GREMLIN Database
GALM - Aldose 1-epimerase
UniProt: P39840 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 325 (288)
Sequences: 5966 (4563)
Seq/√Len: 268.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
78_G91_I3.2421.00
248_I280_L3.1861.00
99_H139_F3.1071.00
194_D236_S3.0961.00
79_T86_T2.8961.00
25_M38_L2.7521.00
222_M227_K2.6911.00
169_A307_E2.6261.00
128_D144_V2.6231.00
290_N294_L2.5261.00
19_G24_E2.5111.00
94_K97_H2.4491.00
258_I319_T2.3941.00
163_M311_E2.3561.00
24_E39_V2.3341.00
128_D142_H2.3291.00
197_W232_V2.3031.00
124_E148_T2.2781.00
142_H167_K2.2361.00
53_T56_S2.1291.00
16_I123_V2.1291.00
37_S46_Q2.1161.00
161_T313_T2.0901.00
124_E146_R2.0501.00
126_E146_R2.0471.00
122_I150_T2.0461.00
27_V125_T2.0441.00
28_V36_I2.0431.00
270_V280_L2.0271.00
90_D104_L1.9991.00
17_K26_I1.9631.00
213_P219_H1.9511.00
247_V256_S1.9501.00
152_K157_F1.9361.00
45_V255_I1.9301.00
307_E310_E1.9281.00
25_M35_V1.9271.00
159_H315_K1.9231.00
127_I136_Q1.9141.00
26_I37_S1.8601.00
198_E208_K1.8531.00
83_R169_A1.8371.00
23_L38_L1.8281.00
81_S86_T1.8221.00
247_V258_I1.8201.00
171_P305_V1.8071.00
33_S125_T1.7781.00
15_A28_V1.7171.00
79_T88_H1.7161.00
33_S67_P1.7101.00
126_E144_V1.6921.00
143_A172_W1.6511.00
183_P250_H1.6431.00
71_P292_V1.6391.00
260_K319_T1.6321.00
76_S290_N1.6201.00
15_A26_I1.6121.00
71_P304_Q1.5871.00
146_R163_M1.5851.00
90_D137_K1.5761.00
16_I114_T1.5751.00
188_L221_G1.5721.00
188_L249_Y1.5711.00
15_A36_I1.5631.00
38_L320_I1.5621.00
82_F305_V1.5581.00
284_P316_S1.5541.00
112_V126_E1.5431.00
190_S247_V1.5261.00
14_P30_E1.5081.00
48_L178_T1.5081.00
250_H255_I1.5071.00
73_N269_V1.4891.00
17_K24_E1.4681.00
134_H168_E1.4681.00
260_K317_S1.4661.00
97_H202_R1.4541.00
265_F314_A1.4351.00
110_N127_I1.4331.00
157_F317_S1.4201.00
83_R168_E1.4161.00
93_E98_N1.4001.00
195_Q211_D1.3881.00
85_R168_E1.3811.00
234_L288_V1.3781.00
265_F287_W1.3721.00
218_L222_M1.3701.00
173_G287_W1.3681.00
264_Q314_A1.3571.00
105_Y110_N1.3471.00
190_S221_G1.3311.00
223_D226_H1.3281.00
222_M226_H1.3221.00
150_T159_H1.2831.00
274_D277_Q1.2791.00
115_K124_E1.2721.00
249_Y256_S1.2711.00
287_W304_Q1.2691.00
290_N293_N1.2511.00
25_M158_K1.2481.00
188_L251_Q1.2401.00
35_V48_L1.2281.00
30_E111_V1.2261.00
18_A151_I1.2041.00
169_A308_P1.1991.00
122_I148_T1.1981.00
144_V165_K1.1841.00
23_L40_D1.1831.00
23_L155_T1.1801.00
196_Q210_M1.1651.00
275_G278_G1.1631.00
27_V123_V1.1631.00
107_E145_V1.1591.00
198_E210_M1.1541.00
199_L203_L1.1541.00
268_W282_P1.1481.00
169_A305_V1.1371.00
23_L151_I1.1361.00
189_F248_I1.1351.00
250_H253_A1.1301.00
172_W312_T1.1291.00
77_D98_N1.1201.00
78_G88_H1.1101.00
232_V267_H1.1001.00
273_A279_Y1.0861.00
68_I175_G1.0851.00
267_H288_V1.0641.00
115_K126_E1.0641.00
161_T315_K1.0631.00
38_L180_F1.0621.00
28_V34_N1.0601.00
147_M160_A1.0501.00
88_H91_I1.0461.00
77_D97_H1.0411.00
216_E231_D1.0411.00
40_D47_L1.0381.00
191_L270_V1.0371.00
74_R100_L1.0331.00
46_Q50_E1.0261.00
212_V219_H1.0221.00
136_Q142_H1.0201.00
20_N151_I1.0151.00
232_V269_V1.0141.00
19_G41_K1.0101.00
121_V150_T1.0001.00
91_I97_H1.0001.00
