GREMLIN Database
PSS - CDP-diacylglycerol--serine O-phosphatidyltransferase
UniProt: P39823 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 177 (164)
Sequences: 2481 (1511)
Seq/√Len: 118.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
102_G124_I7.2421.00
38_G70_T4.8491.00
8_I48_A3.7921.00
10_I62_L3.5251.00
19_A74_A3.3041.00
102_G154_M3.0061.00
149_G153_L2.6551.00
68_L103_M2.5251.00
57_D61_E2.4561.00
97_T151_S2.3461.00
12_N70_T2.2581.00
69_V73_V2.2371.00
40_F44_F2.0871.00
15_C34_F2.0671.00
14_I96_L2.0401.00
10_I100_I1.9921.00
98_Y127_A1.9891.00
17_L99_S1.9321.00
27_N30_S1.9311.00
13_F103_M1.9111.00
76_S99_S1.9071.00
72_G102_G1.8801.00
122_M126_F1.8611.00
15_C41_L1.8601.00
24_L77_M1.8401.00
12_N41_L1.8371.00
101_C155_V1.8321.00
127_A150_L1.8161.00
24_L81_S1.7871.00
23_L78_L1.7451.00
19_A23_L1.7401.00
13_F69_V1.7281.00
72_G124_I1.6991.00
12_N38_G1.6921.00
17_L96_L1.6901.00
20_I74_A1.6531.00
13_F66_A1.6341.00
61_E111_I1.5791.00
58_M104_L1.5431.00
127_A154_M1.5121.00
61_E110_N1.4651.00
64_S110_N1.4411.00
11_G41_L1.4321.00
28_I81_S1.4241.00
84_L91_G1.4161.00
65_F107_S1.4091.00
120_I157_K1.3881.00
122_M160_F1.3691.00
18_L22_S1.3631.00
57_D60_R1.3491.00
19_A78_L1.3231.00
33_L37_T1.2891.00
114_S120_I1.2871.00
47_M163_F1.2831.00
141_I145_I1.2811.00
17_L21_H1.2380.99
148_C152_Y1.2360.99
39_M129_M1.2320.99
101_C151_S1.2190.99
79_A147_T1.2130.99
131_L147_T1.2120.99
94_C148_C1.2100.99
4_I52_L1.1960.99
108_K156_S1.1800.99
83_A86_T1.1680.99
12_N16_G1.1550.99
8_I11_G1.1500.99
118_T159_K1.1220.99
20_I73_V1.0730.98
68_L124_I1.0690.98
23_L81_S1.0530.98
41_L70_T1.0440.98
94_C144_A1.0330.98
76_S95_A1.0320.98
87_L144_A1.0000.97
125_P128_G0.9670.97
5_P54_A0.9400.96
7_M11_G0.9290.96
98_Y102_G0.9280.96
4_I48_A0.9270.96
74_A78_L0.9250.96
32_V82_V0.9070.95
18_L92_I0.9060.95
130_C150_L0.9030.95
35_I132_V0.9010.95
65_F110_N0.9010.95
4_I54_A0.8920.95
10_I104_L0.8900.95
11_G15_C0.8890.95
43_F160_F0.8760.94
8_I47_M0.8760.94
20_I23_L0.8750.94
109_F118_T0.8740.94
79_A143_L0.8720.94
161_P165_K0.8570.93
15_C38_G0.8540.93
29_H33_L0.8490.93
21_H96_L0.8320.92
82_V135_S0.8280.92
20_I77_M0.8240.92
13_F70_T0.8160.92
116_L120_I0.8020.91
17_L95_A0.8010.91
25_Y29_H0.7950.91
114_S157_K0.7940.91
73_V99_S0.7920.90
66_A70_T0.7910.90
41_L125_P0.7900.90
97_T148_C0.7780.90
45_D67_D0.7720.89
15_C37_T0.7550.88
13_F68_L0.7550.88
47_M51_K0.7490.88
143_L147_T0.7460.88
81_S123_P0.7440.87
71_F125_P0.7390.87
85_Y138_Y0.7380.87
16_G74_A0.7340.87
22_S30_S0.7320.87
80_Y84_L0.7310.87
29_H32_V0.7210.86
48_A116_L0.7180.86
9_T107_S0.7170.85
19_A34_F0.7040.84
18_L21_H0.7020.84
97_T139_N0.6950.84
3_Y10_I0.6940.84
77_M96_L0.6930.83
134_L143_L0.6930.83
37_T41_L0.6880.83
