NPRB - BACSU - GREMLIN Contacts

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NPRB - Neutral protease B

UniProt:	P39899	Sequences: MRNLTKTSLLLAGLCTAAQMVFVTHASAEESIEYDHTYQTPSYIIEKSPQKPVQNTTQKESLFSYLDKHQTQFKLKGNANSHFRVSKTIKDPKTKQTFFKLTEVYKGIPIYGFEQAVAMKENKQVKSFFGKVHPQIKDVSVTPSISEKKAIHTARRELEASIGKIEYLDGEPKGELYIYPHDGEYDLAYLVRLSTSEPEPGYWHYFIDAKNGKVIESFNAIHEAAGTGIGVSGDEKSFDVTEQNGRFYLADETRGKGINTFDAKNLNETLFTLLSQLIGYTGKEIVSGTSVFNEPAAVDAHANAQAVYDYYSKTFGRDSFDQNGARITSTVHVGKQWNNAAWNGVQMVYGDGDGSKFKPLSGSLDIVAHEITHAVTQYSAGLLYQGEPGALNESISDIMGAMADRDDWEIGEDVYTPGIAGDSLRSLEDPSKQGNPDHYSNRYTGTEDYGGVHINSSIHNKAAYLLAEGGVHHGVQVEGIGREASEQIYYRALTYYVTASTDFSMMKQAAIEAANDLYGEGSKQSASVEKAYEAVGIL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	538 (466)
Sequences:	1690 (1220)
Seq/√Len:	56.5

BACSU - NPRB NPRE

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
376_T	396_S	5.346	1.00
484_A	524_Q	5.206	1.00
177_Y	188_A	4.854	1.00
497_V	501_T	3.915	1.00
188_A	215_I	3.913	1.00
511_I	525_S	3.766	1.00
497_V	509_A	3.753	1.00
391_L	506_M	3.725	1.00
389_G	452_V	3.584	1.00
260_T	301_H	3.467	1.00
310_Y	315_F	3.466	1.00
98_F	118_A	3.435	1.00
311_Y	372_T	3.230	1.00
380_A	493_L	3.179	1.00
176_L	187_L	3.157	1.00
402_M	486_E	3.100	1.00
394_S	459_H	3.031	1.00
496_Y	516_D	3.001	1.00
230_G	298_V	2.788	1.00
484_A	518_Y	2.785	1.00
120_K	124_Q	2.748	1.00
429_D	432_K	2.744	1.00
315_F	487_Q	2.727	1.00
383_L	500_S	2.699	1.00
186_D	208_D	2.652	1.00
401_A	410_I	2.631	1.00
109_P	175_E	2.556	1.00
390_A	455_N	2.536	1.00
175_E	190_L	2.527	1.00
510_A	532_Y	2.498	1.00
458_I	535_V	2.485	1.00
332_H	351_D	2.476	1.00
320_F	374_A	2.351	1.00
310_Y	486_E	2.343	1.00
325_A	374_A	2.323	1.00
143_P	187_L	2.320	1.00
368_A	400_G	2.298	1.00
437_D	444_T	2.264	1.00
502_D	505_M	2.257	1.00
114_E	499_A	2.222	1.00
337_W	341_A	2.171	1.00
202_Y	343_N	2.168	1.00
417_P	422_D	2.147	1.00
329_S	349_Y	2.131	1.00
207_I	214_V	2.124	1.00
444_T	458_I	2.092	1.00
304_A	329_S	2.083	1.00
366_I	414_V	2.071	1.00
463_A	485_S	2.046	1.00
145_I	189_Y	2.042	1.00
190_L	204_H	2.030	1.00
491_R	516_D	2.014	1.00
344_G	377_Q	2.007	1.00
398_I	489_Y	2.001	1.00
416_T	422_D	2.000	1.00
512_E	516_D	1.987	1.00
511_I	529_E	1.985	1.00
311_Y	375_V	1.944	1.00
150_A	154_A	1.934	1.00
333_V	337_W	1.897	1.00
491_R	495_Y	1.858	1.00
341_A	348_V	1.857	0.99
330_T	346_Q	1.855	0.99
300_A	331_V	1.826	0.99
384_Y	456_S	1.794	0.99
191_V	207_I	1.762	0.99
320_F	325_A	1.759	0.99
85_V	99_F	1.754	0.99
80_N	106_K	1.707	0.99
201_G	219_N	1.707	0.99
466_L	528_V	1.702	0.99
