GREMLIN Database
PSD - Phosphatidylserine decarboxylase proenzyme
UniProt: P39822 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 263 (247)
Sequences: 2230 (1584)
Seq/√Len: 100.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_G238_K4.0761.00
150_S218_E3.9321.00
61_G65_E3.9181.00
54_D70_Q3.4181.00
218_E221_E3.3551.00
154_Q189_N3.1141.00
89_V145_F2.8981.00
91_G135_L2.7831.00
43_S50_W2.3641.00
49_N52_D2.3361.00
126_Q237_E2.2911.00
190_S195_V2.1971.00
194_N237_E2.1721.00
152_R189_N2.1531.00
204_N228_F2.1381.00
200_V231_T2.1351.00
125_H128_N2.1171.00
212_N215_T2.1011.00
187_E196_L2.0981.00
144_R222_E2.0881.00
116_E176_D2.0611.00
89_V135_L2.0581.00
98_I131_Y1.9941.00
23_S27_K1.9921.00
56_T59_D1.9631.00
43_S57_A1.9571.00
85_V236_F1.9191.00
19_H23_S1.9161.00
71_I75_R1.9041.00
151_C188_L1.9011.00
79_S84_A1.8921.00
78_V86_V1.8831.00
55_G59_D1.8571.00
53_V71_I1.8551.00
62_S65_E1.8201.00
150_S191_G1.7931.00
55_G72_N1.7881.00
78_V219_I1.7651.00
54_D59_D1.7481.00
87_S253_V1.7461.00
159_L185_V1.7381.00
79_S86_V1.7371.00
79_S258_L1.6881.00
86_V219_I1.6801.00
126_Q194_N1.6641.00
210_Q214_R1.5971.00
84_A258_L1.5901.00
127_Y130_G1.5881.00
189_N194_N1.5731.00
71_I74_E1.5631.00
14_I18_N1.5581.00
195_V236_F1.5461.00
123_A155_K1.5321.00
101_P128_N1.5251.00
237_E240_A1.4791.00
54_D73_L1.4711.00
149_I195_V1.4281.00
145_F232_V1.4061.00
29_F61_G1.4001.00
119_G159_L1.3861.00
85_V149_I1.3820.99
123_A126_Q1.3800.99
211_T214_R1.3790.99
178_L200_V1.3710.99
117_L233_I1.3680.99
163_S206_N1.3590.99
53_V60_Y1.3340.99
14_I19_H1.3220.99
87_S259_I1.3170.99
158_E182_Y1.3100.99
81_E84_A1.3060.99
123_A187_E1.2980.99
15_E18_N1.2750.99
93_V253_V1.2740.99
236_F241_F1.2700.99
145_F224_G1.2580.99
34_I38_V1.2550.99
97_G132_F1.2470.99
248_A251_Q1.2360.99
241_F260_G1.2280.99
244_S258_L1.2220.99
85_V241_F1.2060.99
197_M223_L1.2050.99
142_Y146_H1.1970.99
89_V232_V1.1860.98
23_S29_F1.1780.98
156_L184_F1.1760.98
199_P223_L1.1710.98
152_R216_E1.1690.98
247_L251_Q1.1660.98
93_V133_V1.1630.98
190_S193_R1.1570.98
78_V220_G1.1540.98
158_E184_F1.1520.98
50_W53_V1.1510.98
118_T196_L1.1470.98
27_K227_S1.1440.98
133_V243_P1.1430.98
70_Q225_Y1.1410.98
14_I23_S1.1360.98
150_S221_E1.1310.98
171_L178_L1.1290.98
212_N216_E1.1220.98
113_S116_E1.1130.98
68_I225_Y1.1110.98
153_Y188_L1.1100.98
149_I192_S1.0970.97
18_N23_S1.0950.97
135_L234_L1.0920.97
70_Q222_E1.0800.97
110_K175_K1.0790.97
24_Y28_G1.0790.97
127_Y187_E1.0780.97
64_S227_S1.0750.97
197_M234_L1.0730.97
23_S31_E1.0730.97
71_I90_D1.0700.97
118_T235_V1.0640.97
115_A121_K1.0610.97
102_N114_F1.0600.97
254_Q257_E1.0530.97
157_A160_G1.0400.96
55_G60_Y1.0290.96
163_S182_Y1.0290.96
