GREMLIN Database
BLTD - Spermine/spermidine acetyltransferase
UniProt: P39909 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 152 (140)
Sequences: 1305 (995)
Seq/√Len: 84.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_T83_F3.3091.00
50_L97_M3.1671.00
95_K131_R3.1641.00
118_I148_M3.0491.00
52_Y93_L2.6581.00
25_Q89_Q2.6291.00
47_P59_F2.5471.00
23_Q26_L2.5031.00
16_I49_G2.4721.00
60_A101_L2.4051.00
58_G84_I2.3551.00
16_I56_L2.3361.00
6_K51_Y2.3211.00
51_Y56_L2.3191.00
55_D88_Y2.2731.00
22_S86_E2.1871.00
37_E41_E2.1621.00
122_N125_A1.9411.00
57_V93_L1.8761.00
88_Y91_K1.8481.00
20_H86_E1.8311.00
84_I93_L1.7661.00
118_I126_I1.7441.00
48_V104_H1.6431.00
126_I130_Q1.6311.00
98_L132_F1.6271.00
30_E81_R1.5671.00
50_L58_G1.5661.00
35_C61_M1.5351.00
39_A47_P1.5160.99
35_C81_R1.4820.99
79_L116_L1.4290.99
19_L83_F1.4230.99
125_A129_Y1.4050.99
4_N54_G1.4000.99
32_T35_C1.3590.99
139_E147_V1.3510.99
109_Y118_I1.3340.99
21_V25_Q1.3250.99
126_I136_F1.2980.98
48_V62_Y1.2950.98
117_S141_D1.2590.98
82_F98_L1.2500.98
95_K99_K1.2350.98
8_V49_G1.2340.98
45_Y80_D1.2130.98
38_D81_R1.2030.97
13_R17_L1.2010.97
116_L129_Y1.1960.97
51_Y54_G1.1800.97
96_K99_K1.1760.97
63_G78_W1.1760.97
32_T81_R1.1610.97
35_C59_F1.1560.97
125_A128_L1.1480.97
76_R113_R1.1200.96
45_Y63_G1.1150.96
130_Q136_F1.1130.96
57_V88_Y1.1070.96
13_R41_E1.0940.95
9_T12_N1.0790.95
102_I114_I1.0770.95
116_L125_A1.0620.95
103_Q106_A1.0420.94
17_L33_K1.0400.94
102_I106_A1.0400.94
50_L84_I1.0360.94
100_A103_Q1.0350.94
6_K12_N1.0320.94
130_Q148_M1.0260.94
12_N51_Y1.0210.93
57_V97_M1.0190.93
79_L98_L1.0180.93
77_V111_C1.0160.93
29_I83_F1.0050.93
10_D43_H0.9940.93
111_C114_I0.9910.92
136_F148_M0.9810.92
99_K103_Q0.9650.91
3_I52_Y0.9590.91
5_I50_L0.9580.91
78_W115_Y0.9560.91
122_N128_L0.9500.91
79_L132_F0.9410.90
49_G56_L0.9400.90
30_E80_D0.9390.90
95_K128_L0.9330.90
35_C83_F0.9240.89
128_L132_F0.9070.89
61_M80_D0.9040.88
126_I148_M0.8980.88
127_R130_Q0.8980.88
14_A34_V0.8950.88
75_G112_K0.8850.87
15_A55_D0.8710.87
5_I97_M0.8620.86
61_M81_R0.8590.86
101_L105_L0.8490.85
53_E107_E0.8430.85
78_W117_S0.8380.84
73_K113_R0.8340.84
15_A56_L0.8330.84
105_L111_C0.8310.84
136_F146_K0.8090.82
28_Y119_F0.8060.82
19_L32_T0.8000.82
82_F97_M0.7970.81
63_G80_D0.7910.81
103_Q107_E0.7880.81
27_S121_N0.7860.80
128_L131_R0.7790.80
13_R42_C0.7680.79
