GREMLIN Database
BLTR - Multidrug-efflux transporter 2 regulator
UniProt: P39842 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 273 (229)
Sequences: 3455 (2935)
Seq/√Len: 193.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_S109_Q5.3351.00
98_I102_K4.9491.00
90_K93_E3.2941.00
95_D105_Q3.2891.00
22_K26_F3.1701.00
97_K100_E2.8511.00
34_F58_I2.8211.00
29_D35_S2.7611.00
48_S51_Q2.5671.00
27_H31_I2.5501.00
62_K68_L2.4551.00
11_T26_F2.4461.00
214_A234_I2.2511.00
232_E236_R2.2421.00
91_S105_Q2.2221.00
31_I68_L2.1921.00
84_L112_V2.1741.00
37_E51_Q2.1511.00
54_T76_K2.1391.00
98_I101_L2.1261.00
88_K116_E2.1071.00
94_I101_L1.9961.00
67_P70_E1.9801.00
91_S95_D1.9501.00
39_K42_N1.9431.00
218_E226_A1.9291.00
204_N208_R1.8831.00
215_V219_I1.8651.00
72_K76_K1.8031.00
10_T13_E1.7981.00
65_G97_K1.7801.00
14_F55_F1.7721.00
94_I105_Q1.7541.00
173_G193_Y1.7321.00
40_K46_Y1.6981.00
32_G35_S1.6931.00
122_D125_S1.6801.00
88_K112_V1.6741.00
92_I96_K1.6711.00
70_E73_C1.6591.00
70_E89_E1.6381.00
214_A233_F1.6381.00
97_K101_L1.6381.00
37_E48_S1.6331.00
27_H68_L1.6201.00
101_L105_Q1.6201.00
98_I105_Q1.5861.00
200_A204_N1.5831.00
84_L116_E1.5821.00
133_E210_K1.5651.00
94_I104_L1.5041.00
66_V74_L1.5001.00
12_G16_K1.4841.00
20_V55_F1.4801.00
24_T27_H1.4701.00
87_L108_L1.4681.00
218_E221_G1.4611.00
27_H30_E1.4551.00
130_Y212_L1.4511.00
91_S112_V1.4361.00
14_F52_F1.4291.00
190_S193_Y1.4191.00
55_F59_S1.3921.00
59_S62_K1.3831.00
182_L185_D1.3801.00
133_E207_V1.3631.00
95_D109_Q1.3371.00
23_Q30_E1.3341.00
13_E16_K1.3191.00
91_S108_L1.2861.00
151_V155_S1.2771.00
54_T75_I1.2721.00
150_Y154_I1.2601.00
112_V116_E1.2471.00
9_F49_Y1.2431.00
153_A156_E1.2391.00
11_T22_K1.2391.00
93_E97_K1.2381.00
173_G177_A1.2311.00
130_Y210_K1.2251.00
93_E96_K1.2251.00
193_Y196_V1.2251.00
28_Y55_F1.2201.00
37_E50_H1.2181.00
196_V199_G1.2181.00
99_N102_K1.2091.00
215_V218_E1.2051.00
214_A218_E1.2011.00
94_I108_L1.1971.00
216_G226_A1.1921.00
14_F51_Q1.1891.00
33_L58_I1.1871.00
214_A217_Y1.1841.00
15_S21_K1.1731.00
157_L161_V1.1691.00
95_D98_I1.1631.00
25_L29_D1.1581.00
10_T46_Y1.1481.00
223_T227_Y1.1381.00
224_E228_R1.1351.00
39_K46_Y1.1281.00
200_A208_R1.1261.00
180_Q186_F1.1001.00
138_L141_K1.0891.00
79_T82_K1.0871.00
29_D45_R1.0731.00
149_K153_A1.0681.00
42_N46_Y1.0671.00
210_K213_Y1.0611.00
183_E186_F1.0551.00
66_V86_V1.0451.00
66_V90_K1.0341.00
156_E160_E1.0241.00
113_T118_A1.0201.00
149_K152_A1.0191.00
96_K99_N1.0181.00
14_F18_C1.0181.00
