GREMLIN Database
MANA3 - Putative mannose-6-phosphate isomerase YvyI
UniProt: P39841 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 316 (287)
Sequences: 3157 (2354)
Seq/√Len: 138.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
128_E156_R4.5081.00
7_F292_D3.6151.00
122_D161_P3.1921.00
59_K67_E3.1851.00
143_T147_S2.9401.00
159_I179_A2.8411.00
20_T24_D2.7151.00
118_W180_L2.5761.00
15_K36_G2.5731.00
103_Y217_A2.5161.00
278_L285_T2.4841.00
278_L306_K2.4741.00
172_L194_V2.4501.00
51_V64_L2.4031.00
102_Y106_E2.3951.00
128_E158_K2.3881.00
142_V146_N2.3631.00
123_C160_K2.3471.00
20_T23_R2.2701.00
166_Y245_G2.2471.00
59_K63_E2.2391.00
280_K285_T2.2281.00
252_K310_T2.1911.00
60_T63_E2.1821.00
44_H47_G2.1801.00
276_S289_K2.1631.00
172_L218_A2.1611.00
278_L287_P2.0711.00
9_T52_A2.0591.00
274_E310_T2.0511.00
103_Y107_N2.0361.00
277_G309_C2.0311.00
137_S140_E2.0221.00
53_N57_K2.0091.00
101_D112_L1.9871.00
111_E190_A1.9271.00
48_P62_I1.9061.00
274_E290_K1.8681.00
289_K292_D1.8671.00
21_A24_D1.8411.00
94_S193_R1.8101.00
286_C294_F1.8091.00
288_L294_F1.8051.00
276_S287_P1.8051.00
46_K189_D1.7751.00
182_L271_S1.7661.00
281_Y284_K1.7421.00
101_D105_G1.7141.00
213_K216_N1.6941.00
63_E67_E1.6811.00
64_L71_V1.6771.00
9_T50_T1.6631.00
271_S293_H1.6621.00
100_D103_Y1.6581.00
280_K306_K1.6491.00
254_D310_T1.6311.00
16_I206_P1.6281.00
192_Y217_A1.6181.00
134_T155_R1.6051.00
62_I66_E1.5991.00
84_T184_T1.5951.00
305_I309_C1.5861.00
280_K304_T1.5641.00
40_A293_H1.5221.00
101_D113_G1.5111.00
272_V275_G1.5101.00
123_C161_P1.5081.00
20_T33_E1.5021.00
50_T60_T1.4771.00
268_L303_F1.4601.00
297_P300_M1.4581.00
97_V217_A1.4321.00
258_E306_K1.4301.00
10_P293_H1.4271.00
7_F286_C1.4271.00
63_E66_E1.4201.00
96_K191_T1.4051.00
84_T182_L1.3861.00
277_G294_F1.3781.00
13_K47_G1.3671.00
23_R35_T1.3641.00
30_I35_T1.3631.00
256_N308_T1.3541.00
23_R26_F1.3511.00
65_W72_F1.3281.00
115_T166_Y1.3201.00
115_T169_S1.3191.00
119_Y250_V1.3171.00
37_E85_K1.3141.00
75_V265_E1.3141.00
94_S207_R1.3001.00
102_Y105_G1.2901.00
160_K163_D1.2801.00
56_Y64_L1.2501.00
138_K216_N1.2371.00
79_R111_E1.2351.00
129_I165_Y1.2341.00
19_G88_D1.2301.00
262_A302_D1.2281.00
16_I91_E1.2241.00
103_Y216_N1.2231.00
142_V215_V1.2221.00
280_K283_D1.2141.00
260_E302_D1.2101.00
97_V218_A1.2031.00
86_L182_L1.2021.00
40_A269_I1.1951.00
281_Y300_M1.1911.00
135_A140_E1.1891.00
130_I156_R1.1871.00
113_G186_Q1.1791.00
122_D180_L1.1741.00
121_I273_I1.1560.99
141_L220_V1.1520.99
79_R112_L1.1450.99
44_H187_N1.1420.99
11_V47_G1.1320.99
38_C293_H1.1160.99
22_L26_F1.1160.99
258_E304_T1.1040.99
83_L185_Q1.1010.99
91_E177_K1.0950.99
10_P38_C1.0950.99
194_V214_A1.0840.99
6_I64_L1.0730.99
88_D180_L1.0710.99
117_C250_V1.0700.99
141_L194_V1.0680.99
184_T250_V1.0640.99
9_T58_G1.0610.99
185_Q191_T1.0560.99
133_H218_A1.0540.99
21_A25_R1.0530.99
44_H48_P1.0480.99
133_H220_V1.0470.99
120_I179_A1.0370.99
277_G288_L1.0350.99
171_T219_T1.0350.99
240_K252_K1.0290.99
159_I165_Y1.0280.99
168_P171_T1.0250.99
21_A180_L1.0220.99
138_K142_V1.0220.99
194_V218_A1.0200.99
