GALM - BACSU - GREMLIN Contacts

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GALM - Aldose 1-epimerase

UniProt:	P39840	Sequences: MANFIEKITYLGTPAIKAGNEHLEMIVVPEWGSNVISLVDKTTNVQLLREPETAESFHDTPTLYGIPILFPPNRISDGTFSFRGRTYHFDINEKDKHNHLHGFLYHEKWNVVTTKQTDEGVIVETEIDLSELPHVQKQFPHHAVVRMTYTIKENTLFKHATVMNKGKEAFPWGIGYHTTFIFPAESSLFSLTADQQWELDERLLPTGKLMDVPYKEALHEGMDLRHKQLDDVFLSSYQKRGGENQAVIYHQHAHISIIYKADEQFKHWVVYNADGKQGYLCPEPYTWVTNAVNLDLPSSLTGLQVLEPGEETTAKSSITIELNHQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	325 (288)
Sequences:	5966 (4563)
Seq/√Len:	268.9

ECOLI - YIHR GALM YPHB
BACSU - GALM
SULSO - Q97V88

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
78_G	91_I	3.242	1.00
248_I	280_L	3.186	1.00
99_H	139_F	3.107	1.00
194_D	236_S	3.096	1.00
79_T	86_T	2.896	1.00
25_M	38_L	2.752	1.00
222_M	227_K	2.691	1.00
169_A	307_E	2.626	1.00
128_D	144_V	2.623	1.00
290_N	294_L	2.526	1.00
19_G	24_E	2.511	1.00
94_K	97_H	2.449	1.00
258_I	319_T	2.394	1.00
163_M	311_E	2.356	1.00
24_E	39_V	2.334	1.00
128_D	142_H	2.329	1.00
197_W	232_V	2.303	1.00
124_E	148_T	2.278	1.00
142_H	167_K	2.236	1.00
53_T	56_S	2.129	1.00
16_I	123_V	2.129	1.00
37_S	46_Q	2.116	1.00
161_T	313_T	2.090	1.00
124_E	146_R	2.050	1.00
126_E	146_R	2.047	1.00
122_I	150_T	2.046	1.00
27_V	125_T	2.044	1.00
28_V	36_I	2.043	1.00
270_V	280_L	2.027	1.00
90_D	104_L	1.999	1.00
17_K	26_I	1.963	1.00
213_P	219_H	1.951	1.00
247_V	256_S	1.950	1.00
152_K	157_F	1.936	1.00
45_V	255_I	1.930	1.00
307_E	310_E	1.928	1.00
25_M	35_V	1.927	1.00
159_H	315_K	1.923	1.00
127_I	136_Q	1.914	1.00
26_I	37_S	1.860	1.00
198_E	208_K	1.853	1.00
83_R	169_A	1.837	1.00
23_L	38_L	1.828	1.00
81_S	86_T	1.822	1.00
247_V	258_I	1.820	1.00
171_P	305_V	1.807	1.00
33_S	125_T	1.778	1.00
15_A	28_V	1.717	1.00
79_T	88_H	1.716	1.00
33_S	67_P	1.710	1.00
126_E	144_V	1.692	1.00
143_A	172_W	1.651	1.00
183_P	250_H	1.643	1.00
71_P	292_V	1.639	1.00
260_K	319_T	1.632	1.00
76_S	290_N	1.620	1.00
15_A	26_I	1.612	1.00
71_P	304_Q	1.587	1.00
146_R	163_M	1.585	1.00
90_D	137_K	1.576	1.00
16_I	114_T	1.575	1.00
188_L	221_G	1.572	1.00
188_L	249_Y	1.571	1.00
15_A	36_I	1.563	1.00
38_L	320_I	1.562	1.00
82_F	305_V	1.558	1.00
284_P	316_S	1.554	1.00
112_V	126_E	1.543	1.00
190_S	247_V	1.526	1.00
14_P	30_E	1.508	1.00
48_L	178_T	1.508	1.00
250_H	255_I	1.507	1.00
73_N	269_V	1.489	1.00
17_K	24_E	1.468	1.00
134_H	168_E	1.468	1.00
260_K	317_S	1.466	1.00
97_H	202_R	1.454	1.00
265_F	314_A	1.435	1.00
110_N	127_I	1.433	1.00
157_F	317_S	1.420	1.00
83_R	168_E	1.416	1.00
93_E	98_N	1.400	1.00
195_Q	211_D	1.388	1.00
85_R	168_E	1.381	1.00
234_L	288_V	1.378	1.00
265_F	287_W	1.372	1.00
218_L	222_M	1.370	1.00
173_G	287_W	1.368	1.00
264_Q	314_A	1.357	1.00
105_Y	110_N	1.347	1.00
190_S	221_G	1.331	1.00