62_K65_G1.0171.00
18_C55_F1.0151.00
162_Q165_E1.0151.00
12_G22_K1.0081.00
92_I95_D1.0071.00
148_R152_A1.0011.00
109_Q113_T1.0001.00
182_L186_F0.9951.00
192_F195_K0.9931.00
174_G177_A0.9860.99
180_Q183_E0.9780.99
58_I71_I0.9770.99
25_L31_I0.9570.99
217_Y221_G0.9440.99
216_G230_I0.9240.99
18_C52_F0.9200.99
21_K27_H0.9200.99
100_E104_L0.9170.99
123_F126_I0.9060.99
173_G176_F0.8930.99
142_T145_L0.8860.99
201_E204_N0.8820.99
87_L112_V0.8820.99
38_I46_Y0.8770.99
141_K145_L0.8680.99
183_E187_Y0.8580.99
21_K24_T0.8550.99
18_C23_Q0.8520.98
117_Q121_T0.8410.98
56_Q111_K0.8400.98
84_L88_K0.8380.98
99_N103_Q0.8320.98
206_H209_P0.8310.98
136_F206_H0.8280.98
20_V24_T0.8270.98
22_K42_N0.8260.98
18_C34_F0.8250.98
217_Y220_G0.8250.98
216_G219_I0.8230.98
101_L104_L0.8230.98
189_Y193_Y0.8230.98
15_S18_C0.8190.98
203_I207_V0.8090.98
11_T15_S0.8070.98
156_E159_H0.8070.98
195_K199_G0.8060.98
205_Y208_R0.8030.98
181_I184_K0.8010.98
151_V154_I0.8000.98
158_I161_V0.7900.98
185_D188_N0.7900.98
177_A191_Y0.7900.98
23_Q26_F0.7800.97
90_K108_L0.7750.97
63_E104_L0.7740.97
39_K51_Q0.7710.97
232_E235_E0.7700.97
171_P175_I0.7700.97
56_Q60_L0.7660.97
38_I42_N0.7640.97
26_F34_F0.7630.97
154_I157_L0.7540.97
218_E222_N0.7490.97
141_K146_P0.7470.97
189_Y192_F0.7460.97
88_K92_I0.7460.97
222_N225_E0.7410.96
11_T45_R0.7390.96
208_R211_G0.7360.96
130_Y133_E0.7360.96
203_I209_P0.7360.96
61_F74_L0.7330.96
97_K104_L0.7310.96
96_K100_E0.7310.96
31_I62_K0.7300.96
70_E90_K0.7260.96
25_L68_L0.7240.96
89_E92_I0.7210.96
90_K104_L0.7210.96
17_L44_Y0.7200.96
201_E207_V0.7130.96
190_S194_I0.7130.96
180_Q184_K0.7130.96
176_F179_E0.7120.95
131_L134_E0.7040.95
23_Q27_H0.6960.95
140_R144_N0.6880.95
153_A157_L0.6880.95
14_F34_F0.6850.94
181_I188_N0.6830.94
73_C77_G0.6760.94
178_R182_L0.6760.94
142_T146_P0.6710.94
180_Q185_D0.6710.94
46_Y51_Q0.6670.94
204_N209_P0.6660.94
29_D62_K0.6640.93
34_F55_F0.6640.93
135_T207_V0.6600.93
128_F131_L0.6570.93
88_K91_S0.6570.93
193_Y199_G0.6570.93
188_N193_Y0.6560.93
152_A156_E0.6540.93
227_Y234_I0.6540.93
189_Y194_I0.6530.93
25_L47_Y0.6510.93
135_T139_S0.6490.93
231_I234_I0.6480.93
85_H89_E0.6460.93
184_K187_Y0.6440.92
194_I197_K0.6430.92
167_D170_Y0.6430.92
214_A230_I0.6380.92
24_T59_S0.6350.92
133_E136_F0.6350.92
215_V221_G0.6330.92
62_K71_I0.6260.91
160_E164_Y0.6260.91
18_C56_Q0.6260.91
12_G15_S0.6230.91
191_Y196_V0.6230.91
41_E46_Y0.6220.91
184_K188_N0.6220.91
81_D85_H0.6190.91
220_G223_T0.6160.91
90_K94_I0.6160.91
