GREMLIN Database
PROA - Gamma-glutamyl phosphate reductase
UniProt: P39821 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 415 (382)
Sequences: 38355 (22680)
Seq/√Len: 1160.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
265_K322_E4.8061.00
268_A320_T3.1671.00
265_K320_T3.0731.00
238_Q274_E3.0141.00
233_E266_A2.7771.00
12_K195_G2.7771.00
156_A159_S2.7461.00
344_T350_A2.7201.00
242_K278_Q2.7141.00
233_E264_H2.6951.00
40_E43_F2.6461.00
298_S305_E2.4991.00
272_G318_V2.4321.00
33_I161_I2.2991.00
162_Y172_I2.2961.00
38_R83_E2.2551.00
352_Y356_A2.2391.00
335_G381_E2.2111.00
297_P301_Q2.2081.00
36_G167_Q2.2041.00
191_T214_E2.2001.00
324_V349_N2.1441.00
12_K197_D2.1241.00
43_F156_A2.1081.00
41_L76_R2.0641.00
187_K191_T2.0501.00
229_I244_V2.0451.00
293_C297_P2.0411.00
112_V404_K2.0371.00
36_G39_K2.0041.00
111_R398_P1.9991.00
276_L280_E1.9981.00
209_D381_E1.9771.00
31_S83_E1.9571.00
270_Q274_E1.9381.00
234_T349_N1.9091.00
307_W319_K1.8851.00
322_E326_E1.8491.00
9_K195_G1.8411.00
5_S188_E1.8371.00
210_L213_R1.8301.00
262_L330_H1.7911.00
22_T25_E1.7901.00
232_D349_N1.7871.00
29_A170_L1.7721.00
32_L35_N1.7301.00
111_R401_T1.7301.00
36_G160_V1.7231.00
158_V177_L1.7221.00
274_E277_D1.7141.00
302_A330_H1.7011.00
47_E156_A1.6741.00
42_D72_E1.6641.00
5_S9_K1.6521.00
243_V343_L1.6501.00
249_T279_L1.6491.00
358_D380_A1.6461.00
324_V352_Y1.6461.00
241_E274_E1.6271.00
20_M356_A1.6261.00
294_E305_E1.6221.00
187_K214_E1.6211.00
25_E28_E1.6121.00
326_E329_K1.6101.00
273_K277_D1.6071.00
264_H321_V1.5991.00
268_A272_G1.5991.00
35_N39_K1.5951.00
229_I258_I1.5731.00
110_I355_T1.5731.00
340_E359_A1.5711.00
278_Q281_N1.5611.00
40_E167_Q1.5571.00
305_E309_T1.5431.00
21_K25_E1.5231.00
262_L321_V1.5131.00
15_A19_I1.5041.00
237_P274_E1.4991.00
326_E330_H1.4781.00
264_H323_N1.4771.00
42_D46_A1.4681.00
46_A50_K1.4661.00
38_R79_A1.4501.00
141_A174_A1.4501.00
40_E156_A1.4461.00
233_E349_N1.4331.00
5_S193_N1.4321.00
187_K210_L1.4161.00
198_V220_L1.4131.00
262_L327_A1.4091.00
294_E298_S1.4021.00
261_L316_L1.4001.00
148_S183_R1.3981.00
267_W270_Q1.3811.00
354_Q406_I1.3781.00
244_V271_H1.3771.00
82_V130_D1.3771.00
269_R320_T1.3631.00
88_L91_P1.3631.00
270_Q273_K1.3621.00
212_V384_I1.3581.00
210_L214_E1.3511.00
41_L72_E1.3501.00
325_Q352_Y1.3461.00
263_I271_H1.3401.00
244_V261_L1.3401.00
325_Q356_A1.3331.00
274_E278_Q1.3311.00
277_D281_N1.3251.00
181_T184_E1.3201.00
