GREMLIN Database
BLAC - Beta-lactamase
UniProt: P39824 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 306 (257)
Sequences: 3197 (2494)
Seq/√Len: 155.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
110_E158_Q4.1791.00
78_A81_P3.0361.00
204_A277_A2.7661.00
80_R83_E2.7591.00
65_G85_F2.6181.00
104_S217_T2.5571.00
67_Y204_A2.5541.00
99_V155_L2.3851.00
65_G200_A2.3401.00
82_N201_K2.3221.00
274_I298_A2.2991.00
69_I208_K2.2851.00
237_L254_A2.2331.00
68_A276_V2.2061.00
157_Q182_F2.1581.00
111_V133_G2.1551.00
95_A152_G2.1531.00
96_A140_S2.0641.00
104_S220_K2.0311.00
96_A224_L2.0141.00
226_D230_G1.9911.00
229_R247_E1.9801.00
237_L260_R1.9331.00
137_K223_I1.9071.00
200_A279_L1.8921.00
203_L279_L1.8811.00
204_A275_V1.8591.00
96_A144_I1.8571.00
99_V140_S1.8461.00
98_A102_K1.8371.00
177_T198_S1.8341.00
278_I294_I1.8071.00
299_K303_N1.8041.00
90_T279_L1.7961.00
141_E145_R1.7421.00
70_D73_S1.7411.00
118_D157_Q1.7301.00
228_M249_G1.7281.00
67_Y201_K1.7241.00
217_T220_K1.7141.00
93_V263_I1.7131.00
101_K105_I1.7051.00
63_R281_N1.6881.00
59_K296_E1.6851.00
113_H133_G1.6791.00
145_R230_G1.6721.00
96_A143_A1.6421.00
56_L293_L1.6211.00
120_V123_S1.5911.00
263_I277_A1.5801.00
98_A168_S1.5581.00
250_D262_D1.5521.00
81_P201_K1.5511.00
207_L263_I1.5401.00
101_K168_S1.4981.00
216_L221_R1.4961.00
238_I298_A1.4771.00
64_L280_S1.4521.00
99_V136_L1.4501.00
147_S251_K1.4481.00
166_E170_K1.4071.00
139_I151_A1.3881.00
139_I155_L1.3861.00
98_A159_L1.3801.00
93_V207_L1.3741.00
92_K147_S1.3671.00
103_N106_E1.3651.00
201_K205_T1.3541.00
103_N108_L1.3531.00
238_I278_I1.3511.00
50_N54_V1.3421.00
168_S172_I1.3401.00
95_A156_L1.3351.00
85_F200_A1.3281.00
89_S147_S1.3271.00
70_D271_R1.3181.00
63_R83_E1.3171.00
266_V274_I1.3091.00
95_A143_A1.3061.00
94_L169_L1.2981.00
60_F293_L1.2901.00
203_L263_I1.2891.00
223_I226_D1.2801.00
276_V298_A1.2751.00
138_E141_E1.2571.00
182_F185_D1.2411.00
229_R249_G1.2411.00
225_T229_R1.2341.00
90_T203_L1.2311.00
100_L223_I1.2271.00
107_K110_E1.2271.00
90_T261_N1.2241.00
267_W273_P1.2231.00
92_K149_N1.2231.00
111_V135_S1.2151.00
237_L252_S1.2091.00
250_D264_A1.2031.00
167_K171_Q1.1951.00
292_A296_E1.1941.00
76_T201_K1.1731.00
239_R250_D1.1721.00
238_I276_V1.1631.00
87_Y198_S1.1591.00
90_T263_I1.1581.00
242_A248_V1.1581.00
89_S92_K1.1541.00
174_D177_T1.1531.00
223_I227_W1.1451.00
260_R291_N1.1421.00
92_K251_K1.1411.00
100_L224_L1.1401.00
169_L177_T1.1391.00
86_A281_N1.1381.00
136_L155_L1.1361.00
93_V228_M1.1311.00
109_N137_K1.1301.00
156_L182_F1.1291.00
52_K55_Q1.1271.00
140_S227_W1.1261.00
91_Y156_L1.1161.00
135_S138_E1.1050.99
94_L97_A1.1010.99
93_V144_I1.0930.99
168_S171_Q1.0910.99
100_L216_L1.0900.99
99_V159_L1.0870.99
298_A302_L1.0850.99
56_L300_V1.0790.99
101_K171_Q1.0710.99
238_I264_A1.0700.99
84_R197_T1.0670.99