9_F66_V0.6160.91
57_V60_L0.6100.90
61_F86_V0.6090.90
9_F13_E0.6080.90
35_S39_K0.6060.90
204_N207_V0.6010.90
164_Y168_E0.5980.89
172_I175_I0.5970.89
129_E215_V0.5960.89
95_D99_N0.5960.89
165_E168_E0.5960.89
24_T55_F0.5930.89
181_I185_D0.5930.89
54_T57_V0.5920.89
228_R232_E0.5920.89
167_D171_P0.5900.89
203_I208_R0.5880.89
91_S94_I0.5880.89
206_H211_G0.5830.88
33_L68_L0.5830.88
207_V210_K0.5820.88
15_S22_K0.5810.88
128_F132_N0.5810.88
10_T29_D0.5800.88
81_D119_L0.5800.88
131_L138_L0.5790.88
8_Y48_S0.5760.88
115_T119_L0.5740.87
137_M140_R0.5740.87
134_E195_K0.5740.87
129_E132_N0.5730.87
176_F190_S0.5730.87
74_L78_K0.5730.87
209_P213_Y0.5730.87
66_V93_E0.5720.87
69_K73_C0.5710.87
133_E137_M0.5700.87
122_D126_I0.5670.87
20_V59_S0.5660.87
51_Q54_T0.5660.87
113_T117_Q0.5660.87
63_E100_E0.5640.86
155_S159_H0.5640.86
178_R181_I0.5620.86
28_Y215_V0.5600.86
151_V157_L0.5590.86
193_Y197_K0.5580.86
172_I176_F0.5580.86
173_G178_R0.5580.86
118_A121_T0.5570.86
152_A155_S0.5550.86
205_Y209_P0.5540.85
18_C220_G0.5530.85
106_T109_Q0.5530.85
174_G178_R0.5470.85
9_F51_Q0.5450.85
218_E224_E0.5420.84
15_S187_Y0.5410.84
55_F62_K0.5400.84
206_H210_K0.5390.84
132_N136_F0.5370.84
38_I51_Q0.5370.84
20_V101_L0.5360.84
139_S192_F0.5360.84
28_Y43_G0.5360.84
134_E208_R0.5330.83
189_Y196_V0.5310.83
207_V211_G0.5300.83
201_E208_R0.5300.83
18_C111_K0.5280.83
95_D102_K0.5270.83
47_Y71_I0.5250.82
65_G90_K0.5230.82
9_F14_F0.5210.82
27_H62_K0.5210.82
128_F212_L0.5210.82
110_T114_L0.5190.82
139_S143_L0.5170.81
150_Y153_A0.5170.81
87_L91_S0.5170.81
66_V70_E0.5160.81
186_F193_Y0.5160.81
11_T42_N0.5150.81
103_Q106_T0.5140.81
131_L211_G0.5140.81
131_L213_Y0.5110.81
24_T68_L0.5110.81
9_F52_F0.5110.81
143_L152_A0.5110.81
191_Y194_I0.5100.80
153_A158_I0.5090.80
179_E183_E0.5090.80
74_L86_V0.5070.80
86_V89_E0.5070.80
25_L34_F0.5060.80
85_H120_E0.5060.80
180_Q188_N0.5040.80
29_D34_F0.5010.79
172_I177_A0.5010.79
68_L83_I0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1r8eA 2 0.9634 100 0.274 Contact Map
3qaoA 2 0.5128 99.9 0.542 Contact Map
3gpvA 2 0.4066 99.9 0.555 Contact Map
3hh0A 4 0.4835 99.9 0.557 Contact Map
2zhgA 2 0.4396 99.9 0.566 Contact Map
2vz4A 2 0.3663 99.9 0.568 Contact Map
3gp4A 4 0.4652 99.9 0.569 Contact Map
1r8dA 2 0.3993 99.9 0.572 Contact Map
1q06A 2 0.4469 99.9 0.574 Contact Map
4ua1A 2 0.4396 99.9 0.59 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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