223_D	226_H	1.328	1.00
222_M	226_H	1.322	1.00
150_T	159_H	1.283	1.00
274_D	277_Q	1.279	1.00
115_K	124_E	1.272	1.00
249_Y	256_S	1.271	1.00
287_W	304_Q	1.269	1.00
290_N	293_N	1.251	1.00
25_M	158_K	1.248	1.00
188_L	251_Q	1.240	1.00
35_V	48_L	1.228	1.00
30_E	111_V	1.226	1.00
18_A	151_I	1.204	1.00
169_A	308_P	1.199	1.00
122_I	148_T	1.198	1.00
144_V	165_K	1.184	1.00
23_L	40_D	1.183	1.00
23_L	155_T	1.180	1.00
196_Q	210_M	1.165	1.00
275_G	278_G	1.163	1.00
27_V	123_V	1.163	1.00
107_E	145_V	1.159	1.00
198_E	210_M	1.154	1.00
199_L	203_L	1.154	1.00
268_W	282_P	1.148	1.00
169_A	305_V	1.137	1.00
23_L	151_I	1.136	1.00
189_F	248_I	1.135	1.00
250_H	253_A	1.130	1.00
172_W	312_T	1.129	1.00
77_D	98_N	1.120	1.00
78_G	88_H	1.110	1.00
232_V	267_H	1.100	1.00
273_A	279_Y	1.086	1.00
68_I	175_G	1.085	1.00
267_H	288_V	1.064	1.00
115_K	126_E	1.064	1.00
161_T	315_K	1.063	1.00
38_L	180_F	1.062	1.00
28_V	34_N	1.060	1.00
147_M	160_A	1.050	1.00
88_H	91_I	1.046	1.00
77_D	97_H	1.041	1.00
216_E	231_D	1.041	1.00
40_D	47_L	1.038	1.00
191_L	270_V	1.037	1.00
74_R	100_L	1.033	1.00
46_Q	50_E	1.026	1.00
212_V	219_H	1.022	1.00
136_Q	142_H	1.020	1.00
20_N	151_I	1.015	1.00
232_V	269_V	1.014	1.00
19_G	41_K	1.010	1.00
121_V	150_T	1.000	1.00
91_I	97_H	1.000	1.00
245_Q	261_A	0.998	1.00
49_R	279_Y	0.995	1.00
244_N	260_K	0.993	1.00
83_R	307_E	0.992	1.00
152_K	155_T	0.992	1.00
172_W	306_L	0.990	1.00
119_E	122_I	0.988	1.00
235_S	245_Q	0.971	1.00
259_Y	284_P	0.968	1.00
81_S	84_G	0.967	1.00
257_I	320_I	0.965	1.00
148_T	161_T	0.963	1.00
115_K	122_I	0.962	1.00
35_V	178_T	0.962	1.00
187_S	250_H	0.961	1.00
76_S	200_D	0.961	1.00
188_L	223_D	0.958	1.00
206_T	209_L	0.956	1.00
20_N	153_E	0.956	1.00
70_F	129_L	0.955	1.00
142_H	166_G	0.953	1.00
107_E	127_I	0.942	1.00
67_P	147_M	0.939	1.00
145_V	174_I	0.939	1.00
67_P	176_Y	0.938	1.00
185_E	277_Q	0.933	1.00
291_A	304_Q	0.931	1.00
190_S	220_E	0.928	1.00
189_F	218_L	0.924	1.00
20_N	155_T	0.924	1.00
244_N	247_V	0.912	1.00
55_E	58_H	0.908	1.00
21_E	153_E	0.904	1.00
306_L	311_E	0.904	1.00
177_H	283_E	0.895	1.00
154_N	319_T	0.891	1.00
244_N	258_I	0.891	1.00
76_S	293_N	0.888	1.00
235_S	261_A	0.883	1.00
174_I	312_T	0.882	1.00
30_E	108_K	0.881	1.00
190_S	249_Y	0.878	1.00
98_N	202_R	0.878	1.00
224_L	280_L	0.877	1.00
114_T	123_V	0.876	1.00
101_H	283_E	0.872	1.00
76_S	204_L	0.866	1.00
75_I	89_F	0.864	1.00
103_F	106_H	0.864	1.00
186_S	223_D	0.862	1.00
129_L	136_Q	0.850	1.00
79_T	293_N	0.844	1.00
155_T	319_T	0.844	1.00
189_F	270_V	0.843	1.00
38_L	48_L	0.842	1.00
192_T	244_N	0.839	1.00
246_A	268_W	0.838	0.99
155_T	317_S	0.835	0.99
171_P	292_V	0.832	0.99
40_D	43_T	0.832	0.99
189_F	282_P	0.832	0.99
125_T	149_Y	0.827	0.99
154_N	157_F	0.825	0.99
163_M	313_T	0.823	0.99
34_N	66_I	0.823	0.99
71_P	171_P	0.821	0.99