163_D229_E1.0180.99
105_G111_E1.0140.99
14_E33_E1.0080.98
115_T186_Q1.0050.98
53_N56_Y0.9980.98
307_G310_T0.9970.98
272_V288_L0.9950.98
296_L303_F0.9930.98
117_C164_F0.9890.98
166_Y248_F0.9860.98
53_N58_G0.9860.98
87_L175_L0.9810.98
110_G190_A0.9690.98
107_N213_K0.9680.98
276_S308_T0.9670.98
17_W94_S0.9630.98
270_C294_F0.9610.98
192_Y213_K0.9580.98
234_R237_I0.9510.98
203_N206_P0.9480.98
130_I176_C0.9480.98
193_R207_R0.9410.98
76_E266_S0.9400.98
19_G179_A0.9390.98
32_S35_T0.9370.98
8_L295_I0.9330.97
10_P40_A0.9260.97
131_Y154_L0.9250.97
20_T32_S0.9190.97
260_E304_T0.9160.97
288_L309_C0.9150.97
86_L121_I0.9110.97
84_T250_V0.9110.97
147_S152_G0.9080.97
117_C184_T0.9080.97
109_E213_K0.9020.97
238_T251_Y0.8970.97
107_N216_N0.8930.97
21_A179_A0.8930.97
37_E83_L0.8930.97
139_T143_T0.8860.97
143_T146_N0.8830.96
71_V297_P0.8750.96
274_E308_T0.8720.96
56_Y59_K0.8720.96
43_A79_R0.8690.96
89_V175_L0.8630.96
140_E144_M0.8580.96
21_A88_D0.8530.96
277_G287_P0.8530.96
71_V295_I0.8510.96
65_W68_H0.8430.95
48_P60_T0.8400.95
25_R290_K0.8390.95
119_Y164_F0.8360.95
113_G247_Y0.8320.95
59_K64_L0.8310.95
227_I230_S0.8290.95
39_W85_K0.8270.95
282_E302_D0.8260.95
101_D186_Q0.8210.95
103_Y106_E0.8140.94
131_Y167_V0.8130.94
28_Y40_A0.8130.94
14_E34_S0.8090.94
7_F52_A0.8040.94
9_T32_S0.8010.94
13_K46_K0.7990.94
92_D177_K0.7930.94
279_L294_F0.7910.94
146_N215_V0.7860.93
15_K189_D0.7830.93
241_T244_Q0.7810.93
120_I123_C0.7810.93
272_V277_G0.7740.93
212_A216_N0.7740.93
295_I298_A0.7730.93
241_T251_Y0.7720.93
23_R33_E0.7710.93
85_K185_Q0.7670.93
100_D219_T0.7640.92
93_T116_E0.7640.92
94_S191_T0.7640.92
69_R75_V0.7630.92
207_R210_H0.7630.92
42_S48_P0.7580.92
10_P49_S0.7570.92
108_E192_Y0.7560.92
129_I159_I0.7530.92
115_T245_G0.7500.92
55_P58_G0.7480.92
144_M152_G0.7470.91
22_L25_R0.7460.91
129_I176_C0.7460.91
87_L190_A0.7450.91
9_T57_K0.7430.91
98_H116_E0.7350.91
90_K177_K0.7330.91
85_K188_S0.7310.91
161_P274_E0.7310.91
128_E177_K0.7300.91
167_V171_T0.7240.90
6_I295_I0.7220.90
72_F76_E0.7210.90
28_Y35_T0.7180.90
65_W80_F0.7170.90
204_G207_R0.7120.89
141_L145_I0.7120.89
28_Y293_H0.7120.89
21_A26_F0.7090.89
130_I154_L0.7040.89
255_I307_G0.7010.89
95_I154_L0.7010.89
191_T207_R0.6980.89
70_E299_Q0.6970.88
56_Y68_H0.6960.88
113_G185_Q0.6950.88
144_M153_L0.6930.88
136_R222_H0.6930.88
28_Y38_C0.6920.88
45_P79_R0.6890.88
123_C128_E0.6870.88
133_H221_P0.6860.88
108_E213_K0.6860.88
97_V171_T0.6820.87
134_T138_K0.6810.87
22_L28_Y0.6810.87
97_V192_Y0.6790.87
255_I309_C0.6790.87
253_W270_C0.6790.87
8_L11_V0.6780.87
84_T271_S0.6780.87
23_R32_S0.6770.87
144_M147_S0.6730.87
300_M303_F0.6710.86
39_W49_S0.6680.86
279_L305_I0.6660.86
26_F290_K0.6650.86
131_Y169_S0.6650.86
164_F243_V0.6610.86
164_F250_V0.6590.85
26_F35_T0.6590.85
156_R176_C0.6580.85
22_L180_L0.6580.85
23_R31_P0.6570.85
273_I310_T0.6550.85
17_W193_R0.6500.85
97_V194_V0.6500.85
279_L286_C0.6500.85
88_D179_A0.6460.84
12_F38_C0.6430.84
15_K87_L0.6410.84
105_G109_E0.6360.83
287_P292_D0.6360.83
117_C271_S0.6330.83
69_R73_G0.6320.83
