BLTR - BACSU - GREMLIN Contacts

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BLTR - Multidrug-efflux transporter 2 regulator

UniProt:	P39842	Sequences: MSEDVKKYFTTGEFSKLCRVKKQTLFHYDEIGLFSPEIKKENGYRYYSYHQFETFQVISLFKELGVPLKEIKCLIKGKTPDKILHVLKEKSIEIDKKINELKQLQTILQTKVTLTEQALETDFSSISFEYLNEETFMLSRKTLNLPERKYVAAISELIHEVQQYELDEGYPIGGIFAREQILEKDFYNYSYFYIKVKDGAENINYHVRPKGLYAVGYEIGGNTEEAYRRIIEFIERNGMQIGENAYEEYMLDEMVVDGYENTYAKILLQVKEV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	273 (229)
Sequences:	3455 (2935)
Seq/√Len:	193.9

BACSU - BLTR YDFL BMRR MTA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
91_S	109_Q	5.335	1.00
98_I	102_K	4.949	1.00
90_K	93_E	3.294	1.00
95_D	105_Q	3.289	1.00
22_K	26_F	3.170	1.00
97_K	100_E	2.851	1.00
34_F	58_I	2.821	1.00
29_D	35_S	2.761	1.00
48_S	51_Q	2.567	1.00
27_H	31_I	2.550	1.00
62_K	68_L	2.455	1.00
11_T	26_F	2.446	1.00
214_A	234_I	2.251	1.00
232_E	236_R	2.242	1.00
91_S	105_Q	2.222	1.00
31_I	68_L	2.192	1.00
84_L	112_V	2.174	1.00
37_E	51_Q	2.151	1.00
54_T	76_K	2.139	1.00
98_I	101_L	2.126	1.00
88_K	116_E	2.107	1.00
94_I	101_L	1.996	1.00
67_P	70_E	1.980	1.00
91_S	95_D	1.950	1.00
39_K	42_N	1.943	1.00
218_E	226_A	1.929	1.00
204_N	208_R	1.883	1.00
215_V	219_I	1.865	1.00
72_K	76_K	1.803	1.00
10_T	13_E	1.798	1.00
65_G	97_K	1.780	1.00
14_F	55_F	1.772	1.00
94_I	105_Q	1.754	1.00
173_G	193_Y	1.732	1.00
40_K	46_Y	1.698	1.00
32_G	35_S	1.693	1.00
122_D	125_S	1.680	1.00
88_K	112_V	1.674	1.00
92_I	96_K	1.671	1.00
70_E	73_C	1.659	1.00
70_E	89_E	1.638	1.00
214_A	233_F	1.638	1.00
97_K	101_L	1.638	1.00
37_E	48_S	1.633	1.00
27_H	68_L	1.620	1.00
101_L	105_Q	1.620	1.00
98_I	105_Q	1.586	1.00
200_A	204_N	1.583	1.00
84_L	116_E	1.582	1.00
133_E	210_K	1.565	1.00
94_I	104_L	1.504	1.00
66_V	74_L	1.500	1.00
12_G	16_K	1.484	1.00
20_V	55_F	1.480	1.00
24_T	27_H	1.470	1.00
87_L	108_L	1.468	1.00
218_E	221_G	1.461	1.00
27_H	30_E	1.455	1.00
130_Y	212_L	1.451	1.00
91_S	112_V	1.436	1.00
14_F	52_F	1.429	1.00
190_S	193_Y	1.419	1.00
55_F	59_S	1.392	1.00
59_S	62_K	1.383	1.00
182_L	185_D	1.380	1.00
133_E	207_V	1.363	1.00
95_D	109_Q	1.337	1.00
23_Q	30_E	1.334	1.00
13_E	16_K	1.319	1.00
91_S	108_L	1.286	1.00
151_V	155_S	1.277	1.00
54_T	75_I	1.272	1.00