230_G	233_G	1.692	0.99
377_Q	381_G	1.685	0.99
330_T	348_V	1.683	0.99
146_S	149_K	1.676	0.99
204_H	220_A	1.672	0.99
262_D	293_N	1.666	0.99
518_Y	524_Q	1.655	0.99
444_T	447_E	1.650	0.99
179_Y	188_A	1.613	0.99
208_D	215_I	1.612	0.99
85_V	101_L	1.599	0.98
208_D	211_N	1.586	0.98
342_W	377_Q	1.584	0.98
388_P	452_V	1.543	0.98
515_N	525_S	1.531	0.98
368_A	403_A	1.525	0.98
143_P	176_L	1.519	0.98
117_V	125_V	1.517	0.98
230_G	234_D	1.514	0.98
471_V	474_G	1.513	0.98
216_E	385_Q	1.511	0.98
409_E	432_K	1.504	0.98
426_S	432_K	1.458	0.97
307_V	311_Y	1.448	0.97
442_R	445_G	1.443	0.97
90_K	97_T	1.441	0.97
111_Y	177_Y	1.438	0.97
399_M	493_L	1.435	0.97
470_G	477_V	1.435	0.97
433_Q	436_P	1.423	0.97
315_F	490_Y	1.413	0.97
91_D	98_F	1.394	0.96
459_H	532_Y	1.394	0.96
242_E	245_G	1.385	0.96
241_T	248_Y	1.380	0.96
230_G	236_K	1.372	0.96
338_N	353_D	1.358	0.96
83_F	101_L	1.356	0.96
428_E	432_K	1.356	0.96
437_D	440_S	1.350	0.96
311_Y	399_M	1.348	0.96
91_D	491_R	1.346	0.96
144_S	210_K	1.343	0.95
379_S	494_T	1.342	0.95
472_H	536_G	1.337	0.95
238_F	249_L	1.336	0.95
470_G	475_V	1.331	0.95
242_E	246_R	1.327	0.95
491_R	517_L	1.327	0.95
523_K	527_S	1.319	0.95
118_A	496_Y	1.317	0.95
480_I	484_A	1.317	0.95
459_H	503_F	1.316	0.95
526_A	529_E	1.304	0.95
457_S	460_N	1.302	0.95
280_Y	285_I	1.301	0.95
462_A	466_L	1.286	0.94
532_Y	537_I	1.281	0.94
525_S	529_E	1.269	0.94
308_Y	319_S	1.268	0.94
501_T	505_M	1.266	0.94
140_S	210_K	1.265	0.94
456_S	460_N	1.264	0.94
526_A	530_K	1.263	0.94
229_I	235_E	1.252	0.93
118_A	129_F	1.252	0.93
280_Y	294_E	1.250	0.93
462_A	528_V	1.249	0.93
192_R	202_Y	1.243	0.93
251_D	254_R	1.242	0.93
398_I	463_A	1.236	0.93
507_K	533_E	1.227	0.93
437_D	447_E	1.223	0.93
63_F	101_L	1.223	0.93
338_N	357_F	1.222	0.93
99_F	119_M	1.200	0.92
157_E	205_Y	1.197	0.92
399_M	486_E	1.197	0.92
180_P	185_Y	1.192	0.92
100_K	116_A	1.184	0.91
333_V	341_A	1.178	0.91
240_V	247_F	1.172	0.91
376_T	493_L	1.171	0.91
514_A	524_Q	1.168	0.91
439_Y	442_R	1.165	0.91
297_A	331_V	1.163	0.91
473_H	476_Q	1.160	0.90
492_A	497_V	1.160	0.90
381_G	499_A	1.160	0.90
372_T	399_M	1.159	0.90
337_W	351_D	1.154	0.90
394_S	398_I	1.152	0.90
46_E	49_P	1.152	0.90
370_E	373_H	1.151	0.90
192_R	204_H	1.139	0.90
193_L	205_Y	1.133	0.89
230_G	299_D	1.131	0.89
436_P	440_S	1.126	0.89
315_F	486_E	1.124	0.89
111_Y	206_F	1.123	0.89
426_S	433_Q	1.119	0.89
282_G	285_I	1.118	0.89
437_D	441_N	1.113	0.89
321_D	378_Y	1.110	0.88
318_D	321_D	1.108	0.88
439_Y	472_H	1.107	0.88
296_A	359_P	1.107	0.88
496_Y	509_A	1.107	0.88
