GREMLIN Database
DACC - D-alanyl-D-alanine carboxypeptidase DacC
UniProt: P39844 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 491 (442)
Sequences: 1512 (1204)
Seq/√Len: 57.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_S451_S5.3131.00
108_D119_N4.9541.00
56_G387_S4.8451.00
325_M409_S4.6911.00
70_E73_G4.0371.00
61_S460_K4.0261.00
326_K421_G3.8461.00
56_G77_M3.5221.00
77_M387_S3.5061.00
213_P230_A3.4421.00
153_N298_K3.4151.00
88_A324_F3.3131.00
74_D388_D3.1751.00
138_M310_L3.0431.00
62_A463_V3.0401.00
101_F339_E2.9321.00
337_V353_G2.7491.00
109_G116_L2.7431.00
451_S465_S2.7331.00
59_V462_L2.7181.00
58_T391_S2.6841.00
88_A325_M2.6811.00
129_T320_L2.6081.00
82_S390_L2.6011.00
125_K160_W2.5381.00
233_T237_S2.5231.00
153_N295_G2.5151.00
456_T462_L2.4621.00
427_R482_D2.4401.00
449_S467_L2.4041.00
107_T309_L2.3941.00
187_T335_V2.3891.00
117_N151_K2.3641.00
411_P439_A2.2861.00
424_L439_A2.2721.00
82_S465_S2.2641.00
106_R123_K2.2591.00
390_L467_L2.2211.00
391_S463_V2.2011.00
102_T313_R2.1561.00
142_L145_S2.1291.00
190_P329_N2.1081.00
439_A450_L2.0751.00
54_M72_S2.0721.00
394_L453_Y2.0551.00
439_A464_F2.0541.00
167_S170_M2.0071.00
119_N153_N1.9971.00
119_N152_G1.9781.00
149_V294_K1.9741.00
412_V421_G1.9651.00
391_S465_S1.9561.00
89_A397_I1.9541.00
437_V464_F1.9511.00
86_L393_L1.9211.00
85_L393_L1.9101.00
188_A281_L1.9061.00
88_A321_F1.8621.00
308_V311_S1.8621.00
112_K117_N1.8571.00
455_E461_K1.8400.99
105_V138_M1.8290.99
143_K148_K1.8160.99
108_D121_Y1.8050.99
58_T67_V1.7970.99
124_G186_L1.7970.99
86_L385_V1.7960.99
324_F333_A1.7870.99
85_L410_L1.7870.99
341_G353_G1.7830.99
104_E123_K1.7700.99
134_D312_H1.7470.99
387_S467_L1.7440.99
142_L291_I1.7300.99
303_P306_S1.7300.99
106_R306_S1.7260.99
161_H339_E1.7250.99
72_S75_T1.7230.99
395_Y463_V1.7120.99
118_G152_G1.7100.99
139_A282_F1.7070.99
205_P232_T1.6710.99
139_A289_Q1.6450.99
111_L114_K1.6420.99
60_R391_S1.6420.99
140_E289_Q1.6300.99
61_S64_T1.6120.99
149_V292_T1.5980.99
424_L450_L1.5840.98
122_L278_A1.5800.98
115_K149_V1.5780.98
86_L390_L1.5760.98
441_T450_L1.5610.98
106_R308_V1.5540.98
67_V70_E1.5400.98
431_T434_Q1.5330.98
210_G232_T1.5070.98
160_W342_K1.5030.98
187_T331_G1.5010.98
105_V142_L1.4980.98
109_G118_G1.4950.98
143_K289_Q1.4850.98
93_S400_Q1.4750.98
135_F188_A1.4640.97
466_I481_E1.4620.97
213_P254_I1.4580.97
406_Y453_Y1.4510.97
158_D275_A1.4470.97
431_T486_V1.4260.97
450_L485_A1.4230.97
403_F407_L1.4220.97
100_S313_R1.4120.97
75_T387_S1.4120.97
147_V309_L1.4100.97
437_V485_A1.4090.97
122_L154_L1.4080.97
111_L116_L1.4070.97
102_T311_S1.4030.97
286_L291_I1.3970.97
398_Q461_K1.3900.96
324_F332_H1.3820.96
396_D400_Q1.3820.96
337_V376_G1.3820.96
206_N232_T1.3770.96
471_L477_G1.3690.96
111_L147_V1.3610.96
347_E352_K1.3450.96
394_L451_S1.3410.96
121_Y303_P1.3400.96