40_P44_K1.0270.96
151_C193_R1.0250.96
127_Y196_L1.0200.96
209_V227_S1.0170.96
153_Y186_Y1.0170.96
20_R24_Y1.0040.96
157_A185_V1.0010.96
147_S153_Y0.9950.95
148_P195_V0.9940.95
155_K187_E0.9880.95
30_C33_K0.9860.95
165_P168_Q0.9850.95
234_L259_I0.9790.95
89_V255_V0.9780.95
185_V198_I0.9730.95
145_F199_P0.9710.95
149_I188_L0.9690.95
22_S204_N0.9630.95
79_S82_A0.9610.94
185_V196_L0.9560.94
152_R214_R0.9560.94
92_V168_Q0.9550.94
48_L66_L0.9510.94
119_G157_A0.9460.94
100_N103_Q0.9400.94
64_S68_I0.9290.93
134_V231_T0.9270.93
81_E258_L0.9220.93
153_Y217_L0.9200.93
104_T111_D0.9110.93
136_Y202_A0.9110.93
92_V141_H0.9020.92
118_T187_E0.8960.92
147_S199_P0.8930.92
211_T215_T0.8920.92
151_C190_S0.8900.92
198_I235_V0.8870.92
27_K62_S0.8800.91
154_Q194_N0.8770.91
191_G216_E0.8730.91
156_L210_Q0.8610.91
31_E35_S0.8590.90
103_Q111_D0.8580.90
35_S39_I0.8580.90
15_E23_S0.8570.90
147_S223_L0.8550.90
19_H22_S0.8540.90
14_I22_S0.8490.90
65_E68_I0.8480.90
71_I76_R0.8470.90
16_L19_H0.8460.90
37_P41_L0.8450.90
195_V237_E0.8430.90
54_D60_Y0.8420.90
60_Y70_Q0.8420.90
186_Y199_P0.8410.89
79_S219_I0.8350.89
209_V212_N0.8320.89
87_S135_L0.8300.89
36_K58_A0.8200.88
130_G238_K0.8110.88
15_E19_H0.8080.88
126_Q187_E0.8040.87
181_N202_A0.8040.87
210_Q215_T0.8030.87
93_V96_V0.8020.87
114_F235_V0.8020.87
157_A187_E0.7990.87
80_K86_V0.7960.87
39_I66_L0.7940.87
78_V258_L0.7920.86
135_L253_V0.7920.86
160_G182_Y0.7900.86
117_L198_I0.7800.86
29_F33_K0.7710.85
105_F114_F0.7680.85
147_S188_L0.7660.85
30_C39_I0.7650.85
174_G177_V0.7590.84
26_I204_N0.7570.84
28_G32_S0.7560.84
23_S204_N0.7560.84
138_S141_H0.7490.83
23_S26_I0.7420.83
166_V202_A0.7350.82
19_H29_F0.7330.82
222_E225_Y0.7310.82
23_S203_M0.7290.82
201_G207_S0.7290.82
197_M232_V0.7270.81
246_H250_G0.7240.81
145_F197_M0.7230.81
211_T216_E0.7170.80
120_C157_A0.7170.80
18_N29_F0.7140.80
178_L231_T0.7130.80
107_V177_V0.7120.80
15_E162_R0.7110.80
115_A128_N0.7080.80
156_L186_Y0.7070.80
119_G185_V0.7060.79
29_F62_S0.7050.79
96_V251_Q0.7030.79
193_R240_A0.7030.79
42_F46_F0.7020.79
98_I129_G0.7000.79
21_L24_Y0.7000.79
74_E255_V0.6950.78
253_V259_I0.6940.78
106_T177_V0.6900.78
68_I227_S0.6890.78
131_Y243_P0.6890.78
211_T225_Y0.6890.78
35_S243_P0.6850.77
63_L159_L0.6810.77
188_L197_M0.6770.77
14_I29_F0.6760.76
94_Q107_V0.6710.76
244_S260_G0.6700.76
116_E180_K0.6690.76
21_L25_L0.6690.76
32_S35_S0.6680.76
141_H166_V0.6680.76
99_I130_G0.6670.76
242_Q245_A0.6660.75
192_S237_E0.6660.75
139_P166_V0.6660.75
110_K176_D0.6650.75
130_G151_C0.6650.75
54_D72_N0.6650.75
164_Y203_M0.6590.75
122_S125_H0.6560.74
144_R225_Y0.6550.74
28_G31_E0.6540.74
120_C124_D0.6540.74
23_S33_K0.6490.74