245_Q261_A0.9981.00
49_R279_Y0.9951.00
244_N260_K0.9931.00
83_R307_E0.9921.00
152_K155_T0.9921.00
172_W306_L0.9901.00
119_E122_I0.9881.00
235_S245_Q0.9711.00
259_Y284_P0.9681.00
81_S84_G0.9671.00
257_I320_I0.9651.00
148_T161_T0.9631.00
115_K122_I0.9621.00
35_V178_T0.9621.00
187_S250_H0.9611.00
76_S200_D0.9611.00
188_L223_D0.9581.00
206_T209_L0.9561.00
20_N153_E0.9561.00
70_F129_L0.9551.00
142_H166_G0.9531.00
107_E127_I0.9421.00
67_P147_M0.9391.00
145_V174_I0.9391.00
67_P176_Y0.9381.00
185_E277_Q0.9331.00
291_A304_Q0.9311.00
190_S220_E0.9281.00
189_F218_L0.9241.00
20_N155_T0.9241.00
244_N247_V0.9121.00
55_E58_H0.9081.00
21_E153_E0.9041.00
306_L311_E0.9041.00
177_H283_E0.8951.00
154_N319_T0.8911.00
244_N258_I0.8911.00
76_S293_N0.8881.00
235_S261_A0.8831.00
174_I312_T0.8821.00
30_E108_K0.8811.00
190_S249_Y0.8781.00
98_N202_R0.8781.00
224_L280_L0.8771.00
114_T123_V0.8761.00
101_H283_E0.8721.00
76_S204_L0.8661.00
75_I89_F0.8641.00
103_F106_H0.8641.00
186_S223_D0.8621.00
129_L136_Q0.8501.00
79_T293_N0.8441.00
155_T319_T0.8441.00
189_F270_V0.8431.00
38_L48_L0.8421.00
192_T244_N0.8391.00
246_A268_W0.8380.99
155_T317_S0.8350.99
171_P292_V0.8320.99
40_D43_T0.8320.99
189_F282_P0.8320.99
125_T149_Y0.8270.99
154_N157_F0.8250.99
163_M313_T0.8230.99
34_N66_I0.8230.99
71_P171_P0.8210.99
101_H177_H0.8200.99
51_P65_G0.8200.99
42_T255_I0.8170.99
192_T236_S0.8160.99
171_P303_L0.8120.99
71_P99_H0.8110.99
229_L270_V0.8090.99
39_V46_Q0.8090.99
80_F87_Y0.8080.99
47_L320_I0.8080.99
239_K243_E0.8070.99
35_V158_K0.8050.99
191_L268_W0.7950.99
91_I99_H0.7930.99
267_H302_G0.7920.99
63_L108_K0.7900.99
83_R305_V0.7860.99
157_F319_T0.7860.99
159_H317_S0.7850.99
259_Y282_P0.7830.99
191_L246_A0.7820.99
16_I125_T0.7800.99
133_P142_H0.7740.99
152_K159_H0.7690.99
70_F143_A0.7660.99
166_G308_P0.7600.99
76_S294_L0.7560.99
284_P314_A0.7560.99
245_Q258_I0.7520.99
186_S252_H0.7460.99
70_F145_V0.7450.99
68_I147_M0.7400.99
70_F102_G0.7390.99
63_L100_L0.7380.99
166_G170_F0.7350.99
16_I30_E0.7330.99
93_E100_L0.7300.99
218_L221_G0.7300.99
216_E233_F0.7290.99
160_A176_Y0.7280.99
195_Q209_L0.7260.99
248_I282_P0.7260.99
107_E143_A0.7250.99
31_W108_K0.7190.98
73_N232_V0.7190.98
232_V285_Y0.7180.98
288_V302_G0.7180.98
145_V162_V0.7150.98
291_A301_T0.7150.98
26_I36_I0.7150.98
35_V176_Y0.7140.98
38_L47_L0.7140.98
99_H102_G0.7080.98
89_F99_H0.7080.98
287_W291_A0.7080.98
196_Q216_E0.7030.98
21_E155_T0.6990.98
180_F318_I0.6990.98
194_D219_H0.6970.98
146_R161_T0.6940.98
182_F187_S0.6940.98
23_L47_L0.6930.98
105_Y137_K0.6920.98
50_E181_I0.6910.98
143_A170_F0.6890.98
54_A58_H0.6890.98
161_T311_E0.6880.98
71_P291_A0.6880.98
40_D255_I0.6870.98
192_T243_E0.6860.98
20_N154_N0.6850.98
259_Y318_I0.6810.98
48_L180_F0.6780.98
23_L41_K0.6780.98
82_F141_H0.6760.98
159_H313_T0.6750.98
94_K98_N0.6700.98
110_N136_Q0.6670.98
183_P251_Q0.6650.97
164_N172_W0.6630.97
51_P57_F0.6610.97
45_V253_A0.6600.97
35_V38_L0.6570.97
80_F89_F0.6460.97
242_G317_S0.6450.97
74_R283_E0.6450.97
90_D99_H0.6450.97
306_L310_E0.6450.97
270_V282_P0.6430.97
56_S59_D0.6430.97