437_V454_A1.3340.95
315_M319_K1.3280.95
83_L383_D1.3190.95
170_M375_D1.3180.95
94_V340_M1.3160.95
323_P327_L1.2850.94
104_E125_K1.2810.94
169_D382_I1.2630.94
424_L428_M1.2600.94
158_D184_S1.2600.94
337_V354_L1.2560.94
206_N211_E1.2500.94
448_S478_K1.2500.94
407_L438_R1.2380.93
448_S481_E1.2350.93
436_K455_E1.2320.93
131_L134_D1.2310.93
92_L409_S1.2120.93
142_L147_V1.2120.93
129_T332_H1.2120.93
68_L462_L1.2050.92
341_G356_V1.2000.92
90_A340_M1.1970.92
337_V357_L1.1940.92
55_A468_L1.1880.92
61_S66_A1.1730.91
334_E377_S1.1620.91
156_G279_L1.1600.91
279_L297_I1.1570.91
157_D160_W1.1540.91
273_E276_G1.1540.91
40_I484_I1.1530.91
397_I402_W1.1500.90
230_A254_I1.1470.90
60_R395_Y1.1460.90
233_T257_S1.1440.90
123_K157_D1.1420.90
118_G147_V1.1400.90
179_Y379_I1.1290.90
142_L309_L1.1280.90
329_N332_H1.1270.89
207_Q210_G1.1260.89
78_R384_A1.1100.89
82_S449_S1.1100.89
58_T463_V1.0990.88
478_K481_E1.0980.88
157_D161_H1.0940.88
116_L152_G1.0920.88
94_V360_T1.0890.88
482_D485_A1.0890.88
390_L451_S1.0850.88
381_H444_L1.0770.87
62_A395_Y1.0770.87
280_D284_Q1.0730.87
334_E350_W1.0710.87
57_I466_I1.0700.87
143_K291_I1.0630.87
414_G423_T1.0550.86
443_S448_S1.0510.86
86_L373_L1.0460.86
454_A485_A1.0420.85
156_G186_L1.0350.85
334_E375_D1.0350.85
93_S360_T1.0250.84
62_A398_Q1.0210.84
236_G261_D1.0150.84
92_L97_E1.0140.84
99_Y339_E1.0070.83
413_A424_L1.0030.83
338_K350_W1.0030.83
321_F409_S1.0020.83
178_Y192_E0.9970.83
91_A95_L0.9960.83
54_M470_G0.9890.82
270_S443_S0.9880.82
54_M75_T0.9760.81
341_G348_G0.9710.81
331_G335_V0.9690.81
130_L135_F0.9680.81
167_S172_W0.9680.81
136_D288_K0.9680.81
190_P332_H0.9680.81
41_D69_Y0.9670.81
325_M410_L0.9660.81
213_P258_V0.9650.81
125_K335_V0.9610.80
354_L373_L0.9570.80
368_S371_L0.9490.80
58_T70_E0.9480.80
131_L190_P0.9460.79
39_Q487_I0.9460.79
410_L424_L0.9450.79
381_H384_A0.9440.79
227_K251_T0.9420.79
96_G314_S0.9390.79
107_T116_L0.9390.79
277_Y281_L0.9380.79
107_T110_T0.9360.79
360_T364_F0.9310.78
346_G352_K0.9310.78
135_F285_S0.9290.78
104_E311_S0.9290.78
366_V393_L0.9280.78
429_K434_Q0.9260.78
201_V254_I0.9260.78
170_M334_E0.9200.77
201_V252_I0.9190.77
171_P180_G0.9190.77
390_L465_S0.9160.77
104_E308_V0.9160.77
123_K302_A0.9140.77
386_S389_Q0.9130.77
241_L245_R0.9120.77
377_S383_D0.9120.77
183_I335_V0.9080.77
138_M312_H0.9070.76
119_N155_I0.9030.76
184_S270_S0.9030.76
157_D185_A0.9020.76
37_S41_D0.9020.76
60_R463_V0.8960.76
181_A277_Y0.8940.75
132_P189_S0.8930.75
110_T116_L0.8930.75
426_N429_K0.8930.75
200_I268_W0.8930.75
172_W384_A0.8890.75
229_D253_T0.8880.75
121_Y302_A0.8870.75
480_I484_I0.8850.75
82_S467_L0.8850.75
229_D255_E0.8840.75
67_V71_H0.8840.75
170_M379_I0.8800.74
370_S389_Q0.8790.74
151_K294_K0.8760.74
105_V147_V0.8760.74
167_S180_G0.8760.74
321_F336_L0.8760.74
203_V215_V0.8710.73
