88
168_V	172_Q	1.296	0.87
62_N	66_F	1.289	0.87
47_D	52_R	1.289	0.87
114_I	204_V	1.276	0.87
309_K	353_M	1.273	0.86
276_I	292_V	1.264	0.86
209_A	234_L	1.258	0.86
42_G	82_G	1.255	0.86
114_I	148_I	1.238	0.85
175_K	201_Y	1.232	0.85
67_E	72_Q	1.224	0.84
131_Y	173_I	1.222	0.84
68_N	72_Q	1.216	0.84
186_I	229_L	1.215	0.84
131_Y	135_A	1.210	0.84
220_A	223_A	1.203	0.83
274_L	279_V	1.203	0.83
344_E	348_N	1.188	0.82
308_A	320_M	1.185	0.82
164_Q	219_K	1.182	0.82
195_I	199_L	1.159	0.81
197_E	201_Y	1.155	0.81
154_F	197_E	1.140	0.80
221_A	224_V	1.136	0.79
176_R	180_E	1.135	0.79
276_I	298_T	1.122	0.79
166_L	173_I	1.122	0.79
238_I	281_I	1.114	0.78
143_K	344_E	1.113	0.78
195_I	221_A	1.109	0.78
148_I	184_A	1.106	0.78
122_I	186_I	1.105	0.77
263_I	273_T	1.102	0.77
36_K	57_N	1.095	0.77
242_I	286_T	1.092	0.77
249_M	254_D	1.075	0.76
140_A	340_I	1.067	0.75
279_V	314_I	1.064	0.75
122_I	184_A	1.059	0.74
140_A	341_P	1.058	0.74
134_V	177_V	1.058	0.74
174_L	185_V	1.051	0.74
274_L	307_T	1.047	0.74
338_M	346_W	1.042	0.73
202_I	205_I	1.040	0.73
178_A	182_D	1.032	0.72
107_V	257_I	1.031	0.72
309_K	350_L	1.030	0.72
141_A	183_L	1.025	0.72
173_I	176_R	1.004	0.70
168_V	200_D	0.998	0.70
199_L	205_I	0.994	0.70
56_N	63_D	0.993	0.70
209_A	332_S	0.992	0.69
69_S	72_Q	0.991	0.69
64_G	68_N	0.990	0.69
276_I	297_S	0.987	0.69
147_K	184_A	0.987	0.69
221_A	251_Q	0.986	0.69
178_A	184_A	0.979	0.68
166_L	169_E	0.975	0.68
323_V	343_F	0.973	0.68
197_E	200_D	0.971	0.68
92_K	239_S	0.965	0.67
269_A	281_I	0.964	0.67
114_I	120_R	0.961	0.67
70_T	90_H	0.960	0.67
308_A	319_V	0.958	0.67
345_K	349_E	0.956	0.67
238_I	278_A	0.954	0.66
107_V	255_Q	0.949	0.66
121_F	343_F	0.946	0.66
298_T	303_L	0.937	0.65
42_G	46_F	0.935	0.65
230_L	248_I	0.934	0.65
42_G	66_F	0.934	0.65
135_A	177_V	0.928	0.64
149_L	177_V	0.920	0.64
216_E	219_K	0.916	0.63
56_N	65_P	0.915	0.63
46_F	51_E	0.910	0.63
189_I	221_A	0.906	0.62
44_N	47_D	0.905	0.62
112_E	120_R	0.901	0.62
110_K	184_A	0.900	0.62
301_R	328_S	0.895	0.61
75_F	78_I	0.894	0.61
38_K	81_A	0.892	0.61
269_A	285_E	0.890	0.61
133_Q	173_I	0.888	0.61
40_A	47_D	0.887	0.61
105_T	287_H	0.887	0.61
199_L	202_I	0.886	0.61
148_I	320_M	0.884	0.60
219_K	251_Q	0.884	0.60
56_N	62_N	0.883	0.60
177_V	181_F	0.873	0.59
175_K	181_F	0.870	0.59
248_I	253_N	0.870	0.59
224_V	251_Q	0.862	0.58
190_V	194_H	0.861	0.58
44_N	48_P	0.859	0.58
195_I	224_V	0.857	0.58
64_G	67_E	0.856	0.58