435_N	457_S	1.104	0.88
314_T	402_M	1.103	0.88
387_E	439_Y	1.101	0.88
347_M	360_L	1.094	0.88
227_T	230_G	1.092	0.88
406_D	482_R	1.092	0.88
228_G	298_V	1.090	0.87
318_D	324_G	1.087	0.87
339_N	453_H	1.087	0.87
304_A	349_Y	1.085	0.87
496_Y	513_A	1.080	0.87
401_A	407_D	1.080	0.87
179_Y	206_F	1.078	0.87
176_L	180_P	1.075	0.87
300_A	329_S	1.074	0.87
471_V	475_V	1.073	0.87
247_F	251_D	1.070	0.87
226_G	240_V	1.070	0.87
153_T	156_R	1.069	0.86
57_T	71_T	1.066	0.86
149_K	152_H	1.065	0.86
237_S	240_V	1.065	0.86
187_L	209_A	1.064	0.86
120_K	126_K	1.063	0.86
321_D	325_A	1.056	0.86
314_T	483_E	1.050	0.85
157_E	217_S	1.050	0.85
392_N	396_S	1.040	0.85
280_Y	284_E	1.036	0.85
301_H	305_Q	1.032	0.84
339_N	452_V	1.030	0.84
368_A	401_A	1.030	0.84
437_D	443_Y	1.026	0.84
240_V	243_Q	1.026	0.84
65_Y	69_H	1.026	0.84
310_Y	314_T	1.026	0.84
496_Y	512_E	1.024	0.84
367_V	371_I	1.022	0.84
267_N	333_V	1.022	0.84
94_T	491_R	1.019	0.84
214_V	217_S	1.017	0.84
401_A	404_D	1.015	0.83
221_I	343_N	1.010	0.83
243_Q	248_Y	1.010	0.83
529_E	533_E	1.006	0.83
524_Q	527_S	1.002	0.83
391_L	503_F	1.002	0.83
410_I	424_L	0.994	0.82
380_A	497_V	0.993	0.82
227_T	235_E	0.993	0.82
492_A	510_A	0.988	0.82
512_E	515_N	0.986	0.82
461_K	465_L	0.983	0.81
108_I	187_L	0.981	0.81
241_T	252_E	0.979	0.81
384_Y	460_N	0.975	0.81
466_L	485_S	0.975	0.81
347_M	371_I	0.975	0.81
430_P	535_V	0.973	0.81
437_D	458_I	0.973	0.81
174_G	191_V	0.971	0.81
333_V	348_V	0.971	0.81
330_T	333_V	0.970	0.81
338_N	416_T	0.966	0.80
465_L	535_V	0.964	0.80
409_E	426_S	0.964	0.80
267_N	334_G	0.961	0.80
530_K	533_E	0.961	0.80
386_G	447_E	0.959	0.80
389_G	411_G	0.958	0.80
472_H	475_V	0.956	0.80
374_A	378_Y	0.956	0.80
395_I	489_Y	0.954	0.79
387_E	452_V	0.953	0.79
340_A	411_G	0.951	0.79
398_I	430_P	0.947	0.79
310_Y	399_M	0.945	0.79
243_Q	247_F	0.943	0.79
398_I	459_H	0.942	0.79
243_Q	246_R	0.940	0.78
431_S	441_N	0.928	0.78
415_Y	422_D	0.928	0.78
151_I	172_P	0.926	0.77
84_R	104_V	0.926	0.77
202_Y	220_A	0.925	0.77
528_V	537_I	0.923	0.77
409_E	412_E	0.917	0.77
206_F	218_F	0.915	0.77
118_A	516_D	0.915	0.77
510_A	528_V	0.914	0.76
508_Q	512_E	0.914	0.76
440_S	443_Y	0.912	0.76
179_Y	215_I	0.910	0.76
466_L	531_A	0.910	0.76
82_H	104_V	0.907	0.76
287_S	291_V	0.907	0.76
376_T	392_N	0.906	0.76
329_S	367_V	0.902	0.76
389_G	456_S	0.902	0.76
391_L	501_T	0.902	0.76
176_L	209_A	0.901	0.75
402_M	482_R	0.900	0.75
507_K	511_I	0.898	0.75
230_G	235_E	0.898	0.75
489_Y	531_A	0.896	0.75
382_L	388_P	0.891	0.75
492_A	509_A	0.890	0.75
463_A	467_A	0.887	0.74