30_E114_T0.6430.97
233_F270_V0.6360.97
113_T126_E0.6330.97
184_A280_L0.6320.97
43_T254_H0.6320.97
212_V217_A0.6290.96
184_A224_L0.6290.96
261_A316_S0.6280.96
129_L142_H0.6280.96
150_T161_T0.6260.96
18_A123_V0.6210.96
20_N23_L0.6210.96
183_P252_H0.6200.96
64_Y106_H0.6180.96
187_S248_I0.6140.96
27_V35_V0.6100.96
128_D133_P0.6090.96
75_I292_V0.6090.96
77_D202_R0.6070.96
107_E129_L0.6060.96
110_N126_E0.6050.96
77_D91_I0.6050.96
185_E188_L0.6040.96
222_M228_Q0.6020.95
221_G249_Y0.6010.95
104_L127_I0.6000.95
185_E228_Q0.6000.95
33_S149_Y0.5990.95
191_L218_L0.5990.95
37_S50_E0.5980.95
72_P285_Y0.5980.95
129_L133_P0.5980.95
21_E41_K0.5960.95
162_V175_G0.5960.95
75_I80_F0.5930.95
26_I39_V0.5920.95
28_V31_W0.5900.95
142_H165_K0.5900.95
196_Q233_F0.5900.95
198_E206_T0.5900.95
71_P75_I0.5890.95
189_F224_L0.5870.95
184_A272_N0.5860.95
129_L135_V0.5860.95
269_V285_Y0.5850.95
134_H137_K0.5840.95
141_H166_G0.5830.95
196_Q231_D0.5820.95
78_G99_H0.5780.94
45_V250_H0.5780.94
264_Q315_K0.5760.94
74_R101_H0.5750.94
34_N60_T0.5730.94
111_V114_T0.5710.94
162_V316_S0.5700.94
22_H153_E0.5680.94
22_H43_T0.5670.94
197_W288_V0.5670.94
144_V163_M0.5660.94
186_S225_R0.5650.94
104_L109_W0.5650.94
67_P162_V0.5650.94
139_F170_F0.5640.94
102_G139_F0.5620.94
51_P56_S0.5590.93
225_R228_Q0.5570.93
67_P149_Y0.5570.93
81_S293_N0.5560.93
79_T91_I0.5560.93
113_T122_I0.5560.93
36_I57_F0.5550.93
31_W111_V0.5550.93
227_K230_D0.5550.93
198_E209_L0.5550.93
82_F89_F0.5530.93
296_L301_T0.5520.93
48_L65_G0.5520.93
72_P287_W0.5480.93
30_E125_T0.5480.93
19_G120_G0.5470.93
76_S202_R0.5460.93
18_A25_M0.5460.93
115_K121_V0.5440.92
176_Y316_S0.5430.92
81_S87_Y0.5410.92
23_L320_I0.5400.92
31_W34_N0.5400.92
184_A187_S0.5390.92
195_Q198_E0.5390.92
271_Y281_C0.5390.92
224_L227_K0.5330.92
240_R243_E0.5330.92
165_K170_F0.5320.92
199_L232_V0.5310.91
229_L233_F0.5300.91
165_K309_G0.5290.91
162_V172_W0.5280.91
172_W314_A0.5250.91
192_T245_Q0.5250.91
257_I318_I0.5250.91
168_E308_P0.5240.91
206_T210_M0.5240.91
121_V153_E0.5230.91
248_I270_V0.5210.91
36_I65_G0.5200.91
104_L145_V0.5200.91
76_S98_N0.5160.90
166_G169_A0.5160.90
100_L289_T0.5150.90
209_L234_L0.5130.90
223_D251_Q0.5120.90
93_E99_H0.5110.90
80_F293_N0.5100.90
105_Y109_W0.5100.90
230_D274_D0.5090.90
75_I78_G0.5090.90
214_Y217_A0.5090.90
68_I72_P0.5090.90
184_A226_H0.5080.90
179_T271_Y0.5080.90
259_Y316_S0.5070.90
178_T284_P0.5060.89
68_I145_V0.5060.89
51_P62_T0.5040.89
148_T163_M0.5040.89
291_A302_G0.5020.89
51_P64_Y0.5010.89
165_K311_E0.5000.89
207_G210_M0.5000.89
162_V166_G0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mwxA 1 0.9908 100 0.191 Contact Map
1z45A 2 0.9446 100 0.213 Contact Map
3os7A 2 0.9877 100 0.217 Contact Map
1ygaA 2 0.92 100 0.247 Contact Map
1lurA 1 0.8923 100 0.25 Contact Map
1snzA 1 0.9385 100 0.251 Contact Map
1nsxA 2 0.9262 100 0.26 Contact Map
4rnlA 1 0.9385 100 0.269 Contact Map
3imhA 3 0.9138 100 0.275 Contact Map
3nreA 1 0.8708 100 0.303 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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