174_D202_A1.0660.99
205_T209_A1.0620.99
176_V199_T1.0560.99
136_L139_I1.0540.99
222_M226_D1.0470.99
123_S127_E1.0450.99
266_V276_V1.0410.99
156_L179_A1.0380.99
141_E230_G1.0380.99
62_A293_L1.0360.99
72_G273_P1.0350.99
114_Y133_G1.0310.99
146_Y232_A1.0260.99
177_T202_A1.0250.99
114_Y154_I1.0220.99
261_N279_L1.0220.99
224_L228_M1.0200.99
125_I146_Y1.0150.99
67_Y76_T1.0140.99
115_S118_D1.0100.99
211_T225_T1.0090.99
103_N107_K1.0090.99
189_A193_D1.0090.99
122_Y126_T0.9890.99
213_D221_R0.9850.99
78_A201_K0.9840.99
95_A155_L0.9820.99
89_S251_K0.9720.99
229_R267_W0.9640.99
94_L206_D0.9460.98
88_A255_G0.9460.98
209_A214_N0.9400.98
207_L265_I0.9400.98
66_V278_I0.9340.98
91_Y95_A0.9330.98
98_A101_K0.9290.98
136_L158_Q0.9250.98
176_V202_A0.9150.98
91_Y152_G0.9120.98
144_I251_K0.9090.98
207_L228_M0.9050.98
237_L291_N0.8920.98
95_A165_F0.8920.98
144_I231_N0.8900.98
240_A295_A0.8880.98
276_V301_V0.8880.98
261_N280_S0.8830.98
249_G265_I0.8810.97
89_S149_N0.8800.97
193_D196_D0.8770.97
254_A260_R0.8750.97
238_I248_V0.8740.97
225_T267_W0.8740.97
149_N251_K0.8600.97
97_A168_S0.8600.97
162_P166_E0.8590.97
69_I204_A0.8560.97
129_H132_T0.8530.97
202_A205_T0.8520.97
97_A210_F0.8510.97
296_E299_K0.8500.97
143_A152_G0.8470.97
249_G267_W0.8420.97
169_L172_I0.8390.97
251_K262_D0.8370.97
248_V264_A0.8370.97
198_S203_L0.8360.97
70_D74_N0.8290.96
231_N250_D0.8290.96
211_T265_I0.8250.96
94_L177_T0.8230.96
102_K159_L0.8170.96
68_A274_I0.8140.96
124_P127_E0.8050.96
52_K300_V0.8030.96
268_P271_R0.7910.95
231_N234_G0.7900.95
103_N220_K0.7870.95
111_V138_E0.7790.95
181_R196_D0.7770.95
66_V301_V0.7730.95
72_G272_A0.7730.95
208_K212_L0.7690.94
120_V184_T0.7650.94
265_I275_V0.7620.94
205_T208_K0.7610.94
53_F297_A0.7560.94
159_L165_F0.7530.94
129_H138_E0.7520.94
47_C50_N0.7500.94
255_G259_T0.7490.94
169_L179_A0.7490.94
166_E179_A0.7470.94
254_A291_N0.7440.93
86_A261_N0.7430.93
70_D272_A0.7420.93
64_L297_A0.7390.93
67_Y81_P0.7390.93
119_L130_L0.7390.93
164_G167_K0.7370.93
212_L275_V0.7320.93
231_N252_S0.7300.93
54_V79_Y0.7270.93
209_A215_T0.7250.93
57_E79_Y0.7210.92
238_I294_I0.7190.92
126_T134_M0.7180.92
55_Q58_K0.7170.92
181_R189_A0.7140.92
56_L296_E0.7130.92
215_T221_R0.7110.92
94_L203_L0.7100.92
86_A255_G0.7080.92
233_T252_S0.7080.92
129_H134_M0.7010.91
152_G183_E0.6950.91
86_A259_T0.6930.91
216_L224_L0.6920.91
181_R193_D0.6890.91
234_G239_R0.6860.90
246_W268_P0.6830.90
242_A302_L0.6780.90
118_D154_I0.6770.90
181_R195_R0.6770.90
49_T300_V0.6770.90
181_R185_D0.6760.90
56_L59_K0.6730.90
238_I266_V0.6720.89
156_L162_P0.6690.89
172_I209_A0.6670.89
48_I52_K0.6660.89
102_K164_G0.6640.89
116_K119_L0.6630.89
145_R232_A0.6630.89
98_A165_F0.6630.89
172_I215_T0.6630.89
115_S131_D0.6570.88
143_A151_A0.6560.88
169_L206_D0.6540.88
56_L60_F0.6540.88