468_L481_E0.8680.73
101_F125_K0.8670.73
413_A437_V0.8670.73
167_S173_S0.8650.73
203_V241_L0.8600.73
162_D338_K0.8560.72
99_Y343_V0.8550.72
90_A357_L0.8540.72
321_F325_M0.8530.72
54_M77_M0.8510.72
34_D38_G0.8510.72
356_V359_S0.8500.72
136_D285_S0.8470.71
167_S171_P0.8470.71
116_L147_V0.8440.71
172_W375_D0.8430.71
348_G352_K0.8410.71
326_K412_V0.8380.71
70_E388_D0.8370.70
413_A428_M0.8350.70
122_L282_F0.8330.70
340_M357_L0.8300.70
115_K118_G0.8280.70
203_V230_A0.8270.70
368_S385_V0.8250.69
414_G422_G0.8220.69
138_M142_L0.8170.69
453_Y469_N0.8170.69
124_G282_F0.8170.69
116_L120_L0.8160.69
80_A379_I0.8120.68
205_P263_N0.8080.68
190_P327_L0.8050.67
371_L389_Q0.8030.67
78_R381_H0.8000.67
80_A330_N0.7990.67
341_G352_K0.7990.67
81_S84_K0.7980.67
136_D140_E0.7960.67
366_V369_K0.7950.66
433_A454_A0.7930.66
392_Q395_Y0.7930.66
97_E303_P0.7910.66
286_L293_V0.7890.66
36_L44_L0.7880.66
58_T388_D0.7870.66
316_P319_K0.7830.65
170_M174_D0.7830.65
184_S187_T0.7810.65
391_S395_Y0.7790.65
361_L366_V0.7780.65
78_R469_N0.7770.65
243_I269_I0.7770.65
375_D383_D0.7740.64
233_T259_P0.7700.64
153_N296_D0.7700.64
171_P382_I0.7630.63
130_L435_G0.7610.63
188_A278_A0.7570.63
116_L119_N0.7560.63
116_L150_I0.7560.63
117_N149_V0.7560.63
178_Y191_N0.7500.62
85_L406_Y0.7500.62
80_A328_S0.7470.62
204_T214_A0.7460.62
455_E459_G0.7430.61
240_D257_S0.7410.61
364_F396_D0.7410.61
206_N209_E0.7390.61
91_A119_N0.7390.61
338_K348_G0.7390.61
136_D289_Q0.7380.61
348_G353_G0.7370.61
92_L406_Y0.7370.61
450_L464_F0.7350.60
328_S442_G0.7330.60
285_S288_K0.7330.60
447_V469_N0.7320.60
180_G375_D0.7270.60
385_V390_L0.7250.59
174_D180_G0.7250.59
170_M180_G0.7250.59
161_H185_A0.7230.59
483_Q486_V0.7220.59
120_L150_I0.7180.59
110_T114_K0.7180.59
327_L332_H0.7160.58
97_E288_K0.7150.58
479_D483_Q0.7150.58
89_A393_L0.7140.58
265_T269_I0.7140.58
59_V291_I0.7140.58
427_R441_T0.7140.58
129_T314_S0.7130.58
58_T73_G0.7130.58
150_I293_V0.7120.58
124_G156_G0.7120.58
199_V269_I0.7120.58
339_E343_V0.7120.58
239_K259_P0.7120.58
191_N383_D0.7110.58
109_G115_K0.7070.57
115_K151_K0.7070.57
61_S458_S0.7060.57
203_V254_I0.7050.57
114_K118_G0.7030.57
162_D349_S0.7020.57
95_L339_E0.7000.57
326_K411_P0.6980.56
321_F398_Q0.6960.56
355_E359_S0.6960.56
183_I338_K0.6950.56
328_S440_K0.6930.56
443_S447_V0.6930.56
99_Y125_K0.6920.56
107_T141_I0.6910.56
241_L254_I0.6910.56
203_V252_I0.6890.55
456_T459_G0.6880.55
129_T315_M0.6870.55
190_P323_P0.6860.55
87_T337_V0.6860.55
118_G155_I0.6860.55
338_K353_G0.6850.55
368_S389_Q0.6850.55
366_V396_D0.6830.55
106_R122_L0.6830.55
56_G224_I0.6810.55
83_L373_L0.6800.54
414_G434_Q0.6790.54
83_L385_V0.6780.54
324_F329_N0.6770.54
326_K441_T0.6740.54
105_V282_F0.6740.54
464_F485_A0.6730.54
413_A433_A0.6720.54
154_L298_K0.6720.54
433_A485_A0.6720.54
182_P272_W0.6710.54