297_P300_K1.3191.00
295_L299_S1.3111.00
129_V144_L1.3111.00
295_L311_F1.3061.00
34_A38_R1.3031.00
303_S308_E1.3011.00
36_G168_S1.2971.00
230_F327_A1.2971.00
119_M142_V1.2961.00
245_V278_Q1.2931.00
395_M398_P1.2881.00
232_D321_V1.2881.00
46_A288_G1.2851.00
277_D280_E1.2781.00
272_G276_L1.2751.00
232_D353_F1.2731.00
321_V330_H1.2721.00
82_V134_L1.2711.00
350_A364_H1.2681.00
50_K152_H1.2661.00
155_K179_E1.2651.00
394_P398_P1.2641.00
269_R273_K1.2621.00
114_L198_V1.2501.00
10_L173_H1.2341.00
15_A141_A1.2331.00
9_K13_E1.2231.00
290_E294_E1.2201.00
21_K29_A1.2141.00
31_S87_D1.2091.00
111_R403_T1.2031.00
32_L36_G1.1981.00
158_V175_V1.1961.00
328_V353_F1.1941.00
8_A196_L1.1931.00
271_H275_L1.1931.00
323_N326_E1.1931.00
108_E351_V1.1871.00
3_E6_V1.1831.00
173_H176_Q1.1791.00
264_H267_W1.1731.00
10_L176_Q1.1721.00
302_A333_Q1.1711.00
159_S167_Q1.1711.00
206_K210_L1.1601.00
340_E362_V1.1601.00
46_A56_K1.1581.00
8_A195_G1.1481.00
108_E408_K1.1361.00
23_T27_D1.1351.00
275_L316_L1.1341.00
212_V219_V1.1271.00
49_A287_R1.1261.00
4_V185_T1.1231.00
295_L298_S1.1211.00
44_L156_A1.1191.00
325_Q329_K1.1171.00
234_T346_N1.1151.00
8_A193_N1.1111.00
236_K345_E1.1071.00
395_M403_T1.1061.00
35_N83_E1.0971.00
239_M345_E1.0941.00
209_D213_R1.0931.00
286_I289_D1.0931.00
95_S394_P1.0911.00
207_L210_L1.0891.00
118_G196_L1.0861.00
324_V353_F1.0841.00
33_I160_V1.0771.00
229_I343_L1.0721.00
161_I175_V1.0721.00
290_E293_C1.0701.00
236_K239_M1.0601.00
38_R76_R1.0591.00
78_I130_D1.0571.00
118_G189_L1.0571.00
40_E160_V1.0561.00
56_K72_E1.0551.00
117_V198_V1.0501.00
36_G40_E1.0481.00
346_N349_N1.0471.00
119_M200_I1.0471.00
239_M243_V1.0461.00
114_L218_P1.0451.00
38_R41_L1.0421.00
28_E32_L1.0401.00
158_V162_Y1.0351.00
6_V10_L1.0351.00
328_V356_A1.0311.00
230_F353_F1.0271.00
351_V355_T1.0271.00
321_V327_A1.0211.00
377_G386_T1.0211.00
329_K333_Q1.0201.00
16_A329_K1.0201.00
308_E335_G1.0201.00
12_K16_A1.0171.00
43_F46_A1.0171.00
237_P241_E1.0151.00
133_T175_V1.0141.00
31_S35_N1.0131.00
155_K159_S1.0131.00
308_E333_Q1.0111.00
27_D31_S1.0071.00
292_V313_A1.0041.00
14_A141_A1.0021.00
379_G402_S1.0011.00
110_I406_I1.0001.00
116_V141_A0.9991.00
33_I82_V0.9961.00
308_E334_Y0.9931.00
230_F331_I0.9931.00
44_L160_V0.9911.00
226_N259_E0.9911.00
386_T402_S0.9871.00
33_I170_L0.9841.00
133_T142_V0.9811.00
40_E159_S0.9741.00
124_R254_V0.9741.00
16_A358_D0.9661.00
148_S181_T0.9651.00
247_A258_I0.9621.00
