MANA3 - BACSU - GREMLIN Contacts

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MANA3 - Putative mannose-6-phosphate isomerase YvyI

UniProt:	P39841	Sequences: MTQSPIFLTPVFKEKIWGGTALRDRFGYSIPSESTGECWAISAHPKGPSTVANGPYKGKTLIELWEEHREVFGGVEGDRFPLLTKLLDVKEDTSIKVHPDDYYAGENEEGELGKTECWYIIDCKENAEIIYGHTARSKTELVTMINSGDWEGLLRRIKIKPGDFYYVPSGTLHALCKGALVLETQQNSDATYRVYDYDRLDSNGSPRELHFAKAVNAATVPHVDGYIDESTESRKGITIKTFVQGEYFSVYKWDINGEAEMAQDESFLICSVIEGSGLLKYEDKTCPLKKGDHFILPAQMPDFTIKGTCTLIVSHI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	316 (287)
Sequences:	3157 (2354)
Seq/√Len:	138.9

ECOLI - MANA
BACSU - MANA3 MANA1 MANA2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
128_E	156_R	4.508	1.00
7_F	292_D	3.615	1.00
122_D	161_P	3.192	1.00
59_K	67_E	3.185	1.00
143_T	147_S	2.940	1.00
159_I	179_A	2.841	1.00
20_T	24_D	2.715	1.00
118_W	180_L	2.576	1.00
15_K	36_G	2.573	1.00
103_Y	217_A	2.516	1.00
278_L	285_T	2.484	1.00
278_L	306_K	2.474	1.00
172_L	194_V	2.450	1.00
51_V	64_L	2.403	1.00
102_Y	106_E	2.395	1.00
128_E	158_K	2.388	1.00
142_V	146_N	2.363	1.00
123_C	160_K	2.347	1.00
20_T	23_R	2.270	1.00
166_Y	245_G	2.247	1.00
59_K	63_E	2.239	1.00
280_K	285_T	2.228	1.00
252_K	310_T	2.191	1.00
60_T	63_E	2.182	1.00
44_H	47_G	2.180	1.00
276_S	289_K	2.163	1.00
172_L	218_A	2.161	1.00
278_L	287_P	2.071	1.00
9_T	52_A	2.059	1.00
274_E	310_T	2.051	1.00
103_Y	107_N	2.036	1.00
277_G	309_C	2.031	1.00
137_S	140_E	2.022	1.00
53_N	57_K	2.009	1.00
101_D	112_L	1.987	1.00
111_E	190_A	1.927	1.00
48_P	62_I	1.906	1.00
274_E	290_K	1.868	1.00
289_K	292_D	1.867	1.00
21_A	24_D	1.841	1.00
94_S	193_R	1.810	1.00
286_C	294_F	1.809	1.00
288_L	294_F	1.805	1.00
276_S	287_P	1.805	1.00
46_K	189_D	1.775	1.00
182_L	271_S	1.766	1.00
281_Y	284_K	1.742	1.00
101_D	105_G	1.714	1.00
213_K	216_N	1.694	1.00
63_E	67_E	1.681	1.00
64_L	71_V	1.677	1.00
9_T	50_T	1.663	1.00
271_S	293_H	1.662	1.00
100_D	103_Y	1.658	1.00
280_K	306_K	1.649	1.00
254_D	310_T	1.631	1.00
16_I	206_P	1.628	1.00
192_Y	217_A	1.618	1.00
134_T	155_R	1.605	1.00
62_I	66_E	1.599	1.00
84_T	184_T	1.595	1.00
305_I	309_C	1.586	1.00
280_K	304_T	1.564	1.00
40_A	293_H	1.522	1.00
101_D	113_G	1.511	1.00
272_V	275_G	1.510	1.00
123_C	161_P	1.508	1.00
20_T	33_E	1.502	1.00
50_T	60_T	1.477	1.00
268_L	303_F	1.460	1.00
297_P	300_M	1.458	1.00
97_V	217_A	1.432	1.00
258_E	306_K	1.430	1.00
10_P	293_H	1.427	1.00
7_F	286_C	1.427	1.00
63_E	66_E	1.420	1.00
96_K	191_T	1.405	1.00
84_T	182_L	1.386	1.00
277_G	294_F	1.378	1.00
13_K	47_G	1.367	1.00
23_R	35_T	1.364	1.00
30_I	35_T	1.363	1.00
256_N	308_T	1.354	1.00
23_R	26_F	1.351	1.00
65_W	72_F	1.328	1.00
115_T	166_Y	1.320	1.00
115_T	169_S	1.319	1.00
119_Y	250_V	1.317	1.00
37_E	85_K	1.314	1.00
75_V	265_E	1.314	1.00