450_L454_A0.6700.53
434_Q486_V0.6670.53
110_T117_N0.6660.53
39_Q42_K0.6640.53
122_L138_M0.6640.53
173_S374_R0.6620.53
123_K306_S0.6620.53
202_E266_K0.6610.52
330_N442_G0.6600.52
126_G161_H0.6580.52
175_E331_G0.6580.52
450_L462_L0.6550.52
241_L257_S0.6550.52
148_K284_Q0.6550.52
353_G356_V0.6550.52
180_G270_S0.6550.52
483_Q487_I0.6540.52
185_A349_S0.6530.52
66_A460_K0.6510.51
109_G121_Y0.6490.51
468_L471_L0.6490.51
330_N440_K0.6490.51
170_M383_D0.6460.51
448_S466_I0.6460.51
118_G146_G0.6420.50
145_S309_L0.6400.50
87_T340_M0.6380.50
121_Y306_S0.6370.50
254_I317_L0.6360.50
137_K304_S0.6360.50
228_N231_K0.6360.50
170_M175_E0.6360.50
40_I466_I0.6360.50
401_S404_S0.6340.49
90_A360_T0.6340.49
332_H336_L0.6320.49
80_A179_Y0.6300.49
318_S321_F0.6300.49
142_L154_L0.6300.49
96_G127_D0.6280.49
109_G152_G0.6260.49
232_T258_V0.6260.49
439_A466_I0.6250.48
89_A406_Y0.6240.48
145_S148_K0.6240.48
141_I399_D0.6230.48
219_P414_G0.6210.48
158_D185_A0.6200.48
42_K292_T0.6200.48
322_V421_G0.6190.48
237_S257_S0.6180.48
85_L451_S0.6170.48
63_E461_K0.6160.47
41_D71_H0.6160.47
141_I310_L0.6140.47
178_Y190_P0.6140.47
172_W374_R0.6130.47
442_G452_G0.6100.47
135_F138_M0.6100.47
92_L405_A0.6100.47
282_F368_S0.6100.47
225_T251_T0.6080.47
199_V272_W0.6080.47
323_P383_D0.6050.46
381_H446_T0.6030.46
157_D300_G0.6020.46
76_R386_S0.6020.46
276_G279_L0.6020.46
125_K279_L0.6000.46
360_T396_D0.6000.46
160_W185_A0.6000.46
134_D361_L0.5990.46
81_S328_S0.5980.46
411_P424_L0.5980.46
38_G251_T0.5970.45
159_T301_E0.5960.45
326_K427_R0.5950.45
387_S397_I0.5950.45
107_T307_D0.5950.45
424_L441_T0.5950.45
339_E342_K0.5940.45
92_L402_W0.5940.45
185_A348_G0.5920.45
74_D476_D0.5910.45
443_S449_S0.5910.45
352_K355_E0.5900.45
108_D305_S0.5880.44
226_I254_I0.5870.44
458_S473_D0.5860.44
203_V265_T0.5850.44
187_T191_N0.5840.44
439_A485_A0.5840.44
172_W380_S0.5840.44
389_Q392_Q0.5840.44
33_Q37_S0.5840.44
112_K115_K0.5830.44
228_N469_N0.5820.44
57_I423_T0.5810.44
35_A367_D0.5810.44
252_I270_S0.5810.44
124_G334_E0.5810.44
191_N403_F0.5770.43
140_E406_Y0.5770.43
38_G41_D0.5760.43
126_G314_S0.5750.43
345_K352_K0.5740.43
130_L278_A0.5730.43
152_G291_I0.5720.43
155_I298_K0.5720.43
35_A38_G0.5720.43
433_A486_V0.5710.43
147_V152_G0.5710.43
377_S444_L0.5690.42
413_A422_G0.5680.42
253_T366_V0.5680.42
101_F187_T0.5680.42
134_D137_K0.5670.42
107_T308_V0.5670.42
124_G377_S0.5660.42
75_T408_N0.5660.42
39_Q49_A0.5660.42
323_P329_N0.5660.42
74_D386_S0.5650.42
184_S444_L0.5650.42
230_A233_T0.5630.42
326_K420_V0.5630.42
177_T375_D0.5630.42
81_S442_G0.5630.42
261_D307_D0.5620.42
367_D370_S0.5620.42
477_G480_I0.5620.42
188_A240_D0.5610.42
69_Y338_K0.5610.42
137_K140_E0.5600.41
157_D256_G0.5590.41
427_R450_L0.5580.41
317_L321_F0.5570.41
165_R390_L0.5570.41
135_F191_N0.5570.41
374_R383_D0.5570.41