20_M355_T0.9571.00
212_V216_T0.9551.00
347_D351_V0.9531.00
18_M174_A0.9441.00
11_A176_Q0.9401.00
43_F159_S0.9361.00
50_K288_G0.9321.00
341_A367_S0.9321.00
52_I150_A0.9321.00
186_A190_F0.9281.00
107_I374_F0.9251.00
31_S86_I0.9251.00
291_L294_E0.9191.00
232_D264_H0.9151.00
159_S162_Y0.9111.00
248_K259_E0.9091.00
4_V118_G0.9071.00
328_V332_Q0.9001.00
34_A79_A0.8981.00
228_H340_E0.8971.00
11_A141_A0.8951.00
183_R187_K0.8931.00
6_V9_K0.8901.00
138_T401_T0.8901.00
238_Q270_Q0.8891.00
298_S301_Q0.8881.00
112_V355_T0.8861.00
112_V379_G0.8851.00
340_E357_V0.8781.00
197_D358_D0.8771.00
95_S395_M0.8771.00
319_K330_H0.8751.00
19_I358_D0.8741.00
232_D344_T0.8741.00
291_L295_L0.8731.00
16_A20_M0.8731.00
347_D350_A0.8721.00
351_V408_K0.8721.00
78_I126_N0.8701.00
241_E278_Q0.8681.00
155_K177_L0.8671.00
116_V196_L0.8671.00
374_F405_Y0.8631.00
39_K167_Q0.8621.00
135_C142_V0.8621.00
208_I221_E0.8581.00
232_D324_V0.8521.00
212_V215_S0.8481.00
130_D157_L0.8461.00
188_E193_N0.8431.00
199_L215_S0.8421.00
269_R272_G0.8401.00
114_L402_S0.8381.00
146_G179_E0.8371.00
49_A71_D0.8371.00
237_P267_W0.8361.00
359_A362_V0.8341.00
213_R216_T0.8291.00
170_L174_A0.8281.00
29_A168_S0.8261.00
106_F351_V0.8251.00
218_P402_S0.8251.00
34_A83_E0.8231.00
144_L154_N0.8211.00
292_V315_V0.8171.00
234_T344_T0.8171.00
190_F211_V0.8131.00
295_L300_K0.8121.00
245_V282_A0.8091.00
293_C296_H0.8071.00
302_A319_K0.8071.00
129_V154_N0.8071.00
342_I353_F0.8071.00
205_K381_E0.8061.00
208_I223_G0.8041.00
49_A56_K0.8031.00
268_A318_V0.8001.00
273_K276_L0.7971.00
188_E191_T0.7971.00
72_E76_R0.7951.00
205_K209_D0.7941.00
293_C300_K0.7921.00
54_N58_N0.7911.00
12_K15_A0.7911.00
32_L168_S0.7911.00
13_E17_E0.7901.00
14_A174_A0.7901.00
240_A244_V0.7891.00
107_I405_Y0.7851.00
228_H331_I0.7781.00
41_L45_L0.7761.00
321_V326_E0.7761.00
114_L140_N0.7731.00
47_E152_H0.7721.00
234_T345_E0.7721.00
162_Y173_H0.7701.00
201_P207_L0.7681.00
295_L305_E0.7681.00
227_C259_E0.7671.00
239_M242_K0.7651.00
56_K288_G0.7591.00
347_D408_K0.7581.00
119_M132_A0.7581.00
190_F214_E0.7581.00
231_I240_A0.7561.00
13_E16_A0.7561.00
118_G199_L0.7561.00
17_E21_K0.7551.00
76_R80_D0.7521.00
327_A330_H0.7481.00
345_E348_K0.7431.00
30_L137_K0.7421.00
43_F47_E0.7421.00
238_Q278_Q0.7421.00
204_G207_L0.7411.00
190_F199_L0.7411.00
126_N153_S0.7401.00
89_A137_K0.7401.00
285_E289_D0.7401.00
129_V133_T0.7391.00
121_Y129_V0.7381.00