193_R237_E0.6450.73
217_L223_L0.6410.73
77_P255_V0.6400.72
65_E98_I0.6390.72
165_P170_G0.6350.72
19_H27_K0.6320.72
153_Y156_L0.6300.71
162_R180_K0.6260.71
15_E203_M0.6250.71
136_Y139_P0.6250.71
41_L44_K0.6230.70
184_F207_S0.6210.70
27_K31_E0.6210.70
208_I233_I0.6210.70
38_V41_L0.6200.70
107_V134_V0.6190.70
82_A191_G0.6190.70
209_V216_E0.6170.70
70_Q144_R0.6140.69
18_N27_K0.6100.69
42_F63_L0.6100.69
145_F185_V0.6090.69
163_S201_G0.6070.68
243_P247_L0.6030.68
217_L221_E0.6020.68
80_K84_A0.6020.68
188_L195_V0.5990.67
23_S228_F0.5960.67
100_N121_K0.5940.67
145_F208_I0.5940.67
136_Y170_G0.5930.67
184_F199_P0.5920.67
247_L259_I0.5910.66
107_V233_I0.5890.66
24_Y30_C0.5860.66
92_V171_L0.5830.65
235_V247_L0.5820.65
245_A249_E0.5820.65
148_P236_F0.5810.65
80_K83_H0.5810.65
120_C123_A0.5780.65
168_Q203_M0.5760.64
26_I228_F0.5760.64
94_Q165_P0.5730.64
196_L235_V0.5730.64
105_F260_G0.5730.64
87_S167_N0.5710.64
84_A219_I0.5700.64
39_I48_L0.5700.64
25_L103_Q0.5680.63
92_V105_F0.5660.63
22_S208_I0.5650.63
206_N224_G0.5640.63
82_A192_S0.5630.63
52_D75_R0.5630.63
96_V243_P0.5630.63
20_R23_S0.5620.63
127_Y151_C0.5620.63
18_N22_S0.5590.62
93_V259_I0.5590.62
139_P146_H0.5590.62
116_E179_S0.5580.62
88_P232_V0.5560.62
93_V135_L0.5560.62
47_R140_R0.5540.61
117_L132_F0.5530.61
22_S27_K0.5520.61
78_V255_V0.5510.61
15_E206_N0.5510.61
99_I235_V0.5500.61
125_H249_E0.5470.61
105_F117_L0.5460.60
74_E77_P0.5440.60
24_Y27_K0.5420.60
209_V225_Y0.5420.60
26_I38_V0.5390.59
161_N206_N0.5370.59
139_P177_V0.5360.59
96_V249_E0.5360.59
167_N203_M0.5290.58
226_F230_S0.5290.58
147_S217_L0.5270.58
76_R90_D0.5260.58
109_G167_N0.5260.58
181_N208_I0.5260.58
100_N111_D0.5250.57
66_L201_G0.5250.57
133_V198_I0.5240.57
210_Q216_E0.5240.57
210_Q223_L0.5230.57
244_S248_A0.5230.57
50_W60_Y0.5220.57
25_L28_G0.5210.57
95_T136_Y0.5210.57
67_F137_L0.5210.57
56_T248_A0.5200.57
16_L22_S0.5170.56
62_S192_S0.5170.56
29_F32_S0.5150.56
150_S216_E0.5150.56
244_S251_Q0.5130.56
166_V205_I0.5120.56
210_Q213_T0.5120.56
115_A120_C0.5100.55
170_G228_F0.5090.55
123_A129_G0.5070.55
47_R100_N0.5040.54
91_G141_H0.5020.54
245_A248_A0.5010.54
166_V181_N0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gprA 1 0.5361 95.7 0.925 Contact Map
1f3zA 2 0.5133 94.3 0.931 Contact Map
3ourB 1 0.5133 92.4 0.936 Contact Map
2d5dA 1 0.2624 84.4 0.945 Contact Map
2xhaA 1 0.5019 79.3 0.948 Contact Map
1ax3A 1 0.4905 77.2 0.949 Contact Map
1dczA 1 0.2928 70 0.951 Contact Map
2kccA 1 0.3194 63.8 0.953 Contact Map
1z6hA 1 0.2738 60.8 0.954 Contact Map
2jkuA 1 0.1331 52.9 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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