101_H	177_H	0.820	0.99
51_P	65_G	0.820	0.99
42_T	255_I	0.817	0.99
192_T	236_S	0.816	0.99
171_P	303_L	0.812	0.99
71_P	99_H	0.811	0.99
229_L	270_V	0.809	0.99
39_V	46_Q	0.809	0.99
80_F	87_Y	0.808	0.99
47_L	320_I	0.808	0.99
239_K	243_E	0.807	0.99
35_V	158_K	0.805	0.99
191_L	268_W	0.795	0.99
91_I	99_H	0.793	0.99
267_H	302_G	0.792	0.99
63_L	108_K	0.790	0.99
83_R	305_V	0.786	0.99
157_F	319_T	0.786	0.99
159_H	317_S	0.785	0.99
259_Y	282_P	0.783	0.99
191_L	246_A	0.782	0.99
16_I	125_T	0.780	0.99
133_P	142_H	0.774	0.99
152_K	159_H	0.769	0.99
70_F	143_A	0.766	0.99
166_G	308_P	0.760	0.99
76_S	294_L	0.756	0.99
284_P	314_A	0.756	0.99
245_Q	258_I	0.752	0.99
186_S	252_H	0.746	0.99
70_F	145_V	0.745	0.99
68_I	147_M	0.740	0.99
70_F	102_G	0.739	0.99
63_L	100_L	0.738	0.99
166_G	170_F	0.735	0.99
16_I	30_E	0.733	0.99
93_E	100_L	0.730	0.99
218_L	221_G	0.730	0.99
216_E	233_F	0.729	0.99
160_A	176_Y	0.728	0.99
195_Q	209_L	0.726	0.99
248_I	282_P	0.726	0.99
107_E	143_A	0.725	0.99
31_W	108_K	0.719	0.98
73_N	232_V	0.719	0.98
232_V	285_Y	0.718	0.98
288_V	302_G	0.718	0.98
145_V	162_V	0.715	0.98
291_A	301_T	0.715	0.98
26_I	36_I	0.715	0.98
35_V	176_Y	0.714	0.98
38_L	47_L	0.714	0.98
99_H	102_G	0.708	0.98
89_F	99_H	0.708	0.98
287_W	291_A	0.708	0.98
196_Q	216_E	0.703	0.98
21_E	155_T	0.699	0.98
180_F	318_I	0.699	0.98
194_D	219_H	0.697	0.98
146_R	161_T	0.694	0.98
182_F	187_S	0.694	0.98
23_L	47_L	0.693	0.98
105_Y	137_K	0.692	0.98
50_E	181_I	0.691	0.98
143_A	170_F	0.689	0.98
54_A	58_H	0.689	0.98
161_T	311_E	0.688	0.98
71_P	291_A	0.688	0.98
40_D	255_I	0.687	0.98
192_T	243_E	0.686	0.98
20_N	154_N	0.685	0.98
259_Y	318_I	0.681	0.98
48_L	180_F	0.678	0.98
23_L	41_K	0.678	0.98
82_F	141_H	0.676	0.98
159_H	313_T	0.675	0.98
94_K	98_N	0.670	0.98
110_N	136_Q	0.667	0.98
183_P	251_Q	0.665	0.97
164_N	172_W	0.663	0.97
51_P	57_F	0.661	0.97
45_V	253_A	0.660	0.97
35_V	38_L	0.657	0.97
80_F	89_F	0.646	0.97
242_G	317_S	0.645	0.97
74_R	283_E	0.645	0.97
90_D	99_H	0.645	0.97
306_L	310_E	0.645	0.97
270_V	282_P	0.643	0.97
56_S	59_D	0.643	0.97
30_E	114_T	0.643	0.97
233_F	270_V	0.636	0.97
113_T	126_E	0.633	0.97
184_A	280_L	0.632	0.97
43_T	254_H	0.632	0.97
212_V	217_A	0.629	0.96
184_A	224_L	0.629	0.96
261_A	316_S	0.628	0.96
129_L	142_H	0.628	0.96
150_T	161_T	0.626	0.96
18_A	123_V	0.621	0.96
20_N	23_L	0.621	0.96
183_P	252_H	0.620	0.96
64_Y	106_H	0.618	0.96
187_S	248_I	0.614	0.96
27_V	35_V	0.610	0.96
128_D	133_P	0.609	0.96
75_I	292_V	0.609	0.96
77_D	202_R	0.607	0.96
107_E	129_L	0.606	0.96
110_N	126_E	0.605	0.96
77_D	91_I	0.605	0.96
185_E	188_L	0.604	0.96
222_M	228_Q	0.602	0.95
221_G	249_Y	0.601	0.95
104_L	127_I	0.600	0.95
185_E	228_Q	0.600	0.95
33_S	149_Y	0.599	0.95
191_L	218_L	0.599	0.95
37_S	50_E	0.598	0.95
72_P	285_Y	0.598	0.95
129_L	133_P	0.598	0.95