40_A	44_N	0.855	0.58
187_S	207_I	0.854	0.58
39_E	64_G	0.854	0.58
109_I	114_I	0.850	0.57
137_V	340_I	0.848	0.57
195_I	205_I	0.847	0.57
135_A	178_A	0.844	0.57
38_K	82_G	0.843	0.57
65_P	100_K	0.842	0.57
117_G	354_V	0.841	0.57
43_V	53_T	0.840	0.56
349_E	352_P	0.840	0.56
303_L	306_P	0.838	0.56
56_N	100_K	0.838	0.56
175_K	202_I	0.836	0.56
189_I	198_A	0.832	0.56
51_E	66_F	0.829	0.55
61_N	90_H	0.828	0.55
130_S	166_L	0.825	0.55
47_D	53_T	0.821	0.55
139_A	143_K	0.820	0.55
120_R	148_I	0.813	0.54
146_I	347_L	0.813	0.54
305_L	321_A	0.812	0.54
54_M	63_D	0.812	0.54
292_V	311_A	0.812	0.54
67_E	70_T	0.811	0.54
199_L	225_K	0.806	0.53
123_V	323_V	0.805	0.53
191_T	236_A	0.802	0.53
237_T	264_R	0.801	0.53
144_Q	340_I	0.800	0.53
118_Q	147_K	0.799	0.53
134_V	149_L	0.794	0.52
45_R	80_K	0.792	0.52
136_E	325_P	0.791	0.52
142_K	183_L	0.788	0.52
93_A	285_E	0.782	0.51
306_P	311_A	0.782	0.51
209_A	308_A	0.779	0.51
234_L	266_Y	0.778	0.51
133_Q	137_V	0.778	0.51
352_P	355_K	0.777	0.51
142_K	180_E	0.776	0.51
200_D	276_I	0.774	0.50
167_G	194_H	0.773	0.50
42_G	64_G	0.773	0.50
116_D	120_R	0.773	0.50
43_V	55_L	0.769	0.50
325_P	337_Q	0.769	0.50
47_D	50_R	0.765	0.50
108_D	112_E	0.760	0.49
190_V	257_I	0.756	0.49
205_I	224_V	0.756	0.49
43_V	47_D	0.756	0.49
277_S	311_A	0.755	0.49
162_D	239_S	0.755	0.49
312_L	354_V	0.739	0.47
313_A	353_M	0.738	0.47
130_S	331_L	0.735	0.47
305_L	345_K	0.735	0.47
130_S	332_S	0.735	0.47
109_I	204_V	0.734	0.47
112_E	148_I	0.731	0.46
199_L	224_V	0.730	0.46
58_I	89_D	0.729	0.46
57_N	63_D	0.729	0.46
134_V	332_S	0.728	0.46
276_I	311_A	0.727	0.46
135_A	139_A	0.726	0.46
297_S	332_S	0.725	0.46
140_A	344_E	0.724	0.46
239_S	335_A	0.723	0.46
112_E	147_K	0.722	0.46
136_E	139_A	0.721	0.46
146_I	149_L	0.720	0.45
177_V	183_L	0.719	0.45
149_L	183_L	0.715	0.45
89_D	94_L	0.713	0.45
40_A	43_V	0.713	0.45
298_T	337_Q	0.708	0.44
225_K	251_Q	0.707	0.44
68_N	90_H	0.707	0.44
204_V	228_V	0.705	0.44
167_G	190_V	0.705	0.44
195_I	198_A	0.703	0.44
54_M	65_P	0.698	0.43
131_Y	177_V	0.698	0.43
159_S	243_N	0.696	0.43
176_R	179_D	0.691	0.43
267_E	270_T	0.690	0.43
63_D	85_L	0.689	0.43
338_M	342_E	0.689	0.43
58_I	94_L	0.686	0.42
45_R	48_P	0.680	0.42
161_Y	246_E	0.678	0.42
308_A	346_W	0.675	0.41
130_S	137_V	0.674	0.41
192_P	216_E	0.674	0.41
346_W	350_L	0.671	0.41
40_A	107_V	0.671	0.41
77_E	86_Q	0.670	0.41
92_K	162_D	0.669	0.41
238_I	282_L	0.669	0.41
348_N	351_K	0.668	0.41