128_F	134_P	0.881	0.74
145_I	212_G	0.881	0.74
465_L	470_G	0.877	0.73
436_P	439_Y	0.876	0.73
314_T	487_Q	0.874	0.73
145_I	153_T	0.871	0.73
392_N	456_S	0.870	0.73
423_S	426_S	0.870	0.73
317_R	490_Y	0.868	0.73
377_Q	392_N	0.867	0.73
465_L	534_A	0.866	0.72
241_T	250_A	0.865	0.72
402_M	463_A	0.863	0.72
300_A	361_S	0.862	0.72
480_I	524_Q	0.862	0.72
443_Y	446_T	0.858	0.72
322_Q	490_Y	0.856	0.72
149_K	153_T	0.856	0.72
125_V	128_F	0.855	0.72
468_E	482_R	0.855	0.72
438_H	536_G	0.852	0.71
384_Y	389_G	0.852	0.71
248_Y	279_G	0.848	0.71
240_V	245_G	0.847	0.71
469_G	527_S	0.846	0.71
458_I	503_F	0.844	0.71
86_S	102_T	0.833	0.70
394_S	532_Y	0.831	0.69
289_T	292_F	0.831	0.69
230_G	295_P	0.827	0.69
108_I	178_I	0.824	0.69
255_G	261_F	0.823	0.69
338_N	415_Y	0.821	0.68
228_G	231_V	0.819	0.68
329_S	371_I	0.818	0.68
469_G	534_A	0.815	0.68
111_Y	383_L	0.814	0.68
436_P	455_N	0.808	0.67
458_I	462_A	0.808	0.67
416_T	423_S	0.805	0.67
245_G	251_D	0.802	0.67
229_I	233_G	0.801	0.67
49_P	54_Q	0.801	0.67
384_Y	388_P	0.800	0.66
314_T	486_E	0.798	0.66
402_M	467_A	0.798	0.66
347_M	374_A	0.797	0.66
141_V	178_I	0.797	0.66
427_L	460_N	0.795	0.66
154_A	205_Y	0.795	0.66
376_T	379_S	0.794	0.66
372_T	395_I	0.793	0.66
409_E	423_S	0.793	0.66
415_Y	423_S	0.792	0.66
436_P	443_Y	0.792	0.66
389_G	392_N	0.790	0.65
318_D	322_Q	0.790	0.65
280_Y	283_K	0.787	0.65
431_S	461_K	0.787	0.65
309_D	313_K	0.786	0.65
314_T	322_Q	0.784	0.65
410_I	427_L	0.782	0.65
382_L	456_S	0.781	0.65
303_N	367_V	0.781	0.65
178_I	185_Y	0.778	0.64
158_L	193_L	0.777	0.64
505_M	508_Q	0.777	0.64
398_I	464_Y	0.776	0.64
48_S	54_Q	0.771	0.64
387_E	442_R	0.771	0.64
241_T	245_G	0.770	0.63
49_P	68_K	0.769	0.63
338_N	360_L	0.768	0.63
471_V	476_Q	0.768	0.63
310_Y	487_Q	0.768	0.63
366_I	424_L	0.766	0.63
384_Y	452_V	0.765	0.63
279_G	282_G	0.764	0.63
507_K	532_Y	0.754	0.62
488_I	524_Q	0.753	0.62
296_A	299_D	0.750	0.61
153_T	157_E	0.750	0.61
145_I	149_K	0.750	0.61
254_R	257_G	0.749	0.61
239_D	258_I	0.747	0.61
229_I	298_V	0.747	0.61
76_K	81_S	0.746	0.61
459_H	510_A	0.744	0.61
382_L	460_N	0.743	0.61
337_W	348_V	0.740	0.60
375_V	399_M	0.739	0.60
55_N	59_K	0.739	0.60
232_S	235_E	0.738	0.60
260_T	297_A	0.736	0.60
202_Y	377_Q	0.734	0.60
115_Q	128_F	0.734	0.60
228_G	232_S	0.732	0.60
441_N	444_T	0.732	0.60
411_G	414_V	0.731	0.59
360_L	424_L	0.729	0.59
242_E	248_Y	0.726	0.59
488_I	514_A	0.726	0.59
483_E	486_E	0.725	0.59
202_Y	221_I	0.723	0.59
439_Y	443_Y	0.723	0.59
58_Q	61_S	0.723	0.59
411_G	452_V	0.722	0.58
186_D	213_K	0.721	0.58