21_E	41_K	0.596	0.95
162_V	175_G	0.596	0.95
75_I	80_F	0.593	0.95
26_I	39_V	0.592	0.95
28_V	31_W	0.590	0.95
142_H	165_K	0.590	0.95
196_Q	233_F	0.590	0.95
198_E	206_T	0.590	0.95
71_P	75_I	0.589	0.95
189_F	224_L	0.587	0.95
184_A	272_N	0.586	0.95
129_L	135_V	0.586	0.95
269_V	285_Y	0.585	0.95
134_H	137_K	0.584	0.95
141_H	166_G	0.583	0.95
196_Q	231_D	0.582	0.95
78_G	99_H	0.578	0.94
45_V	250_H	0.578	0.94
264_Q	315_K	0.576	0.94
74_R	101_H	0.575	0.94
34_N	60_T	0.573	0.94
111_V	114_T	0.571	0.94
162_V	316_S	0.570	0.94
22_H	153_E	0.568	0.94
22_H	43_T	0.567	0.94
197_W	288_V	0.567	0.94
144_V	163_M	0.566	0.94
186_S	225_R	0.565	0.94
104_L	109_W	0.565	0.94
67_P	162_V	0.565	0.94
139_F	170_F	0.564	0.94
102_G	139_F	0.562	0.94
51_P	56_S	0.559	0.93
225_R	228_Q	0.557	0.93
67_P	149_Y	0.557	0.93
81_S	293_N	0.556	0.93
79_T	91_I	0.556	0.93
113_T	122_I	0.556	0.93
36_I	57_F	0.555	0.93
31_W	111_V	0.555	0.93
227_K	230_D	0.555	0.93
198_E	209_L	0.555	0.93
82_F	89_F	0.553	0.93
296_L	301_T	0.552	0.93
48_L	65_G	0.552	0.93
72_P	287_W	0.548	0.93
30_E	125_T	0.548	0.93
19_G	120_G	0.547	0.93
76_S	202_R	0.546	0.93
18_A	25_M	0.546	0.93
115_K	121_V	0.544	0.92
176_Y	316_S	0.543	0.92
81_S	87_Y	0.541	0.92
23_L	320_I	0.540	0.92
31_W	34_N	0.540	0.92
184_A	187_S	0.539	0.92
195_Q	198_E	0.539	0.92
271_Y	281_C	0.539	0.92
224_L	227_K	0.533	0.92
240_R	243_E	0.533	0.92
165_K	170_F	0.532	0.92
199_L	232_V	0.531	0.91
229_L	233_F	0.530	0.91
165_K	309_G	0.529	0.91
162_V	172_W	0.528	0.91
172_W	314_A	0.525	0.91
192_T	245_Q	0.525	0.91
257_I	318_I	0.525	0.91
168_E	308_P	0.524	0.91
206_T	210_M	0.524	0.91
121_V	153_E	0.523	0.91
248_I	270_V	0.521	0.91
36_I	65_G	0.520	0.91
104_L	145_V	0.520	0.91
76_S	98_N	0.516	0.90
166_G	169_A	0.516	0.90
100_L	289_T	0.515	0.90
209_L	234_L	0.513	0.90
223_D	251_Q	0.512	0.90
93_E	99_H	0.511	0.90
80_F	293_N	0.510	0.90
105_Y	109_W	0.510	0.90
230_D	274_D	0.509	0.90
75_I	78_G	0.509	0.90
214_Y	217_A	0.509	0.90
68_I	72_P	0.509	0.90
184_A	226_H	0.508	0.90
179_T	271_Y	0.508	0.90
259_Y	316_S	0.507	0.90
178_T	284_P	0.506	0.89
68_I	145_V	0.506	0.89
51_P	62_T	0.504	0.89
148_T	163_M	0.504	0.89
291_A	302_G	0.502	0.89
51_P	64_Y	0.501	0.89
165_K	311_E	0.500	0.89
207_G	210_M	0.500	0.89
162_V	166_G	0.500	0.89

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3mwxA	1	0.9908	100	0.191	Contact Map
1z45A	2	0.9446	100	0.213	Contact Map
3os7A	2	0.9877	100	0.217	Contact Map
1ygaA	2	0.92	100	0.247	Contact Map
1lurA	1	0.8923	100	0.25	Contact Map
1snzA	1	0.9385	100	0.251	Contact Map
1nsxA	2	0.9262	100	0.26	Contact Map
4rnlA	1	0.9385	100	0.269	Contact Map
3imhA	3	0.9138	100	0.275	Contact Map
3nreA	1	0.8708	100	0.303	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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