83_L	86_Q	0.667	0.41
131_Y	134_V	0.666	0.41
42_G	80_K	0.666	0.41
207_I	266_Y	0.665	0.41
135_A	176_R	0.664	0.40
175_K	185_V	0.664	0.40
142_K	248_I	0.663	0.40
345_K	348_N	0.662	0.40
209_A	320_M	0.660	0.40
93_A	269_A	0.659	0.40
119_Q	353_M	0.659	0.40
137_V	140_A	0.656	0.40
35_G	82_G	0.656	0.40
281_I	286_T	0.655	0.40
312_L	350_L	0.655	0.40
270_T	277_S	0.654	0.40
281_I	300_R	0.653	0.39
189_I	199_L	0.652	0.39
142_K	181_F	0.652	0.39
114_I	122_I	0.649	0.39
118_Q	143_K	0.648	0.39
166_L	170_G	0.648	0.39
37_A	41_Q	0.646	0.39
172_Q	197_E	0.646	0.39
70_T	88_E	0.644	0.39
41_Q	80_K	0.644	0.39
281_I	285_E	0.643	0.39
66_F	89_D	0.643	0.39
225_K	253_N	0.640	0.38
129_E	260_E	0.638	0.38
277_S	280_P	0.637	0.38
52_R	59_I	0.636	0.38
122_I	204_V	0.633	0.38
62_N	68_N	0.633	0.38
179_D	201_Y	0.632	0.38
58_I	62_N	0.632	0.38
60_E	88_E	0.630	0.37
109_I	112_E	0.629	0.37
144_Q	321_A	0.627	0.37
185_V	190_V	0.626	0.37
33_E	292_V	0.625	0.37
277_S	298_T	0.625	0.37
251_Q	254_D	0.625	0.37
170_G	267_E	0.625	0.37
105_T	110_K	0.623	0.37
157_R	296_H	0.622	0.37
239_S	244_A	0.621	0.37
300_R	303_L	0.617	0.36
281_I	284_Q	0.615	0.36
54_M	62_N	0.613	0.36
56_N	220_A	0.612	0.36
46_F	64_G	0.612	0.36
264_R	273_T	0.610	0.36
109_I	255_Q	0.609	0.36
101_K	105_T	0.609	0.36
190_V	221_A	0.606	0.35
43_V	46_F	0.605	0.35
238_I	269_A	0.605	0.35
225_K	254_D	0.603	0.35
127_A	331_L	0.602	0.35
301_R	305_L	0.600	0.35
191_T	194_H	0.599	0.35
295_T	346_W	0.598	0.35
45_R	49_V	0.598	0.35
267_E	278_A	0.597	0.35
198_A	216_E	0.593	0.34
97_S	235_A	0.592	0.34
39_E	42_G	0.591	0.34
284_Q	303_L	0.590	0.34
263_I	267_E	0.590	0.34
109_I	148_I	0.589	0.34
215_F	250_S	0.589	0.34
215_F	243_N	0.586	0.34
98_R	284_Q	0.586	0.34
185_V	202_I	0.586	0.34
102_P	177_V	0.586	0.34
137_V	173_I	0.585	0.34
97_S	167_G	0.583	0.33
270_T	273_T	0.582	0.33
347_L	350_L	0.581	0.33
168_V	171_L	0.581	0.33
257_I	282_L	0.579	0.33
185_V	205_I	0.577	0.33
127_A	228_V	0.575	0.33
241_F	278_A	0.574	0.33
308_A	350_L	0.572	0.33
139_A	181_F	0.572	0.33
66_F	69_S	0.569	0.32
133_Q	332_S	0.567	0.32
322_E	337_Q	0.566	0.32
239_S	267_E	0.566	0.32
276_I	337_Q	0.566	0.32
79_F	84_E	0.565	0.32
239_S	268_T	0.561	0.32
239_S	269_A	0.560	0.32
222_G	251_Q	0.557	0.31
120_R	147_K	0.557	0.31
127_A	209_A	0.556	0.31
101_K	254_D	0.556	0.31
239_S	282_L	0.556	0.31
301_R	337_Q	0.556	0.31
148_I	183_L	0.555	0.31
127_A	332_S	0.555	0.31
65_P	89_D	0.554	0.31
114_I	257_I	0.554	0.31