491_R	513_A	0.721	0.58
253_T	257_G	0.721	0.58
409_E	428_E	0.719	0.58
350_G	360_L	0.719	0.58
238_F	243_Q	0.719	0.58
263_A	269_T	0.717	0.58
342_W	374_A	0.714	0.58
105_Y	110_I	0.714	0.58
254_R	309_D	0.713	0.58
171_E	174_G	0.713	0.58
364_L	404_D	0.711	0.57
357_F	424_L	0.710	0.57
393_E	397_D	0.707	0.57
392_N	493_L	0.704	0.57
462_A	535_V	0.702	0.56
484_A	488_I	0.702	0.56
56_T	60_E	0.702	0.56
240_V	251_D	0.701	0.56
356_K	415_Y	0.699	0.56
53_V	61_S	0.699	0.56
197_E	200_P	0.698	0.56
262_D	265_N	0.696	0.56
69_H	73_F	0.696	0.56
267_N	337_W	0.694	0.55
236_K	240_V	0.694	0.55
238_F	242_E	0.692	0.55
80_N	152_H	0.691	0.55
154_A	193_L	0.688	0.55
296_A	361_S	0.686	0.55
56_T	64_S	0.684	0.54
226_G	230_G	0.683	0.54
57_T	60_E	0.681	0.54
463_A	535_V	0.680	0.54
447_E	454_I	0.679	0.54
438_H	442_R	0.678	0.54
357_F	415_Y	0.677	0.54
130_G	536_G	0.676	0.54
399_M	490_Y	0.675	0.53
436_P	454_I	0.674	0.53
106_K	178_I	0.673	0.53
306_A	363_S	0.673	0.53
117_V	150_A	0.673	0.53
176_L	189_Y	0.673	0.53
177_Y	215_I	0.672	0.53
319_S	325_A	0.672	0.53
364_L	423_S	0.671	0.53
260_T	349_Y	0.670	0.53
174_G	513_A	0.669	0.53
440_S	447_E	0.669	0.53
141_V	187_L	0.669	0.53
53_V	56_T	0.668	0.53
247_F	488_I	0.668	0.53
338_N	356_K	0.666	0.52
349_Y	371_I	0.666	0.52
372_T	375_V	0.665	0.52
241_T	253_T	0.663	0.52
228_G	277_L	0.662	0.52
116_A	498_T	0.661	0.52
372_T	376_T	0.661	0.52
475_V	530_K	0.660	0.52
513_A	516_D	0.658	0.52
135_Q	138_D	0.658	0.52
497_V	510_A	0.658	0.52
195_T	198_P	0.658	0.52
231_V	295_P	0.658	0.52
463_A	486_E	0.657	0.51
437_D	442_R	0.657	0.51
231_V	234_D	0.655	0.51
467_A	485_S	0.654	0.51
353_D	422_D	0.653	0.51
513_A	517_L	0.652	0.51
379_S	493_L	0.651	0.51
341_A	424_L	0.650	0.51
278_I	282_G	0.650	0.51
240_V	244_N	0.648	0.50
57_T	73_F	0.647	0.50
250_A	259_N	0.647	0.50
144_S	149_K	0.646	0.50
152_H	156_R	0.646	0.50
363_S	412_E	0.644	0.50
53_V	57_T	0.644	0.50
369_H	373_H	0.641	0.50
60_E	64_S	0.640	0.50
368_A	464_Y	0.640	0.50
489_Y	510_A	0.637	0.49
92_P	95_K	0.637	0.49
320_F	378_Y	0.633	0.49
407_D	468_E	0.633	0.49
519_G	524_Q	0.633	0.49
408_W	468_E	0.633	0.49
401_A	412_E	0.632	0.49
495_Y	513_A	0.630	0.49
294_E	298_V	0.629	0.48
431_S	437_D	0.629	0.48
143_P	210_K	0.629	0.48
463_A	466_L	0.629	0.48
153_T	207_I	0.628	0.48
72_Q	410_I	0.626	0.48
477_V	527_S	0.625	0.48
241_T	251_D	0.625	0.48
442_R	503_F	0.625	0.48
313_K	487_Q	0.623	0.48
487_Q	494_T	0.623	0.48
488_I	510_A	0.622	0.48
369_H	397_D	0.621	0.48
304_A	371_I	0.621	0.48
240_V	249_L	0.620	0.47
228_G	233_G	0.619	0.47
319_S	324_G	0.619	0.47