264_H324_V0.7361.00
254_V257_A0.7351.00
16_A19_I0.7341.00
45_L72_E0.7331.00
294_E297_P0.7321.00
35_N38_R0.7311.00
215_S219_V0.7301.00
45_L49_A0.7281.00
114_L197_D0.7251.00
5_S195_G0.7241.00
118_G186_A0.7241.00
129_V157_L0.7221.00
31_S90_D0.7201.00
276_L279_L0.7191.00
241_E275_L0.7191.00
241_E271_H0.7181.00
181_T185_T0.7161.00
156_A160_V0.7161.00
18_M29_A0.7121.00
107_I407_I0.7111.00
231_I271_H0.7101.00
238_Q242_K0.7101.00
354_Q364_H0.7091.00
24_A28_E0.7091.00
262_L307_W0.7091.00
17_E20_M0.7081.00
46_A49_A0.7061.00
37_L78_I0.7051.00
212_V221_E0.7051.00
279_L282_A0.7041.00
48_N51_D0.7011.00
144_L175_V0.6991.00
110_I404_K0.6981.00
324_V356_A0.6981.00
45_L56_K0.6971.00
25_E29_A0.6971.00
54_N74_R0.6971.00
229_I341_A0.6971.00
302_A307_W0.6961.00
34_A76_R0.6961.00
263_I267_W0.6961.00
7_K178_I0.6931.00
8_A143_V0.6921.00
184_E187_K0.6921.00
199_L211_V0.6911.00
330_H333_Q0.6911.00
109_K403_T0.6881.00
324_V328_V0.6881.00
237_P270_Q0.6861.00
182_S185_T0.6841.00
162_Y167_Q0.6841.00
19_I356_A0.6831.00
4_V188_E0.6831.00
16_A356_A0.6831.00
183_R210_L0.6831.00
7_K176_Q0.6811.00
218_P399_A0.6811.00
328_V352_Y0.6791.00
220_L399_A0.6771.00
287_R315_V0.6761.00
245_V275_L0.6741.00
244_V275_L0.6731.00
341_A368_T0.6721.00
23_T137_K0.6711.00
240_A271_H0.6681.00
14_A17_E0.6621.00
237_P271_H0.6581.00
76_R79_A0.6581.00
348_K351_V0.6581.00
18_M136_L0.6581.00
398_P403_T0.6571.00
32_L167_Q0.6561.00
19_I113_P0.6531.00
241_E245_V0.6521.00
350_A354_Q0.6491.00
358_D379_G0.6461.00
48_N153_S0.6451.00
161_I170_L0.6401.00
140_N401_T0.6391.00
379_G386_T0.6391.00
108_E406_I0.6391.00
19_I112_V0.6371.00
248_K316_L0.6361.00
265_K268_A0.6341.00
77_D81_A0.6321.00
4_V8_A0.6291.00
302_A329_K0.6291.00
344_T349_N0.6281.00
339_S363_Y0.6281.00
132_A200_I0.6281.00
238_Q277_D0.6271.00
398_P401_T0.6271.00
27_D137_K0.6271.00
16_A332_Q0.6251.00
105_L366_A0.6241.00
296_H315_V0.6231.00
28_E31_S0.6231.00
295_L309_T0.6201.00
363_Y366_A0.6201.00
311_F315_V0.6191.00
146_G154_N0.6181.00
10_L172_I0.6141.00
34_A86_I0.6121.00
10_L13_E0.6101.00
348_K352_Y0.6091.00
262_L302_A0.6061.00
133_T144_L0.6061.00
132_A387_Q0.6061.00
126_N157_L0.6011.00
152_H155_K0.6001.00
247_A367_S0.5991.00
9_K12_K0.5961.00
92_I401_T0.5941.00
219_V384_I0.5931.00
148_S210_L0.5911.00
231_I235_A0.5901.00
29_A169_A0.5881.00
261_L271_H0.5861.00
242_K246_N0.5861.00
331_I357_V0.5851.00
342_I364_H0.5841.00
183_R206_K0.5841.00
37_L79_A0.5831.00