45_Y67_E0.7650.79
116_L122_N0.7520.77
136_F140_L0.7440.77
78_W116_L0.7290.75
113_R138_G0.7280.75
3_I93_L0.7200.74
140_L143_N0.7160.74
139_E146_K0.7150.74
62_Y80_D0.7140.74
8_V12_N0.7140.74
119_F148_M0.7050.73
52_Y91_K0.6990.72
27_S54_G0.6890.71
52_Y57_V0.6890.71
62_Y101_L0.6830.70
11_D15_A0.6830.70
13_R34_V0.6820.70
32_T59_F0.6770.70
8_V56_L0.6770.70
15_A18_D0.6770.70
6_K9_T0.6760.69
8_V94_G0.6720.69
4_N100_A0.6660.68
79_L82_F0.6650.68
24_N91_K0.6620.68
25_Q124_H0.6510.67
20_H33_K0.6490.66
58_G89_Q0.6450.66
48_V78_W0.6440.66
3_I50_L0.6410.65
123_I127_R0.6370.65
24_N27_S0.6370.65
13_R37_E0.6310.64
110_K132_F0.6310.64
29_I119_F0.6250.63
73_K76_R0.6240.63
4_N103_Q0.6220.63
29_I47_P0.6220.63
15_A52_Y0.6140.62
63_G141_D0.6140.62
33_K37_E0.6010.60
52_Y96_K0.5990.60
5_I100_A0.5970.60
118_I146_K0.5960.60
8_V39_A0.5900.59
30_E61_M0.5890.59
37_E40_K0.5850.58
53_E123_I0.5770.57
85_D134_F0.5750.57
45_Y61_M0.5740.57
67_E76_R0.5740.57
46_K108_L0.5710.57
8_V16_I0.5680.56
17_L83_F0.5650.56
47_P61_M0.5610.55
48_V60_A0.5570.55
29_I81_R0.5520.54
20_H26_L0.5500.54
29_I32_T0.5490.54
46_K64_L0.5490.54
114_I126_I0.5480.54
84_I89_Q0.5480.54
23_Q100_A0.5470.53
36_L83_F0.5470.53
29_I61_M0.5460.53
143_N146_K0.5450.53
137_N147_V0.5450.53
19_L29_I0.5440.53
10_D13_R0.5400.52
19_L61_M0.5380.52
36_L94_G0.5380.52
80_D117_S0.5370.52
5_I60_A0.5370.52
107_E135_Q0.5370.52
29_I35_C0.5360.52
46_K62_Y0.5300.51
3_I100_A0.5290.51
127_R135_Q0.5270.51
46_K125_A0.5270.51
103_Q135_Q0.5260.51
126_I146_K0.5260.51
95_K101_L0.5240.50
15_A99_K0.5240.50
61_M129_Y0.5230.50
52_Y88_Y0.5230.50
32_T36_L0.5200.50
140_L146_K0.5190.50
77_V114_I0.5190.50
118_I125_A0.5180.50
30_E117_S0.5170.49
110_K124_H0.5160.49
65_F80_D0.5120.49
56_L79_L0.5110.49
39_A45_Y0.5100.49
13_R114_I0.5030.48
49_G83_F0.5020.47
29_I116_L0.5000.47
94_G124_H0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fl4A 2 0.9539 99.9 0.522 Contact Map
1tiqA 1 0.9868 99.8 0.564 Contact Map
3fixA 2 0.9276 99.8 0.565 Contact Map
2ob0A 1 0.9474 99.8 0.568 Contact Map
3d8pA 1 0.9408 99.8 0.569 Contact Map
2r7hA 2 0.9539 99.8 0.572 Contact Map
1ufhA 3 0.9145 99.8 0.572 Contact Map
4qc6A 1 1 99.8 0.573 Contact Map
3d3sA 2 0.9474 99.8 0.573 Contact Map
2oh1A 1 0.9671 99.8 0.574 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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