394_S	460_N	0.618	0.47
148_K	151_I	0.616	0.47
203_W	217_S	0.616	0.47
353_D	414_V	0.615	0.47
483_E	487_Q	0.614	0.47
337_W	360_L	0.613	0.47
55_N	58_Q	0.613	0.47
230_G	240_V	0.613	0.47
441_N	458_I	0.610	0.46
70_Q	75_L	0.609	0.46
511_I	528_V	0.609	0.46
527_S	531_A	0.608	0.46
311_Y	490_Y	0.608	0.46
200_P	337_W	0.607	0.46
312_S	432_K	0.606	0.46
75_L	83_F	0.605	0.46
58_Q	99_F	0.605	0.46
241_T	244_N	0.601	0.45
440_S	446_T	0.601	0.45
341_A	360_L	0.600	0.45
105_Y	136_I	0.600	0.45
55_N	64_S	0.599	0.45
511_I	533_E	0.599	0.45
190_L	206_F	0.599	0.45
304_A	361_S	0.598	0.45
260_T	263_A	0.598	0.45
50_Q	60_E	0.597	0.45
332_H	350_G	0.597	0.45
357_F	361_S	0.596	0.45
242_E	247_F	0.595	0.45
150_A	212_G	0.594	0.45
370_E	393_E	0.594	0.45
401_A	406_D	0.594	0.45
138_D	182_D	0.593	0.45
325_A	378_Y	0.593	0.45
154_A	191_V	0.592	0.44
475_V	533_E	0.592	0.44
373_H	393_E	0.591	0.44
300_A	360_L	0.591	0.44
170_G	193_L	0.591	0.44
239_D	242_E	0.590	0.44
410_I	482_R	0.589	0.44
259_N	266_L	0.589	0.44
83_F	519_G	0.588	0.44
371_I	374_A	0.587	0.44
501_T	513_A	0.587	0.44
97_T	223_E	0.585	0.44
75_L	132_V	0.584	0.44
430_P	461_K	0.583	0.43
491_R	496_Y	0.583	0.43
357_F	366_I	0.583	0.43
376_T	460_N	0.582	0.43
232_S	236_K	0.582	0.43
132_V	138_D	0.580	0.43
398_I	486_E	0.580	0.43
430_P	457_S	0.579	0.43
466_L	527_S	0.579	0.43
309_D	511_I	0.579	0.43
265_N	293_N	0.577	0.43
91_D	118_A	0.576	0.43
241_T	246_R	0.576	0.43
83_F	124_Q	0.576	0.43
465_L	468_E	0.576	0.43
226_G	280_Y	0.575	0.43
98_F	129_F	0.574	0.42
62_L	85_V	0.574	0.42
382_L	396_S	0.574	0.42
122_N	208_D	0.574	0.42
309_D	323_N	0.574	0.42
263_A	348_V	0.574	0.42
395_I	398_I	0.571	0.42
459_H	506_M	0.571	0.42
70_Q	74_K	0.569	0.42
353_D	424_L	0.568	0.42
408_W	430_P	0.567	0.42
53_V	64_S	0.567	0.42
62_L	117_V	0.564	0.41
310_Y	483_E	0.564	0.41
300_A	304_A	0.564	0.41
211_N	375_V	0.563	0.41
428_E	464_Y	0.563	0.41
239_D	257_G	0.562	0.41
331_V	361_S	0.557	0.41
105_Y	185_Y	0.557	0.41
307_V	403_A	0.555	0.40
338_N	414_V	0.555	0.40
267_N	336_Q	0.555	0.40
387_E	459_H	0.554	0.40
488_I	528_V	0.553	0.40
244_N	248_Y	0.553	0.40
394_S	456_S	0.552	0.40
83_F	103_E	0.552	0.40
176_L	179_Y	0.552	0.40
261_F	277_L	0.552	0.40
395_I	506_M	0.552	0.40
102_T	114_E	0.551	0.40
177_Y	206_F	0.551	0.40
260_T	304_A	0.550	0.40
386_G	454_I	0.550	0.40
258_I	327_I	0.550	0.40
319_S	323_N	0.547	0.40
57_T	181_H	0.546	0.40
338_N	417_P	0.545	0.39
333_V	351_D	0.544	0.39
396_S	493_L	0.543	0.39
443_Y	447_E	0.543	0.39
388_P	460_N	0.543	0.39
329_S	347_M	0.542	0.39
318_D	325_A	0.542	0.39