117_V140_N0.5821.00
47_E50_K0.5821.00
138_T397_L0.5821.00
307_W317_S0.5821.00
143_V176_Q0.5811.00
190_F210_L0.5801.00
11_A116_V0.5801.00
184_E188_E0.5791.00
353_F357_V0.5781.00
170_L175_V0.5781.00
361_A370_F0.5771.00
364_H408_K0.5761.00
11_A143_V0.5751.00
127_V131_A0.5751.00
327_A331_I0.5751.00
116_V197_D0.5751.00
342_I350_A0.5731.00
275_L279_L0.5711.00
75_I79_A0.5701.00
54_N124_R0.5701.00
44_L126_N0.5691.00
263_I318_V0.5671.00
157_L161_I0.5651.00
49_A53_V0.5641.00
189_L196_L0.5641.00
36_G169_A0.5621.00
112_V358_D0.5621.00
136_L175_V0.5611.00
75_I78_I0.5601.00
10_L14_A0.5591.00
261_L318_V0.5591.00
305_E308_E0.5581.00
148_S206_K0.5561.00
200_I400_L0.5551.00
323_N329_K0.5551.00
275_L318_V0.5551.00
249_T282_A0.5551.00
131_A392_R0.5531.00
198_V399_A0.5521.00
206_K209_D0.5481.00
87_D90_D0.5461.00
328_V357_V0.5461.00
71_D74_R0.5451.00
12_K116_V0.5451.00
296_H300_K0.5441.00
239_M343_L0.5441.00
182_S186_A0.5411.00
33_I36_G0.5401.00
148_S182_S0.5401.00
194_D335_G0.5391.00
27_D86_I0.5381.00
121_Y128_T0.5381.00
349_N352_Y0.5381.00
37_L157_L0.5371.00
27_D90_D0.5371.00
229_I261_L0.5371.00
130_D134_L0.5361.00
237_P240_A0.5361.00
52_I250_Q0.5361.00
250_Q254_V0.5361.00
362_V404_K0.5361.00
233_E267_W0.5361.00
205_K335_G0.5341.00
292_V299_S0.5331.00
42_D56_K0.5321.00
306_D311_F0.5321.00
358_D402_S0.5321.00
366_A369_R0.5321.00
302_A308_E0.5301.00
37_L44_L0.5301.00
23_T86_I0.5291.00
49_A288_G0.5291.00
92_I397_L0.5271.00
351_V354_Q0.5271.00
48_N126_N0.5251.00
235_A240_A0.5231.00
252_P314_P0.5211.00
31_S34_A0.5211.00
48_N52_I0.5201.00
296_H299_S0.5191.00
141_A176_Q0.5191.00
120_I211_V0.5181.00
117_V142_V0.5171.00
48_N74_R0.5171.00
255_C310_E0.5161.00
82_V133_T0.5151.00
45_L75_I0.5141.00
88_L394_P0.5131.00
37_L126_N0.5111.00
227_C339_S0.5101.00
150_A154_N0.5081.00
340_E353_F0.5061.00
384_I402_S0.5031.00
258_I341_A0.5021.00
105_L407_I0.5001.00
247_A257_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ek1A 5 0.9398 100 0.121 Contact Map
3u4jA 4 0.9446 100 0.123 Contact Map
4pz2A 4 0.9446 100 0.124 Contact Map
4lihA 5 0.9349 100 0.124 Contact Map
1a4sA 4 0.9422 100 0.125 Contact Map
3r31A 4 0.9253 100 0.125 Contact Map
4yweA 5 0.9325 100 0.125 Contact Map
2d4eA 4 0.9446 100 0.125 Contact Map
2o2pA 5 0.9398 100 0.126 Contact Map
4o5hA 4 0.9422 100 0.126 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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