150_I291_I0.5560.41
361_L389_Q0.5560.41
405_A438_R0.5540.41
336_L349_S0.5530.41
50_L68_L0.5510.40
171_P444_L0.5510.40
321_F402_W0.5510.40
239_K265_T0.5500.40
360_T400_Q0.5500.40
111_L145_S0.5490.40
258_V265_T0.5480.40
273_E280_D0.5480.40
266_K467_L0.5480.40
226_I373_L0.5470.40
154_L270_S0.5470.40
177_T267_E0.5470.40
91_A336_L0.5460.40
132_P188_A0.5460.40
100_S153_N0.5460.40
137_K351_E0.5450.40
199_V222_D0.5450.40
99_Y102_T0.5440.40
379_I444_L0.5430.40
126_G315_M0.5420.40
77_M467_L0.5410.39
81_S440_K0.5400.39
346_G410_L0.5400.39
86_L368_S0.5390.39
182_P250_N0.5380.39
267_E331_G0.5380.39
90_A243_I0.5360.39
293_V309_L0.5360.39
185_A300_G0.5360.39
35_A366_V0.5340.39
412_V433_A0.5330.39
396_D399_D0.5330.39
318_S405_A0.5330.39
143_K296_D0.5330.39
58_T387_S0.5320.38
105_V141_I0.5310.38
284_Q287_K0.5300.38
289_Q309_L0.5290.38
390_L393_L0.5290.38
105_V310_L0.5280.38
292_T363_E0.5270.38
309_L319_K0.5260.38
186_L279_L0.5260.38
203_V258_V0.5250.38
43_I68_L0.5250.38
405_A409_S0.5250.38
240_D243_I0.5250.38
81_S330_N0.5250.38
107_T142_L0.5250.38
283_K287_K0.5230.38
324_F337_V0.5220.37
205_P213_P0.5220.37
199_V219_P0.5220.37
175_E182_P0.5190.37
212_E313_R0.5190.37
67_V388_D0.5190.37
107_T248_G0.5190.37
185_A326_K0.5180.37
121_Y387_S0.5180.37
268_W448_S0.5180.37
60_R65_G0.5180.37
128_P332_H0.5170.37
327_L425_R0.5170.37
115_K297_I0.5170.37
371_L385_V0.5160.37
296_D304_S0.5160.37
109_G451_S0.5150.37
133_S190_P0.5140.37
444_L447_V0.5140.37
428_M441_T0.5140.37
340_M353_G0.5130.37
117_N294_K0.5130.37
57_I373_L0.5130.37
41_D45_A0.5130.37
454_A462_L0.5130.37
73_G388_D0.5120.36
130_L485_A0.5120.36
428_M482_D0.5110.36
113_G426_N0.5100.36
245_R252_I0.5100.36
89_A396_D0.5100.36
85_L394_L0.5090.36
141_I144_H0.5080.36
438_R443_S0.5080.36
436_K454_A0.5080.36
178_Y327_L0.5080.36
76_R384_A0.5070.36
223_Y280_D0.5070.36
78_R375_D0.5060.36
96_G99_Y0.5060.36
115_K148_K0.5050.36
274_P334_E0.5050.36
324_F336_L0.5050.36
349_S393_L0.5040.36
74_D307_D0.5040.36
105_V274_P0.5040.36
334_E338_K0.5040.36
480_I483_Q0.5030.36
185_A295_G0.5030.36
102_T123_K0.5020.35
282_F285_S0.5020.35
132_P281_L0.5020.35
55_A139_A0.5020.35
334_E383_D0.5010.35
124_G279_L0.5000.35
131_L332_H0.5000.35
227_K365_G0.5000.35
170_M173_S0.5000.35
107_T121_Y0.5000.35
279_L283_K0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w5dA 1 0.9308 100 0.25 Contact Map
1w79A 1 0.9185 100 0.275 Contact Map
2ex2A 2 0.8921 100 0.319 Contact Map
3a3dA 2 0.8982 100 0.323 Contact Map
3v39A 1 0.7251 100 0.492 Contact Map
4mxgA 1 0.4929 99.9 0.817 Contact Map
1w7fA 1 0.4929 99.9 0.818 Contact Map
4ryeA 1 0.4969 99.9 0.822 Contact Map
2j9oA 1 0.5336 99.9 0.822 Contact Map
3p09A 3 0.4969 99.9 0.822 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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