130_C160_F0.6870.83
58_M111_I0.6870.83
151_S155_V0.6860.83
61_E65_F0.6840.83
11_G70_T0.6820.83
6_C62_L0.6720.82
86_T141_I0.6710.81
59_G67_D0.6670.81
16_G126_F0.6610.81
137_T140_P0.6540.80
33_L136_F0.6510.80
45_D59_G0.6500.79
25_Y145_I0.6480.79
64_S71_F0.6480.79
114_S117_P0.6440.79
50_R56_S0.6420.79
147_T151_S0.6410.78
9_T64_S0.6400.78
86_T152_Y0.6370.78
116_L165_K0.6370.78
32_V136_F0.6330.78
18_L146_G0.6320.77
28_I78_L0.6270.77
23_L31_A0.6250.77
7_M10_I0.6250.77
8_I41_L0.6240.77
58_M62_L0.6230.76
35_I78_L0.6200.76
65_F158_I0.6190.76
104_L111_I0.6190.76
25_Y141_I0.6190.76
5_P50_R0.6150.76
125_P131_L0.6150.76
14_I100_I0.6130.75
6_C103_M0.6130.75
98_Y131_L0.6120.75
42_D45_D0.6110.75
152_Y158_I0.6110.75
85_Y142_L0.6100.75
22_S27_N0.6060.75
91_G94_C0.6020.74
34_F37_T0.6020.74
6_C10_I0.5990.74
68_L157_K0.5990.74
12_N66_A0.5990.74
120_I134_L0.5990.74
56_S107_S0.5980.74
131_L150_L0.5930.73
28_I82_V0.5920.73
80_Y130_C0.5870.72
23_L77_M0.5850.72
31_A78_L0.5850.72
90_I148_C0.5820.72
60_R151_S0.5820.72
18_L34_F0.5800.71
87_L140_P0.5770.71
148_C151_S0.5760.71
142_L145_I0.5750.71
43_F161_P0.5740.71
89_F145_I0.5710.70
10_I58_M0.5690.70
98_Y151_S0.5670.70
57_D137_T0.5660.69
22_S141_I0.5650.69
61_E64_S0.5650.69
57_D115_K0.5640.69
8_I34_F0.5640.69
106_L121_G0.5620.69
14_I21_H0.5600.69
102_G127_A0.5590.68
69_V75_P0.5570.68
106_L109_F0.5500.67
63_D67_D0.5490.67
78_L135_S0.5480.67
61_E107_S0.5470.67
141_I144_A0.5420.66
100_I104_L0.5390.66
108_K124_I0.5390.66
65_F103_M0.5390.66
14_I18_L0.5370.65
130_C146_G0.5370.65
35_I74_A0.5360.65
86_T147_T0.5360.65
39_M60_R0.5360.65
45_D63_D0.5320.65
14_I17_L0.5300.64
23_L43_F0.5300.64
89_F138_Y0.5280.64
112_E120_I0.5280.64
64_S107_S0.5270.64
79_A82_V0.5250.64
76_S98_Y0.5240.64
22_S34_F0.5230.63
101_C104_L0.5220.63
16_G70_T0.5210.63
5_P52_L0.5210.63
12_N60_R0.5190.63
42_D67_D0.5180.63
93_L148_C0.5170.63
79_A131_L0.5170.63
133_I160_F0.5170.63
52_L62_L0.5170.63
11_G39_M0.5150.62
19_A31_A0.5150.62
15_C60_R0.5140.62
21_H77_M0.5120.62
21_H28_I0.5120.62
139_N143_L0.5120.62
6_C122_M0.5080.61
77_M81_S0.5050.61
149_G152_Y0.5040.61
145_I148_C0.5020.60
31_A132_V0.5020.60
6_C56_S0.5010.60
39_M114_S0.5010.60
69_V103_M0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mndA 2 0.9096 99.8 0.638 Contact Map
4o6mA 2 0.9322 99.7 0.658 Contact Map
3tx3A 2 0.8249 17.3 0.946 Contact Map
3wu2Z 1 0.2316 9.6 0.952 Contact Map
2kncB 1 0.322 8.7 0.953 Contact Map
2za4B 1 0.4859 3 0.962 Contact Map
2cx6A 1 0.4689 2.5 0.964 Contact Map
4w251 1 0.2938 2.1 0.965 Contact Map
1rh5A 1 0.2938 1.7 0.967 Contact Map
2y69J 1 0.0395 1.6 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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