157_R	299_G	0.553	0.31
34_I	53_T	0.553	0.31
325_P	340_I	0.553	0.31
149_L	270_T	0.552	0.31
240_E	267_E	0.551	0.31
122_I	229_L	0.550	0.31
109_I	184_A	0.549	0.31
171_L	175_K	0.547	0.31
138_A	183_L	0.547	0.31
141_A	347_L	0.547	0.31
127_A	190_V	0.547	0.31
158_T	215_F	0.545	0.30
195_I	207_I	0.544	0.30
209_A	213_Q	0.544	0.30
295_T	304_L	0.544	0.30
236_A	244_A	0.543	0.30
207_I	226_K	0.543	0.30
276_I	280_P	0.543	0.30
91_S	285_E	0.543	0.30
172_Q	179_D	0.541	0.30
221_A	225_K	0.541	0.30
166_L	331_L	0.539	0.30
41_Q	45_R	0.539	0.30
198_A	205_I	0.537	0.30
41_Q	48_P	0.537	0.30
123_V	321_A	0.536	0.30
127_A	154_F	0.536	0.30
235_A	272_N	0.536	0.30
143_K	312_L	0.536	0.30
127_A	157_R	0.534	0.30
241_F	258_L	0.534	0.30
228_V	248_I	0.533	0.30
113_K	118_Q	0.531	0.29
300_R	342_E	0.529	0.29
276_I	281_I	0.529	0.29
351_K	354_V	0.528	0.29
169_E	173_I	0.528	0.29
65_P	94_L	0.528	0.29
329_V	335_A	0.527	0.29
277_S	307_T	0.527	0.29
209_A	241_F	0.525	0.29
132_E	139_A	0.525	0.29
36_K	39_E	0.523	0.29
67_E	89_D	0.521	0.29
264_R	267_E	0.521	0.29
92_K	190_V	0.520	0.29
77_E	83_L	0.520	0.29
194_H	303_L	0.519	0.28
103_E	291_F	0.518	0.28
322_E	332_S	0.517	0.28
127_A	272_N	0.517	0.28
269_A	272_N	0.517	0.28
129_E	263_I	0.516	0.28
272_N	298_T	0.516	0.28
213_Q	343_F	0.515	0.28
136_E	140_A	0.513	0.28
58_I	88_E	0.513	0.28
81_A	88_E	0.512	0.28
313_A	317_D	0.512	0.28
205_I	221_A	0.511	0.28
193_A	196_E	0.511	0.28
69_S	90_H	0.511	0.28
341_P	344_E	0.510	0.28
189_I	216_E	0.508	0.28
220_A	283_K	0.506	0.27
248_I	256_I	0.506	0.27
95_L	137_V	0.506	0.27
110_K	185_V	0.506	0.27
128_V	183_L	0.505	0.27
267_E	277_S	0.505	0.27
45_R	76_K	0.505	0.27
100_K	340_I	0.503	0.27
67_E	71_I	0.503	0.27
109_I	241_F	0.503	0.27
180_E	291_F	0.502	0.27
143_K	335_A	0.501	0.27
276_I	314_I	0.501	0.27
172_Q	302_D	0.500	0.27
235_A	263_I	0.500	0.27
297_S	337_Q	0.500	0.27
223_A	341_P	0.500	0.27

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1vr6A	4	0.9441	100	0.36	Contact Map
3nvtA	4	0.9693	100	0.416	Contact Map
1vs1A	4	0.757	100	0.508	Contact Map
4c1lA	4	0.7318	100	0.508	Contact Map
4lu0A	4	0.676	100	0.54	Contact Map
2qkfA	4	0.676	100	0.549	Contact Map
1o60A	4	0.7011	100	0.552	Contact Map
3tmlA	4	0.6648	100	0.552	Contact Map
3fs2A	4	0.6844	100	0.553	Contact Map
3tqkA	2	0.7458	100	0.555	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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