150_Y	154_I	1.260	1.00
112_V	116_E	1.247	1.00
9_F	49_Y	1.243	1.00
153_A	156_E	1.239	1.00
11_T	22_K	1.239	1.00
93_E	97_K	1.238	1.00
173_G	177_A	1.231	1.00
130_Y	210_K	1.225	1.00
93_E	96_K	1.225	1.00
193_Y	196_V	1.225	1.00
28_Y	55_F	1.220	1.00
37_E	50_H	1.218	1.00
196_V	199_G	1.218	1.00
99_N	102_K	1.209	1.00
215_V	218_E	1.205	1.00
214_A	218_E	1.201	1.00
94_I	108_L	1.197	1.00
216_G	226_A	1.192	1.00
14_F	51_Q	1.189	1.00
33_L	58_I	1.187	1.00
214_A	217_Y	1.184	1.00
15_S	21_K	1.173	1.00
157_L	161_V	1.169	1.00
95_D	98_I	1.163	1.00
25_L	29_D	1.158	1.00
10_T	46_Y	1.148	1.00
223_T	227_Y	1.138	1.00
224_E	228_R	1.135	1.00
39_K	46_Y	1.128	1.00
200_A	208_R	1.126	1.00
180_Q	186_F	1.100	1.00
138_L	141_K	1.089	1.00
79_T	82_K	1.087	1.00
29_D	45_R	1.073	1.00
149_K	153_A	1.068	1.00
42_N	46_Y	1.067	1.00
210_K	213_Y	1.061	1.00
183_E	186_F	1.055	1.00
66_V	86_V	1.045	1.00
66_V	90_K	1.034	1.00
156_E	160_E	1.024	1.00
113_T	118_A	1.020	1.00
149_K	152_A	1.019	1.00
96_K	99_N	1.018	1.00
14_F	18_C	1.018	1.00
62_K	65_G	1.017	1.00
18_C	55_F	1.015	1.00
162_Q	165_E	1.015	1.00
12_G	22_K	1.008	1.00
92_I	95_D	1.007	1.00
148_R	152_A	1.001	1.00
109_Q	113_T	1.000	1.00
182_L	186_F	0.995	1.00
192_F	195_K	0.993	1.00
174_G	177_A	0.986	0.99
180_Q	183_E	0.978	0.99
58_I	71_I	0.977	0.99
25_L	31_I	0.957	0.99
217_Y	221_G	0.944	0.99
216_G	230_I	0.924	0.99
18_C	52_F	0.920	0.99
21_K	27_H	0.920	0.99
100_E	104_L	0.917	0.99
123_F	126_I	0.906	0.99
173_G	176_F	0.893	0.99
142_T	145_L	0.886	0.99
201_E	204_N	0.882	0.99
87_L	112_V	0.882	0.99
38_I	46_Y	0.877	0.99
141_K	145_L	0.868	0.99
183_E	187_Y	0.858	0.99
21_K	24_T	0.855	0.99
18_C	23_Q	0.852	0.98
117_Q	121_T	0.841	0.98
56_Q	111_K	0.840	0.98
84_L	88_K	0.838	0.98
99_N	103_Q	0.832	0.98
206_H	209_P	0.831	0.98
136_F	206_H	0.828	0.98
20_V	24_T	0.827	0.98
22_K	42_N	0.826	0.98
18_C	34_F	0.825	0.98
217_Y	220_G	0.825	0.98
216_G	219_I	0.823	0.98
101_L	104_L	0.823	0.98
189_Y	193_Y	0.823	0.98
15_S	18_C	0.819	0.98
203_I	207_V	0.809	0.98
11_T	15_S	0.807	0.98
156_E	159_H	0.807	0.98
195_K	199_G	0.806	0.98
205_Y	208_R	0.803	0.98
181_I	184_K	0.801	0.98
151_V	154_I	0.800	0.98
158_I	161_V	0.790	0.98
185_D	188_N	0.790	0.98
177_A	191_Y	0.790	0.98
23_Q	26_F	0.780	0.97
90_K	108_L	0.775	0.97