485_S	532_Y	0.542	0.39
308_Y	325_A	0.539	0.39
404_D	412_E	0.538	0.39
238_F	244_N	0.538	0.39
370_E	397_D	0.538	0.39
384_Y	396_S	0.537	0.39
240_V	285_I	0.537	0.39
285_I	292_F	0.536	0.38
373_H	397_D	0.536	0.38
62_L	99_F	0.535	0.38
111_Y	190_L	0.534	0.38
88_T	99_F	0.533	0.38
430_P	463_A	0.533	0.38
335_K	341_A	0.533	0.38
157_E	372_T	0.532	0.38
384_Y	455_N	0.532	0.38
229_I	232_S	0.531	0.38
312_S	316_G	0.531	0.38
358_K	416_T	0.530	0.38
292_F	295_P	0.528	0.38
144_S	168_L	0.528	0.38
317_R	379_S	0.527	0.38
368_A	404_D	0.527	0.38
408_W	464_Y	0.526	0.37
320_F	396_S	0.526	0.37
116_A	129_F	0.526	0.37
269_T	272_T	0.525	0.37
244_N	247_F	0.525	0.37
143_P	161_S	0.525	0.37
132_V	136_I	0.525	0.37
462_A	489_Y	0.524	0.37
138_D	141_V	0.524	0.37
108_I	183_G	0.524	0.37
67_D	72_Q	0.523	0.37
442_R	446_T	0.522	0.37
353_D	357_F	0.522	0.37
103_E	374_A	0.521	0.37
261_F	330_T	0.521	0.37
435_N	454_I	0.521	0.37
501_T	506_M	0.520	0.37
278_I	281_T	0.519	0.37
151_I	174_G	0.519	0.37
465_L	469_G	0.518	0.37
457_S	461_K	0.517	0.37
281_T	284_E	0.517	0.37
387_E	504_S	0.517	0.37
306_A	364_L	0.516	0.36
260_T	329_S	0.515	0.36
228_G	238_F	0.515	0.36
146_S	156_R	0.515	0.36
177_Y	302_A	0.514	0.36
426_S	454_I	0.514	0.36
308_Y	317_R	0.514	0.36
279_G	283_K	0.514	0.36
443_Y	454_I	0.513	0.36
259_N	326_R	0.513	0.36
361_S	367_V	0.513	0.36
514_A	520_E	0.513	0.36
255_G	309_D	0.512	0.36
70_Q	132_V	0.511	0.36
54_Q	61_S	0.511	0.36
483_E	518_Y	0.511	0.36
386_G	455_N	0.510	0.36
208_D	212_G	0.509	0.36
439_Y	536_G	0.509	0.36
353_D	415_Y	0.509	0.36
461_K	535_V	0.508	0.36
426_S	455_N	0.508	0.36
309_D	312_S	0.508	0.36
140_S	187_L	0.507	0.36
194_S	202_Y	0.507	0.36
86_S	152_H	0.507	0.36
83_F	158_L	0.506	0.35
490_Y	494_T	0.506	0.35
363_S	376_T	0.505	0.35
457_S	535_V	0.505	0.35
101_L	104_V	0.505	0.35
340_A	425_R	0.504	0.35
382_L	497_V	0.503	0.35
226_G	241_T	0.502	0.35
238_F	247_F	0.502	0.35
231_V	361_S	0.502	0.35
286_V	289_T	0.502	0.35
59_K	63_F	0.502	0.35
497_V	505_M	0.500	0.35
79_A	84_R	0.500	0.35

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4gerA	1	0.5651	100	0.396	Contact Map
4n4eE	1	0.5781	100	0.404	Contact Map
1bqbA	1	0.5502	100	0.423	Contact Map
3nqxA	1	0.5242	100	0.483	Contact Map
2vqxA	1	0.5632	100	0.488	Contact Map
4k89A	1	0.5279	100	0.497	Contact Map
4k90A	1	0.5929	100	0.508	Contact Map
3nqzA	1	0.3197	100	0.788	Contact Map
4k90B	1	0.3253	99.9	0.809	Contact Map
2o3oA	2	0.368	98.4	0.921	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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