121_T127_E0.6540.88
87_Y91_Y0.6530.88
122_Y146_Y0.6520.88
122_Y125_I0.6470.88
134_M139_I0.6450.87
60_F296_E0.6440.87
165_F169_L0.6430.87
54_V58_K0.6420.87
225_T249_G0.6420.87
60_F280_S0.6410.87
163_K167_K0.6400.87
50_N77_I0.6400.87
101_K104_S0.6390.87
214_N221_R0.6380.87
68_A77_I0.6360.87
154_I158_Q0.6340.87
180_K193_D0.6320.86
297_A301_V0.6320.86
113_H131_D0.6310.86
87_Y179_A0.6310.86
43_N46_S0.6310.86
202_A206_D0.6300.86
142_A146_Y0.6280.86
259_T281_N0.6240.86
57_E64_L0.6230.86
216_L220_K0.6220.86
120_V150_T0.6190.85
139_I154_I0.6180.85
280_S294_I0.6170.85
241_G302_L0.6170.85
144_I228_M0.6170.85
254_A262_D0.6160.85
211_T273_P0.6120.85
103_N136_L0.6090.84
172_I206_D0.6090.84
73_S76_T0.6070.84
87_Y261_N0.6040.84
114_Y118_D0.6040.84
125_I134_M0.6030.84
67_Y200_A0.6010.84
45_A50_N0.5990.83
211_T267_W0.5990.83
262_D265_I0.5980.83
290_D294_I0.5970.83
96_A99_V0.5970.83
49_T301_V0.5960.83
126_T142_A0.5950.83
100_L108_L0.5950.83
69_I76_T0.5900.82
92_K253_G0.5880.82
70_D75_K0.5870.82
123_S126_T0.5870.82
124_P128_K0.5860.82
241_G295_A0.5860.82
149_N253_G0.5850.82
163_K244_I0.5840.82
51_K55_Q0.5830.82
121_T184_T0.5800.81
116_K127_E0.5760.81
137_K141_E0.5760.81
82_N176_V0.5750.81
190_I193_D0.5730.81
123_S184_T0.5710.80
189_A259_T0.5700.80
153_N252_S0.5690.80
153_N177_T0.5660.80
49_T68_A0.5640.80
252_S262_D0.5590.79
242_A266_V0.5580.79
185_D188_S0.5560.79
211_T275_V0.5540.78
50_N289_Y0.5500.78
233_T261_N0.5460.77
43_N48_I0.5450.77
89_S253_G0.5440.77
287_A291_N0.5400.77
168_S215_T0.5390.76
57_E297_A0.5370.76
125_I142_A0.5360.76
141_E146_Y0.5340.76
103_N217_T0.5340.76
90_T252_S0.5320.76
49_T53_F0.5320.76
51_K109_N0.5300.75
283_F290_D0.5260.75
280_S297_A0.5240.74
76_T79_Y0.5230.74
114_Y131_D0.5230.74
91_Y183_E0.5220.74
234_G252_S0.5220.74
291_N295_A0.5220.74
290_D293_L0.5200.74
160_G164_G0.5200.74
220_K224_L0.5200.74
177_T206_D0.5190.74
234_G250_D0.5180.74
93_V203_L0.5160.73
298_A301_V0.5150.73
280_S290_D0.5130.73
119_L124_P0.5100.72
48_I51_K0.5090.72
141_E227_W0.5090.72
71_I275_V0.5070.72
189_A281_N0.5070.72
183_E187_N0.5060.72
88_A259_T0.5050.72
180_K197_T0.5050.72
287_A290_D0.5050.72
229_R232_A0.5040.72
266_V302_L0.5030.71
226_D229_R0.5020.71
122_Y127_E0.5010.71
278_I301_V0.5010.71
134_M138_E0.5010.71
183_E255_G0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w7fA 1 0.8333 100 0.387 Contact Map
3qhyA 1 0.8431 100 0.406 Contact Map
3dw0A 1 0.8366 100 0.411 Contact Map
3p09A 3 0.8301 100 0.415 Contact Map
3ny4A 1 0.8464 100 0.417 Contact Map
4m3kA 1 0.8431 100 0.423 Contact Map
3lezA 2 0.8431 100 0.426 Contact Map
1bueA 1 0.8497 100 0.429 Contact Map
1hzoA 1 0.8497 100 0.429 Contact Map
4zj1A 1 0.8497 100 0.43 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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