63_E	104_L	0.774	0.97
39_K	51_Q	0.771	0.97
232_E	235_E	0.770	0.97
171_P	175_I	0.770	0.97
56_Q	60_L	0.766	0.97
38_I	42_N	0.764	0.97
26_F	34_F	0.763	0.97
154_I	157_L	0.754	0.97
218_E	222_N	0.749	0.97
141_K	146_P	0.747	0.97
189_Y	192_F	0.746	0.97
88_K	92_I	0.746	0.97
222_N	225_E	0.741	0.96
11_T	45_R	0.739	0.96
208_R	211_G	0.736	0.96
130_Y	133_E	0.736	0.96
203_I	209_P	0.736	0.96
61_F	74_L	0.733	0.96
97_K	104_L	0.731	0.96
96_K	100_E	0.731	0.96
31_I	62_K	0.730	0.96
70_E	90_K	0.726	0.96
25_L	68_L	0.724	0.96
89_E	92_I	0.721	0.96
90_K	104_L	0.721	0.96
17_L	44_Y	0.720	0.96
201_E	207_V	0.713	0.96
190_S	194_I	0.713	0.96
180_Q	184_K	0.713	0.96
176_F	179_E	0.712	0.95
131_L	134_E	0.704	0.95
23_Q	27_H	0.696	0.95
140_R	144_N	0.688	0.95
153_A	157_L	0.688	0.95
14_F	34_F	0.685	0.94
181_I	188_N	0.683	0.94
73_C	77_G	0.676	0.94
178_R	182_L	0.676	0.94
142_T	146_P	0.671	0.94
180_Q	185_D	0.671	0.94
46_Y	51_Q	0.667	0.94
204_N	209_P	0.666	0.94
29_D	62_K	0.664	0.93
34_F	55_F	0.664	0.93
135_T	207_V	0.660	0.93
128_F	131_L	0.657	0.93
88_K	91_S	0.657	0.93
193_Y	199_G	0.657	0.93
188_N	193_Y	0.656	0.93
152_A	156_E	0.654	0.93
227_Y	234_I	0.654	0.93
189_Y	194_I	0.653	0.93
25_L	47_Y	0.651	0.93
135_T	139_S	0.649	0.93
231_I	234_I	0.648	0.93
85_H	89_E	0.646	0.93
184_K	187_Y	0.644	0.92
194_I	197_K	0.643	0.92
167_D	170_Y	0.643	0.92
214_A	230_I	0.638	0.92
24_T	59_S	0.635	0.92
133_E	136_F	0.635	0.92
215_V	221_G	0.633	0.92
62_K	71_I	0.626	0.91
160_E	164_Y	0.626	0.91
18_C	56_Q	0.626	0.91
12_G	15_S	0.623	0.91
191_Y	196_V	0.623	0.91
41_E	46_Y	0.622	0.91
184_K	188_N	0.622	0.91
81_D	85_H	0.619	0.91
220_G	223_T	0.616	0.91
90_K	94_I	0.616	0.91
9_F	66_V	0.616	0.91
57_V	60_L	0.610	0.90
61_F	86_V	0.609	0.90
9_F	13_E	0.608	0.90
35_S	39_K	0.606	0.90
204_N	207_V	0.601	0.90
164_Y	168_E	0.598	0.89
172_I	175_I	0.597	0.89
129_E	215_V	0.596	0.89
95_D	99_N	0.596	0.89
165_E	168_E	0.596	0.89
24_T	55_F	0.593	0.89
181_I	185_D	0.593	0.89
54_T	57_V	0.592	0.89
228_R	232_E	0.592	0.89
167_D	171_P	0.590	0.89
203_I	208_R	0.588	0.89
91_S	94_I	0.588	0.89
206_H	211_G	0.583	0.88
33_L	68_L	0.583	0.88
207_V	210_K	0.582	0.88
15_S	22_K	0.581	0.88
128_F	132_N	0.581	0.88
10_T	29_D	0.580	0.88
81_D	119_L	0.580	0.88