94_S	207_R	1.300	1.00
102_Y	105_G	1.290	1.00
160_K	163_D	1.280	1.00
56_Y	64_L	1.250	1.00
138_K	216_N	1.237	1.00
79_R	111_E	1.235	1.00
129_I	165_Y	1.234	1.00
19_G	88_D	1.230	1.00
262_A	302_D	1.228	1.00
16_I	91_E	1.224	1.00
103_Y	216_N	1.223	1.00
142_V	215_V	1.222	1.00
280_K	283_D	1.214	1.00
260_E	302_D	1.210	1.00
97_V	218_A	1.203	1.00
86_L	182_L	1.202	1.00
40_A	269_I	1.195	1.00
281_Y	300_M	1.191	1.00
135_A	140_E	1.189	1.00
130_I	156_R	1.187	1.00
113_G	186_Q	1.179	1.00
122_D	180_L	1.174	1.00
121_I	273_I	1.156	0.99
141_L	220_V	1.152	0.99
79_R	112_L	1.145	0.99
44_H	187_N	1.142	0.99
11_V	47_G	1.132	0.99
38_C	293_H	1.116	0.99
22_L	26_F	1.116	0.99
258_E	304_T	1.104	0.99
83_L	185_Q	1.101	0.99
91_E	177_K	1.095	0.99
10_P	38_C	1.095	0.99
194_V	214_A	1.084	0.99
6_I	64_L	1.073	0.99
88_D	180_L	1.071	0.99
117_C	250_V	1.070	0.99
141_L	194_V	1.068	0.99
184_T	250_V	1.064	0.99
9_T	58_G	1.061	0.99
185_Q	191_T	1.056	0.99
133_H	218_A	1.054	0.99
21_A	25_R	1.053	0.99
44_H	48_P	1.048	0.99
133_H	220_V	1.047	0.99
120_I	179_A	1.037	0.99
277_G	288_L	1.035	0.99
171_T	219_T	1.035	0.99
240_K	252_K	1.029	0.99
159_I	165_Y	1.028	0.99
168_P	171_T	1.025	0.99
21_A	180_L	1.022	0.99
138_K	142_V	1.022	0.99
194_V	218_A	1.020	0.99
163_D	229_E	1.018	0.99
105_G	111_E	1.014	0.99
14_E	33_E	1.008	0.98
115_T	186_Q	1.005	0.98
53_N	56_Y	0.998	0.98
307_G	310_T	0.997	0.98
272_V	288_L	0.995	0.98
296_L	303_F	0.993	0.98
117_C	164_F	0.989	0.98
166_Y	248_F	0.986	0.98
53_N	58_G	0.986	0.98
87_L	175_L	0.981	0.98
110_G	190_A	0.969	0.98
107_N	213_K	0.968	0.98
276_S	308_T	0.967	0.98
17_W	94_S	0.963	0.98
270_C	294_F	0.961	0.98
192_Y	213_K	0.958	0.98
234_R	237_I	0.951	0.98
203_N	206_P	0.948	0.98
130_I	176_C	0.948	0.98
193_R	207_R	0.941	0.98
76_E	266_S	0.940	0.98
19_G	179_A	0.939	0.98
32_S	35_T	0.937	0.98
8_L	295_I	0.933	0.97
10_P	40_A	0.926	0.97
131_Y	154_L	0.925	0.97
20_T	32_S	0.919	0.97
260_E	304_T	0.916	0.97
288_L	309_C	0.915	0.97
86_L	121_I	0.911	0.97
84_T	250_V	0.911	0.97
147_S	152_G	0.908	0.97
117_C	184_T	0.908	0.97
109_E	213_K	0.902	0.97
238_T	251_Y	0.897	0.97
107_N	216_N	0.893	0.97
21_A	179_A	0.893	0.97
37_E	83_L	0.893	0.97
139_T	143_T	0.886	0.97
143_T	146_N	0.883	0.96
71_V	297_P	0.875	0.96
274_E	308_T	0.872	0.96
56_Y	59_K	0.872	0.96
43_A	79_R	0.869	0.96
89_V	175_L	0.863	0.96
140_E	144_M	0.858	0.96
21_A	88_D	0.853	0.96
277_G	287_P	0.853	0.96
71_V	295_I	0.851	0.96
65_W	68_H	0.843	0.95
48_P	60_T	0.840	0.95
25_R	290_K	0.839	0.95
119_Y	164_F	0.836	0.95
113_G	247_Y	0.832	0.95
59_K	64_L	0.831	0.95
227_I	230_S	0.829	0.95
39_W	85_K	0.827	0.95
282_E	302_D	0.826	0.95
101_D	186_Q	0.821	0.95
103_Y	106_E	0.814	0.94
131_Y	167_V	0.813	0.94
28_Y	40_A	0.813	0.94
14_E	34_S	0.809	0.94
7_F	52_A	0.804	0.94
9_T	32_S	0.801	0.94