103_Y213_K0.6320.83
86_L271_S0.6300.83
123_C127_A0.6270.83
64_L68_H0.6270.83
93_T96_K0.6220.82
110_G188_S0.6220.82
204_G210_H0.6220.82
139_T142_V0.6200.82
66_E78_D0.6200.82
299_Q304_T0.6180.82
109_E191_T0.6160.81
143_T262_A0.6140.81
131_Y165_Y0.6120.81
100_D170_G0.6110.81
23_R30_I0.6100.81
239_I251_Y0.6100.81
221_P224_D0.6070.81
65_W69_R0.6060.80
29_S32_S0.6060.80
25_R180_L0.6050.80
96_K193_R0.6050.80
136_R221_P0.6030.80
237_I257_G0.6020.80
15_K34_S0.6020.80
192_Y207_R0.6010.80
297_P301_P0.6010.80
12_F30_I0.6010.80
148_G152_G0.6000.80
134_T154_L0.5990.80
43_A62_I0.5990.80
123_C179_A0.5990.80
106_E216_N0.5940.79
114_K189_D0.5920.79
52_A292_D0.5910.79
9_T29_S0.5910.79
12_F35_T0.5900.79
185_Q210_H0.5900.79
17_W207_R0.5900.79
118_W165_Y0.5880.78
115_T247_Y0.5830.78
239_I305_I0.5790.77
97_V119_Y0.5760.77
176_C179_A0.5720.76
12_F40_A0.5700.76
62_I79_R0.5700.76
119_Y171_T0.5690.76
119_Y182_L0.5690.76
278_L281_Y0.5680.76
263_Q302_D0.5670.76
112_L186_Q0.5660.76
274_E278_L0.5660.76
81_P188_S0.5650.76
23_R29_S0.5650.76
123_C158_K0.5640.75
113_G245_G0.5630.75
94_S210_H0.5630.75
270_C296_L0.5610.75
117_C182_L0.5600.75
6_I53_N0.5600.75
83_L188_S0.5600.75
44_H188_S0.5600.75
26_F119_Y0.5600.75
39_W83_L0.5580.75
283_D302_D0.5580.75
39_W42_S0.5570.75
119_Y252_K0.5570.75
74_G265_E0.5560.74
93_T174_A0.5540.74
192_Y210_H0.5540.74
11_V49_S0.5530.74
16_I204_G0.5500.74
31_P35_T0.5500.74
26_F291_G0.5490.74
255_I277_G0.5490.74
299_Q303_F0.5480.73
104_A190_A0.5460.73
39_W44_H0.5440.73
273_I290_K0.5440.73
244_Q249_S0.5440.73
37_E188_S0.5430.73
264_D268_L0.5430.73
40_A84_T0.5380.72
6_I51_V0.5370.72
165_Y176_C0.5360.72
97_V141_L0.5350.72
175_L185_Q0.5340.71
23_R28_Y0.5340.71
20_T35_T0.5340.71
40_A121_I0.5310.71
89_V176_C0.5310.71
207_R214_A0.5310.71
130_I157_I0.5310.71
104_A110_G0.5300.71
262_A304_T0.5300.71
130_I174_A0.5300.71
182_L250_V0.5280.71
83_L189_D0.5270.71
238_T253_W0.5270.71
92_D272_V0.5260.70
12_F15_K0.5260.70
100_D111_E0.5240.70
42_S187_N0.5240.70
148_G257_G0.5240.70
69_R72_F0.5230.70
157_I165_Y0.5230.70
225_G229_E0.5220.70
100_D217_A0.5200.70
284_K289_K0.5190.69
117_C243_V0.5190.69
280_K284_K0.5180.69
237_I253_W0.5170.69
212_A215_V0.5170.69
24_D70_E0.5140.69
85_K114_K0.5140.69
97_V170_G0.5140.69
171_T225_G0.5130.68
7_F294_F0.5100.68
213_K217_A0.5100.68
89_V179_A0.5080.68
40_A86_L0.5080.68
281_Y301_P0.5070.68
258_E307_G0.5060.67
20_T27_G0.5050.67
25_R121_I0.5040.67
87_L93_T0.5030.67
192_Y208_E0.5020.67
159_I176_C0.5010.67
69_R78_D0.5000.67
13_K36_G0.5000.67
36_G207_R0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qwrA 1 0.9968 100 0.124 Contact Map
1zx5A 1 0.9114 100 0.201 Contact Map
2wfpA 1 0.9399 100 0.204 Contact Map
1pmiA 1 0.9494 100 0.236 Contact Map
3rnsA 1 0.6329 99.7 0.813 Contact Map
3bu7A 3 0.8418 99.5 0.833 Contact Map
3nw4A 3 0.8861 98.8 0.877 Contact Map
3myxA 1 0.712 98.7 0.88 Contact Map
1y3tA 2 0.7595 98.7 0.883 Contact Map
3h7jA 1 0.6487 98.6 0.885 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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