131_L	138_L	0.579	0.88
8_Y	48_S	0.576	0.88
115_T	119_L	0.574	0.87
137_M	140_R	0.574	0.87
134_E	195_K	0.574	0.87
129_E	132_N	0.573	0.87
176_F	190_S	0.573	0.87
74_L	78_K	0.573	0.87
209_P	213_Y	0.573	0.87
66_V	93_E	0.572	0.87
69_K	73_C	0.571	0.87
133_E	137_M	0.570	0.87
122_D	126_I	0.567	0.87
20_V	59_S	0.566	0.87
51_Q	54_T	0.566	0.87
113_T	117_Q	0.566	0.87
63_E	100_E	0.564	0.86
155_S	159_H	0.564	0.86
178_R	181_I	0.562	0.86
28_Y	215_V	0.560	0.86
151_V	157_L	0.559	0.86
193_Y	197_K	0.558	0.86
172_I	176_F	0.558	0.86
173_G	178_R	0.558	0.86
118_A	121_T	0.557	0.86
152_A	155_S	0.555	0.86
205_Y	209_P	0.554	0.85
18_C	220_G	0.553	0.85
106_T	109_Q	0.553	0.85
174_G	178_R	0.547	0.85
9_F	51_Q	0.545	0.85
218_E	224_E	0.542	0.84
15_S	187_Y	0.541	0.84
55_F	62_K	0.540	0.84
206_H	210_K	0.539	0.84
132_N	136_F	0.537	0.84
38_I	51_Q	0.537	0.84
20_V	101_L	0.536	0.84
139_S	192_F	0.536	0.84
28_Y	43_G	0.536	0.84
134_E	208_R	0.533	0.83
189_Y	196_V	0.531	0.83
207_V	211_G	0.530	0.83
201_E	208_R	0.530	0.83
18_C	111_K	0.528	0.83
95_D	102_K	0.527	0.83
47_Y	71_I	0.525	0.82
65_G	90_K	0.523	0.82
9_F	14_F	0.521	0.82
27_H	62_K	0.521	0.82
128_F	212_L	0.521	0.82
110_T	114_L	0.519	0.82
139_S	143_L	0.517	0.81
150_Y	153_A	0.517	0.81
87_L	91_S	0.517	0.81
66_V	70_E	0.516	0.81
186_F	193_Y	0.516	0.81
11_T	42_N	0.515	0.81
103_Q	106_T	0.514	0.81
131_L	211_G	0.514	0.81
131_L	213_Y	0.511	0.81
24_T	68_L	0.511	0.81
9_F	52_F	0.511	0.81
143_L	152_A	0.511	0.81
191_Y	194_I	0.510	0.80
153_A	158_I	0.509	0.80
179_E	183_E	0.509	0.80
74_L	86_V	0.507	0.80
86_V	89_E	0.507	0.80
25_L	34_F	0.506	0.80
85_H	120_E	0.506	0.80
180_Q	188_N	0.504	0.80
29_D	34_F	0.501	0.79
172_I	177_A	0.501	0.79
68_L	83_I	0.500	0.79

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1r8eA	2	0.9634	100	0.274	Contact Map
3qaoA	2	0.5128	99.9	0.542	Contact Map
3gpvA	2	0.4066	99.9	0.555	Contact Map
3hh0A	4	0.4835	99.9	0.557	Contact Map
2zhgA	2	0.4396	99.9	0.566	Contact Map
2vz4A	2	0.3663	99.9	0.568	Contact Map
3gp4A	4	0.4652	99.9	0.569	Contact Map
1r8dA	2	0.3993	99.9	0.572	Contact Map
1q06A	2	0.4469	99.9	0.574	Contact Map
4ua1A	2	0.4396	99.9	0.59	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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