13_K	46_K	0.799	0.94
92_D	177_K	0.793	0.94
279_L	294_F	0.791	0.94
146_N	215_V	0.786	0.93
15_K	189_D	0.783	0.93
241_T	244_Q	0.781	0.93
120_I	123_C	0.781	0.93
272_V	277_G	0.774	0.93
212_A	216_N	0.774	0.93
295_I	298_A	0.773	0.93
241_T	251_Y	0.772	0.93
23_R	33_E	0.771	0.93
85_K	185_Q	0.767	0.93
100_D	219_T	0.764	0.92
93_T	116_E	0.764	0.92
94_S	191_T	0.764	0.92
69_R	75_V	0.763	0.92
207_R	210_H	0.763	0.92
42_S	48_P	0.758	0.92
10_P	49_S	0.757	0.92
108_E	192_Y	0.756	0.92
129_I	159_I	0.753	0.92
115_T	245_G	0.750	0.92
55_P	58_G	0.748	0.92
144_M	152_G	0.747	0.91
22_L	25_R	0.746	0.91
129_I	176_C	0.746	0.91
87_L	190_A	0.745	0.91
9_T	57_K	0.743	0.91
98_H	116_E	0.735	0.91
90_K	177_K	0.733	0.91
85_K	188_S	0.731	0.91
161_P	274_E	0.731	0.91
128_E	177_K	0.730	0.91
167_V	171_T	0.724	0.90
6_I	295_I	0.722	0.90
72_F	76_E	0.721	0.90
28_Y	35_T	0.718	0.90
65_W	80_F	0.717	0.90
204_G	207_R	0.712	0.89
141_L	145_I	0.712	0.89
28_Y	293_H	0.712	0.89
21_A	26_F	0.709	0.89
130_I	154_L	0.704	0.89
255_I	307_G	0.701	0.89
95_I	154_L	0.701	0.89
191_T	207_R	0.698	0.89
70_E	299_Q	0.697	0.88
56_Y	68_H	0.696	0.88
113_G	185_Q	0.695	0.88
144_M	153_L	0.693	0.88
136_R	222_H	0.693	0.88
28_Y	38_C	0.692	0.88
45_P	79_R	0.689	0.88
123_C	128_E	0.687	0.88
133_H	221_P	0.686	0.88
108_E	213_K	0.686	0.88
97_V	171_T	0.682	0.87
134_T	138_K	0.681	0.87
22_L	28_Y	0.681	0.87
97_V	192_Y	0.679	0.87
255_I	309_C	0.679	0.87
253_W	270_C	0.679	0.87
8_L	11_V	0.678	0.87
84_T	271_S	0.678	0.87
23_R	32_S	0.677	0.87
144_M	147_S	0.673	0.87
300_M	303_F	0.671	0.86
39_W	49_S	0.668	0.86
279_L	305_I	0.666	0.86
26_F	290_K	0.665	0.86
131_Y	169_S	0.665	0.86
164_F	243_V	0.661	0.86
164_F	250_V	0.659	0.85
26_F	35_T	0.659	0.85
156_R	176_C	0.658	0.85
22_L	180_L	0.658	0.85
23_R	31_P	0.657	0.85
273_I	310_T	0.655	0.85
17_W	193_R	0.650	0.85
97_V	194_V	0.650	0.85
279_L	286_C	0.650	0.85
88_D	179_A	0.646	0.84
12_F	38_C	0.643	0.84
15_K	87_L	0.641	0.84
105_G	109_E	0.636	0.83
287_P	292_D	0.636	0.83
117_C	271_S	0.633	0.83
69_R	73_G	0.632	0.83
103_Y	213_K	0.632	0.83
86_L	271_S	0.630	0.83
123_C	127_A	0.627	0.83
64_L	68_H	0.627	0.83
93_T	96_K	0.622	0.82
110_G	188_S	0.622	0.82
204_G	210_H	0.622	0.82
139_T	142_V	0.620	0.82
66_E	78_D	0.620	0.82
299_Q	304_T	0.618	0.82
109_E	191_T	0.616	0.81
143_T	262_A	0.614	0.81
131_Y	165_Y	0.612	0.81
100_D	170_G	0.611	0.81
23_R	30_I	0.610	0.81
239_I	251_Y	0.610	0.81
221_P	224_D	0.607	0.81
65_W	69_R	0.606	0.80
29_S	32_S	0.606	0.80
25_R	180_L	0.605	0.80
96_K	193_R	0.605	0.80
136_R	221_P	0.603	0.80
237_I	257_G	0.602	0.80
15_K	34_S	0.602	0.80
192_Y	207_R	0.601	0.80
297_P	301_P	0.601	0.80
12_F	30_I	0.601	0.80
148_G	152_G	0.600	0.80
134_T	154_L	0.599	0.80
43_A	62_I	0.599	0.80
123_C	179_A	0.599	0.80
106_E	216_N	0.594	0.79
114_K	189_D	0.592	0.79
52_A	292_D	0.591	0.79
9_T	29_S	0.591	0.79
12_F	35_T	0.590	0.79
185_Q	210_H	0.590	0.79
17_W	207_R	0.590	0.79
118_W	165_Y	0.588	0.78
115_T	247_Y	0.583	0.78
239_I	305_I	0.579	0.77
97_V	119_Y	0.576	0.77
176_C	179_A	0.572	0.76
12_F	40_A	0.570	0.76
62_I	79_R	0.570	0.76
119_Y	171_T	0.569	0.76
119_Y	182_L	0.569	0.76
278_L	281_Y	0.568	0.76
263_Q	302_D	0.567	0.76
112_L	186_Q	0.566	0.76
274_E	278_L	0.566	0.76
81_P	188_S	0.565	0.76
23_R	29_S	0.565	0.76
123_C	158_K	0.564	0.75
113_G	245_G	0.563	0.75
94_S	210_H	0.563	0.75
270_C	296_L	0.561	0.75
117_C	182_L	0.560	0.75
6_I	53_N	0.560	0.75
83_L	188_S	0.560	0.75
44_H	188_S	0.560	0.75
26_F	119_Y	0.560	0.75
39_W	83_L	0.558	0.75
283_D	302_D	0.558	0.75
39_W	42_S	0.557	0.75
119_Y	252_K	0.557	0.75
74_G	265_E	0.556	0.74
93_T	174_A	0.554	0.74
192_Y	210_H	0.554	0.74
11_V	49_S	0.553	0.74
16_I	204_G	0.550	0.74
31_P	35_T	0.550	0.74
26_F	291_G	0.549	0.74
255_I	277_G	0.549	0.74
299_Q	303_F	0.548	0.73
104_A	190_A	0.546	0.73
39_W	44_H	0.544	0.73
273_I	290_K	0.544	0.73
244_Q	249_S	0.544	0.73
37_E	188_S	0.543	0.73
264_D	268_L	0.543	0.73
40_A	84_T	0.538	0.72
6_I	51_V	0.537	0.72
165_Y	176_C	0.536	0.72
97_V	141_L	0.535	0.72
175_L	185_Q	0.534	0.71
23_R	28_Y	0.534	0.71
20_T	35_T	0.534	0.71
40_A	121_I	0.531	0.71
89_V	176_C	0.531	0.71
207_R	214_A	0.531	0.71
130_I	157_I	0.531	0.71
104_A	110_G	0.530	0.71
262_A	304_T	0.530	0.71
130_I	174_A	0.530	0.71
182_L	250_V	0.528	0.71
83_L	189_D	0.527	0.71
238_T	253_W	0.527	0.71
92_D	272_V	0.526	0.70
12_F	15_K	0.526	0.70
100_D	111_E	0.524	0.70
42_S	187_N	0.524	0.70
148_G	257_G	0.524	0.70
69_R	72_F	0.523	0.70
157_I	165_Y	0.523	0.70
225_G	229_E	0.522	0.70
100_D	217_A	0.520	0.70
284_K	289_K	0.519	0.69
117_C	243_V	0.519	0.69
280_K	284_K	0.518	0.69
237_I	253_W	0.517	0.69
212_A	215_V	0.517	0.69
24_D	70_E	0.514	0.69
85_K	114_K	0.514	0.69
97_V	170_G	0.514	0.69
171_T	225_G	0.513	0.68
7_F	294_F	0.510	0.68
213_K	217_A	0.510	0.68
89_V	179_A	0.508	0.68
40_A	86_L	0.508	0.68
281_Y	301_P	0.507	0.68
258_E	307_G	0.506	0.67
20_T	27_G	0.505	0.67
25_R	121_I	0.504	0.67
87_L	93_T	0.503	0.67
192_Y	208_E	0.502	0.67
159_I	176_C	0.501	0.67
69_R	78_D	0.500	0.67
13_K	36_G	0.500	0.67
36_G	207_R	0.500	0.67

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1qwrA	1	0.9968	100	0.124	Contact Map
1zx5A	1	0.9114	100	0.201	Contact Map
2wfpA	1	0.9399	100	0.204	Contact Map
1pmiA	1	0.9494	100	0.236	Contact Map
3rnsA	1	0.6329	99.7	0.813	Contact Map
3bu7A	3	0.8418	99.5	0.833	Contact Map
3nw4A	3	0.8861	98.8	0.877	Contact Map
3myxA	1	0.712	98.7	0.88	Contact Map
1y3tA	2	0.7595	98.7	0.883	Contact Map
3h7jA	1	0.6487	98.6	0.885	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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